Connexin43 modulation of osteoblast/osteocyte apoptosis: A potential therapeutic target?

Journal of Bone and Mineral Research

Volumn 23, Issue 11, 2008, Pages 1709-1711

  Civitelli, Roberto ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; ANTIARRHYTHMIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; CONNEXIN 43; CORTICOSTEROID; PARATHYROID HORMONE[1-34]; PREDNISOLONE; STEROID;

APOPTOSIS; BONE CELL; BONE MASS; BONE MINERALIZATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CELL SURVIVAL; DRUG MECHANISM; DRUG TARGETING; EXPERIMENTAL MOUSE; GAP JUNCTION; GENETIC LINKAGE; IN VITRO STUDY; MECHANICAL STIMULATION; MOLECULAR BIOLOGY; NONHUMAN; NOTE; OSTEOBLAST; OSTEOCYTE; OSTEOLYSIS; OSTEOPOROSIS; WILD TYPE;

ANIMALS; APOPTOSIS; BONE DENSITY; CONNEXIN 43; HUMANS; MICE; OSTEOBLASTS; OSTEOCYTES;

EID: 54249095989     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.0811c     Document Type: Note

References (27)

1. Unger VM, Kumar NM, Gilula NB, Yeager M 1999 Three-dimensional structure of a recombinant gap junction membrane channel. Science 283:1176-1180.
2. Goodenough DA, Goliger JA, Paul DL 1996 Connexins, connexons, and intercellular communication. Annu Rev Biochem 65:475-502.
3. Genetos DC, Kephart CJ, Zhang Y, Yellowley CE, Donahue HJ 2007 Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes. J Cell Physiol 212:207-214.
4. Ishihara Y, Kamioka H, Honjo T, Ueda H, Takano-Yamamoto T, Yamashiro T 2008 Hormonal, pH, and calcium regulation of connexin 43-mediated dye transfer in osteocytes in chick calvaria. J Bone Miner Res 23:350-360.
5. Stains JP, Civitelli R 2005 Gap junctions in skeletal development and function. Biochim Biophys Acta 1719:69-81.
6. Civitelli R 2008 Cell-cell communication in the osteoblast/osteocyte lineage. Arch Biochem Biophys 473:188-192.
7. Paznekas WA, Boyadjiev SA, Shapiro RE, Daniels O, Wollnik B, Keegan CE, Innis JW, Dinulos MB, Christian C, Hannibal MC 2003 Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia. Am J Hum Genet 72:408-418.
8. Kjaer KW, Hansen L, Eiberg H, Leicht P, Opitz JM, Tommerup N 2004 Novel connexin 43 (GJA1) mutation causes oculo-dento-digital dysplasia with curly hair. Am J Med Genet 127A:152-157.
9. Dobrowolski R, Sasse P, Schrickel JW, Watkins M, Kim JS, Rackauskas M, Troatz C, Ghanem A, Tiemann K, Degen J 2008 The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans. Hum Mol Genet 17:539-554.
10. Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JE, Gong XQ, Kelsey LB, Lounsbury C, Moreno L 2005 A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development 132:4375-4386.
11. Goodenough DA, Paul DL 2003 Beyond the gap: functions of unpaired connexon channels. Nat Rev Mol Cell Biol 4:285-294.
12. Cherian PP, Siller-Jackson AJ, Gu S, Wang X, Bonewald LF, Sprague E, Jiang JX 2005 Mechanical strain opens connexin 43 hemichannels in osteocytes: A novel mechanism for the release of prostaglandin. Molec Biol Cell 16:3100-3106.
13. Plotkin LI, Weinstein RS, Parfitt AM, Roberson PK, Manolagas SC, Bellido T 1999 Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J Clin Invest 104:1363-1374.
14. Follet H, Li J, Phipps RJ, Hui S, Condon K, Burr DB 2007 Risedronate and alendronate suppress osteocyte apoptosis following cyclic fatigue loading. Bone 40:1172-1177.
15. Plotkin LI, Bellido T 2001 Bisphosphonate-induced, hemichannel-mediated, anti-apoptosis through the Src/ERK pathway: A gap junction-independent action of connexin43. Cell Commun Adhes 8:377-382.
16. Plotkin LI, Manolagas SC, Bellido T 2002 Transduction of cell survival signals by connexin-43 hemichannels. J Biol Chem 277:8648-8657.
17. Plotkin LI, Aguirre JI, Kousteni S, Manolagas SC, Bellido T 2005 Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation. J Biol Chem 280:7317-7325.
18. Plotkin LI, Lezcano V, Thostenson J, Weinstein RS, Manolagas SC, Bellido T 2008 Connexin 43 is required for the antiapoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo. J Bone Miner Res 23:1712-1721.
19. Manolagas SC 2000 Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev 21:115-137.
20. Idris AI, Rojas J, Greig IR, Van't Hof RJ, Ralston SH 2008 Aminobisphosphonates cause osteoblast apoptosis and inhibit bone nodule formation in vitro. Calcif Tissue Int 82:191-201.
21. Van der Molen MA, Rubin CT, McLeod KJ, McCauley LK, Donahue HJ 1996 Gap junctional intercellular communication contributes to hormonal responsiveness in osteoblastic networks. J Biol Chem 271:12165-12171.
22. Schiller PC, D'Ippolito G, Balkan W, Roos BA, Howard GA 2001 Gap-junctional communication mediates parathyroid hormone stimulation of mineralization in osteoblastic cultures. Bone 28:38-44.
23. Chung DJ, Castro CH, Watkins M, Stains JP, Chung MY, Szejnfeld VL, Willecke K, Theis M, Civitelli R 2006 Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43. J Cell Sci 119:4187-4198.
24. Grimston SK, Brodt MD, Silva MJ, Civitelli R 2008 Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1). J Bone Miner Res 23:879-886.
25. Stains JP, Civitelli R 2005 Gap junctions regulate extracellular signal-regulated kinase signaling to affect gene transcription. Molec Biol Cell 16:64-72.
26. Haugan K, Marcussen N, Kjolbye AL, Nielsen MS, Hennan JK, Petersen JS 2006 Treatment with the gap junction modifier rotigaptide (ZP123) reduces infarct size in rats with chronic myocardial infarction. J Cardiovasc Pharmacol 47:236-242.
27. Jorgensen NR, Teilmann SC, Henriksen Z, Meier E, Hansen SS, Jensen JE, Sorensen OH, Petersen JS 2005 The antiarrhythmic peptide analog rotigaptide (ZP123) stimulates gap junction intercellular communication in human osteoblasts and prevents decrease in femoral trabecular bone strength in ovariectomized rats. Endocrinology 146:4745-4754.