Poly(lactide-co-glycolide) nanocapsules containing benzocaine: Influence of the composition of the oily nucleus on physico-chemical properties and anesthetic activity

Pharmaceutical Research

Volumn 28, Issue 8, 2011, Pages 1984-1994

  De Melo, Nathalie Ferreira Silva ^a,b   Grillo, Renato ^a,b   Guilherme, Viviane Aparecida ^b   De Araujo, Daniele Ribeiro ^b,c   De Paula, Eneida ^b   Rosa, André Henrique ^a   Fraceto, Leonardo Fernandes ^a,b  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c UNIVERSIDADE FEDERAL DO ABC   (Brazil)

Author keywords

benzocaine; local anesthetic; nanocapsule; oily nucleus; PLGA

Indexed keywords

BENZOCAINE; CELLULOSE; MINERAL OIL; NANOCAPSULE; POLYGLACTIN;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; IN VITRO STUDY; MALE; MOUSE; NANOENCAPSULATION; NERVE BLOCK; NONHUMAN; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SCIATIC NERVE; ZETA POTENTIAL;

ANESTHETICS, LOCAL; ANIMALS; BENZOCAINE; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; HYDROGEN-ION CONCENTRATION; LACTIC ACID; MALE; MICE; NANOCAPSULES; OILS; PAIN; PARTICLE SIZE; POLYGLYCOLIC ACID; SOLUBILITY; SUSPENSIONS;

EID: 79961173176     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0425-6     Document Type: Article

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