Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2

European Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2011, Pages 547-555

  Brogi, Simone ^a   Corelli, Federico ^a   Di Marzo, Vincenzo ^b   Ligresti, Alessia ^b   Mugnaini, Claudia ^a   Pasquini, Serena ^a   Tafi, Andrea ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b CNR   (Italy)

Author keywords

3D QSSR; Cannabinoid receptor 2; Computer aided drug design; Quinolones; Selective ligands

Indexed keywords

CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; N (ADAMANTAN 1 YL) 4 OXO 8 METHYL 1 PENTYL 1,4 DIHYDROQUINOLINE 3 CARBOXAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; PHARMACOPHORE; QUANTITATIVE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL IMAGING;

COMPUTER SIMULATION; DRUG DESIGN; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINOLONES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; RECOMBINANT PROTEINS; STEREOISOMERISM;

EID: 79151478285     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.11.034     Document Type: Article

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