A new look at the hemolytic effect of local anesthetics, considering their real membrane/water partitioning at pH 7.4

Biophysical Chemistry

Volumn 110, Issue 3, 2004, Pages 213-221

  Malheiros, Sônia V P ^a,b   Pinto, Luciana M A ^a   Gottardo, Luciane ^a   Yokaichiya, Daniela K ^a   Fraceto, Leonardo F ^a,c   Meirelles, Nilce C ^a   De Paula, Eneida ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b FACULDADE DE MEDICINA DE JUNDIAÍ   (Brazil)

^c UNIVERSITY OF SOROCABA   (Brazil)

Author keywords

benzocaine; bupivacaine; BVC; BZC; charged species; chloroprocaine; CLP; DBC; dibucaine; egg phosphatidylcholine; EPC; Erythrocytes; Hemolysis; Ionization; LA; LA+; LA:; LDC; lidocaine; local anesthetic; Local anesthetics; Membrane; MVC; Partition; uncharged species

Indexed keywords

BENZOCAINE; BUPIVACAINE; CHLOROPROCAINE; CINCHOCAINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; MEPIVACAINE; PHOSPHOLIPID; PRILOCAINE; PROCAINE; TETRACAINE; WATER;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; ARTIFICIAL MEMBRANE; CORRELATION ANALYSIS; DRUG EFFECT; DRUG POTENCY; ERYTHROCYTE; HEMOLYSIS; HYDROPHOBICITY; IONIZATION; MEASUREMENT; MOLECULAR INTERACTION; NONHUMAN; PH; PHOSPHOLIPID BILAYER; PHYSICAL CHEMISTRY; PREDICTION; PRIORITY JOURNAL; RAT; SOLUBILIZATION;

AMIDES; AMINATION; ANESTHETICS, LOCAL; ANIMALS; BENZOCAINE; ERYTHROCYTE MEMBRANE; ETHERS; HEMOLYSIS; HYDROGEN-ION CONCENTRATION; IONS; MICE; MOLECULAR STRUCTURE; WATER;

EID: 3042515541     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpc.2004.01.013     Document Type: Article

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