Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues

Journal of Medicinal Chemistry

Volumn 54, Issue 15, 2011, Pages 5508-5521

  Cueva, Juan Pablo ^b   Gallardo Godoy, Alejandra ^c   Juncosa, Jose I ^a   Vidi, Pierre A ^a   Lill, Markus A ^a   Watts, Val J ^a   Nichols, David E ^a  

^a PURDUE UNIVERSITY   (United States)

^b University of Bath   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7ALPHA METHYL SUBSTITUTED DIHYDREXIDINE; 7BETA METHYL SUBSTITUTED DIHYDREXIDINE; 8ALPHA METHYL SUBSTITUTED DIHYDREXIDINE; 8BETA METHYL SUBSTITUTED DIHYDREXIDINE; DIHYDREXIDINE; DOPAMINE 1 RECEPTOR; PHENYLALANINE; SERINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CYCLIZATION; DRUG SYNTHESIS; METHYLATION; MOLECULAR MODEL; PHOTOCHEMISTRY; SUBSTITUTION REACTION;

BINDING SITES; COMPUTER SIMULATION; DOPAMINE AGONISTS; HUMANS; MODELS, MOLECULAR; PHENANTHRIDINES; PROTEIN BINDING; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79961213322     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200334c     Document Type: Article

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