Function and specificity of synthetic Hox transcription factors in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 9, 2010, Pages 4087-4092

  Papadopoulos, Dimitrios K ^a   Vukojević, Vladana ^b   Adachi, Yoshitsugu ^c   Terenius, Lars ^b   Rigler, Rudolf ^b,d   Gehring, Walter J ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d EPFL   (Switzerland)

Author keywords

Homeotic transformations; Hox genes; Sex combs reduced; Synthetic genes; Transcriptional specificity

Indexed keywords

HOMEODOMAIN PROTEIN; HOX PROTEIN; SEX COMBS REDUCED PROTEIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; FLY; GENE MUTATION; GENETIC VARIABILITY; HOMEOBOX; IN VIVO STUDY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SALIVARY GLAND; TRANSCRIPTION INITIATION;

DNA; HOMEODOMAIN PROTEINS; KINETICS; SPECTROMETRY, FLUORESCENCE; TRANSCRIPTION FACTORS;

EID: 77749239787     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0914595107     Document Type: Article

References (54)

1. Gehring WJ (1987) Homeo boxes in the study of development. Science 236(4806):1245-1252.
2. Lewis EB (1978) A gene complex controlling segmentation in Drosophila. Nature 276(5688):565-570.
3. Mann RS, Morata G (2000) The developmental and molecular biology of genes that subdivide the body of Drosophila. Annu Rev Cell Dev Biol 16:243-271.
4. McGinnis W, Krumlauf R (1992) Homeobox genes and axial patterning. Cell 68(2):283-302.
5. Kappen C, Ruddle FH (1993) Evolution of a regulatory gene family: HOM/HOX genes. Curr Opin Genet Dev 3(6):931-938.
6. Kmita-Cunisse M, Loosli F, Bierne J, Gehring WJ (1998) Homeobox genes in the ribbonworm Lineus sanguineus: Evolutionary implications. Proc Natl Acad Sci USA 95(6):3030-3035.
7. Affolter M, Schier A, Gehring WJ (1990) Homeodomain proteins and the regulation of gene expression. Curr Opin Cell Biol 2(3):485-495.
8. Scott MP, Tamkun JW, Hartzell GW 3rd (1989) The structure and function of the homeodomain. Biochim Biophys Acta 989(1):25-48.
9. Ryoo HD, Mann RS (1999) The control of trunk Hox specificity and activity by Extradenticle. Genes Dev 13(13):1704-1716.
10. Odenwald WF, Garbern J, Arnheiter H, Tournier-Lasserve E, Lazzarini RA (1989) The Hox-1.3 homeo box protein is a sequence-specific DNA-binding phosphoprotein. Genes Dev 3(2):158-172.
11. Ekker SC, et al. (1994) The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. EMBO J 13(15):3551-3560.
12. Muller M, et al. (1988) Isolation and sequence-specific DNA binding of the Antennapedia homeodomain. EMBO J 7(13):4299-4304.
13. Qian YQ, et al. (1992) NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein. Proc Natl Acad Sci USA 89(22):10738-10742.
14. Phelan ML, Rambaldi I, Featherstone MS (1995) Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif. Mol Cell Biol 15(8):3989-3997.
15. Johnson FB, Parker E, Krasnow MA (1995) Extradenticle protein is a selective cofactor for the Drosophila homeotics: Role of the homeodomain and YPWM amino acid motif in the interaction. Proc Natl Acad Sci USA 92(3):739-743.
16. Passner JM, Ryoo HD, Shen L, Mann RS, Aggarwal AK (1999) Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. Nature 397(6721):714-719.
17. Prince F, et al. (2008) The YPWM motif links Antennapedia to the basal transcriptional machinery. Development 135(9):1669-1679.
18. Galant R, Walsh CM, Carroll SB (2002) Hox repression of a target gene: Extradenticle-independent, additive action through multiple monomer binding sites. Development 129(13):3115-3126.
19. Berry M, Gehring W (2000) Phosphorylation status of the SCR homeodomain determines its functional activity: Essential role for protein phosphatase 2A,B′. EMBO J 19(12):2946-2957.
20. Panzer S, Weigel D, Beckendorf SK (1992) Organogenesis in Drosophila melanogaster: Embryonic salivary gland determination is controlled by homeotic and dorsoventral patterning genes. Development 114(1):49-57.
21. Abzhanov A, Holtzman S, Kaufman TC (2001) The Drosophila proboscis is specified by two Hox genes, proboscipedia and Sex combs reduced, via repression of leg and antennal appendage genes. Development 128(14):2803-2814.
22. Andrew DJ, Henderson KD, Seshaiah P (2000) Salivary gland development in Drosophila melanogaster. Mech Dev 92(1):5-17.
23. Haberman AS, Isaac DD, Andrew DJ (2003) Specification of cell fates within the salivary gland primordium. Dev Biol 258(2):443-453.
24. Percival-Smith A, Weber J, Gilfoyle E, Wilson P (1997) Genetic characterization of the role of the two HOX proteins, Proboscipedia and Sex Combs Reduced, in determination of adult antennal, tarsal, maxillary palp and proboscis identities in Drosophila melanogaster. Development 124(24):5049-5062.
25. Kerman BE, Cheshire AM, Andrew DJ (2006) From fate to function: The Drosophila trachea and salivary gland as models for tubulogenesis. Differentiation 74(7):326-348.
26. Andrew DJ, Horner MA, Petitt MG, Smolik SM, Scott MP (1994) Setting limits on homeotic gene function: Restraint of Sex combs reduced activity by teashirt and other homeotic genes. EMBO J 13(5):1132-1144.
27. Yao LC, Liaw GJ, Pai CY, Sun YH (1999) A common mechanism for antenna-to-Leg transformation in Drosophila: Suppression of homothorax transcription by four HOM-C genes. Dev Biol 211(2):268-276.
28. Zhao JJ, Lazzarini RA, Pick L (1993) The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene. Genes Dev 7(3):343-354.
29. Calleja M, Moreno E, Pelaz S, Morata G (1996) Visualization of gene expression in living adult Drosophila. Science 274(5285):252-255.
30. Plaza S, et al. (2008) Cross-regulatory protein-protein interactions between Hox and Pax transcription factors. Proc Natl Acad Sci USA 105(36):13439-13444.
31. Plaza S, et al. (2001) Molecular basis for the inhibition of Drosophila eye development by Antennapedia. EMBO J 20(4):802-811.
32. Gehring WJ, Kloter U, Suga H (2009) Evolution of the Hox gene complex from an evolutionary ground state. Curr Top Dev Biol 88:35-61.
33. Wagner-Bernholz JT, Wilson C, Gibson G, Schuh R, Gehring WJ (1991) Identification of target genes of the homeotic gene Antennapedia by enhancer detection. Genes Dev 5(12b):2467-2480.
34. Emerald BS, Curtiss J, Mlodzik M, Cohen SM (2003) Distal antenna and distal antenna related encode nuclear proteins containing pipsqueak motifs involved in antenna development in Drosophila. Development 130(6):1171-1180.
35. Casares F, Mann RS (2001) The ground state of the ventral appendage in Drosophila. Science 293(5534):1477-1480.
36. Casares F, Mann RS (1998) Control of antennal versus leg development in Drosophila. Nature 392(6677):723-726.
37. Dong PD, Chu J, Panganiban G (2000) Coexpression of the homeobox genes Distal-less and homothorax determines Drosophila antennal identity. Development 127(2):209-216.
38. Brown S, Castelli-Gair Hombria J (2000) Drosophila grain encodes a GATA transcription factor required for cell rearrangement during morphogenesis. Development 127(22):4867-4876.
39. Grieder NC, Morata G, Affolter M, Gehring WJ (2009) Spalt major controls the development of the notum and of wing hinge primordia of the Drosophila melanogaster wing imaginal disc. Dev Biol 329(2):315-326.
40. Curtiss J, Burnett M, Mlodzik M (2007) Distal antenna and distal antenna-related function in the retinal determination network during eye development in Drosophila. Dev Biol 306(2):685-702.
41. Vukojevic V, et al. (2008) Quantitative single-molecule imaging by confocal laser scanning microscopy. Proc Natl Acad Sci USA 105(47):18176-18181.
42. Vukojević V, Papadopoulos DK, Terenius L, Gehring WJ, Rigler R Quantitative study of synthetic Hox transcription factor-DNA interactions in live cells. Proc Natl Acad Sci USA doi:10.XXXX/XXXXXXXXXX.
43. Gehring WJ, et al. (1994) Homeodomain-DNA recognition. Cell 78(2):211-223.
44. Gibson G, Schier A, LeMotte P, Gehring WJ (1990) The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain. Cell 62(6):1087-1103.
45. Morata G, Sanchez-Herrero E (1999) Patterning mechanisms in the body trunk and the appendages of Drosophila. Development 126(13):2823-2828.
46. Wakimoto BT, Kaufman TC (1981) Analysis of larval segmentation in lethal genotypes associated with the antennapedia gene complex in Drosophila melanogaster. Dev Biol 81(1):51-64.
47. Otting G, et al. (1990) Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution. EMBO J 9(10):3085-3092.
48. Tour E, Hittinger CT, McGinnis W (2005) Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax. Development 132(23):5271-5281.
49. Zhao JJ, Lazzarini RA, Pick L (1996) Functional dissection of the mouse Hox-a5 gene. EMBO J 15(6):1313-1322.
50. Sivanantharajah L, Percival-Smith A (2009) Analysis of the sequence and phenotype of Drosophila Sex combs reduced alleles reveals potential functions of conserved protein motifs of the Sex combs reduced protein. Genetics 182(1):191-203.
51. Benner SA, Sismour AM (2005) Synthetic biology. Nat Rev Genet 6(7):533-543.
52. Kaznessis YN (2007) Models for synthetic biology. BMC Syst Biol 1(47).
53. Mayo AE, Setty Y, Shavit S, Zaslaver A, Alon U (2006) Plasticity of the cis-regulatory input function of a gene. PLoS Biol 4(4):e45.
54. Spradling AC, Rubin GM (1982) Transposition of cloned P elements into Drosophila germ line chromosomes. Science 218(4570):341-347.