Glycation of insulin in the islets of Langerhans of normal and diabetic animals

Diabetes

Volumn 45, Issue 11, 1996, Pages 1489-1496

  Abdel Wahab, Yasser H A ^a   O'Harte, Finbarr P M ^a   Ratcliff, Helen ^a   McClenaghan, Neville H ^a   Barnett, Christopher R ^a   Flatt, Peter R ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; GLYCATION; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERGLYCEMIA; INSULIN RESISTANCE; LIPOGENESIS; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; RADIOIMMUNOASSAY; STREPTOZOCIN DIABETES;

EID: 0029909202     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.11.1489     Document Type: Article

References (31)

1. Reiser KM, Amigable MA, Last JA: Nonenzymatic glycation of type I collagen. J Biol Chem 267:24207-24216,1992
2. Beswick HT, Harding JJ: Conformational changes induced in lens α- and γ-crystallins by modification with glucose 6-phosphate. Biochem J 246:761-769,1987
3. Arai K, Maguchi S, Fuji S, Ishibashi H, Oikawa K, Taniguichi N: Glycation and inactivation of human Cu-Zn Superoxide dismutase. J Biol Chem 262:16969-16972,1987
4. Brownlee M: Nonenzymatic glycosylation of macromolecules. Diabetes 41 (Suppl. 2):57-60,1992
5. Vlassara H, Brownlee M, Cerami A: Nonenzymatic glycosylation: role in the pathogenesis of diabetic complications. Clin Chem 32:37-41,1986
6. O'Harte FPM, Højrup P, Flatt PR: Identification of the site of glycation of human insulin. Peptides. In press
7. Dolhofer R, Wieland OH: Preparation and biological properties of glycosylated insulin. FEBS Lett 100:133-136,1979
8. Lapolla A, Tessari P, Poli T, Valerio A, Duner E, Iori E, Fedele D, Crepaldi G: Reduced in vivo biological activity of in vitro glycosylated insulin. Diabetes 37:787-791,1988
9. Sherwin RS, Kramer KJ, Tobin JD, Insel PA, Liljenquist E, Berman M, Andres R: A model for kinetics of insulin in man. J Clin Invest 53:1481-1492,1974
10. Bailey CJ, Flatt PR: Animal models of diabetes. In Recent Advances in Diabetes. Vol. 2. Nattrass M, Ed. Edinburgh, Churchill Livingstone, 1986, p. 71-89
11. 15Ca uptake by isolated mouse pancreatic islets. Biomed Res 4:557-566,1983
12. Gould BJ, Flatt PR, Kotecha S, Collett S, Swanston-Flatt SK: Measurement of glycosylated hemoglobin and glycosylated plasma proteins in animal models with diabetes or inappropriate hypoglycemia. Horm Metab Res 18:7915-799,1986
13. Salicinski PRP, McLean C, Sykes JEC, Clement-Jones W, Lowry PJ: Iodination of proteins, glycoproteins and peptides, using a solid phase oxidizing agent: 1,3,4,6-tetrachloro-3α,6α-diphenylglycouril (Iodogen). Ann Biochem 117:136-146,1981
14. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal Biochem 72:248-254,1976
15. Halban PA, Rhodes CJ, Shoelson SE: High performance liquid chromatography (HPLC): a rapid, flexible and sensitive method for separating islet proinsulin and insulin. Diabetologia 29:893-896,1989
16. Neerman-Arbez M, Halban PA: Novel, non-crinophagic degradation of connecting peptide in transformed pancreatic beta cells. J Biol Chem 268:16248-16252,1993
17. Flatt PR, Bailey CJ: Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice. Diabetologia 20:573-577,1981
18. Stevens VJ: Determination of glucose by automatic analyzer. Clin Chem 32:9199-9201,1971
19. Leahy JL: Increased proinsulin/insulin ratio in pancreas extracts of hyperglycemic rats. Diabetes 42:22-27,1993
20. Bailey CJ, Flatt PR, Atkins TW: Influence of genetic background and age on the expression of the obese hyperglycaemic syndrome in Aston ob/ob mice. Int J Obesity 6:11-21,1980
21. Abdel-Wahab YHA, O'Harte FPM, Barnett CR, Flatt PR: Characterization of insulin glycation in insulin-secreting cells maintained in tissue culture. J Endocrinol. In press
22. Flatt PR, Abdel-Wahab YHA, Boyd AC, Barnett CR, O'Harte FPM: Pancreatic β-cell dysfunction and glucose toxicity in non-insulin-dependent diabetes. Proc Nutr Soc. In press
23. Thorens B, Sarkar HK, Kaback HR, Lodish HF: Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney and β-pancreatic islet cells. Cell 55:281-290,1988
24. Lenzen S: Glucokinase: signal recognition enzyme for glucose-induced insulin secretion. In Nutrient Regulation of Insulin Secretion. Flatt PR, Ed. London, Portland Press, 1992, p. 101-124
25. Waddell ID, Burchell A: Identification, purification and genetic deficiencies of the glucose-6-phosphatase system transport proteins. Eur J Pediatr 152 (Suppl. 1):S14-S17,1993
26. Dolhofer R, Wieland OH: In vitro glycosylation of haemoglobin by different sugars and sugar phosphates. FEBS Lett 85:86-90,1978
27. Stevens VJ, Vlassara H, Monnier VM, Cerami A: Diabetic cataract formation: role of glycosylation of lens crystallins. Proc Natl Acad Sci USA 75:2918-2922,1978
28. Halban P: Proinsulin processing in the regulated and the constitutive secretory pathway. Diabetologia 37 (Suppl. 2):S65-S72,1994
29. Hales CN: The pathogenesis of NIDDM. Diabetologia 37 (Suppl. 2):S162-S168,1994
30. Kahn SE, Prigeon EL, Porte D Jr: Insulin and proinsulin in normal and diabetic humans. In Frontiers of Insulin Secretion and Pancreatic B-cell Research. Flatt PR, Lenzen S, Eds. London, Smith-Gordon & Co. Ltd., 1994, p. 391-402
31. Rhodes CJ, Alarcon C: What β-cell defect could lead to hyperproinsulinemia in NIDDM? Diabetes 43:511-517,1994