Receptor for advanced glycation end-products signals through ras during tobacco smoke-induced pulmonary inflammation

American Journal of Respiratory Cell and Molecular Biology

Volumn 45, Issue 2, 2011, Pages 411-418

  Reynolds, Paul R ^a   Kasteler, Stephen D ^b   Schmitt, Robert E ^b   Hoidal, John R ^b  

^a BRIGHAM YOUNG UNIVERSITY   (United States)

^b UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

Inflammation; Lung; RAGE; Ras; Tobacco

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; RANTES; RAS PROTEIN; SMALL INTERFERING RNA; TOBACCO SMOKE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CARCINOGENESIS; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; LEUKOCYTE; LUNG ALVEOLUS EPITHELIUM; MOUSE; NONHUMAN; PNEUMONIA; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; IMMUNOENZYME TECHNIQUES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; PNEUMONIA; RAS PROTEINS; RATS; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TOBACCO;

ANIMALIA; MUS; NICOTIANA TABACUM; RATTUS;

EID: 80051612741     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2010-0231OC     Document Type: Article

References (56)

1. Thornally PJ. Cell activation by glycated proteins: AGE receptors, receptor recognition factors and functional classsification of AGEs. Cell Mol Biol (Noisy-Le-Grand) 1998;44:1013-1023.
2. Schmidt AM, Stern DM. RAGE: a new target for the prevention and treatment of the vascular and inflammatory complications of diabetes. Trends Endocrinol Metab 2000;11:368-375.
3. Hofmann MA, Drury S, Fu C, Qu W, Taguchi A, Lu Y, Avila C, Kambham N, Bierhaus A, Nawroth P. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell 1999;97:889-901. (Pubitemid 29375048)
4. Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, Qu W, Tanji N, Lu Y, Lalla E, Fu C. Blockade of amphoterin/RAGE signalling suppresses tumor growth and metastases. Nature 2000;405:354-360. (Pubitemid 30337069)
5. Yan SD, Chen X, Fu J, Chen M, Zhu H, Roher A, Slattery T, Nagashima M, Morser J, Migheli A. RAGE and amyloid beta peptide neurotoxicity in Alzheimer's disease. Nature 1996;382:685-691. (Pubitemid 26282167)
6. Reynolds PR, Kasteller S, Cosio MG, Sturrock A, Huecksteadt TP, Hoidal JR. RAGE: developmental expression and positive feedback regulation by Egr-1 during cigarette smoke exposure in pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol 2008;294:L1094-L1101.
7. Reynolds PR, Hoidal JR. Cigarette smoke-induced Egr-1 upregulates pro-inflammatory cytokines in pulmonary epithelial cells. Am J Respir Cell Mol Biol 2006;35:314-319. (Pubitemid 44353399)
8. Donovan S, Shannon KM, Bollag G. GTPase activating proteins: critical regulators of intracellular signaling. BBA Rev Cancer 2002;1602:23-45. (Pubitemid 34311898)
9. Barbacid M. Ras genes. Annu Rev Biochem 1987;56:779-827.
10. Lowy DR, Willumsen BM. Function and regulation of ras. Annu Rev Biochem 1993;62:851-891. (Pubitemid 23237890)
11. Downward J. Cell cycle: routine role for Ras. Curr Biol 1997;7:R258-R260. (Pubitemid 27176846)
12. Winston JT, Coats SR, Wang YZ, Pledger WJ. Regulation of the cell cycle machinery by oncogenic ras. Oncogene 1996;12:127-134. (Pubitemid 26041248)
13. Wong CK, Zhang J, Ip WK, Lam CW. Intracellular signal transduction in eosinophils and its clinical significance. Innunopharmacol Immunotoxicol 2002;24:165-186. (Pubitemid 34596510)
14. Chi H, Flavell RA. Acetylation of MKP-1 and the control of inflammation. Sci Signal 2008;1:pe44.
15. Fruman DA, Bismuth G. Fine tuning the immune response with PI3K. Immunol Rev 2009;228:253-272.
16. Downward J. Targeting Ras signaling pathways in cancer therapy. Nat Rev Cancer 2003;3:11-22. (Pubitemid 37328883)
17. Koslowski R, Barth K, Augstein A, Tschernig T, Bargsten G, Aufderheide M, Kasper M. A new rat type I-like alveolar epithelial cell line R3/1: bleomycin effects on caveolin expression. Histochem Cell Biol 2004;121:509-519. (Pubitemid 38916439)
18. Guerassimov A, Hoshino Y, Takubo Y, Turcotte A, Yamamoto M, Ghezzo H, Triantafillopoulos A, Whittaker K, Hoidal JR, Cosio MG. The development of emphysema in cigarette smoke-exposed mice is strain dependent. Am J Respir Crit Care Med 2004;170:974-980. (Pubitemid 39425693)
19. Reynolds PR, Mucenski ML, Le Cras TD, Nichols WC, Whitsett JA. Midkine is regulated by hypoxia and causes pulmonary vascular remodeling. J Biol Chem 2004;279:37124-37132. (Pubitemid 39129063)
20. Lander HM, Tauras JM, Ogiste JS, Hori O, Moss RA, Schmidt AM. Activation of the advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress. J Biol Chem 1997;272:17810-17814. (Pubitemid 27311222)
21. Huttunen HJ, Fagas C, Rauvala H. Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytosolic domain of the receptor but different downstream signaling pathways. J Biol Chem 1999;274:19919-19924.
22. Bianchi R, Giambanco I, Donato R. S100B/RAGE-dependent activation of microglia via NF-kappaB and AP-1 Co-regulation of Cox-2 expression by S100B, IL-1beta and TNF-alpha. Neurobiol Aging 2008;Epub ahead of print.
23. Nicholl ID, Bacala R. Advanced glycation endproducts and cigarette smoking. Cell Mol Biol 1998;44:1025-1033.
24. Nicholl ID, Stitt AW, Moore JE, Ritchie AJ, Archer DB, Bucala R. Increased levels of advanced glycation endproducts in the lenses and blood vessels of cigarette smokers. Mol Med 1998;4:594-601. (Pubitemid 28523112)
25. Porta M, Crous-Bou M, Wark PA, Vineis P, Real FX, Malats N, Kampman E. Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: Etiopathogenic similarities, differences and paradoxes. Mutat Res 2009; Epub ahead of print.
26. Shacter E, Weitzman SA. Chronic inflammation and cancer. Oncology 2002;16:217-226, 229, 230-232.
27. Lee YL, Chen W, Tsai WK, Lee JC, Chiou HL, Shih CM, Wang YC. Polymorphisms of p53 and p21 genes in chronic obstructive pulmonary disease. J Lab Clin Med 2006;147:228-233. (Pubitemid 43668481)
28. Anderson D, Hughes JA, Cebulska-Wasilewska A, Nizankowska E, Graca B. Ras p21 protein levels in human plasma from patients with chronic obstructive pulmonary disease (COPD) compared with lung cancer patients and healthy controls. Mutat Res 1998;403:229-235. (Pubitemid 28383664)
29. Bartling B, Hofmann HS, Weigle B, Silber RE, Simm A. Downregulation of the receptor for advanced glycation end-products (RAGE) supports non-small cell lung carcinoma. Carcinogenesis 2005;26:293-301. (Pubitemid 40246550)
30. Gebhardt C, Riehl A, Durchdewald M, Nemeth J, Furstenberger G, Muller-Decker K, Enk A, Arnold B, Bierhaus A, Nawroth PP, et al. RAGE signaling sustains inflammation and promotes tumor development. J Exp Med 2008;205:275-285. (Pubitemid 351281593)
31. Schmidt AM, Yan SD, Yan SF, Stern DM. The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest 2001;108:949-955. (Pubitemid 32946067)
32. Sparvero LJ, Asafu-Adjei D, Kang R, Tang D, Amin N, Im J, Rutledge R, Lin B, Amoscato AA, Zeh HJ, et al. RAGE (receptor for advanced glycation end products), RAGE ligands, and their role in cancer and inflammation. J Transl Med 2009;7:17.
33. Srikrishna G, Huttunen HJ, Johansson L, Weigle B, Yamaguchi Y, Rauvala H, Freese HH. N-glycans on the receptors for advanced glycation end products influence amphoterin binding and neurite outgrowth. J Neurochem 2002;80:998-1008. (Pubitemid 34809952)
34. Aggarwal BB. Nuclear factor-kappaB: the enemy within. Cancer Cell 2004;6:203-208.
35. Sweeney C, Li L, Shanmugam R. Nuclear factor-kappaB is constitutively activated in prostate cancer in vitro and is overexpressed in prostatic intraepithelial neoplasia and adenocarcinoma of the prostate. Clin Cancer Res 2004;10:5501-5507. (Pubitemid 39100488)
36. Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, Gutkovich-Pyest E, Urieli-Shoval S, Galun E, Ben-Neriah Y. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 2004;431:461-466. (Pubitemid 39329586)
37. Luo JL, Maeda S, Hsu LC, Yagita H, Karin M. Inhibition of NF-kappaB in cancer cells converts inflammation-induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell 2004;6:297-305. (Pubitemid 39222042)
38. Ballaz S, Mulshine JL. The potential contributions of chronic inflammation to lung carcinogenesis. Clin Lung Cancer 2003;5:46-62. (Pubitemid 36974741)
39. Anderson GP, Bozinovski S. Acquired somatic mutations in the molecular pathogenesis of COPD. Trends Pharmacol Sci 2003;24:71-76. (Pubitemid 36135879)
40. Chung KF. Cytokines in chronic obstructive pulmonary disease. Eur Respir J 2001;18:50s-59s. (Pubitemid 34760609)
41. Dinarello CA. Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme. Ann N Y Acad Sci 1998;29:1-11. (Pubitemid 28517331)
42. Kato T, Kitagawa S. Regulation of neutrophil functions by proinflammatory cytokines. Int J Hematol 2006;84:205-209. (Pubitemid 44619239)
43. Rollins BJ. Cytokines. Blood 1997;90:909-928.
44. Costa CH, Rufino R, Silva JR. Inflammatory cells and their mediators in COPD pathogenesis. Rev Assoc Med Bras 2009;55:347-354.
45. Tetley TD. Inflammatory cells and chronic obstructive pulmonary disease. Curr Drug Targets Inflamm Allergy 2005;4:607-618. (Pubitemid 41722371)
46. Yamin M, Holbrook EH, Gray ST, Harold R, Busaba N, Sridhar A, Powell KJ, Hamilos DL. Cigarette smoke combined with till-like receptor 3 signaling triggers exaggerated epithelial regulated upon activation, normal T-cell expressed and secreted/CCL5 expression in chronic rhinosinusitis. J Allergy Clin Immunol 2008;122:1145-1153.
47. Kubo S, Kobayashi M, Masunaga Y, Ishii H, Hirano Y, Takahashi K, Shimizu Y. Cytokine and chemokine expression in cigarette smoke-induced lung injury in guinea pigs. Eur Respir J 2005;26:993-1001. (Pubitemid 41829928)
48. Brozyna S, Ahem J, Hodge G, Naim J, Holmes M, Reynolds PN, Hodge S. Chemotactic mediators of Th1 T-cell trafficking in smokers and COPD patients. COPD 2009;6:4-18.
49. Barnes PJ, Shapiro SD, Pauwels RA. Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J 2003;22:672-688. (Pubitemid 37258549)
50. Castro P, Legora-Machado A, Cardilo-Reis L, Valenca S, Porto LC, Walker C, Zuany-Amorium C, Koatz VL. Inhibition of interleukin-1β reduces mouse lung inflammation induced by exposure to cigarette smoke. Eur J Pharmacol 2004;498:279-286. (Pubitemid 39208090)
51. Hellermann GR, Nagy SB, Kong X, Lockey RF, Mohapatra SS. Mechanism of sigarette smoke condensate-induced acute inflammatory response in human bronchial epithelial cells. Respir Res 2002;3:22-29.
52. Bracke KR, D'hulst AI, Maes T, Demedts IK, Moerloose KB, Kuziel WA, Joos GF, Brusselle GG. Cigarette smoke-induced pulmonary inflammation, but nor airway remodeling, is attenuated in chemokine receptor-5 deficient mice. Clin Exp Allergy 2007;37:1467-1479.
53. Costa C, Rufino R, Traves SL, Lapa E, Silva JR, Barnes PJ, Donnelly LE. CXCR3 and CCR5 chemokines in induced sputum from patients with COPD. Chest 2008;133:26-33.
54. Di Stefano A, Caramori G, Gnemmi I, Contoli M, Bristot L, Capelli A, Ricciardolo FL, Mango F, D'Anna SE, Zanini A, et al. Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD. Thorax 2009;64:968-975.
55. Dougan M, Dranoff G. Inciting inflammation: the RAGE about tumor promotion. J Exp Med 2008;205:267-270. (Pubitemid 351281591)
56. Sparvero LJ, Asafu-Adjei D, Kang R, Tang D, Amin N, Im J, Rutledge R, Lin B, Amoscato AA, Zeh HJ, et al. RAGE (receptors for advanced glycation endproducts), RAGE ligands, and their role in cancer and inflammation. J Transl Med 2009;17:7-17.