Workshop overview: Arsenic research and risk assessment

Toxicology and Applied Pharmacology

Volumn 222, Issue 3, 2007, Pages 245-251

  Sams II, Reeder ^a   Wolf, Douglas C ^b   Ramasamy, Santhini ^c   Ohanian, Ed ^c   Chen, Jonathan ^d   Lowit, Anna ^d  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c National Institute of Arthritis Musculoskeletal and Skin Diseases   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Arsenic; Cancer guidelines; Mode of action; Risk assessment

Indexed keywords

ARSENIC; CACODYLIC ACID; CARCINOGEN; DRINKING WATER; METHANEARSONIC ACID; ORGANOARSENIC DERIVATIVE; PESTICIDE;

ARSENIC POISONING; ARTICLE; BLADDER TUMOR; CANCER; CANCER RISK; CARCINOGENICITY; ECONOMIC ASPECT; ENVIRONMENTAL EXPOSURE; HEALTH CARE POLICY; HEALTH HAZARD; HUMAN; HYPERPLASIA; LONG TERM EXPOSURE; METABOLITE; NONHUMAN; POPULATION RESEARCH; PRACTICE GUIDELINE; RISK ASSESSMENT; SAFETY; STATISTICAL MODEL; TRANSITIONAL CELL CARCINOMA; UROGENITAL TRACT DISEASE; WATER CONTAMINATION;

ARSENIC; ARSENIC POISONING; ARSENICALS; HUMANS; NEOPLASMS; RISK ASSESSMENT; WATER SUPPLY;

EID: 34547690687     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.01.007     Document Type: Article

References (56)

1. Andrewes P., Demarini D.M., Funasaka K., Wallace K., Lai V.W., Sun H., Cullen W.R., and Kitchin K.T. Do arsenosugars pose a risk to human health? The comparative toxicities of a trivalent and pentavalent arsenosugar. Environ. Sci. Technol. 38 (2004) 4140-4148
2. Arnold L.L., Cano M., St John M., Eldan M., van Gemert M., and Cohen S.M. Effects of dietary dimethylarsinic acid on the urine and urothelium of rats. Carcinogenesis 20 (1999) 2171-2179
3. Arnold L.L., Cano M., Cohen S.M., Le X.C., and Lu X. Effects of the dose of dimethylarsinic acid (DMA) on the urinary concentration of dimethylarsinous acid (DMAIII). Toxicologist 72 (2003) 232
4. Bates M.N., Smith A.H., and Cantor K.P. Case-control study of bladder cancer and arsenic in drinking water. Am. J. Epidemiol. 141 (1995) 523-530
5. Bates M.N., Rey O.A., Biggs M.L., Hopenhayn C., Moore L.E., Kalman D., Steinmaus C., and Smith A.H. Case-control study of bladder cancer and exposure to arsenic in Argentina. Am. J. Epidemiol. 159 (2004) 381-389
6. Bogdanffy M.S., Daston G., Faustman E.M., Kimmel C.A., Kimmel G.L., Seed J., and Vu V. Harmonization of cancer and noncancer risk assessment: proceedings of a consensus-building workshop. Toxicol. Sci. 61 (2001) 18-31
7. Buchet J.P., Lauwerys R., and Roels H. Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsinate in man. Int. Arch. Occup. Environ. Health 48 (1981) 71-79
8. Chen C.J., Kuo T.L., and Wu M.M. Arsenic and cancers. Lancet 1 (1988) 414-415
9. Chen C.J., Chen C.W., Wu M.M., and Kuo T.L. Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. Br. J. Cancer 66 (1992) 888-892
10. Cohen S.M. Toxic and nontoxic changes induced in the urothelium by xenobiotics. Toxicol. Appl. Pharmacol. 101 (1989) 484-498
11. Cohen S.M. Urinary bladder carcinogenesis. Toxicol. Pathol. 26 (1998) 121-127
12. Cohen S.M., Anderson T.A., de Oliveira L.M., and Arnold L.L. Tumorigenicity of sodium ascorbate in male rats. Cancer Res. 58 (1998) 2557-2561
13. Cohen S.M., Yamamoto S., Cano M., and Arnold L.L. Urothelial cytotoxicity and regeneration induced by dimethylarsinic acid in rats. Toxicol. Sci. 59 (2001) 68-74
14. Cohen S.M., Arnold L.L., Uzvolgyi E., Cano M., St John M., Yamamoto S., Lu X., and Le X.C. Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat. Chem. Res. Toxicol. 15 (2002) 1150-1157
15. Cohen S.M., Arnold L.L., Eldan M., Lewis A.S., and Beck B.D. Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment. Crit. Rev. Toxicol. 36 (2006) 99-133
16. Cui X., Wakai T., Shirai Y., Hatakeyama K., and Hirano S. Chronic oral exposure to inorganic arsenate interferes with methylation status of p16INK4a and RASSF1A and induces lung cancer in A/J mice. Toxicol. Sci. 91 (2006) 372-381
17. Devesa V., Adair B.M., Liu J., Waalkes M.P., Diwan B.A., Styblo M., and Thomas D.J. Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite. Toxicology 224 (2006) 147-155
18. Dopp E., Hartmann L.M., Florea A.M., von Recklinghausen U., Pieper R., Shokouhi B., Rettenmeier A.W., Hirner A.V., and Obe G. Uptake of inorganic and organic derivatives of arsenic associated with induced cytotoxic and genotoxic effects in Chinese hamster ovary (CHO) cells. Toxicol. Appl. Pharmacol. 201 (2004) 156-165
19. Drobna Z., Waters S.B., Walton F.S., LeCluyse E.L., Thomas D.J., and Styblo M. Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes. Toxicol. Appl. Pharmacol. 201 (2004) 166-177
20. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Some drinking-water disinfectants and contaminants, including arsenic vol. 84 (2004), IARC Press, Lyon
21. Kayajanian G. Arsenic, cancer, and thoughtless policy. Ecotoxicol. Environ. Saf. 55 (2003) 139-142
22. Kitchin K.T. Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Toxicol. Appl. Pharmacol. 172 (2001) 249-261
23. Lamm S.H., Byrd D.M., Kruse M.B., Feinleib M., and Lai S.H. Bladder cancer and arsenic exposure: differences in the two populations enrolled in a study in southwest Taiwan. Biomed. Environ. Sci. 16 (2003) 355-368
24. Lamm S.H., Engel A., Kruse M.B., Feinleib M., Byrd D.M., Lai S., and Wilson R. Arsenic in drinking water and bladder cancer mortality in the United States: an analysis based on 133 U.S. counties and 30 years of observation. J. Occup. Environ. Med. 46 (2004) 298-306
25. Lamm S.H., Engel A., Penn C.A., Chen R., and Feinleib M. Arsenic cancer risk confounder in southwest Taiwan data set. Environ. Health Perspect. 114 (2006) 1077-1082
26. Le X.C., Lu X., Ma M., Cullen W.R., Aposhian H.V., and Zheng B. Speciation of key arsenic metabolic intermediates in human urine. Anal. Chem. 72 (2000) 5172-5177
27. Lerman S.A., Clarkson T.W., and Gerson R.J. Arsenic uptake and metabolism by liver cells is dependent on arsenic oxidation state. Chem.-Biol. Interact. 45 (1983) 401-406
28. Lewis D.R., Southwick J.W., Ouellet-Hellstrom R., Rench J., and Calderon R.L. Drinking water arsenic in Utah: a cohort mortality study. Environ. Health Perspect. 107 (1999) 359-365
29. Lutz W.K. A true threshold dose in chemical carcinogenesis cannot be defined for a population, irrespective of the mode of action. Human Exp. Toxicol. 19 (2000) 566-568 (discussion 571-562)
30. Lutz W.K. Susceptibility differences in chemical carcinogenesis linearize the dose-response relationship: threshold doses can be defined only for individuals. Mutat. Res. 482 (2001) 71-76
31. Marafante E., Vahter M., Norin H., Envall J., Sandstrom M., Christakopoulos A., and Ryhage R. Biotransformation of dimethylarsinic acid in mouse, hamster and man. J. Appl. Toxicol. 7 (1987) 111-117
32. Meek M.E., Bucher J.R., Cohen S.M., Dellarco V., Hill R.N., Lehman-McKeeman L.D., Longfellow D.G., Pastoor T., Seed J., and Patton D.E. A framework for human relevance analysis of information on carcinogenic modes of action. Crit. Rev. Toxicol. 33 (2003) 591-653
33. Michaud D.S., Wright M.E., Cantor K.P., Taylor P.R., Virtamo J., and Albanes D. Arsenic concentrations in prediagnostic toenails and the risk of bladder cancer in a cohort study of male smokers. Am. J. Epidemiol. 160 (2004) 853-859
34. Milton A.H., Smith W., Rahman B., Hasan Z., Kulsum U., Dear K., Rakibuddin M., and Ali A. Chronic arsenic exposure and adverse pregnancy outcomes in Bangladesh. Epidemiology 16 (2005) 82-86
35. Ng J.C., Wang J., and Shraim A. A global health problem caused by arsenic from natural sources. Chemosphere 52 (2003) 1353-1359
36. NRC. Arsenic in Drinking Water (1999), National Academy Press, Washington, DC
37. NRC. Arsenic in Drinking Water, 2001 Update (2001), National Academy Press, Washington, DC
38. Schoen A., Beck B., Sharma R., and Dube E. Arsenic toxicity at low doses: epidemiological and mode of action considerations. Toxicol. Appl. Pharmacol. 198 (2004) 253-267
39. Seed J., Carney E.W., Corley R.A., Crofton K.M., DeSesso J.M., Foster P.M., Kavlock R., Kimmel G., Klaunig J., Meek M.E., Preston R.J., Slikker Jr. W., Tabacova S., Williams G.M., Wiltse J., Zoeller R.T., Fenner-Crisp P., and Patton D.E. Overview: using mode of action and life stage information to evaluate the human relevance of animal toxicity data. Crit. Rev. Toxicol. 35 (2005) 664-672
40. Shiobara Y., Ogra Y., and Suzuki K.T. Animal species difference in the uptake of dimethylarsinous acid (DMA(III)) by red blood cells. Chem. Res. Toxicol. 14 (2001) 1446-1452
41. Sonich-Mullin C., Fielder R., Wiltse J., Baetcke K., Dempsey J., Fenner-Crisp P., Grant D., Hartley M., Knaap A., Kroese D., Mangelsdorf I., Meek E., Rice J.M., and Younes M. IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis. Regul. Toxicol. Pharmacol. 34 (2001) 146-152
42. Steinmaus C., Yuan Y., Bates M.N., and Smith A.H. Case-control study of bladder cancer and drinking water arsenic in the western United States. Am. J. Epidemiol. 158 (2003) 1193-1201
43. Styblo M., Del Razo L.M., LeCluyse E.L., Hamilton G.A., Wang C., Cullen W.R., and Thomas D.J. Metabolism of arsenic in primary cultures of human and rat hepatocytes. Chem. Res. Toxicol. 12 (1999) 560-565
44. Styblo M., Del Razo L.M., Vega L., Germolec D.R., LeCluyse E.L., Hamilton G.A., Reed W., Wang C., Cullen W.R., and Thomas D.J. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Arch. Toxicol. 74 (2000) 289-299
45. USEPA (1988). Recommendations for and documentation of biological values for use in risk assessment. EPA 600/6-78/008, NTIS PB88-179874/AS.
46. USEPA, 1998. Integrated risk information system for inorganic arsenic. U.S. Environmental Protection Agency. Carcinogenesis Assessment last revised 1998. Available at: .
47. USEPA, 2001. National primary drinking water regulations; arsenic and clarifications to compliance and new source contaminants monitoring. 66 FR 14:6975-7022.
48. USEPA, 2005. Guidelines for carcinogen risk assessment. EPA/630/P-03/001B. Available at: .
49. USEPA, 2006. Revised Science Issue Paper: Mode of carcinogenic action for cacodylic acid (dimethylarsinic acid, DMAV) and recommendations for dose-response extrapolation. January 30. Available at: , Docket ID: EPA-HQ-OPP-2006-201-0012.
50. Waalkes M.P., Liu J., Ward J.M., and Diwan B.A. Animal models for arsenic carcinogenesis: inorganic arsenic is a transplacental carcinogen in mice. Toxicol. Appl. Pharmacol. 198 (2004) 377-384
51. Waalkes M.P., Liu J., Ward J.M., and Diwan B.A. Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen. Toxicol. Appl. Pharmacol. 215 (2006) 295-305
52. Wanibuchi H., Yamamoto S., Chen H., Yoshida K., Endo G., Hori T., and Fukushima S. Promoting effects of dimethylarsinic acid on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in rats. Carcinogenesis 17 (1996) 2435-2439
53. Wei W.C., and Yang M.H. Determination of phosphorus and arsenic in trichlorosilane by electrothermal vaporization-inductively coupled plasma mass spectrometry with prior concentration by cuprous chloride. Anal. BioAnal. Chem. 353 (1995) 167-170
54. Wei M., Wanibuchi H., Morimura K., Iwai S., Yoshida K., Endo G., Nakae D., and Fukushima S. Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. Carcinogenesis 23 (2002) 1387-1397
55. Wu M.M., Kuo T.L., Hwang Y.H., and Chen C.J. Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases. Am. J. Epidemiol. 130 (1989) 1123-1132
56. Yoshida T., Yamauchi H., and Fan Sun G. Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review. Toxicol. Appl. Pharmacol. 198 (2004) 243-252