Two distinct types of repression domain in engrailed: One interacts with the Groucho corepressor and is preferentially active on integrated target genes

Molecular and Cellular Biology

Volumn 18, Issue 5, 1998, Pages 2804-2814

  Tolkunova, Elena N ^a   Fujioka, Miki ^a   Kobayashi, Masatomo ^a   Deka, Deepali ^a   Jaynes, James B ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DROSOPHILA; EMBRYO; GENE EXPRESSION REGULATION; GENE LOCUS; GENE TARGETING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; REPRESSOR GENE; TRANSCRIPTION REGULATION;

EID: 0031895523     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.5.2804     Document Type: Article

References (41)

1. Aronson, B. D., A. L. Fisher, K. Blechman, M. Caudy, and J. P. Gergen. 1997. Groucho-dependent and -independent repression activities of Runt domain proteins. Mol. Cell. Biol. 17:5581-5587.
2. Biggin, M. D., and R. Tjian. 1989. A purified Drosophila homeodomain protein represses transcription in vitro. Cell 58:433-440.
3. Desplan, C., J. Theis, and P. H. O'Farrell. 1988. The sequence specificity of homeodomain-DNA interaction. Cell 54:1081-90.
4. Dimitri, P., and C. Pisano. 1989. Position effect variegation in Drosophila melanogaster: Relationship between suppression effect and the amount of Y chromosome. Genetics 122:793-800.
5. Dorsett, D., G. A. Viglianti, B. J. Rutledge, and M. Meselson. 1989. Alteration of hsp82 gene expression by the gypsy transposon and suppressor genes in Drosophila melanogaster. Genes Dev. 3:454-468.
6. Durfee, T., K. Becherer, P. Chen, S. Yeh, Y. Yang, A. E. Kilburn, W. Lee, and S. J. Elledge. 1993. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7:555-569.
7. Edgar, B., and P. H. O'Farrell. 1990. The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string. Cell 62:469-80.
8. Fisher, A. L., S. Ohsako, and M. Caudy. 1996. The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain. Mol. Cell. Biol. 16:2670-77.
9. Fujioka, M., J. B. Jaynes, and T. Goto. 1995. Early even-skipped stripes act as morphogenetic gradients at the single cell level to establish engrailed expression Development 121:4371-4382.
10. Guichet, A., J. W. R. Copeland, M. Erdélyi, D. Hlousek, P. Závorszky, J. Ho, S. Brown, A. Percival-Smith, H. M. Krause, and A. Ephrussi. 1997. The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors. Nature 385:548-552.
11. Han, K., and J. L. Manley. 1993. Functional domains of the Drosophila Engrailed protein. EMBO J. 12:2723-2733.
12. Han, K., and J. L. Manley. 1993. Transcriptional repression by the Drosophila Even-skipped protein, definition of a minimal repression domain. Genes Dev. 7:491-503.
13. Hanna-Rose, W., and U. Hansen. 1996. Active repression mechanisms of eukaryotic transcription repressors. Trends Genet. 12:229-234.
14. Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816.
15. Heemskerk, J., S. DiNardo, R. Kostriken, and P. H. O'Farrell. 1991. Multiple modes of engrailed regulation in the progression towards cell fate determination. Nature 352:404-410.
16. Jaynes, J. B., and P. H. O'Farrell. 1988. Activation and repression of transcription by homoeodomain-containing proteins that bind a common site. Nature 336:744-749.
17. Jaynes, J. B., and P. H. O'Farrell. Unpublished observations.
18. Jaynes, J. B., J. Vincent, and P. H. O'Farrell. 1990. Drosophila homeodomain-containing proteins regulate transcription, p. 47-64. In A. P. Mahowald (ed.). Genetics of pattern formation and growth control. Wiley-Liss Inc., New York, N.Y.
19. Jaynes, J. B., and P. H. O'Farrell. 1991. Active repression of transcription by the engrailed homeodomain protein. EMBO J. 10:1427-1433.
20. Jiang, J., T. Hoey, and M. Levine. 1991. Autoregulation of a segmentation gene in Drosophila: combinatorial interaction of the even-skipped homeo box protein with a distal enhancer element. Genes Dev. 5:265-277.
21. Jiménez, G., Z. Paroush, and D. Ish-Horowicz. 1997. Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed. Genes Dev. 11:3072-3082.
22. John, A., S. T. Smith, and J. B. Jaynes. 1995. Inserting the Ftz homeodomain into Engrailed creates a dominant transcriptional repressor that specifically turns off Ftz target genes in vivo. Development 121:1801-1813.
23. Keleher, C. A., M. J. Redd, J. Schultz, M. Carlson, and A. D. Johnson. 1992. Ssn6-Tup1 is a general repressor of transcription in yeast. Cell 68:709-719.
24. Latchman, D. S. 1996. Inhibitory transcription factors. Int. J. Biochem. Cell Biol. 28:965-974.
25. Lin, L., and W. McGinnis. 1992. Mapping functional specificity in the Dfd and Ubx homeo domains. Genes Dev. 6:1071-1081.
26. Logan, C., M. C. Hanks, S. Noble-Topham, D. Nallainathan, N. J. Provart, and A. L. Joyner. 1992. Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions. Dev. Genet. 13:345-358.
27. Mann, R. S., and D. S. Hogness. 1990. Functional dissection of Ultrabithorax proteins in D. melanogaster. Cell 60:597-610.
28. Mann, R. S., and S. K. Chan. 1996. Extra specificity from extradendicle: the partnership between HOX and PBX/EXD homeodomain proteins. Trends Genet. 12:258-262.
29. Manoukian, A. S., and H. M. Krause. 1992. Concentration-dependent activities of the even-skipped protein in Drosophila embryos. Genes Dev. 6:1740-1751.
30. Paroush, Z., R. Finley, T. Kidd, S. M. Wainwright, P. Ingham, R. Brent, and D. Ish-Horowicz. 1994. Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell 79:805-815.
31. Peltenburg, L. T., and C. Murre. 1996. Engrailed and Hox homeodomain proteins contain a related Pbx interaction motif that recognizes a common structure present in Pbx. EMBO J. 15:3385-3393.
32. Schier, A. F., and W. J. Gehring. 1992. Direct homeodomain-DNA interaction in the autoregulation of the fushi tarazu gene. Nature 356:804-807.
33. Smith, S. T., and J. B. Jaynes. 1996. A conserved region of engrailed, shared among all en-, gsc-, Nk1-, Nk2-, and msh-class homeoproteins, mediates active transcriptional repression in vivo. Development 122:3141-3150.
34. Spradling, A. C., and G. M. Rubin. 1982. Genetic transformation of Drosophila with transposable element vectors. Science 218:341-347.
35. Tabata, T., S. Eaton, and T. B. Kornberg. 1992. The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Genes Dev. 6:2635-2645.
36. Tata, F., and D. A. Hartley. 1993. The role of the Enhancer of Split complex during cell fate determination in Drosophila, p. 139-148. In P. Ingham, A. Brown, and A. M. Arias (ed.). Signals, polarity, and adhesion in development. Development 1993 supplement. The Company of Biologists Ltd., Cambridge, United Kingdom.
37. Wieschaus, E., and C. Nüsslein-Volhard. 1986. Looking at embryos, p. 199-228. In D. B. Roberts (ed.). Drosophila: a practical approach. IRL Press, Oxford, England.
38. Winslow, G. M., S. Hayashi, M. Krasnow, D. S. Hogness, and M. P. Scott. 1989. Transcriptional activation by the Antennapedia and fushi tarazu proteins in cultured Drosophila cells. Cell 57:1017-1030.
39. Yoshinaga, S. K., C. L. Peterson, I. Herskowitz, and K. R. Yamamoto. 1993. Roles of SWI1, SWI2, and SWI3 proteins for transcriptional enhancement by steroid receptors. Science 258:1598-1604.
40. Yu, Y., W. Li, K. Su, M. Yussa, W. Han, N. Perrimon, and L. Pick. 1997. The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz. Nature 385:552-554.
41. Zeng, W., D. J. Andrew, L. D. Mathies, M. A. Horner, and M. P. Scott. 1993. Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity. Development 118:339-352.