Graviresponses of osteocytes under altered gravity

Advances in Space Research

Volumn 48, Issue 6, 2011, Pages 1161-1166

  Di, S M ^a   Qian, A R ^a   Qu, L N ^b   Zhang, W ^a   Wang, Z ^a   Ding, C ^a   Li, Y H ^b   Ren, H G ^b   Shang, P ^a  

^a NORTHWESTERN POLYTECHNICAL UNIVERSITY   (China)

^b China Astronaut Research and Training Center 5132 13   (China)

Author keywords

Hyper gravity; Hypo gravity; Osteocyte; Parabolic flight

Indexed keywords

BONE; CELLS; GRAVITATION; PROTEINS;

CELL MORPHOLOGY; COMPREHENSIVE EFFECT; HYPERGRAVITY; MECHANICAL STIMULUS; MECHANOTRANSDUCTION; MICROTUBULE ORGANIZING CENTERS; OSTEOCYTES; PARABOLIC FLIGHT;

CYTOLOGY;

EID: 79961001473     PISSN: 02731177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.asr.2011.05.030     Document Type: Article

References (29)

1. J.I. Aguirre, L.I. Plotkin, and S.A. Stewart Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss J. Bone Miner. Res. 21 4 2006 605 615
2. A. Bakker, J. Klein-Nulend, and E. Burger Shear stress inhibits while disuse promotes osteocyte apoptosis Biochem. Biophys. Res. Commun. 320 4 2004 1163 1168 (Pubitemid 38916665)
3. L. Bonewald Osteocytes as multifunctional cells J. Musculoskelet. Neuronal. Interact. 6 4 2006 331 333 (Pubitemid 46099703)
4. L. Bonewald Establishment and characterization of an osteocyte-like cell line, MLO-Y4 J. Bone Miner. Metab. 17 1 1999 61 65 (Pubitemid 29117755)
5. L.B. Buravkova, Y.A. Romanov, and N.A. Konstantinova Cultured stem cells are sensitive to gravity changes Acta Astronaut. 63 5-6 2008 603 608
6. S. Burra, D.P. Nicolella, and W.L. Francis Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels Proc. Natl. Acad. Sci. USA 107 31 2010 13648 13653
7. S.I. Carlsson, M.T. Bertilaccio, and E. Ballabio Endothelial stress by gravitational unloading: effects on cell growth and cytoskeletal organization BBA - Mol. Cell Res. 1642 3 2003 173 179 (Pubitemid 37315660)
8. R. Civitelli Connexin 43 modulation of osteoblast/osteocyte apoptosis: a potential therapeutic target? J. Bone Miner. Res. 23 11 2008 1709 1711
9. D. Ingber How cells (might) sense microgravity Faseb J. 13 Suppl. 1999 s3 s15
10. J. Klein-Nulend, A. van der Plas, and C.M. Semeins Sensitivity of osteocytes to biomechanical stress in vitro Faseb J. 9 5 1995 441 445
11. M. Li, X. Wang, and M.K. Meintzer Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta Mol. Cell. Biol. 20 24 2000 9356 9363 (Pubitemid 32246120)
12. C. Liu, Y. Li, and M. Semenov Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism Cell 108 6 2002 837 847 (Pubitemid 34327534)
13. J. Matsuda, K. Kurata, and T. Fukunaga Bone marrow cell differentiation regulated by gel-embedded osteocyte under multi-dimensional gravity J. Biomech. 39 Suppl. 2006 s469
14. J.C. McPhee, and R.J. White Physiology, medicine, long-duration space flight and the NSBRI Acta Astronaut. 53 4-10 2003 239 248
15. M.G. Mullender, and R. Huiskes Osteocytes and bone lining cells: which are the best candidates for mechano-sensors in cancellous bone? Bone 20 6 1997 527 532 (Pubitemid 27270466)
16. A. Nicogossian Medicine and space exploration Lancet 362 Suppl. 2003 s8 s9
17. L.I. Plotkin, I. Mathov, and J.I. Aguirre Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs Am. J. Physiol. Cell Physiol. 289 3 2005 C633 C643
18. A.R. Qian, W. Zhang, and L. Xie Simulated weightlessness alters biological characteristics of human breast cancer cell line MCF-7 Acta Astronaut. 63 7-10 2008 947 958
19. A.R. Qian, W. Zhang, and Y.Y. Weng Gravitational environment produced by a superconducting magnet affects osteoblast morphology and functions Acta Astronaut. 63 7-10 2008 929 946
20. A.R. Qian, P.F. Yang, and L.F. Hu High magnetic gradient environment causes alterations of cytoskeleton and cytoskeleton-associated genes in human osteoblasts cultured in vitro Adv. Space Res. 46 6 2010 687 700
21. A.R. Qian, L.F. Hu, and X. Gao Large gradient high magnetic field affects the association of MACF1 with actin and microtubule cytoskeleton Bioelectromagnetics 30 7 2009 545 555
22. N.V. Rodionova, V.S. Oganov, and N.V. Zolotova Ultrastructural changes in osteocytes in microgravity conditions Adv. Space Res. 30 4 2002 765 770
23. A. Santos, A.D. Bakker, and J. Klein-Nulend The role of osteocytes in bone mechanotransduction Osteoporosis Int. 20 6 2009 1027 1031
24. S.M. Strauch, P. Richter, and M. Schuster The beating pattern of the flagellum of Euglena gracilis under altered gravity during parabolic flights J. Plant Physiol. 167 1 2010 41 46
25. S. Tatsumi, K. Ishii, and N. Amizuka Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction Cell Metab. 5 6 2007 464 475 (Pubitemid 46825494)
26. J. Vernikos, and V.S. Schneider Space, gravity and the physiology of aging: parallel or convergent disciplines? A mini-review Gerontology 56 2 2010 157 166
27. F. Yang, Z. Dai, and Y. Tan Effects of altered gravity on the cytoskeleton of neonatal rat cardiocytes Microgravity Sci. Technol. 22 1 2010 45 52
28. J. You, C.E. Yellowley, and H.J. Donahue Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow J. Biomech. Eng. 122 4 2000 387 393
29. S. Yuvaraj, J.J. Blanchard, and G. Daughtridge Microarray profile of gene expression during osteoclast differentiation in modeled microgravity J. Cell. Biochem. 111 5 2010 1179 1187