The role of osteocytes in bone mechanotransduction

Osteoporosis International

Volumn 20, Issue 6, 2009, Pages 1027-1031

  Santos, A ^a   Bakker, A D ^a   Klein Nulend, J ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CONNEXIN 43; CYCLOOXYGENASE 2; HERMES ANTIGEN; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTACYCLIN; PROSTAGLANDIN E2; PROTEIN C JUN; SECRETED FRIZZLED RELATED PROTEIN 4; WNT3A PROTEIN; WNT5A PROTEIN;

BONE REMODELING; CELL FUNCTION; CELL ULTRASTRUCTURE; CONFERENCE PAPER; CYTOSKELETON; GENE EXPRESSION REGULATION; HUMAN; MECHANICAL STRESS; MECHANOTRANSDUCTION; NONHUMAN; OSTEOCYTE; PRIORITY JOURNAL;

BONE AND BONES; BONE REMODELING; CELL DIFFERENTIATION; EVIDENCE-BASED MEDICINE; HUMANS; MECHANOTRANSDUCTION, CELLULAR; OSTEOCYTES; STRESS, MECHANICAL; WEIGHT-BEARING;

EID: 67349109815     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-009-0858-5     Document Type: Conference Paper

References (53)

1. Wolff JD (1892) Das Gesetz der Transformation der Knochen. A Hirschwald, Berlin
2. SC Cowin L Moss-Salentijn ML Moss 1991 Candidates for the mechanosensory system in bone J Biomed Eng 113 191 197
3. MG Mullender R Huiskes 1995 Proposal for the regulatory mechanism of Wolff's law J Orthop Res 13 503 512
4. MG Mullender R Huiskes 1997 Osteocytes and bone lining cells: which are the best candidates for mechano-sensors in cancellous bone? Bone 20 527 532
5. J Klein-Nulend A Van der Plas CM Semeins 1995 Sensitivity of osteocytes to biomechanical stress in vitro FASEB J 9 441 445
6. LC Gowen DN Petersen AL Mansolf 2003 Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass J Biol Chem 278 1998 2007
7. W Balemans M Ebeling N Patel 2001 Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST) Hum Mol Genet 10 537 543
8. JQ Feng LM Ward S Liu 2006 Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism Nat Genet 38 1310 1315
9. A Vatsa TH Smit J Klein-Nulend 2007 Extracellular NO signalling from a mechanically stimulated osteocyte J Biomech 40 S89 S95
10. TM Skerry L Bitensky J Chayen 1989 Early strain-related changes in enzyme activity in osteocytes following bone loading in vivo J Bone Miner Res 4 783 788
11. AJ El-Haj SL Minter SCF Rawlinson 1990 Cellular responses to mechanical loading in vitro J Bone Miner Res 5 923 932
12. SL Dallas G Zaman MJ Pead 1993 Early strain-related changes in cultured embryonic chick tibiotarsi parallel those associated with adaptive modeling in vivo J Bone Miner Res 8 251 259
13. JM Lean CJ Jagger TJ Chambers 1995 Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation Am J Physiol 268 E318 E327
14. MR Forwood WL Kelly NF Worth 1998 Localization of prostaglandin endoperoxidase H synthase (PGHS)-1 and PGHS-2 in bone following mechanical loading in vivo Anat Rec 252 580 586
15. K Terai T Takano-Yamamoto Y Ohba 1999 Role of osteopontin in bone remodeling caused by mechanical stress J Bone Miner Res 14 839 849
16. S Tatsumi K Ishi N Amizuka 2007 Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction Cell Metab 5 464 475
17. SC Cowin S Weinbaum Y Zeng 1995 A case for bone canaliculi as the anatomical site of strain generated potentials J Biomech 28 1281 1297
18. J You CE Yellowley HJ Donahue 2000 Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading induced oscillating fluid flow J Biomech Eng 122 387 393
19. A Vatsa RG Breuls CM Semeins 2008 Osteocyte morphology in fibula and calvaria-is there a role for mechanosensing? Bone 43 3 452 458
20. A Vatsa CM Semeins TH Smit 2008 Paxillin localisation in osteocytes-is it determined by the direction of loading? Biochem Biophys Res Commun 377 4) 1019 1024
21. Y Wang LM [tmp] McNamara MB Schaffler 2007 A model for the role of integrins in flow induced mechanotransduction in osteocytes Proc Natl Acad Sci USA 104 15846 15941
22. Y Han SC Cowin MB Schaffler 2004 Mechanotransduction and strain amplification in osteocyte cell processes Proc Natl Acad Sci USA 101 16689 16694
23. A Vatsa D Mizuno TH Smit 2006 Bio imaging of intracellular NO production in single bone cells after mechanical stimulation J Bone Miner Res 21 1722 1728
24. CH Turner I Owan DS Jacobs 1997 Effects of nitric oxide synthase inhibitors on bone formation in rats Bone 21 487 490
25. JW Chow SW Fox JM Lean 1998 Role of nitric oxide and prostaglandins in mechanically induced bone formation J Bone Miner Res 13 1039 1044
26. Z Xiao S Zhang J Mahlios 2006 Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and runx2 expression J Biol Chem 281 30884 30895
27. AM Malone CT Anderson P Tummala 2007 Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism Proc Natl Acad Sci USA 104 13325 13330
28. P Nordstrom U Pettersson R Lorentzon 1998 Type of physical activity, muscle strength, and pubertal stage as determinants of bone mineral density and bone area in adolescent boys J Bone Miner Res 13 1141 1148
29. RG Bacabac TH Smit MG Mullender 2004 Nitric oxide production by bone cells is fluid shear stress rate dependent Biochem Biophys Res Commun 315 823 829
30. RG Bacabac TH Smit JJWA Van Loon 2006 Bone cell responses to high-frequency vibration stress: does the nucleus oscillate within the cytoplasm? FASEB J 20 858 864
31. 2, by bone cells depends on fluid flow frequency J Orthop Res 24 1170 1177
32. RG Bacabac TH Smit MG Mullender 2005 Initial stress-kick is required for fluid shear stress-induced rate dependent activation of bone cells Ann Biomed Eng 33 104 110
33. RG Bacabac D Mizuno CF Schmidt 2006 Microrheology and force traction of mechanosensitive bone cells J Biomech 39 Suppl. 1 S231 S232
34. RG Bacabac D Mizuno CF Schmidt 2008 Bone cell morphology, elasticity, and mechanosensing J Biomech 41 1590 1598
35. CT Hung SR Pollack TM Reilly 1995 Realtime calcium response of cultured bone cells to fluid flow Clin Orthop Rel Res 313 256 269
36. CT Hung FD Allen SR Pollack 1996 Intracellular calcium stores and extracellular calcium are required in the real-time calcium response of bone cells experiencing fluid flow J Biomech 29 1411 1417
37. CT Hung FD Allen SR Pollack 1996 What is the role of the convective current density in the real-time calcium response of cultured bone cells to fluid flow? J Biomech 29 1403 1409
38. 2 production by cultured osteocytes Am J Physiol 276 E171 E178
39. NX Chen KD Ryder FM Pavalko 2000 Ca(2+) regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts Am J Physiol 278 C989 C997
40. DA Goodenough DL Paul 2003 Beyond the gap: functions of unpaired connexon channels Nat Rev Mol Cell Biol 4 285 294
41. DC Genetos CJ Kephart Y Zhang 2007 Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes J Cell Physiol 212 207 214
42. J Klein-Nulend CM Semeins NE Ajubi 1995 Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts-correlation with prostaglandin upregulation Biochem Biophys Res Commun 217 640 648
43. NE Ajubi J Klein-Nulend PJ Nijweide 1996 Pulsating fluid flow increases prostaglandin production by cultured chicken osteocytes-a cytoskeleton-dependent process Biochem Biophys Res Commun 225 62 68
44. J Klein-Nulend EH Burger CM Semeins 1997 Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells J Bone Miner Res 12 45 51
45. AD Bakker J Klein-Nulend EH Burger 2003 Mechanotransduction in bone cells proceeds via activation of COX-2 but not COX-1 Biochem Biophys Res Commun 305 677 683
46. I Westbroek NE Ajubi MJ Alblas 2000 Differential stimulation of prostaglandin G/H synthase-2 in osteocytes and other osteogenic cells by pulsating fluid flow Biochem Biophys Res Commun 268 414 419
47. MR Forwood 1996 Inducible cyclooxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo J Bone Miner Res 11 1688 1693
48. Y Gong RB Slee N Fukai 2001 LDL-receptor related protein 5 (LRP5) affects bone accrual and eye development Cell 107 513 523
49. LM Boyden J Mao J Belsky 2002 High bone density due to a mutation in LDL-receptor-related protein 5 N Engl J Med 346 1513 1521
50. P Babij W Zhao C Small 2003 High bone mass in mice expressing a mutant LRP5 gene J Bone Miner Res 18 960 974
51. rth Ann Meeting Orthop Res Soc 33: abstract # 0160
52. PS Vezeridis CM Semeins Q Chen 2005 Osteocytes subjected to pulsating fluid flow regulate osteoblast proliferation and differentiation Biochem Biophys Res Commun 348 1082 1088
53. SD Tan TJ de Vries AM Kuijpers-Jagtman 2007 Osteocytes subjected to fluid flow inhibit osteoclast formation and bone resorption Bone 41 745 751