메뉴 건너뛰기




Volumn 31, Issue 7, 2011, Pages 572-578

Homocysteine homeostasis in the rat is maintained by compensatory changes in cystathionine β-synthase, betaine-homocysteine methyltransferase, and phosphatidylethanolamine N-methyltransferase gene transcription occurring in response to maternal protein and folic acid intake during pregnancy and fat intake after weaning

Author keywords

BHMT; CBS; Fetal programming; Homocysteine; PEMT; Rats

Indexed keywords

BETAINE HOMOCYSTEINE METHYLTRANSFERASE; CYSTATHIONINE BETA SYNTHASE; FAT; FOLIC ACID; HOMOCYSTEINE; LARD; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE; PROTEIN;

EID: 80051601162     PISSN: 02715317     EISSN: 18790739     Source Type: Journal    
DOI: 10.1016/j.nutres.2011.07.001     Document Type: Article
Times cited : (5)

References (46)
  • 1
    • 77951121781 scopus 로고    scopus 로고
    • Homocysteine metabolism and its relation to health and disease
    • Williams K.T., Schalinske K.L. Homocysteine metabolism and its relation to health and disease. Biofactors 2010, 36(1):19-24.
    • (2010) Biofactors , vol.36 , Issue.1 , pp. 19-24
    • Williams, K.T.1    Schalinske, K.L.2
  • 2
    • 48249126469 scopus 로고    scopus 로고
    • Public health significance of elevated homocysteine
    • Selhub J. Public health significance of elevated homocysteine. Food Nutr Bull 2008, 29(2 Suppl):S116-125.
    • (2008) Food Nutr Bull , vol.29 , Issue.2 SUPPL.
    • Selhub, J.1
  • 3
    • 33846821508 scopus 로고    scopus 로고
    • New insights into the regulation of methyl group and homocysteine metabolism
    • Williams K.T., Schalinske K.L. New insights into the regulation of methyl group and homocysteine metabolism. J Nutr 2007, 137(2):311-314.
    • (2007) J Nutr , vol.137 , Issue.2 , pp. 311-314
    • Williams, K.T.1    Schalinske, K.L.2
  • 5
    • 77649211144 scopus 로고    scopus 로고
    • Polymorphism of genes encoding homocysteine metabolism-related enzymes and risk for cardiovascular disease
    • Malinowska A., Chmurzynska A. Polymorphism of genes encoding homocysteine metabolism-related enzymes and risk for cardiovascular disease. Nutr Res 2009, 29(10):685-695.
    • (2009) Nutr Res , vol.29 , Issue.10 , pp. 685-695
    • Malinowska, A.1    Chmurzynska, A.2
  • 6
    • 36849084656 scopus 로고    scopus 로고
    • Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine
    • Finkelstein J.D. Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine. Clin Chem Lab Med 2007, 45(12):1694-1699.
    • (2007) Clin Chem Lab Med , vol.45 , Issue.12 , pp. 1694-1699
    • Finkelstein, J.D.1
  • 8
    • 21044434160 scopus 로고    scopus 로고
    • A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project
    • Souto J.C., Blanco-Vaca F., Soria J.M., Buil A., Almasy L., Ordoñez-Llanos J., et al. A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project. Am J Hum Genet 2005, 76(6):925-933.
    • (2005) Am J Hum Genet , vol.76 , Issue.6 , pp. 925-933
    • Souto, J.C.1    Blanco-Vaca, F.2    Soria, J.M.3    Buil, A.4    Almasy, L.5    Ordoñez-Llanos, J.6
  • 10
    • 65649117791 scopus 로고    scopus 로고
    • What are maternal effects (and what are they not)?
    • Wolf J.B., Wade M.J. What are maternal effects (and what are they not)?. Philos Trans R SocLond BBiolSci 2009, 364(1520):1107-1115.
    • (2009) Philos Trans R SocLond BBiolSci , vol.364 , Issue.1520 , pp. 1107-1115
    • Wolf, J.B.1    Wade, M.J.2
  • 11
    • 77950357572 scopus 로고    scopus 로고
    • Fetal programming: link between early nutrition, DNA methylation, and complex diseases
    • Chmurzynska A. Fetal programming: link between early nutrition, DNA methylation, and complex diseases. Nutr Rev 2010, 68(2):87-98.
    • (2010) Nutr Rev , vol.68 , Issue.2 , pp. 87-98
    • Chmurzynska, A.1
  • 12
    • 57649238863 scopus 로고    scopus 로고
    • Fetal programming of glucose-insulin metabolism
    • Jones R.H., Ozanne S.E. Fetal programming of glucose-insulin metabolism. Mol Cell Endocrinol 2009, 297(1-2):4-9.
    • (2009) Mol Cell Endocrinol , vol.297 , Issue.1-2 , pp. 4-9
    • Jones, R.H.1    Ozanne, S.E.2
  • 13
    • 77958185978 scopus 로고    scopus 로고
    • Metabolic imprinting, programming and epigenetics-a review of present priorities and future opportunities
    • Hanley B., Dijane J., Fewtrell M., Grynberg A., Hummel S., Junien C., et al. Metabolic imprinting, programming and epigenetics-a review of present priorities and future opportunities. Br J Nutr 2010, 104(Suppl 1):S1-25.
    • (2010) Br J Nutr , vol.104 , Issue.SUPPL. 1
    • Hanley, B.1    Dijane, J.2    Fewtrell, M.3    Grynberg, A.4    Hummel, S.5    Junien, C.6
  • 15
    • 33745037552 scopus 로고    scopus 로고
    • The consequences of being born small-an adaptive perspective
    • Gluckman P.D., Hanson M.A. The consequences of being born small-an adaptive perspective. Horm Res 2006, 65(Suppl 3):5-14.
    • (2006) Horm Res , vol.65 , Issue.SUPPL. 3 , pp. 5-14
    • Gluckman, P.D.1    Hanson, M.A.2
  • 16
    • 67649448941 scopus 로고    scopus 로고
    • Nutrition in early life, and risk of cancer and metabolic disease: alternative endings in an epigenetic tale?
    • Burdge G.C., Lillycrop K.A., Jackson A.A. Nutrition in early life, and risk of cancer and metabolic disease: alternative endings in an epigenetic tale?. Br J Nutr 2009, 101(5):619-630.
    • (2009) Br J Nutr , vol.101 , Issue.5 , pp. 619-630
    • Burdge, G.C.1    Lillycrop, K.A.2    Jackson, A.A.3
  • 17
    • 0021160199 scopus 로고
    • Gestational undernutrition and the development of obesity in rats
    • Jones A.P., Simson E.L., Friedman M.I. Gestational undernutrition and the development of obesity in rats. J Nutr 1984, 114(8):1484-1492.
    • (1984) J Nutr , vol.114 , Issue.8 , pp. 1484-1492
    • Jones, A.P.1    Simson, E.L.2    Friedman, M.I.3
  • 18
    • 34547987563 scopus 로고    scopus 로고
    • Prenatal exposure to undernutrition and programming of responses to high-fat feeding in the rat
    • Erhuma A., Bellinger L., Langley-Evans S.C., Bennett A.J. Prenatal exposure to undernutrition and programming of responses to high-fat feeding in the rat. Br J Nutr 2007, 98(3):517-524.
    • (2007) Br J Nutr , vol.98 , Issue.3 , pp. 517-524
    • Erhuma, A.1    Bellinger, L.2    Langley-Evans, S.C.3    Bennett, A.J.4
  • 19
    • 38949115583 scopus 로고    scopus 로고
    • The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption
    • Burdge G.C., Lillycrop K.A., Jackson A.A., Gluckman P.D., Hanson M.A. The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption. Br J Nutr 2008, 99(3):540-549.
    • (2008) Br J Nutr , vol.99 , Issue.3 , pp. 540-549
    • Burdge, G.C.1    Lillycrop, K.A.2    Jackson, A.A.3    Gluckman, P.D.4    Hanson, M.A.5
  • 20
    • 36649032888 scopus 로고    scopus 로고
    • Hepatic structural alteration in adult programmed offspring (severe maternal protein restriction) is aggravated by post-weaning high-fat diet
    • Souza-Mello V., Mandarim-de-Lacerda C.A., Aguila M.B. Hepatic structural alteration in adult programmed offspring (severe maternal protein restriction) is aggravated by post-weaning high-fat diet. Br J Nutr 2007, 98(6):1159-1169.
    • (2007) Br J Nutr , vol.98 , Issue.6 , pp. 1159-1169
    • Souza-Mello, V.1    Mandarim-de-Lacerda, C.A.2    Aguila, M.B.3
  • 21
    • 70349231260 scopus 로고    scopus 로고
    • Epigenetics-potential contribution to fetal programming
    • Mathers J.C., McKay J.A. Epigenetics-potential contribution to fetal programming. AdvExp Med Biol 2009, 646:119-123.
    • (2009) AdvExp Med Biol , vol.646 , pp. 119-123
    • Mathers, J.C.1    McKay, J.A.2
  • 22
    • 34247469154 scopus 로고    scopus 로고
    • Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life?
    • Burdge G.C., Hanson M.A., Slater-Jefferies J.L., Lillycrop K.A. Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life?. Br J Nutr 2007, 97(6):1036-1046.
    • (2007) Br J Nutr , vol.97 , Issue.6 , pp. 1036-1046
    • Burdge, G.C.1    Hanson, M.A.2    Slater-Jefferies, J.L.3    Lillycrop, K.A.4
  • 23
    • 50049108528 scopus 로고    scopus 로고
    • Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring
    • Lillycrop K.A., Phillips E.S., Torrens C., Hanson M.A., Jackson A.A., Burdge G.C. Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring. Br J Nutr 2008, 100:278-282.
    • (2008) Br J Nutr , vol.100 , pp. 278-282
    • Lillycrop, K.A.1    Phillips, E.S.2    Torrens, C.3    Hanson, M.A.4    Jackson, A.A.5    Burdge, G.C.6
  • 24
    • 0036322831 scopus 로고    scopus 로고
    • Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring
    • Cooney C.A., Dave A.A., Wolff G.L. Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring. J Nutr 2002, 132(Suppl 8):2393S-2400S.
    • (2002) J Nutr , vol.132 , Issue.SUPPL. 8
    • Cooney, C.A.1    Dave, A.A.2    Wolff, G.L.3
  • 25
    • 0043093697 scopus 로고    scopus 로고
    • Transposable elements: targets for early nutritional effects on epigenetic gene regulation
    • Waterland R.A., Jirtle R.L. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 2003, 23:5293-5300.
    • (2003) Mol Cell Biol , vol.23 , pp. 5293-5300
    • Waterland, R.A.1    Jirtle, R.L.2
  • 27
    • 20444411948 scopus 로고    scopus 로고
    • Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
    • Lillycrop K.A., Phillips E.S., Jackson A.A., Hanson M.A., Burdge G.C. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 2005, 135(6):1382-1386.
    • (2005) J Nutr , vol.135 , Issue.6 , pp. 1382-1386
    • Lillycrop, K.A.1    Phillips, E.S.2    Jackson, A.A.3    Hanson, M.A.4    Burdge, G.C.5
  • 28
    • 77951248416 scopus 로고    scopus 로고
    • Supplementation of a maternal low-protein diet in rat pregnancy with folic acid ameliorates programming effects upon feeding behaviour in the absence of disturbances to the methionine-homocysteine cycle
    • Engeham S.F., Haase A., Langley-Evans S.C. Supplementation of a maternal low-protein diet in rat pregnancy with folic acid ameliorates programming effects upon feeding behaviour in the absence of disturbances to the methionine-homocysteine cycle. Br J Nutr 2010, 103(7):996-1007.
    • (2010) Br J Nutr , vol.103 , Issue.7 , pp. 996-1007
    • Engeham, S.F.1    Haase, A.2    Langley-Evans, S.C.3
  • 29
    • 58149497235 scopus 로고    scopus 로고
    • Developmental and epigenetic pathways to obesity: an evolutionary-developmental perspective
    • Gluckman P.D., Hanson M.A. Developmental and epigenetic pathways to obesity: an evolutionary-developmental perspective. Int J Obes (Lond) 2008, 32(Suppl 7):S62-71.
    • (2008) Int J Obes (Lond) , vol.32 , Issue.SUPPL. 7
    • Gluckman, P.D.1    Hanson, M.A.2
  • 30
    • 77953724327 scopus 로고    scopus 로고
    • Perinatal environment and its influences on metabolic programming of offspring
    • Tamashiro K.L., Moran T.H. Perinatal environment and its influences on metabolic programming of offspring. Physiol Behav 2010, 100(5):560-566.
    • (2010) Physiol Behav , vol.100 , Issue.5 , pp. 560-566
    • Tamashiro, K.L.1    Moran, T.H.2
  • 31
    • 64449087605 scopus 로고    scopus 로고
    • Homocysteine and lipids: S-adenosyl methionine as a key intermediate
    • Obeid R., Herrmann W. Homocysteine and lipids: S-adenosyl methionine as a key intermediate. FEBS Lett 2009, 583(8):1215-1225.
    • (2009) FEBS Lett , vol.583 , Issue.8 , pp. 1215-1225
    • Obeid, R.1    Herrmann, W.2
  • 32
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002, 3:1-12.
    • (2002) Genome Biol , vol.3 , pp. 1-12
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6
  • 33
    • 70350654067 scopus 로고    scopus 로고
    • Determination of N-Acetylcysteine and main endogenous thiols in human plasma by HPLC with ultraviolet detection in the form of their S-quinolinium derivatives
    • GŁowacki R., Bald E. Determination of N-Acetylcysteine and main endogenous thiols in human plasma by HPLC with ultraviolet detection in the form of their S-quinolinium derivatives. J Liq Chrom Rel Techn 2009, 32:2530-2544.
    • (2009) J Liq Chrom Rel Techn , vol.32 , pp. 2530-2544
    • Głowacki, R.1    Bald, E.2
  • 34
    • 70249128338 scopus 로고    scopus 로고
    • Fully automated method for simultaneous determination of total cysteine, cysteinylglycine, glutathione and homocysteine in plasma by HPLC with UV absorbance detection
    • GŁowacki R., Bald E. Fully automated method for simultaneous determination of total cysteine, cysteinylglycine, glutathione and homocysteine in plasma by HPLC with UV absorbance detection. J Chromatogr B Analyt Technol Biomed Life Sci 2009, 877(28):3400-3404.
    • (2009) J Chromatogr B Analyt Technol Biomed Life Sci , vol.877 , Issue.28 , pp. 3400-3404
    • Głowacki, R.1    Bald, E.2
  • 35
    • 33845508214 scopus 로고    scopus 로고
    • Betainehomocysteine S-methyltransferase: just a regulator of homocysteine metabolism?
    • Pajares M.A., Pérez-Sala D. Betainehomocysteine S-methyltransferase: just a regulator of homocysteine metabolism?. Cell Mol Life Sci 2006, 63(23):2792-2803.
    • (2006) Cell Mol Life Sci , vol.63 , Issue.23 , pp. 2792-2803
    • Pajares, M.A.1    Pérez-Sala, D.2
  • 36
    • 0033583210 scopus 로고    scopus 로고
    • Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteinemethyltransferase gene expression and organization of the human gene
    • Park E.I., Garrow T.A. Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteinemethyltransferase gene expression and organization of the human gene. J BiolChem 1999, 274(12):7816-7824.
    • (1999) J BiolChem , vol.274 , Issue.12 , pp. 7816-7824
    • Park, E.I.1    Garrow, T.A.2
  • 37
    • 0028937163 scopus 로고
    • Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocysteinemia
    • Watanabe M., Osada J., Aratani Y., Kluckman K., Reddick R., Malinow M.R., et al. Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocysteinemia. Proc Natl Acad Sci USA 1995, 92(5):1585-1589.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.5 , pp. 1585-1589
    • Watanabe, M.1    Osada, J.2    Aratani, Y.3    Kluckman, K.4    Reddick, R.5    Malinow, M.R.6
  • 38
    • 2642513835 scopus 로고    scopus 로고
    • Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice
    • Wang L., Jhee K.H., Hua X., DiBello P.M., Jacobsen D.W., Kruger W.D. Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice. Circ Res 2004, 94(10):1318-1324.
    • (2004) Circ Res , vol.94 , Issue.10 , pp. 1318-1324
    • Wang, L.1    Jhee, K.H.2    Hua, X.3    DiBello, P.M.4    Jacobsen, D.W.5    Kruger, W.D.6
  • 40
    • 33644654468 scopus 로고    scopus 로고
    • Methionine-induced elevation of plasma homocysteine concentration is associated with an increase of plasma cholesterol in adult rats
    • Hirche F., Schroder A., Knoth B., Stangl G.I., Eder K. Methionine-induced elevation of plasma homocysteine concentration is associated with an increase of plasma cholesterol in adult rats. Ann Nutr Metab 2006, 50(2):139-146.
    • (2006) Ann Nutr Metab , vol.50 , Issue.2 , pp. 139-146
    • Hirche, F.1    Schroder, A.2    Knoth, B.3    Stangl, G.I.4    Eder, K.5
  • 41
    • 33750097736 scopus 로고    scopus 로고
    • Maternal protein restriction and fetal growth: lack of evidence of a role for homocysteine in fetal programming
    • Langley-Evans S.C., Lilley C., McMullen S. Maternal protein restriction and fetal growth: lack of evidence of a role for homocysteine in fetal programming. Br J Nutr 2006, 96(3):578-586.
    • (2006) Br J Nutr , vol.96 , Issue.3 , pp. 578-586
    • Langley-Evans, S.C.1    Lilley, C.2    McMullen, S.3
  • 42
    • 0036850973 scopus 로고    scopus 로고
    • Serum concentrations of homocysteine are elevated during early pregnancy in rodent models of fetal programming
    • Petrie L., Duthie S.J., Rees W.D., McConnell J.M. Serum concentrations of homocysteine are elevated during early pregnancy in rodent models of fetal programming. Br J Nutr 2002, 88(5):471-477.
    • (2002) Br J Nutr , vol.88 , Issue.5 , pp. 471-477
    • Petrie, L.1    Duthie, S.J.2    Rees, W.D.3    McConnell, J.M.4
  • 43
    • 0343526326 scopus 로고    scopus 로고
    • Maternal protein deficiency causes hypermethylation of DNA in the livers of rat fetuses
    • Rees W.D., Hay S.M., Brown D.S., Antipatis C., Palmer R.M. Maternal protein deficiency causes hypermethylation of DNA in the livers of rat fetuses. J Nutr 2000, 130(7):1821-1826.
    • (2000) J Nutr , vol.130 , Issue.7 , pp. 1821-1826
    • Rees, W.D.1    Hay, S.M.2    Brown, D.S.3    Antipatis, C.4    Palmer, R.M.5
  • 44
    • 0033976772 scopus 로고    scopus 로고
    • Critical differences between two low protein diet protocols in the programming of hypertension in the rat
    • Langley-Evans S.C. Critical differences between two low protein diet protocols in the programming of hypertension in the rat. Int J Food Sci Nutr 2000, 51(1):11-17.
    • (2000) Int J Food Sci Nutr , vol.51 , Issue.1 , pp. 11-17
    • Langley-Evans, S.C.1
  • 45
    • 33646523122 scopus 로고    scopus 로고
    • An imbalance in the methionine content of the maternal diet reduces postnatal growth in the rat
    • Rees W.D., Hay S.M., Cruickshank M. An imbalance in the methionine content of the maternal diet reduces postnatal growth in the rat. Metabolism 2006, 55(6):763-770.
    • (2006) Metabolism , vol.55 , Issue.6 , pp. 763-770
    • Rees, W.D.1    Hay, S.M.2    Cruickshank, M.3
  • 46
    • 33646786463 scopus 로고    scopus 로고
    • Sulfur amino acid metabolism in pregnancy: the impact of methionine in the maternal diet
    • Rees W.D., Wilson F.A., Maloney C.A. Sulfur amino acid metabolism in pregnancy: the impact of methionine in the maternal diet. J Nutr 2006, 136(6 Suppl):1701S-1705S.
    • (2006) J Nutr , vol.136 , Issue.6 SUPPL.
    • Rees, W.D.1    Wilson, F.A.2    Maloney, C.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.