Simulated weightlessness alters biological characteristics of human breast cancer cell line MCF-7

Acta Astronautica

Volumn 63, Issue 7-10, 2008, Pages 947-958

  Qian, Airong ^a   Zhang, Wei ^a   Xie, Li ^a   Weng, Yuanyuan ^a   Yang, Pengfei ^a   Wang, Zhe ^a   Hu, Lifang ^a   Xu, Huiyun ^a   Tian, Zongcheng ^a   Shang, Peng ^a  

^a NORTHWESTERN POLYTECHNICAL UNIVERSITY   (China)

Author keywords

Adhesion; Apoptosis; Breast cancer; Cell cycle; Invasion; Simulated microgravity

Indexed keywords

ADHESION; CELL CULTURE; CELL DEATH; MICROGRAVITY; MICROGRAVITY PROCESSING;

APOPTOSIS; BIOLOGICAL CHARACTERISTICS; BREAST CANCER CELLS; CELL APOPTOSIS; CELL CYCLING; CLINOSTAT; GELATINASE; HUMAN BREAST CANCER CELL LINE; MCF 7 CELLS; SIMULATED MICROGRAVITY; TUMOR METASTASIS; VINCULIN;

CELLS;

EID: 48549100952     PISSN: 00945765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actaastro.2008.01.024     Document Type: Article

References (34)

1. Pamnani M.B., Mo Z., Chen S., Bryant H.J., White R.J., and Haddy F.J. Effects of head down tilt on hemodynamics, fluid volumes, and plasma Na-K pump inhibitor in rats. Aviation Space and Environmental Medicine 66 (1996) 928-934
2. Hughens-Fulford M., and Lewis M.L. Effects of microgravity on osteoblast growth activation. Experimental Cell Research 224 (1996) 103-109
3. Carlsson S.I., Bertilaccio M.T., Ballabio E., and Maier J.A. Endothelial stress by gravitational unloading: effects on cell growth and cytoskeletal organization. Biochimica et Biophysica Acta 1642 (2003) 173-179
4. Vassy J., Portet S., Beil M., Millot G., Fauvel-Lafe've F., Karniguian A., and Gasset G. Effect of weightlessness on cytoskeleton architecture and proliferation of human breast cancer cell line MCF-7. FASEB Journal 15 (2001) 1104-1106
5. Cogoli-Greuter M. Effect of gravity changes on the cytoskeleton in human lymphocytes. ASGSB Bulletin 17 (2004) 27-37
6. Ward N.E., Pellis N.R., Risin S.A., et al. Gene expression alterations in activated human T-cells induced by modeled microgravity. Journal of Cellular Biochemistry 99 (2006) 1187-1202
7. Lewis M.L., and Hughes-Fulford M. Cellular responses to microgravity. In: Churchill S. (Ed). Fundamentals of Space Life Sciences (1996), Krieger Publishing, Melbourne, FL 21-39
8. Cogoli A., Tschopp A., and Fuchs-Bislin P. Cell sensitivity to gravity. Science 225 (1984) 228-230
9. Hammond T.G., Lewis F.C., Goodwin T.J., Linnehan R.M., Wolf D.A., Hire K.P., Campbell W.C., Benes E., O'Reilly K.C., Globus R.K., and Kaysen J.H. Gene expression in space. Nature Medicine 5 (1999) 359
10. Martin A., Zhou A., Gordon R.E., Henderson S.C., Schwartz A.E., Friedman E.W., and Davies T.F. Thyroid organoid formation in simulated microgravity: influence of keratinocyte growth factor. Thyroid 10 (2000) 481-487
11. Khaoustov V.I., Darlington G.J., Soriano H.E., Krishnan B., Risin D., Pellis N.R., and Yoffe B. Induction of three-dimensional assembly of human liver cells by simulated microgravity. In Vitro Cellular & Developmental Biology-Animal 35 (1999) 501-509
12. Ingram M., Techy G.B., Saroufeem R., Yazan O., Narayan K.S., Goodwin T.J., and Spaulding G.F. Three-dimensional growth patterns of various human tumor cell lines in simulated microgravity of a NASA bioreactor. In Vitro Cellular Developmental Biology-Animal 33 (1997) 459-466
13. Zhau H.E., Goodwin T.J., Chang S.M., Baker T.L., and Chung L.W. Establishment of a three-dimensional human prostate organoid coculture under microgravity simulated conditions: evaluation of androgen-induced growth and PSA expression. In Vitro Cellular Developmental Biology-Animal 33 (1997) 375-380
14. Vassy J., Portet S., Beil M., Millot G., Fauvel-Lafeve F., Gasset G., and Schoevaert D. Weightlessness acts on human breast cancer cell line MCF-7. Advances in Space Research 32 (2003) 1595-1603
15. Goldman R.D., Chou Y.H., Prahlad V., and Yoon M. Intermediate filaments: dynamic processes regulating their assembly, motility and interactions with other cytoskeletal systems. FASEB Journal 13 (1999) S261-S265
16. Janssen M.E., Kim E., Liu H., Fujimoto L.M., Bobkov A., Volkmann N., and Hanein D. Three-dimensional structure of vinculin bound to actin filaments. Molecular Cell 21 (2006) 271-281
17. Nhieu G.T., and Izard T. Vinculin binding in its closed conformation by a helix addition mechanism. The EMBO Journal 26 (2007) 4588-4596
18. Cogoli A. Changes observed in lymphocyte behavior during gravitational unloading. ASGSB Bulletin 4 (1991) 107-115
19. Schatten H., Lewis M.L., and Chakrabarti A. Spaceflight and clinorotation cause cytoskeleton and mitochondria changes and increases in apoptosis in cultured cells. Acta Astronautica 49 (2001) 399-418
20. Kleiner D.E., and Stetler-Stevenson W.G. Quantitative zymography: detection of picogram quantities of gelatinases. Analytical Biochemistry 218 (1994) 325-329
21. Cogoli M. The fast rotating clinostat: a history of its use in gravitational biology and a comparison of ground-based and flight experiment results. ASGSB Bulletin 5 (1992) 59-68
22. Walther I., Cogoli A., Pippia P., Meloni M.A., Cossu G., Cogoli M., Schwarzenberg M., Turrini F., and Mannu F. Human immune cells as space travelers. European Journal of Medical Research 4 (1999) 361-363
23. Moore R. Comparative effectiveness of a clinostat and a slow-turning lateral vessel at mimicking the ultrastructural effects of microgravity in plant cells. Annals of Botany 65 (1990) 213-216
24. Vassy J., Portet S., Beil M., Millot G., Fauvel-Lafeve F., Gasset G., and Schoevaert D. Weightlessness acts on human breast cancer cell line MCF-7. Advances in Space Research 32 (2003) 1595-1603
25. Vassy J., Portet S., Beil M., Millot G., Fauvel-Lafeve F., Karniguian A., Gasset G., Irinopoulou T., Calvo F., Rigaut J.P., and Schoevaert D. Effects of weightlessness on cytoskeleton architecture and proliferation of human breast cancer cell line MCF-7. FASEB Journal 15 (2001) 1104-1106
26. Cowger N.L., Benes E., Allen P.L., and Hammond T.G. Expression of renal cell protein markers is dependent on initial mechanical culture conditions. Journal of Applied Physiology 92 (2002) 691-700
27. Hammond T.G., and Hammond J.M. Optimized suspension culture: the rotating-wall vessel. American Journal of Physiology-Renal 281 (2001) F12-F25
28. Rucci N., Migliaccio S., Zani B.M., et al. Characterization of the osteoblast-like cell phenotype under microgravity conditions in the NASA-approved rotating wall vessel bioreactor (RWV). Journal of Cellular Biochemistry 85 (2002) 167-179
29. Jessup J.M., Frantz M., Sonmez-Alpan E., Locker J., Skena K., Waller H., Battle P., Nachman A., Weber M.E., Thomas D.A., Curbeam R.L., Baker T.L., and Goodwin T.J. Microgravity culture reduces apoptosis and increases the differentiation of a human colorectal carcinoma cell line. In Vitro Cellular Developmental Biology - Animal 36 (2000) 367-373
30. Nakamura K., Kuga H., Morisaki T., Baba E., Sato N., Mizumoto K., Sueishi K., Tanaka M., and Katano M. Simulated microgravity culture system for a 3-D carcinoma tissue mode1. Biotechniques 33 (2002) 1068-1070
31. Kossmehl P., Shakibaei M., Cogoli A., Infanger M., Curcio F., Schonberger J., Eilles C., Bauer J., Pickenhahn H., Schulze-Tanzil G., Paul M., and Grimm D. Weightlessness induced apoptosis in normal thyroid cells and papillary thyroid carcinoma cells via extrinsic and intrinsic pathways. Endocrinology 144 (2003) 4172-4179
32. Clejan S., O'Connor K., and Rosensweig N. Tri-dimensional prostate cell cultures in simulated microgravity and induced changes in lipid second messengers and signal transduction. Journal of Cellular and Molecular Medicine 5 (2001) 60-73
33. Coll J.L., Ben-Ze'ev A., Ezzell R.M., Rodríguez Fernández J.L., Baribault H., Oshima R.G., and Adamson E.D. Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology adhesion and locomotion. Proceedings of the National Academy of Sciences of the USA 92 (1995) 9161-9165
34. Subauste M.C., Pertz O., Adamson E.D., Turner C.E., Junger S., and Hahn K.M. Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. Journal of Cell Biology 165 (2004) 371-381