ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Sirbu, Bianca M ^a   Lachmayer, Sarah J ^a,b   Wülfing, Verena ^a,b   Marten, Lara M ^a,b   Clarkson, Katie E ^a   Lee, Linda W ^a   Gheorghiu, Liliana ^a   Zou, Lee ^a,d   Powell, Simon N ^c   Dahm Daphi, Jochen ^b,d   Willers, Henning ^a,e  

^a MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^b UNIVERSITY OF HAMBURG   (Germany)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CYTOTOXIC AGENT; DNA; MITOMYCIN C; PROTEIN P53; REPLICATION FACTOR A; SERINE; ATR PROTEIN, HUMAN; CELL CYCLE PROTEIN; CROSS LINKING REAGENT; MITOMYCIN; PROTEIN SERINE THREONINE KINASE; RAD51 PROTEIN; THYMIDINE;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA INTERSTRAND CROSSLINK REPAIR; DNA REPAIR; DNA REPLICATION; DNA REPLICATIVE STRESS; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; EMBRYO; ENZYME REGULATION; FIBROBLAST; GENETIC ANALYSIS; HOMOLOGOUS RECOMBINATION; LUNG CANCER; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSACTIVATION; ANIMAL; CELL CULTURE; CELL SURVIVAL; DNA DAMAGE; DRUG EFFECT; FLOW CYTOMETRY; GENETICS; HUMAN; LUNG TUMOR; METABOLISM; MUTATION; PATHOLOGY; RNA INTERFERENCE; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

MAMMALIA;

ANIMALS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; CROSS-LINKING REAGENTS; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; FLOW CYTOMETRY; HOMOLOGOUS RECOMBINATION; HUMANS; LUNG NEOPLASMS; MICE; MITOMYCIN; MUTATION; PROTEIN-SERINE-THREONINE KINASES; RAD51 RECOMBINASE; RNA INTERFERENCE; THYMIDINE; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 80051611505     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023053     Document Type: Article

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