Successful generation of primary virus-specific and anti-tumor T-cell responses from the naïve donor T-cell repertoire is determined by the balance between antigen-specific precursor T cells and regulatory T cells

Haematologica

Volumn 96, Issue 8, 2011, Pages 1204-1212

  Jedema, Inge ^a   van de Meent, Marian ^a   Pots, Jeanette ^a   Kester, Michel G D ^a   van der Beek, Martha T ^a   Frederik Falkenburg, J H ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

CMV; Immunotherapy; Minor histocompatibility anti gens; Primary immune responses; Regulatory T cells

Indexed keywords

CD137 ANTIGEN; CD45RO ANTIGEN; CD8 ANTIGEN; MINOR HISTOCOMPATIBILITY ANTIGEN; TETRAMER; VIRUS ANTIGEN;

ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; BLOOD DONOR; CD8+ T LYMPHOCYTE; CELL ISOLATION; CELLULAR IMMUNITY; COCULTURE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DENDRITIC CELL; HUMAN; HUMAN CELL; LYMPHOCYTE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRE T LYMPHOCYTE; REGULATORY T LYMPHOCYTE; T CELL DEPLETION; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD; ANTIGENS, VIRAL; CYTOKINES; CYTOMEGALOVIRUS; EPITOPES; GRAFT VS HOST DISEASE; HLA-A ANTIGENS; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE DEPLETION; NEOPLASMS; PRECURSOR CELLS, T-LYMPHOID; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY; TISSUE DONORS; VIRUSES;

EID: 79961089176     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2010.039099     Document Type: Article

References (45)

1. Storb R. Allogeneic hematopoietic stem cell transplantation--yesterday, today, and tomorrow. Exp Hematol. 2003;31(1):1-10
2. Marmont AM, Horowitz MM, Gale RP, Sobocinski K, Ash RC, van Bekkum DW, et al. T-cell depletion of HLA-identical transplants in leukemia. Blood. 1991;78(8):2120-2130.
3. Apperley JF, Jones L, Hale G, Waldmann H, Hows J, Rombos Y, et al. Bone marrow transplantation for patients with chronic myeloid leukaemia: T-cell depletion withCampath-1 reduces the incidence of graftversus-host disease but may increase the risk of leukaemic relapse. Bone Marrow Transplant. 1986;1(1):53-66
4. Boeckh M, Leisenring W, Riddell SR, Bowden RA, Huang ML, Myerson D, et al. Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity. Blood. 2003;101 (2):407-414
5. Gandhi MK, Khanna R. Human cyto - megalovirus: clinical aspects, immune regulation, and emerging treatments. LancetInfect Dis. 2004;4(12):725-738
6. Wingard JR. Opportunistic infections after blood and marrow transplantation. Transpl Infect Dis. 1999;1(1):3-20
7. Miller JS, Warren EH, van den Brink MR, Ritz J, Shlomchik WD, Murphy WJ, et al. NCI First International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic Stem cell transplantation: report from the Committee on the Biology Underlying Recurrence of Malignant Disease following Allogeneic HSCT: graft-versus-tumor/ leukemia reaction. Biol Blood MarrowTransplant. 2010;16(5):565-586
8. Porter D, Levine JE. Graft-versus-host disease and graft-versus-leukemia after donor leukocyte infusion. Semin Hematol. 2006; 43(1):53-61
9. Kolb HJ. Graft-versus-leukemia effects of transplantation and donor lymphocytes. Blood. 2008;112(12):4371-4383
10. Peggs KS, Verfuerth S, Pizzey A, Khan N, Guiver M, Moss PA, et al. Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines. Lancet. 2003;362(9393):1375-1377
11. Bissinger AL, Rauser G, Hebart H, Frank F, Jahn G, Einsele H. Isolation and expansion of human cytomegalovirus-specific cytotoxic T lymphocytes using interferongamma secretion assay. Exp Hematol. 2002;30(10):1178-1184
12. Rauser G, Einsele H, Sinzger C, Wernet D, Kuntz G, Assenmacher M, et al. Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants. Blood. 2004;103(9):3565-3572
13. Einsele H, Roosnek E, Rufer N, Sinzger C, Riegler S, Loffler J, et al. Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood. 2002;99(11):3916-3922
14. Feuchtinger T, Richard C, Joachim S, Scheible MH, Schumm M, Hamprecht K, et al. Clinical grade generation of hexon-specific T cells for adoptive T-cell transfer as a treatment of adenovirus infection after allogeneic stem cell transplantation. J Immunother. 2008;31(2):199-206
15. Leen AM, Myers GD, Sili U, Huls MH, Weiss H, Leung KS, et al. Monoculturederived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nat Med. 2006;12(10):1160-1166
16. Walter EA, Greenberg PD, Gilbert MJ, Finch RJ, Watanabe KS, Thomas ED, et al. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med. 1995;333 (16):1038-1044
17. Zandvliet ML, van LE, Jedema I, Veltrop-Duits LA, Willemze R, Guchelaar HJ, et al. Co-ordinated isolation of CD8(+) and CD4(+) T cells recognizing a broad repertoire of cytomegalovirus pp65 and IE1 epitopes for highly specific adoptive immuno - therapy. Cytotherapy. 2010;12(7): 933-944
18. Cobbold M, Khan N, Pourgheysari B, Tauro S, McDonald D, Osman H, et al. Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramers. J Exp Med. 2005;202(3):379-386
19. Wehler TC, Karg M, Distler E, Konur A, Nonn M, Meyer RG, et al. Rapid identification and sorting of viable virus-reactive CD4(+) and CD8(+) T cells based on antigen-triggered CD137 expression. J Immunol Methods. 2008;339(1):23-37
20. Peggs KS, Mackinnon S. Clinical trials with CMV-specific T cells. Cytotherapy. 2002; 4(1):21-28
21. Oelke M, Maus MV, Didiano D, June CH, Mackensen A, Schneck JP. Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig-coated artificial antigen-presenting cells. Nat Med. 2003; 9(5):619-624
22. Ho WY, Nguyen HN, Wolfl M, Kuball J, Greenberg PD. In vitro methods for generating CD8+ T-cell clones for immunotherapy from the naive repertoire. J Immunol Methods. 2006;310(1-2):40-52
23. Wolfl M, Kuball J, Ho WY, Nguyen H, Manley TJ, Bleakley M, et al. Activationinduced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities. Blood. 2007;110(1): 201-210
24. Hanley PJ, Cruz CR, Savoldo B, Leen AM, Stanojevic M, Khalil M, et al. Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes. Blood. 2009;114(9):1958-1967
25. Bleakley M, Otterud BE, Richardt JL, Mollerup AD, Hudecek M, Nishida T, et al. Leukemia-associated minor histocompatibility antigen discovery using T-cell clones isolated by in vitro stimulation of naive CD8+ T cells. Blood. 2010;115(23):4923-4933
26. Jedema I, van der Werff NM, Barge RM, Willemze R, Falkenburg JH. New CFSEbased assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population. Blood. 2004;103(7):2677-2682
27. Heemskerk MH, Hoogeboom M, Hagedoorn R, Kester MG, Willemze R, Falkenburg JH. Reprogramming of virusspecific T cells into leukemia-reactive T cells using T cell receptor gene transfer. J Exp Med. 2004;199(7):885-894
28. Fry TJ, Mackall CL. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J Immunol. 2005;174(11): 6571-6576
29. Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25high regulatory cells in human peripheral blood. J Immunol. 2001;167(3):1245-1253
30. Jonuleit H, Schmitt E, Stassen M, Tuetten - berg A, Knop J, Enk AH. Ident ification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med. 2001;193(11):1285-1294
31. Dieckmann D, Plottner H, Berchtold S, Berger T, Schuler G. Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med. 2001;193(11):1303-1310
32. Booth NJ, McQuaid AJ, Sobande T, Kissane S, Agius E, Jackson SE, et al. Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO. J Immunol. 2010;184(8):4317-4326
33. Hoffmann P, Eder R, Boeld TJ, Doser K, Piseshka B, Andreesen R, et al. Only the CD45RA+ subpopulation of CD4+ CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitroexpansion. Blood. 2006;108(13):4260-4267
34. Valmori D, Merlo A, Souleimanian NE, Hesdorffer CS, Ayyoub M. A peripheral circulating compartment of natural naive CD4 Tregs. J Clin Invest. 2005;115(7):1953-1962
35. Li Y, Bleakley M, Yee C. IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response. J Immunol. 2005;175(4):2261-2269
36. Rosenthal R, Groeper C, Bracci L, Adamina M, Feder-Mengus C, Zajac P, et al. Differential responsiveness to IL-2, IL-7, and IL-15 common receptor gamma chain cytokines by antigen-specific peripheral blood naive or memory cytotoxic CD8+ T cells from healthy donors and melanoma patients. J Immunother. 2009;32(3):252-261
37. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med. 2006;203(7):1701-1711
38. Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med. 2006;203(7):1693-1700
39. Hartigan-O'Connor DJ, Poon C, Sinclair E, McCune JM. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor a chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods. 2007;319(1-2):41-52
40. Alanio C, Lemaitre F, Law HK, Hasan M, Albert ML. Enumeration of human antigenspecific naive CD8+ T cells reveals conserved precursor frequencies. Blood. 2010; 115(18):3718-3725
41. Waller EC, McKinney N, Hicks R, Carmichael AJ, Sissons JG, Wills MR. Differential costimulation through CD137 (4-1BB) restores proliferation of human virus-specific effector memory (CD28(-) CD45RA(HI)) CD8(+) T cells. Blood. 2007; 110(13):4360-4366
42. Cannons JL, Lau P, Ghumman B, DeBenedette MA, Yagita H, Okumura K, et al. 4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy. J Immunol. 2001;167(3):1313-1324
43. Lee AW, Truong T, Bickham K, Fonteneau JF, Larsson M, Da S, I, et al. A clinical grade cocktail of cytokines and PGE2 results in uniform maturation of human monocytederived dendritic cells: implications for immunotherapy. Vaccine. 2002;20 (Suppl 4)A8-A22.
44. Jonuleit H, Kuhn U, Muller G, Steinbrink K, Paragnik L, Schmitt E, et al. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol. 1997;27(12): 3135-3142
45. Altman JD, Moss PA, Goulder PJ, Barouch DH, McHeyzer-Williams MG, Bell JI, et al. Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996;274(5284):94-96.