메뉴 건너뛰기




Volumn 108, Issue 29, 2011, Pages 11959-11964

Functional synthetic Antennapedia genes and the dual roles of YPWM motif and linker size in transcriptional activation and repression

Author keywords

Antenna to tarsus transformation; Homeotic transformations; Hox specificity; Synthetic genes

Indexed keywords

ALANINE; ANTENNAPEDIA PROTEIN; SYNTHETIC DNA; SYNTHETIC PEPTIDE;

EID: 79961072841     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1108686108     Document Type: Article
Times cited : (20)

References (49)
  • 1
    • 0023239424 scopus 로고
    • Homeo boxes in the study of development
    • Gehring WJ (1987) Homeo boxes in the study of development. Science 236: 1245-1252.
    • (1987) Science , vol.236 , pp. 1245-1252
    • Gehring, W.J.1
  • 2
    • 0018240421 scopus 로고
    • A gene complex controlling segmentation in Drosophila
    • Lewis EB (1978) A gene complex controlling segmentation in Drosophila. Nature 276: 565-570.
    • (1978) Nature , vol.276 , pp. 565-570
    • Lewis, E.B.1
  • 3
    • 0026504525 scopus 로고
    • Homeobox genes and axial patterning
    • McGinnis W, Krumlauf R (1992) Homeobox genes and axial patterning. Cell 68: 283-302.
    • (1992) Cell , vol.68 , pp. 283-302
    • McGinnis, W.1    Krumlauf, R.2
  • 4
    • 0021255982 scopus 로고
    • A conserved DNA sequence in homoeotic genes of the Drosophila antennapedia and bithorax complexes
    • McGinnis W, Levine MS, Hafen E, Kuroiwa A, Gehring WJ (1984) A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes. Nature 308:428-433. (Pubitemid 14130914)
    • (1984) Nature , vol.308 , Issue.5958 , pp. 428-433
    • McGinnis, W.1    Levine, M.S.2    Hafen, E.3
  • 5
    • 67749143699 scopus 로고    scopus 로고
    • Evolution of the Hox gene complex from an evolutionary ground state
    • Gehring WJ, Kloter U, Suga H (2009) Evolution of the Hox gene complex from an evolutionary ground state. Curr Top Dev Biol 88:35-61.
    • (2009) Curr Top Dev Biol , vol.88 , pp. 35-61
    • Gehring, W.J.1    Kloter, U.2    Suga, H.3
  • 7
    • 0344902715 scopus 로고
    • Structural relationships among genes that control development: Sequence homology between the antennapedia, ultrabithorax, and fushi tarazu loci of Drosophila
    • Scott MP, Weiner AJ (1984) Structural relationships among genes that control development: Sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila. Proc Natl Acad Sci USA 81:4115-4119. (Pubitemid 14054531)
    • (1984) Proceedings of the National Academy of Sciences of the United States of America , vol.81 , Issue.13 I , pp. 4115-4119
    • Scott, M.P.1    Weiner, A.J.2
  • 9
    • 67749095703 scopus 로고    scopus 로고
    • Hox specificity unique roles for cofactors and collaborators
    • Mann RS, Lelli KM, Joshi R (2009) Hox specificity unique roles for cofactors and collaborators. Curr Top Dev Biol 88:63-101.
    • (2009) Curr Top Dev Biol , vol.88 , pp. 63-101
    • Mann, R.S.1    Lelli, K.M.2    Joshi, R.3
  • 10
    • 53149142761 scopus 로고    scopus 로고
    • Shaping segments: Hox gene function in the genomic age
    • Hueber SD, Lohmann I (2008) Shaping segments: Hox gene function in the genomic age. Bioessays 30:965-979.
    • (2008) Bioessays , vol.30 , pp. 965-979
    • Hueber, S.D.1    Lohmann, I.2
  • 11
    • 28944438404 scopus 로고    scopus 로고
    • Modulating Hox gene functions during animal body patterning
    • DOI 10.1038/nrg1726
    • Pearson JC, Lemons D, McGinnis W (2005) Modulating Hox gene functions during animal body patterning. Nat Rev Genet 6:893-904. (Pubitemid 41782157)
    • (2005) Nature Reviews Genetics , vol.6 , Issue.12 , pp. 893-904
    • Pearson, J.C.1    Lemons, D.2    McGinnis, W.3
  • 14
    • 0025188768 scopus 로고
    • The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain
    • Gibson G, Schier A, LeMotte P, Gehring WJ (1990) The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain. Cell 62:1087-1103.
    • (1990) Cell , vol.62 , pp. 1087-1103
    • Gibson, G.1    Schier, A.2    LeMotte, P.3    Gehring, W.J.4
  • 16
    • 0028170530 scopus 로고
    • Groucho is required for drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins
    • DOI 10.1016/0092-8674(94)90070-1
    • Paroush Z, et al. (1994) Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell 79:805-815. (Pubitemid 24371971)
    • (1994) Cell , vol.79 , Issue.5 , pp. 805-815
    • Paroush, Z.1    Finley Jr., R.L.2    Kidd, T.3    Wainwright, S.M.4    Ingham, P.W.5    Brent, R.6    Ish-Horowicz, D.7
  • 17
    • 0023755660 scopus 로고
    • Alternative RNA splicing that is spatially regulated G generation of transcripts from the Antennapedia gene of Drosophila melanogaster with different protein-coding regions
    • Stroeher VL, Gaiser JC, Garber RL (1988) Alternative RNA splicing that is spatially regulated G generation of transcripts from the Antennapedia gene of Drosophila melanogaster with different protein-coding regions. Mol Cell Biol 8:4143-4154.
    • (1988) Mol Cell Biol , vol.8 , pp. 4143-4154
    • Stroeher, V.L.1    Gaiser, J.C.2    Garber, R.L.3
  • 18
    • 0031845609 scopus 로고    scopus 로고
    • Spatial and temporal targeting of gene expression in Drosophila by means of a tetracycline-dependent transactivator system
    • Bello B, Resendez-Perez D, Gehring WJ (1998) Spatial and temporal targeting of gene expression in Drosophila by means of a tetracycline-dependent transactivator system. Development 125:2193-2202. (Pubitemid 28336381)
    • (1998) Development , vol.125 , Issue.12 , pp. 2193-2202
    • Bello, B.1    Resendez-Perez, D.2    Gehring, W.J.3
  • 19
    • 0023892067 scopus 로고
    • Head and thoracic transformations caused by ectopic expression of Antennapedia during Drosophila development
    • Gibson G, Gehring WJ (1988) Head and thoracic transformations caused by ectopic expression of Antennapedia during Drosophila development. Development 102: 657-675.
    • (1988) Development , vol.102 , pp. 657-675
    • Gibson, G.1    Gehring, W.J.2
  • 20
    • 0027288479 scopus 로고
    • Ectopic expression and function of the Antp and Scr homeotic genes: The N terminus of the homeodomain is critical to functional specificity
    • Zeng W, Andrew DJ, Mathies LD, Horner MA, Scott MP (1993) Ectopic expression and function of the Antp and Scr homeotic genes: The N terminus of the homeodomain is critical to functional specificity. Development 118:339-352. (Pubitemid 23214023)
    • (1993) Development , vol.118 , Issue.2 , pp. 339-352
    • Zeng, W.1    Andrew, D.J.2    Mathies, L.D.3    Horner, M.A.4    Scott, M.P.5
  • 21
    • 0028329632 scopus 로고
    • Setting limits on homeotic gene function: Restraint of Sex combs reduced activity by teashirt and other homeotic genes
    • Andrew DJ, Horner MA, Petitt MG, Smolik SM, Scott MP (1994) Setting limits on homeotic gene function: Restraint of Sex combs reduced activity by teashirt and other homeotic genes. EMBO J 13:1132-1144. (Pubitemid 24074720)
    • (1994) EMBO Journal , vol.13 , Issue.5 , pp. 1132-1144
    • Andrew, D.J.1    Horner, M.A.2    Petitt, M.G.3    Smolik, S.M.4    Scott, M.P.5
  • 22
    • 0029126104 scopus 로고
    • Homeotic response elements are tightly linked to tissue-specific elements in a transcriptional enhancer of the teashirt gene
    • McCormick A, Coré N, Kerridge S, Scott MP (1995) Homeotic response elements are tightly linked to tissue-specific elements in a transcriptional enhancer of the teashirt gene. Development 121:2799-2812.
    • (1995) Development , vol.121 , pp. 2799-2812
    • McCormick, A.1    Coré, N.2    Kerridge, S.3    Scott, M.P.4
  • 23
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118:401-415. (Pubitemid 23214028)
    • (1993) Development , vol.118 , Issue.2 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 24
    • 29644440598 scopus 로고    scopus 로고
    • Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax
    • DOI 10.1242/dev.02138
    • Tour E, Hittinger CT, McGinnis W (2005) Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax. Development 132:5271-5281. (Pubitemid 43020181)
    • (2005) Development , vol.132 , Issue.23 , pp. 5271-5281
    • Tour, E.1    Hittinger, C.T.2    McGinnis, W.3
  • 25
    • 0019796926 scopus 로고
    • A homoeotic mutation transforming leg to antenna in Drosophila
    • Struhl G (1981) A homoeotic mutation transforming leg to antenna in Drosophila. Nature 292:635-638.
    • (1981) Nature , vol.292 , pp. 635-638
    • Struhl, G.1
  • 26
    • 0026287693 scopus 로고
    • Identification of target genes of the homeotic gene Antennapedia by enhancer detection
    • Wagner-Bernholz JT, Wilson C, Gibson G, Schuh R, Gehring WJ (1991) Identification of target genes of the homeotic gene Antennapedia by enhancer detection. Genes Dev 5(12B):2467-2480. (Pubitemid 21905932)
    • (1991) Genes and Development , vol.5 , Issue.12 PART B , pp. 2467-2480
    • Wagner-Bernholz, J.T.1    Wilson, C.2    Gibson, G.3    Schuh, R.4    Gehring, W.J.5
  • 27
    • 0037350693 scopus 로고    scopus 로고
    • Distal antenna and distal antenna related encode nuclear proteins containing pipsqueak motifs involved in antenna development in Drosophila
    • DOI 10.1242/dev.00323
    • Emerald BS, Curtiss J, Mlodzik M, Cohen SM (2003) Distal antenna and distal antenna related encode nuclear proteins containing pipsqueak motifs involved in antenna development in Drosophila. Development 130:1171-1180. (Pubitemid 36395698)
    • (2003) Development , vol.130 , Issue.6 , pp. 1171-1180
    • Emerald, B.S.1    Curtiss, J.2    Mlodzik, M.3    Cohen, S.M.4
  • 28
    • 67349138186 scopus 로고    scopus 로고
    • Spalt major controls the development of the notum and of wing hinge primordia of the Drosophila melanogaster wing imaginal disc
    • Grieder NC, Morata G, Affolter M, Gehring WJ (2009) Spalt major controls the development of the notum and of wing hinge primordia of the Drosophila melanogaster wing imaginal disc. Dev Biol 329:315-326.
    • (2009) Dev Biol , vol.329 , pp. 315-326
    • Grieder, N.C.1    Morata, G.2    Affolter, M.3    Gehring, W.J.4
  • 29
    • 77749239787 scopus 로고    scopus 로고
    • Function and specificity of synthetic Hox transcription factors in vivo
    • Papadopoulos DK, et al. (2010) Function and specificity of synthetic Hox transcription factors in vivo. Proc Natl Acad Sci USA 107:4087-4092.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4087-4092
    • Papadopoulos, D.K.1
  • 30
    • 0026660035 scopus 로고
    • In vivo analysis of the helix-turn-helix motif of the fushi tarazu homeo domain of Drosophila melanogaster
    • Furukubo-Tokunaga K, et al. (1992) In vivo analysis of the helix-turn-helix motif of the fushi tarazu homeo domain of Drosophila melanogaster. Genes Dev 6:1082-1096.
    • (1992) Genes Dev , vol.6 , pp. 1082-1096
    • Furukubo-Tokunaga, K.1
  • 31
    • 0033602242 scopus 로고    scopus 로고
    • Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex
    • Passner JM, Ryoo HD, Shen L, Mann RS, Aggarwal AK (1999) Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. Nature 397:714-719.
    • (1999) Nature , vol.397 , pp. 714-719
    • Passner, J.M.1    Ryoo, H.D.2    Shen, L.3    Mann, R.S.4    Aggarwal, A.K.5
  • 32
    • 0033582545 scopus 로고    scopus 로고
    • Structure of a HoxB1-Pbx1 heterodimer bound to DNA: Role of the hexapeptide and a fourth homeodomain helix in complex formation
    • Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C (1999) Structure of a HoxB1-Pbx1 heterodimer bound to DNA: Role of the hexapeptide and a fourth homeodomain helix in complex formation. Cell 96:587-597. (Pubitemid 29106845)
    • (1999) Cell , vol.96 , Issue.4 , pp. 587-597
    • Piper, D.E.1    Batchelor, A.H.2    Chang, C.-P.3    Cleary, M.L.4    Wolberger, C.5
  • 33
    • 0008231153 scopus 로고    scopus 로고
    • The control of trunk Hox specificity and activity by extradenticle
    • Ryoo HD, Mann RS (1999) The control of trunk Hox specificity and activity by Extradenticle. Genes Dev 13:1704-1716. (Pubitemid 29325875)
    • (1999) Genes and Development , vol.13 , Issue.13 , pp. 1704-1716
    • Ryoo, H.D.1    Mann, R.S.2
  • 34
    • 0034954166 scopus 로고    scopus 로고
    • The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger
    • Gangloff YG, et al. (2001) The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger. Mol Cell Biol 21:5109-5121.
    • (2001) Mol Cell Biol , vol.21 , pp. 5109-5121
    • Gangloff, Y.G.1
  • 36
    • 0031895523 scopus 로고    scopus 로고
    • Two distinct types of repression domain in engrailed: One interacts with the Groucho corepressor and is preferentially active on integrated target genes
    • Tolkunova EN, Fujioka M, Kobayashi M, Deka D, Jaynes JB (1998) Two distinct types of repression domain in engrailed: One interacts with the groucho corepressor and is preferentially active on integrated target genes. Mol Cell Biol 18:2804-2814. (Pubitemid 28183449)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.5 , pp. 2804-2814
    • Tolkunova, E.N.1    Fujioka, M.2    Kobayashi, M.3    Deka, D.4    Jaynes, J.B.5
  • 37
    • 17144415299 scopus 로고    scopus 로고
    • Cofactor-interaction motifs and the cooption of a homeotic Hox protein into the segmentation pathway of Drosophila melanogaster
    • Löhr U, Pick L (2005) Cofactor-interaction motifs and the cooption of a homeotic Hox protein into the segmentation pathway of Drosophila melanogaster. Curr Biol 15: 643-649.
    • (2005) Curr Biol , vol.15 , pp. 643-649
    • Löhr, U.1    Pick, L.2
  • 38
    • 0023955437 scopus 로고
    • Alternative RNA products from the Ultrabithorax domain of the bithorax complex
    • O'Connor MB, Binari R, Perkins LA, Bender W (1988) Alternative RNA products from the Ultrabithorax domain of the bithorax complex. EMBO J 7:435-445.
    • (1988) EMBO J , vol.7 , pp. 435-445
    • O'Connor, M.B.1    Binari, R.2    Perkins, L.A.3    Bender, W.4
  • 39
    • 0037991521 scopus 로고    scopus 로고
    • The hexapeptide and linker regions of the AbdA Hox protein regulate its activating and repressive functions
    • DOI 10.1016/S1534-5807(03)00126-6, PII S1534580703001266
    • Merabet S, et al. (2003) The hexapeptide and linker regions of the AbdA Hox protein regulate its activating and repressive functions. Dev Cell 4:761-768. (Pubitemid 36564905)
    • (2003) Developmental Cell , vol.4 , Issue.5 , pp. 761-768
    • Merabet, S.1    Kambris, Z.2    Capovilla, M.3    Berenger, H.4    Pradel, J.5    Graba, Y.6
  • 40
    • 77950625598 scopus 로고    scopus 로고
    • Alternative splicing modulates Ubx protein function in Drosophila melanogaster
    • Reed HC, et al. (2010) Alternative splicing modulates Ubx protein function in Drosophila melanogaster. Genetics 184:745-758.
    • (2010) Genetics , vol.184 , pp. 745-758
    • Reed, H.C.1
  • 41
    • 0034933213 scopus 로고    scopus 로고
    • Two distinct domains of Bicoid mediate its transcriptional downregulation by the Torso pathway
    • Janody F, Sturny R, Schaeffer V, Azou Y, Dostatni N (2001) Two distinct domains of Bicoid mediate its transcriptional downregulation by the Torso pathway. Development 128:2281-2290. (Pubitemid 32633361)
    • (2001) Development , vol.128 , Issue.12 , pp. 2281-2290
    • Janody, F.1    Sturny, R.2    Schaeffer, V.3    Azou, Y.4    Dostatni, N.5
  • 42
    • 0029917042 scopus 로고    scopus 로고
    • Functional dissection of the mouse Hox-a5 gene
    • Zhao JJ, Lazzarini RA, Pick L (1996) Functional dissection of the mouse Hox-a5 gene. EMBO J 15:1313-1322. (Pubitemid 26093467)
    • (1996) EMBO Journal , vol.15 , Issue.6 , pp. 1313-1322
    • Zhao, J.J.1    Lazzarini, R.A.2    Pick, L.3
  • 43
    • 67649378411 scopus 로고    scopus 로고
    • Internal regulatory interactions determine DNA binding specificity by a Hox transcription factor
    • Liu Y, Matthews KS, Bondos SE (2009) Internal regulatory interactions determine DNA binding specificity by a Hox transcription factor. J Mol Biol 390:760-774.
    • (2009) J Mol Biol , vol.390 , pp. 760-774
    • Liu, Y.1    Matthews, K.S.2    Bondos, S.E.3
  • 44
    • 77954854598 scopus 로고    scopus 로고
    • Dissecting the functional specificities of two Hox proteins
    • Joshi R, Sun L, Mann R (2010) Dissecting the functional specificities of two Hox proteins. Genes Dev 24:1533-1545.
    • (2010) Genes Dev , vol.24 , pp. 1533-1545
    • Joshi, R.1    Sun, L.2    Mann, R.3
  • 45
    • 70349786412 scopus 로고    scopus 로고
    • Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo
    • Yallowitz AR, Gong KQ, Swinehart IT, Nelson LT, Wellik DM (2009) Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo. Dev Biol 335:156-165.
    • (2009) Dev Biol , vol.335 , pp. 156-165
    • Yallowitz, A.R.1    Gong, K.Q.2    Swinehart, I.T.3    Nelson, L.T.4    Wellik, D.M.5
  • 46
    • 0141757323 scopus 로고    scopus 로고
    • Reprogramming control of an allosteric signaling switch through modular recombination
    • DOI 10.1126/science.1085945
    • Dueber JE, Yeh BJ, Chak K, Lim WA (2003) Reprogramming control of an allosteric signaling switch through modular recombination. Science 301:1904-1908. (Pubitemid 37221395)
    • (2003) Science , vol.301 , Issue.5641 , pp. 1904-1908
    • Dueber, J.E.1    Yeh, B.J.2    Chak, K.3    Lim, W.A.4
  • 47
    • 34249894454 scopus 로고    scopus 로고
    • Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors
    • DOI 10.1038/nature05851, PII NATURE05851
    • Yeh BJ, Rutigliano RJ, Deb A, Bar-Sagi D, Lim WA (2007) Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors. Nature 447: 596-600. (Pubitemid 46868045)
    • (2007) Nature , vol.447 , Issue.7144 , pp. 596-600
    • Yeh, B.J.1    Rutigliano, R.J.2    Deb, A.3    Bar-Sagi, D.4    Lim, W.A.5
  • 48
    • 0019967916 scopus 로고
    • Transposition of cloned P elements into Drosophila germ line chromosomes
    • Spradling AC, Rubin GM (1982) Transposition of cloned P elements into Drosophila germ line chromosomes. Science 218:341-347. (Pubitemid 12037602)
    • (1982) Science , vol.218 , Issue.4570 , pp. 341-347
    • Spradling, A.C.1    Rubin, G.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.