메뉴 건너뛰기




Volumn 4, Issue 185, 2011, Pages

β2-adrenergic receptor polymorphisms and signaling: Do variants influence the "memory" of receptor activation?

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; GLYCINE;

EID: 80051642891     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2002352     Document Type: Review
Times cited : (10)

References (30)
  • 1
    • 34548763986 scopus 로고    scopus 로고
    • G-proteins and GPCRs: From the beginning
    • H. R. Bourne, G-proteins and GPCRs: From the beginning. Ernst Schering Found. Symp. Proc. 2, 1-21 (2006).
    • (2006) Ernst Schering Found. Symp. Proc. , vol.2 , pp. 1-21
    • Bourne, H.R.1
  • 2
    • 34147137118 scopus 로고    scopus 로고
    • Seven transmembrane receptors: Something old, something new
    • R. J. Lefkowitz, Seven transmembrane receptors: Something old, something new. Acta Physiol. (Oxf.) 190, 9-19 (2007).
    • (2007) Acta Physiol. (Oxf.) , vol.190 , pp. 9-19
    • Lefkowitz, R.J.1
  • 3
    • 50649099120 scopus 로고    scopus 로고
    • Discovery of G protein signaling
    • Z. Selinger, Discovery of G protein signaling. Annu. Rev. Biochem. 77, 1-13 (2008).
    • (2008) Annu. Rev. Biochem. , vol.77 , pp. 1-13
    • Selinger, Z.1
  • 4
    • 77951844975 scopus 로고    scopus 로고
    • Teaching old receptors new tricks: Biasing seventransmembrane receptors
    • S. Rajagopal, K. Rajagopal, R. J. Lefkowitz, Teaching old receptors new tricks: Biasing seventransmembrane receptors. Nat. Rev. Drug Discov. 9, 373-386 (2010).
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 373-386
    • Rajagopal, S.1    Rajagopal, K.2    Lefkowitz, R.J.3
  • 5
    • 42149181885 scopus 로고    scopus 로고
    • Structural diversity of G protein-coupled receptors and significance for drug discovery
    • M. C. Lagerström, H. B. Schiöth, Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat. Rev. Drug Discov. 7, 339-357 (2008).
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 339-357
    • Lagerström, M.C.1    Schiöth, H.B.2
  • 9
    • 45549108603 scopus 로고    scopus 로고
    • Insights into signaling from the beta2-adrenergic receptor structure
    • M. Audet, M. Bouvier, Insights into signaling from the beta2-adrenergic receptor structure. Nat. Chem. Biol. 4, 397-403 (2008).
    • (2008) Nat. Chem. Biol. , vol.4 , pp. 397-403
    • Audet, M.1    Bouvier, M.2
  • 10
    • 77955779227 scopus 로고    scopus 로고
    • Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by x-ray crystallography
    • D. Wacker, G. Fenalti, M. A. Brown, V. Katritch, R. Abagyan, V. Cherezov, R. C. Stevens, Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by x-ray crystallography. J. Am. Chem. Soc. 132, 11443-11445 (2010).
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 11443-11445
    • Wacker, D.1    Fenalti, G.2    Brown, M.A.3    Katritch, V.4    Abagyan, R.5    Cherezov, V.6    Stevens, R.C.7
  • 14
    • 77955608819 scopus 로고    scopus 로고
    • Common ADRB2 haplotypes derived from 26 polymorphic sites direct beta2-adrenergic receptor expression and regulation phenotypes
    • A. Panebra, W. C. Wang, M. M. Malone, D. R. Pitter, S. T. Weiss, G. A. Hawkins, S. B. Liggett, Common ADRB2 haplotypes derived from 26 polymorphic sites direct beta2-adrenergic receptor expression and regulation phenotypes. PLoS ONE 5, e11819 (2010).
    • (2010) PLoS ONE , vol.5
    • Panebra, A.1    Wang, W.C.2    Malone, M.M.3    Pitter, D.R.4    Weiss, S.T.5    Hawkins, G.A.6    Liggett, S.B.7
  • 15
    • 0041506933 scopus 로고    scopus 로고
    • Pharmacology and physiology of human adrenergic receptor polymorphisms
    • K. M. Small, D. W. McGraw, S. B. Liggett, Pharmacology and physiology of human adrenergic receptor polymorphisms. Annu. Rev. Pharmacol. Toxicol. 43, 381-411 (2003).
    • (2003) Annu. Rev. Pharmacol. Toxicol. , vol.43 , pp. 381-411
    • Small, K.M.1    McGraw, D.W.2    Liggett, S.B.3
  • 16
    • 79951809896 scopus 로고    scopus 로고
    • Cardiovascular pharmacogenomics of adrenergic receptor signaling: Clinical implications and future directions
    • J. A. Johnson, S. B. Liggett, Cardiovascular pharmacogenomics of adrenergic receptor signaling: Clinical implications and future directions. Clin. Pharmacol. Ther. 89, 366-378 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 366-378
    • Johnson, J.A.1    Liggett, S.B.2
  • 17
    • 79551619357 scopus 로고    scopus 로고
    • Pharmacogenetics of β2 adrenergic receptor gene polymorphisms, long-acting β-agonists and asthma
    • L. P. Chung, G. Waterer, P. J. Thompson, Pharmacogenetics of β2 adrenergic receptor gene polymorphisms, long-acting β-agonists and asthma. Clin. Exp. Allergy 41, 312-326 (2011).
    • (2011) Clin. Exp. Allergy , vol.41 , pp. 312-326
    • Chung, L.P.1    Waterer, G.2    Thompson, P.J.3
  • 18
    • 70450208863 scopus 로고    scopus 로고
    • Beta-2 adrenergic receptor genetic polymorphisms and asthma
    • N. Hizawa, Beta-2 adrenergic receptor genetic polymorphisms and asthma. J. Clin. Pharm. Ther. 34, 631-643 (2009).
    • (2009) J. Clin. Pharm. Ther. , vol.34 , pp. 631-643
    • Hizawa, N.1
  • 21
    • 0037224730 scopus 로고    scopus 로고
    • Biochemical characterization of beta2-adrenergic receptor dimers and oligomers
    • A. Salahpour, H. Bonin, S. Bhalla, U. Petäjä-Repo, M. Bouvier, Biochemical characterization of beta2-adrenergic receptor dimers and oligomers. Biol. Chem. 384, 117-123 (2003).
    • (2003) Biol. Chem. , vol.384 , pp. 117-123
    • Salahpour, A.1    Bonin, H.2    Bhalla, S.3    Petäjä-Repo, U.4    Bouvier, M.5
  • 22
    • 79952046779 scopus 로고    scopus 로고
    • Internalization dissociates β2-adrenergic receptors
    • T. H. Lan, S. Kuravi, N. A. Lambert, Internalization dissociates β2-adrenergic receptors. PLoS ONE 6, e17361 (2011).
    • (2011) PLoS ONE , vol.6
    • Lan, T.H.1    Kuravi, S.2    Lambert, N.A.3
  • 23
    • 24144462378 scopus 로고    scopus 로고
    • G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3- associated microdomains in adult cardiac myocytes
    • B. P. Head, H. H. Patel, D. M. Roth, N. C. Lai, I. R. Niesman, M. G. Farquhar, P. A. Insel, G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3- associated microdomains in adult cardiac myocytes. J. Biol. Chem. 280, 31036-31044 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 31036-31044
    • Head, B.P.1    Patel, H.H.2    Roth, D.M.3    Lai, N.C.4    Niesman, I.R.5    Farquhar, M.G.6    Insel, P.A.7
  • 24
    • 54049106162 scopus 로고    scopus 로고
    • Cholesterol-dependent separation of the beta2-adrenergic receptor from its partners determines signaling efficacy: Insight into nanoscale organization of signal transduction
    • S. M. Pontier, Y. Percherancier, S. Galandrin, A. Breit, C. Galés, M. Bouvier, Cholesterol-dependent separation of the beta2-adrenergic receptor from its partners determines signaling efficacy: Insight into nanoscale organization of signal transduction. J. Biol. Chem. 283, 24659-24672 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 24659-24672
    • Pontier, S.M.1    Percherancier, Y.2    Galandrin, S.3    Breit, A.4    Galés, C.5    Bouvier, M.6
  • 25
    • 58249102214 scopus 로고    scopus 로고
    • G-protein-coupled receptor-associated A-kinase anchoring proteins AKAP5 and AKAP12: Differential signaling to MAPK and GPCR recycling
    • J. Tao, C. C. Malbon, G-protein-coupled receptor-associated A-kinase anchoring proteins AKAP5 and AKAP12: Differential signaling to MAPK and GPCR recycling. J. Mol. Signal. 3, 19 (2008).
    • (2008) J. Mol. Signal. , vol.3 , pp. 19
    • Tao, J.1    Malbon, C.C.2
  • 26
    • 79960346334 scopus 로고    scopus 로고
    • Compartmentalization of β-adrenergic signals in cardiomyocytes
    • Y. K. Xiang, Compartmentalization of β-adrenergic signals in cardiomyocytes. Circ. Res. 109, 231-244 (2011).
    • (2011) Circ. Res. , vol.109 , pp. 231-244
    • Xiang, Y.K.1
  • 27
    • 33751162165 scopus 로고    scopus 로고
    • Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy
    • S. Galandrin, M. Bouvier, Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol. Pharmacol. 70, 1575-1584 (2006).
    • (2006) Mol. Pharmacol. , vol.70 , pp. 1575-1584
    • Galandrin, S.1    Bouvier, M.2
  • 29
  • 30
    • 80051661772 scopus 로고    scopus 로고
    • note
    • Acknowledgments: A. Wilderman helped to prepare the draft of Fig. 2. Funding: Work in the author's laboratory is supported by grants from NIH.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.