Inclusion complexation of amide-typed local anaesthetics with β-cyclodextrin and its derivatives. II. Evaluation of affinity constants and in vitro transfer rate constants

International Journal of Pharmaceutics

Volumn 136, Issue 1-2, 1996, Pages 165-174

  Dollo, Gilles ^a   Le Corre, Pascal ^a   Chevanne, Francois ^a   Le Verge, Roger ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

Author keywords

Cyclodextrins; Inclusion compound; Local anaesthetics; Phase solubility analysis; Stability constant; Transfere rate constant; Two phase system

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; BETA CYCLODEXTRIN; BUPIVACAINE; DICHLOROMETHANE; ETIDOCAINE; HEPTAKIS(2,6 O DIMETHYL) BETA CYCLODEXTRIN; KLEPTOSE; LIDOCAINE; LOCAL ANESTHETIC AGENT; MEPIVACAINE; OCTANOL; PRILOCAINE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; DRUG SOLUBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHASE TRANSITION; PRIORITY JOURNAL; TEMPERATURE;

EID: 0029890777     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(96)04512-7     Document Type: Article

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