Inhibition of SIRT1 increases EZH2 protein level and enhances the repression of EZH2 on target gene expression

Chinese Medical Sciences Journal

Volumn 26, Issue 2, 2011, Pages 77-84

  Lu, Lu ^a   Li, Lei ^a   Lü, Xiang ^a   Wu, Xue Song ^a   Liu, De Pei ^a   Liang, Chih Chuan ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

EZH2; Polycomb repression complex; SIRT1; trimethylated H3K27

Indexed keywords

MESSENGER RNA; SIRTUIN 1; TRANSCRIPTION FACTOR EZH2; DNA BINDING PROTEIN; EZH2 PROTEIN, HUMAN; REPRESSOR PROTEIN; SIRT1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ARTICLE; CELL LEVEL; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN STABILITY; RNA INTERFERENCE; SATB1 GENE; CHEMISTRY; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; HELA CELL; PHYSIOLOGY;

DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; REPRESSOR PROTEINS; SIRTUIN 1; TRANSCRIPTION FACTORS;

EID: 79961101685     PISSN: 10019294     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1001-9294(11)60024-2     Document Type: Article

References (33)

1. JA Kennison The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function Annu Rev Genet 29 1995 289 303
2. AP Bracken, N Dietrich, D Pasini et al. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions Genes Dev 20 2006 1123 1136
3. YB Schwartz, TG Kahn, DA Nix et al. Genome-wide analysis of Polycomb targets in Drosophila melanogaster Nat Genet 38 2006 700 705 (Pubitemid 43927314)
4. LA Boyer, K Plath, J Zeitlinger et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells Nature 441 2006 349 353 (Pubitemid 44050199)
5. B Czermin, R Melfi, D McCabe et al. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites Cell 111 2002 185 196 (Pubitemid 35292439)
6. J Müller, CM Hart, NJ Francis et al. Histone methyltransferase activity of a Drosophila Polycomb group repressor complex Cell 111 2002 197 208 (Pubitemid 35292440)
7. A Kuzmichev, K Nishioka, H Erdjument-Bromage et al. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein Genes Dev 16 2002 2893 2905 (Pubitemid 35334738)
8. R Cao, L Wang, H Wang et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing Science 298 2002 1039 1043 (Pubitemid 35247314)
9. D Pasini, AP Bracken, MR Jensen et al. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity EMBO J 23 2004 4061 4071 (Pubitemid 39472427)
10. JA Simon, CA Lange Roles of the EZH2 histone methyltransferase in cancer epigenetics Mutat Res 647 2008 21 29
11. AA Mills Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins Nat Rev Cancer 10 2010 669 682
12. AP Bracken, D Pasini, M Capra et al. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer EMBO J 22 2003 5323 5335 (Pubitemid 37279943)
13. LR Bohrer, S Chen, TC Hallstrom et al. Androgens suppress EZH2 expression via retinoblastoma (RB) and p130-dependent pathways: a potential mechanism of androgen-refractory progression of prostate cancer Endocrinology 151 2010 5136 5145
14. S Varambally, Q Cao, RS Mani et al. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer Science 322 2008 1695 1699
15. R Ciarapica, G Russo, F Verginelli et al. Deregulated expression of miR-26a and Ezh2 in rhabdomyosarcoma Cell Cycle 8 2009 172 175
16. AH Juan, RM Kumar, JG Marx et al. Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells Mol Cell 36 2009 61 74
17. T Kisliouk, S Yosefi, N Meiri MiR-138 inhibits EZH2 methyltransferase expression and methylation of histone H3 at lysine 27, and affects thermotolerance acquisition Eur J Neurosci 33 2011 224 235
18. J Tan, X Yang, L Zhuang et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells Genes Dev 21 2007 1050 1063 (Pubitemid 46686474)
19. M Dimri, PV Bommi, AA Sahasrabuddhem et al. Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells Carcinogenesis 31 2010 489 495
20. W Fiskus, M Pranpat, M Balasis et al. Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells Mol Cancer Ther 5 2006 3096 3104 (Pubitemid 46092051)
21. MC Haigis, DA Sinclair Mammalian sirtuins: biological insights and disease relevance Annu Rev Pathol 5 2010 253 295
22. A Kuzmichev, R Margueron, A Vaquero et al. Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation Proc Natl Acad Sci U S A 102 2005 1859 1864 (Pubitemid 40261977)
23. L Li, L Lu, X Lü et al. Epigenetic repression of SATB1 by Polycomb group protein EZH2 in epithelial cells Chin Med Sci J 25 2010 199 205
24. H Vaziri, SK Dessain, E Ng Eaton et al. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase Cell 107 2001 149 159 (Pubitemid 33035942)
25. A Brunet, LB Sweeney, JF Sturgill et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase Science 303 2004 2011 2015 (Pubitemid 38393275)
26. WY Chen, DH Wang, RC Yen et al. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses Cell 123 2005 437 448 (Pubitemid 41546674)
27. C Wang, L Chen, X Hou et al. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage Nat Cell Biol 8 2006 1025 1031 (Pubitemid 44314735)
28. A Vaquero, M Scher, H Erdjument-Bromage et al. SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation Nature 450 2007 440 444 (Pubitemid 350126745)
29. A Vaquero, M Scher, D Lee et al. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin Mol Cell 16 2004 93 105 (Pubitemid 39330155)
30. SK Kurdistani, S Tavazoie, M Grunstein Mapping global histone acetylation patterns to gene expression Cell 117 2004 721 733 (Pubitemid 38748889)
31. K Pruitt, RL Zinn, JE Ohm et al. Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation PLoS Genet 2 2006 e40
32. RH Wang, K Sengupta, C Li et al. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice Cancer Cell 14 2008 312 323
33. CX Deng SIRT1, is it a tumor promoter or tumor suppressor? Int J Biol Sci 5 2009 147 152