Automated analysis of zebrafish images for phenotypic changes in drug discovery

Journal of Neuroscience Methods

Volumn 200, Issue 2, 2011, Pages 229-236

  Chen, Shiye ^a   Zhu, Yongxu ^a   Xia, Weimina ^b   Xia, Shunren ^a   Xu, Xiaoyin ^c  

^a ZHEJIANG UNIVERSITY   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Automatic creation of ROI; Digital image processing; Image alignment; Quantification of gene expression; Zebrafish

Indexed keywords

GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR;

ALGORITHM; ALZHEIMER DISEASE; ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; AUTOMATION; CONTROLLED STUDY; DRUG DESIGN; EMBRYO; GENE EXPRESSION; HEAD; HIGH THROUGHPUT SCREENING; IMAGE PROCESSING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGION OF INTEREST; TRUNK; ZEBRA FISH;

AGE FACTORS; ALGORITHMS; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CLINICAL LABORATORY TECHNIQUES; DIAGNOSTIC IMAGING; DIPEPTIDES; DRUG DISCOVERY; EMBRYO, NONMAMMALIAN; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMAGE PROCESSING, COMPUTER-ASSISTED; OLIGOPEPTIDES; PHENOTYPE; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 80051600149     PISSN: 01650270     EISSN: 1872678X     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2011.06.015     Document Type: Article

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