Glycosidic bond cleavage is not required for phytosteryl glycoside-induced reduction of cholesterol absorption in mice

Lipids

Volumn 46, Issue 8, 2011, Pages 701-708

  Lin, Xiaobo ^a   Ma, Lina ^a   Moreau, Robert A ^b   Ostlund Jr , Richard E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EASTERN REGIONAL RESEARCH CENTER   (United States)

Author keywords

Lipid absorption; Mass spectrometry; Plant sterols; Stable isotopes

Indexed keywords

ACYLATED STERYL GLYCOSIDE; CHOLESTEROL; DEACYLATED STERYL GLYCOSIDE; GLYCINE CLEAVAGE SYSTEM; GLYCOSIDE; PHYTOSTEROL; PHYTOSTERYL GLYCOSIDE; SITOSTANOL; SOYBEAN OIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; DIETARY INTAKE; FECES ANALYSIS; LIPID ABSORPTION; MALE; MOUSE; NONHUMAN; STOMACH MUCOSA;

ANIMALS; CHOLESTEROL; CHROMATOGRAPHY, GAS; FECES; GLYCOSIDES; HUMANS; INTESTINAL ABSORPTION; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; PHYTOSTEROLS;

ANIMALIA; GLYCINE MAX; MUS;

EID: 79961208831     PISSN: 00244201     EISSN: 15589307     Source Type: Journal    
DOI: 10.1007/s11745-011-3560-2     Document Type: Article

References (27)

1. RE Ostlund Jr 2002 Phytosterols in human nutrition Ann Rev Nutr 22 533 549 10.1146/annurev.nutr.22.020702.075220 1:CAS:528:DC%2BD38XmtF2htbs%3D (Pubitemid 35221472)
2. RE Ostlund Jr SB Racette A Okeke WF Stenson 2002 Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humans Am J Clin Nutr 75 6 1000 1004 12036805 1:CAS:528: DC%2BD38XktlSmsbg%3D (Pubitemid 34547528)
3. RE Ostlund Jr SB Racette WF Stenson 2003 Inhibition of cholesterol absorption by phytosterol-replete wheat germ compared with phytosterol-depleted wheat germ Am J Clin Nutr 77 6 1385 1389 12791614 1:CAS:528:DC%2BD3sXntlanurk%3D (Pubitemid 39655270)
4. P Nestel M Cehun S Pomeroy M Abbey G Weldon 2001 Cholesterol-lowering effects of plant sterol esters and non-esterified stanols in margarine, butter and low-fat foods Eur J Clin Nutr 55 12 1084 1090 11781675 10.1038/sj.ejcn. 1601264 1:CAS:528:DC%2BD38XisFemsA%3D%3D (Pubitemid 33114681)
5. MR Law 2000 Plant sterol and stanol margarines and health West J Med 173 1 43 47 10903294 10.1136/ewjm.173.1.43 1:STN:280:DC%2BD3czpvFCgsA%3D%3D (Pubitemid 30457122)
6. TT Nguyen 1999 The cholesterol-lowering action of plant stanol esters J Nutr 129 12 2109 2112 10573535 1:CAS:528:DyaK1MXns1yjtb4%3D
7. WS Aronow 2001 Cholesterol 2001. Rationale for lipid-lowering in older patients with or without CAD Geriatrics 56 9 22 30 11582971 1:STN:280: DC%2BD3MrjsFOmsQ%3D%3D (Pubitemid 32905880)
8. Expert Panel on Detection 2001 Executive summary of the third report of the national cholesterol education program (NCEP) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) JAMA 285 19 2486 2497 10.1001/jama.285.19.2486
9. RE Ostlund Jr CA Spilburg WF Stenson 1999 Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans Am J Clin Nutr 70 5 826 831 10539742 1:CAS:528:DyaK1MXntFCgtbc%3D (Pubitemid 29512907)
10. G Gremaud E Dalan C Piguet M Baumgartner P Ballabeni B Decarli ME Leser A Berger LB Fay 2002 Effects of non-esterified stanols in a liquid emulsion on cholesterol absorption and synthesis in hypercholesterolemic men Eur J Nutr 41 2 54 60 12083314 10.1007/s003940200008 1:CAS:528:DC%2BD38XltFSiu7k%3D (Pubitemid 36056336)
11. CA Spilburg AC Goldberg JB McGill WF Stenson SB Racette J Bateman TB McPherson RE Ostlund Jr 2003 Fat-free foods supplemented with soy stanol-lecithin powder reduce cholesterol absorption and LDL cholesterol J Am Diet Assoc 103 5 577 581 12728215 10.1053/jada.2003.50110 (Pubitemid 38368718)
12. MB Katan SM Grundy P Jones M Law T Miettinen R Paoletti 2003 Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels Mayo Clin Proc 78 8 965 978 12911045 10.4065/78.8.965 1:CAS:528:DC%2BD3sXmvFShs70%3D (Pubitemid 36936128)
13. RA Moreau BD Whitaker KB Hicks 2002 Phytosterols, phytostanols, and their conjugates in foods: structural diversity, quantitative analysis, and health-promoting uses Prog Lipid Res 41 6 457 500 12169300 10.1016/S0163- 7827(02)00006-1 1:CAS:528:DC%2BD38XmtVSks7k%3D
14. SB Racette X Lin M Lefevre CA Spearie MM Most L Ma RE Ostlund Jr 2010 Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study Am J Clin Nutr 91 1 32 38 19889819 10.3945/ajcn.2009.28070 1:CAS:528:DC%2BD1MXhs1WlsbjK
15. X Lin SB Racette M Lefevre CA Spearie M Most L Ma RE Ostlund Jr 2010 The effects of phytosterols present in natural food matrices on cholesterol metabolism and LDL-cholesterol: a controlled feeding trial Eur J Clin Nutr 64 12 1481 1487 20808333 10.1038/ejcn.2010.180 1:CAS:528:DC%2BC3cXhsV2gurvI
16. D Jonker GD van der Hoek JFC Glatz C Homan MA Posthumus MB Katan 1985 Combined determination of free, esterified and glycosylated plant sterols in foods Nutr Rep Int 32 943 951 1:CAS:528:DyaL28XkvFyquw%3D%3D (Pubitemid 16254522)
17. L Normén S Bryngelsson M Johnsson J Evheden LBH Ellegard H Brants H Andersson P Dutta 2002 The phytosterol content of some cereal foods commonly consumed in Sweden and in the Netherlands J Food Comp Anal 15 6 693 704 10.1006/jfca.2002.1098 (Pubitemid 35446545)
18. L Normen M Johnsson H Andersson Y van Gameren P Dutta 1999 Plant sterols in vegetables and fruits commonly consumed in Sweden Eur J Clin Nutr 38 84 89 10.1007/s003940050048 1:CAS:528:DyaK1MXjt1alt7Y%3D (Pubitemid 29262086)
19. X Lin L Ma SB Racette CL Anderson Spearie RE Ostlund Jr 2009 Phytosterol glycosides reduce cholesterol absorption in humans Am J Physiol Gastrointest Liver Physiol 296 4 G931 G935 19246636 10.1152/ajpgi.00001.2009 1:CAS:528:DC%2BD1MXkvVygsrk%3D
20. RA Moreau KB Hicks 2004 The in vitro hydrolysis of phytosterol conjugates in food matrices by mammalian digestive enzymes Lipids 39 8 769 776 15638245 1:CAS:528:DC%2BD2cXhtFSht7zF (Pubitemid 39602528)
21. N Weber 1988 Metabolism of sitosteryl beta-d-glucoside and its nutritional effects in rats Lipids 23 1 42 47 3352471 10.1007/BF02535303 1:CAS:528:DyaL1cXhs1Kht70%3D
22. X Lin L Ma C Gopalan RE Ostlund 2009 d-chiro-Inositol is absorbed but not synthesised in rodents Br J Nutr 102 10 1426 1434 19586572 10.1017/ S0007114509990456 1:CAS:528:DC%2BD1MXhsFOgs7nF
23. EG Bligh WJ Dyer 1959 A rapid method of total lipid extraction and purification Can J Biochem Physiol 37 8 911 917 13671378 10.1139/o59-099 1:CAS:528:DyaG1MXhtVSgt70%3D
24. RE Ostlund Jr FF Hsu MS Bosner WF Stenson DL Hachey 1996 Quantification of cholesterol tracers by gas chromatography-negative ion chemical ionization mass spectrometry J Mass Spectrom 31 11 1291 1296 8946736 10.1002/(SICI)1096- 9888(199611)31:11<1291::AID-JMS424>3.0.CO;2-5 (Pubitemid 26392426)
25. SB Racette CA Spearie KM Phillips X Lin L Ma RE Ostlund Jr 2009 Phytosterol-deficient and high-phytosterol diets developed for controlled feeding studies J Am Diet Assoc 109 2043 2051 19942022 10.1016/j.jada.2009.09. 009 1:CAS:528:DC%2BC3cXisFKnu7g%3D
26. RE Ostlund Jr JB McGill CM Zeng DF Covey J Stearns WF Stenson CA Spilburg 2002 Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans Am J Physiol Endocrinol Metab 282 4 E911 E916 11882512 1:CAS:528:DC%2BD38XivVels7o%3D
27. KM Moreau RAS MJ Haas 2008 The identification and quantification of steryl glucosides in precipitates from commercial biodiesel J Am Oil Chem Soc 85 761 770 10.1007/s11746-008-1264-4