메뉴 건너뛰기




Volumn 10, Issue , 2011, Pages

LXR agonist increases apoE secretion from HepG2 spheroid, together with an increased production of VLDL and apoE-rich large HDL

Author keywords

ApoE rich HDL; Apolipoprotein E; LXR agonist; Spheroid HepG2 cells; VLDL

Indexed keywords

ALBUMIN; APOLIPOPROTEIN A1; APOLIPOPROTEIN E; CELL NUCLEUS RECEPTOR; HIGH DENSITY LIPOPROTEIN; LIVER X RECEPTOR AGONIST; LIVER X RECEPTOR ALPHA; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; VERY LOW DENSITY LIPOPROTEIN; ALGINIC ACID; APOA1 PROTEIN, HUMAN; FLUORINATED HYDROCARBON; GLUCURONIC ACID; HEXURONIC ACID; HYPOCHOLESTEROLEMIC AGENT; LIVER X RECEPTOR; MICROSPHERE; ORPHAN NUCLEAR RECEPTOR; SULFONAMIDE; TO-901317;

EID: 79961102521     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-10-134     Document Type: Article
Times cited : (20)

References (30)
  • 1
    • 0029989388 scopus 로고    scopus 로고
    • Apolipoprotein E produced by human monocyte-derived macrophages mediates cholesterol efflux that occurs in the absence of added cholesterol acceptors
    • DOI 10.1074/jbc.271.45.28641
    • Apolipoprotein E produced by human monocyte-derived macrophages mediates cholesterol efflux that occurs in the absence of added cholesterol acceptors. Zhang WY, Gaynor PM, Kruth HS, J Biol Chem 1996 271 28641 6 10.1074/jbc.271.45. 28641 8910497 (Pubitemid 26374691)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.45 , pp. 28641-28646
    • Zhang, W.-Y.1    Gaynor, P.M.2    Kruth, H.S.3
  • 3
    • 0033999663 scopus 로고    scopus 로고
    • Markedly increased secretion of VLDL triglycerides induced by gene transfer of apolipoprotein E isoforms in apoE-deficient mice
    • Markedly increased secretion of VLDL triglycerides induced by gene transfer of apolipoprotein E isoforms in apoE-deficient mice. Tsukamoto K, Maugeais C, Glick JM, Rader DJ, J Lipid Res 2000 41 253 9 10681409 (Pubitemid 30117866)
    • (2000) Journal of Lipid Research , vol.41 , Issue.2 , pp. 253-259
    • Tsukamoto, K.1    Maugeais, C.2    Glick, J.M.3    Rader, D.J.4
  • 4
    • 0027471464 scopus 로고
    • A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice
    • A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice. Simonet WS, Bucay N, Lauer SJ, Taylor JM, J Biol Chem 1993 268 8221 9 7681840 (Pubitemid 23120410)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.11 , pp. 8221-8229
    • Simonet, W.S.1    Bucay, N.2    Lauer, S.J.3    Taylor, J.M.4
  • 5
    • 0030663731 scopus 로고    scopus 로고
    • Two hepatic enhancers, HCR.1 and HCR.2, coordinate the liver expression of the entire human apolipoprotein E/C-I/C-IV/C-II gene cluster
    • DOI 10.1074/jbc.272.46.29113
    • Two hepatic enhancers, HCR.1 and HCR.2, coordinate the liver expression of the entire human apolipoprotein E/C-I/C-IV/C-II gene cluster. Allan CM, Taylor S, Taylor JM, J Biol Chem 1997 272 29113 9 10.1074/jbc.272.46.29113 9360987 (Pubitemid 27498200)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.46 , pp. 29113-29119
    • Allan, C.M.1    Taylor, S.2    Taylor, J.M.3
  • 6
    • 0034644663 scopus 로고    scopus 로고
    • Duplicated downstream enhancers control expression of the human apolipoprotein e gene in macrophages and adipose tissue
    • 10893248
    • Duplicated downstream enhancers control expression of the human apolipoprotein E gene in macrophages and adipose tissue. Shih SJ, Allan C, Grehan S, Tse E, Moran C, Taylor JM, J Biol Chem 2000 275 31567 72 10893248
    • (2000) J Biol Chem , vol.275 , pp. 31567-72
    • Shih, S.J.1    Allan, C.2    Grehan, S.3    Tse, E.4    Moran, C.5    Taylor, J.M.6
  • 8
    • 0025057613 scopus 로고
    • Apoprotein E biosynthesis in the cholesterol-fed guinea pig
    • Apoprotein E biosynthesis in the cholesterol-fed guinea pig. Driscoll DM, Mazzone T, Matsushima T, Getz GS, Arteriosclerosis 1990 10 31 9 10.1161/01.ATV.10.1.31 2297345 (Pubitemid 20035102)
    • (1990) Arteriosclerosis , vol.10 , Issue.1 , pp. 31-39
    • Driscoll, D.M.1    Mazzone, T.2    Matsushima, T.3    Getz, G.S.4
  • 9
    • 0026553082 scopus 로고
    • Effects of dietary fats and cholesterol on liver lipid content and hepatic apolipoprotein A-I, B, and e and LDL receptor mRNA levels in cebus monkeys
    • 1314879
    • Effects of dietary fats and cholesterol on liver lipid content and hepatic apolipoprotein A-I, B, and E and LDL receptor mRNA levels in cebus monkeys. Hennessy LK, Osada J, Ordovas JM, Nicolosi RJ, Stucchi AF, Brousseau ME, Schaefer EJ, J Lipid Res 1992 33 351 60 1314879
    • (1992) J Lipid Res , vol.33 , pp. 351-60
    • Hennessy, L.K.1    Osada, J.2    Ordovas, J.M.3    Nicolosi, R.J.4    Stucchi, A.F.5    Brousseau, M.E.6    Schaefer, E.J.7
  • 10
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
    • DOI 10.1016/S0092-8674(00)81432-4
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, Mangelsdorf DJ, Cell 1998 93 693 704 10.1016/S0092-8674(00)81432-4 9630215 (Pubitemid 28257577)
    • (1998) Cell , vol.93 , Issue.5 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3    Janowski, B.A.4    Lobaccaro, J.-M.A.5    Hammer, R.E.6    Mangelsdorf, D.J.7
  • 11
    • 0035137478 scopus 로고    scopus 로고
    • Human hepatocyte cell lines proliferating as cohesive spheroid colonies in alginate markedly upregulate both synthetic and detoxificatory liver function
    • DOI 10.1016/S0168-8278(00)00080-5, PII S0168827800000805
    • Human hepatocyte cell lines proliferating as cohesive spheroid colonies in alginate markedly upregulate both synthetic and detoxificatory liver function. Khalil M, Shariat-Panahi A, Tootle R, Ryder T, McCloskey P, Roberts E, Hodgson H, Selden C, J Hepatol 2001 34 68 77 11211910 (Pubitemid 32102554)
    • (2001) Journal of Hepatology , vol.34 , Issue.1 , pp. 68-77
    • Khalil, M.1    Shariat-Panahi, A.2    Tootle, R.3    Ryder, T.4    McCloskey, P.5    Roberts, E.6    Hodgson, H.7    Selden, C.8
  • 13
    • 33845583282 scopus 로고    scopus 로고
    • Liver X receptor inhibits the synthesis and secretion of apolipoprotein A1 by human liver-derived cells
    • DOI 10.1021/bi061378y
    • Liver × receptor inhibits the synthesis and secretion of apolipoprotein A1 by human liver-derived cells. Huuskonen J, Vishnu M, Chau P, Fielding PE, Fielding CJ, Biochemistry 2006 45 15068 74 10.1021/bi061378y 17154544 (Pubitemid 44937019)
    • (2006) Biochemistry , vol.45 , Issue.50 , pp. 15068-15074
    • Huuskonen, J.1    Vishnu, M.2    Chau, P.3    Fielding, P.E.4    Fielding, C.J.5
  • 14
    • 12844261729 scopus 로고    scopus 로고
    • Induction of apolipoprotein e expression by TR4 orphan nuclear receptor via 5′ proximal promoter region
    • DOI 10.1016/j.bbrc.2004.12.146, PII S0006291X04029717
    • Induction of apolipoprotein E expression by TR4 orphan nuclear receptor via 5' proximal promoter region. Kim E, Yang Z, Liu NC, Chang C, Biochem Biophys Res Commun 2005 328 85 90 10.1016/j.bbrc.2004.12.146 15670754 (Pubitemid 40164639)
    • (2005) Biochemical and Biophysical Research Communications , vol.328 , Issue.1 , pp. 85-90
    • Kim, E.1    Yang, Z.2    Liu, N.-C.3    Chang, C.4
  • 15
    • 69749097150 scopus 로고    scopus 로고
    • Hepatic VLDL assembly is disturbed in a rat model of nonalcoholic fatty liver disease: Is there a role for dietary coenzyme Q?
    • 19608932
    • Hepatic VLDL assembly is disturbed in a rat model of nonalcoholic fatty liver disease: is there a role for dietary coenzyme Q? Cano A, Ciaffoni F, Safwat GM, Aspichueta P, Ochoa B, Bravo E, Botham KM, J Appl Physiol 2009 107 707 17 19608932
    • (2009) J Appl Physiol , vol.107 , pp. 707-17
    • Cano, A.1    Ciaffoni, F.2    Safwat, G.M.3    Aspichueta, P.4    Ochoa, B.5    Bravo, E.6    Botham, K.M.7
  • 16
    • 0035196704 scopus 로고    scopus 로고
    • Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress
    • 11668021
    • Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress. Robertson G, Leclercq I, Farrell GC, Am J Physiol Gastrointest Liver Physiol 2001 281 1135 9 11668021
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.281 , pp. 71135-9
    • Robertson, G.1    Leclercq, I.2    Farrell, G.C.3
  • 17
    • 0345098365 scopus 로고    scopus 로고
    • The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse
    • DOI 10.1194/jlr.M300135-JLR200
    • The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. Chisholm JW, Hong J, Mills SA, Lawn RM, J Lipid Res 2003 44 2039 48 10.1194/jlr.M300135-JLR200 12923232 (Pubitemid 37509619)
    • (2003) Journal of Lipid Research , vol.44 , Issue.11 , pp. 2039-2048
    • Chisholm, J.W.1    Hong, J.2    Mills, S.A.3    Lawn, R.M.4
  • 18
    • 0037072732 scopus 로고    scopus 로고
    • Stimulation of lipogenesis by pharmacological activation of the liver × receptor leads to production of large, triglyceride-rich very low density lipoprotein particles
    • 10.1074/jbc.M204887200 12097330
    • Stimulation of lipogenesis by pharmacological activation of the liver × receptor leads to production of large, triglyceride-rich very low density lipoprotein particles. Grefhorst A, Elzinga BM, Voshol PJ, Plosch T, Kok T, Bloks VW, van der Sluijs FH, Havekes LM, Romijn JA, Verkade HJ, Kuipers F, J Biol Chem 2002 277 34182 90 10.1074/jbc.M204887200 12097330
    • (2002) J Biol Chem , vol.277 , pp. 34182-90
    • Grefhorst, A.1    Elzinga, B.M.2    Voshol, P.J.3    Plosch, T.4    Kok, T.5    Bloks, V.W.6    Van Der Sluijs, F.H.7    Havekes, L.M.8    Romijn, J.A.9    Verkade, H.J.10    Kuipers, F.11
  • 19
    • 64749086695 scopus 로고    scopus 로고
    • LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: Time course and mechanisms
    • 18757914
    • LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms. Verschuren L, de Vries-van der Weij J, Zadelaar S, Kleemann R, Kooistra T, J Lipid Res 2009 50 301 11 18757914
    • (2009) J Lipid Res , vol.50 , pp. 301-11
    • Verschuren, L.1    De Vries-Van Der Weij, J.2    Zadelaar, S.3    Kleemann, R.4    Kooistra, T.5
  • 20
    • 54349097048 scopus 로고    scopus 로고
    • Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver × receptor agonist in low-density lipoprotein receptor-deficient mice
    • 10.1124/jpet.108.142687 18723776
    • Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver × receptor agonist in low-density lipoprotein receptor-deficient mice. Peng D, Hiipakka RA, Dai Q, Guo J, Reardon CA, Getz GS, Liao S, J Pharmacol Exp Ther 2008 327 332 42 10.1124/jpet.108.142687 18723776
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 332-42
    • Peng, D.1    Hiipakka, R.A.2    Dai, Q.3    Guo, J.4    Reardon, C.A.5    Getz, G.S.6    Liao, S.7
  • 21
    • 0037432165 scopus 로고    scopus 로고
    • T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice
    • DOI 10.1016/S0014-5793(02)03578-0, PII S0014579302035780
    • T-0901317, a synthetic liver × receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice. Terasaka N, Hiroshima A, Koieyama T, Ubukata N, Morikawa Y, Nakai D, Inaba T, FEBS Lett 2003 536 6 11 10.1016/S0014-5793(02)03578-0 12586329 (Pubitemid 36206397)
    • (2003) FEBS Letters , vol.536 , Issue.1-3 , pp. 6-11
    • Terasaka, N.1    Hiroshima, A.2    Koieyama, T.3    Ubukata, N.4    Morikawa, Y.5    Nakai, D.6    Inaba, T.7
  • 22
    • 1542677276 scopus 로고    scopus 로고
    • Enlargement of high density lipoprotein in mice via liver × receptor activation requires apolipoprotein e and is abolished by cholesteryl ester transfer protein expression
    • 10.1074/jbc.M304274200 12947111
    • Enlargement of high density lipoprotein in mice via liver × receptor activation requires apolipoprotein E and is abolished by cholesteryl ester transfer protein expression. Jiang XC, Beyer TP, Li Z, Liu J, Quan W, Schmidt RJ, Zhang Y, Bensch WR, Eacho PI, Cao G, J Biol Chem 2003 278 49072 8 10.1074/jbc.M304274200 12947111
    • (2003) J Biol Chem , vol.278 , pp. 49072-8
    • Jiang, X.C.1    Beyer, T.P.2    Li, Z.3    Liu, J.4    Quan, W.5    Schmidt, R.J.6    Zhang, Y.7    Bensch, W.R.8    Eacho, P.I.9    Cao, G.10
  • 24
    • 50049130053 scopus 로고    scopus 로고
    • The LXR agonist T0901317 promotes the reverse cholesterol transport from macrophages by increasing plasma efflux potential
    • 10.1194/jlr.M700254-JLR200 18252848
    • The LXR agonist T0901317 promotes the reverse cholesterol transport from macrophages by increasing plasma efflux potential. Zanotti I, Poti F, Pedrelli M, Favari E, Moleri E, Franceschini G, Calabresi L, Bernini F, J Lipid Res 2008 49 954 60 10.1194/jlr.M700254-JLR200 18252848
    • (2008) J Lipid Res , vol.49 , pp. 954-60
    • Zanotti, I.1    Poti, F.2    Pedrelli, M.3    Favari, E.4    Moleri, E.5    Franceschini, G.6    Calabresi, L.7    Bernini, F.8
  • 25
    • 34247139296 scopus 로고    scopus 로고
    • Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol
    • DOI 10.1074/jbc.M611063200
    • Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol. Beyea MM, Heslop CL, Sawyez CG, Edwards JY, Markle JG, Hegele RA, Huff MW, J Biol Chem 2007 282 5207 16 17186944 (Pubitemid 47093759)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.8 , pp. 5207-5216
    • Beyea, M.M.1    Heslop, C.L.2    Sawyez, C.G.3    Edwards, J.Y.4    Markle, J.G.5    Hegele, R.A.6    Huff, M.W.7
  • 27
    • 0025900899 scopus 로고
    • Effect of rat plasma high density lipoprotein with or without apolipoprotein e on the cholesterol uptake and on the induction of the corticosteroid biosynthetic pathway in newborn rat adrenocortical cell cultures
    • 10.1016/0167-4889(91)90003-G 1892898
    • Effect of rat plasma high density lipoprotein with or without apolipoprotein E on the cholesterol uptake and on the induction of the corticosteroid biosynthetic pathway in newborn rat adrenocortical cell cultures. Hammami M, Meunier S, Maume G, Gambert P, Maume BF, Biochim Biophys Acta 1991 1094 153 60 10.1016/0167-4889(91)90003-G 1892898
    • (1991) Biochim Biophys Acta , vol.1094 , pp. 153-60
    • Hammami, M.1    Meunier, S.2    Maume, G.3    Gambert, P.4    Maume, B.F.5
  • 28
    • 33847179481 scopus 로고    scopus 로고
    • Adrenal cholesterol utilization
    • 17208360
    • Adrenal cholesterol utilization. Kraemer FB, Mol Cell Endocrinol 2007 265-266 42 5 17208360
    • (2007) Mol Cell Endocrinol , vol.265-266 , pp. 42-5
    • Kraemer, F.B.1
  • 29
    • 33646409606 scopus 로고    scopus 로고
    • HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway
    • 10.1172/JCI27602 16670775
    • HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway. Matsuura F, Wang N, Chen W, Jiang XC, Tall AR, J Clin Invest 2006 116 1435 42 10.1172/JCI27602 16670775
    • (2006) J Clin Invest , vol.116 , pp. 1435-42
    • Matsuura, F.1    Wang, N.2    Chen, W.3    Jiang, X.C.4    Tall, A.R.5
  • 30
    • 0142042353 scopus 로고    scopus 로고
    • Structural and functional properties of human plasma high density-sized lipoprotein containing only apoE particles
    • DOI 10.1194/jlr.M200273-JLR200
    • Structural and functional properties of human plasma high density-sized lipoprotein containing only apoE particles. Krimbou L, Marcil M, Chiba H, Genest J Jr, J Lipid Res 2003 44 884 92 10.1194/jlr.M200273-JLR200 12611904 (Pubitemid 37279648)
    • (2003) Journal of Lipid Research , vol.44 , Issue.5 , pp. 884-892
    • Krimbou, L.1    Marcil, M.2    Chiba, H.3    Genes Jr., J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.