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Volumn 22, Issue 8, 2011, Pages 325-332

Emerging roles of JAK-STAT signaling pathways in adipocytes

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; JANUS KINASE; STAT PROTEIN;

EID: 79960913754     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2011.03.007     Document Type: Review
Times cited : (88)

References (94)
  • 1
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • Darnell J.E. STATs and gene regulation. Science 1997, 277:1630-1635.
    • (1997) Science , vol.277 , pp. 1630-1635
    • Darnell, J.E.1
  • 2
    • 0036256836 scopus 로고    scopus 로고
    • Series introduction JAK-STAT signaling in human disease
    • Schindler C.W. Series introduction JAK-STAT signaling in human disease. J. Clin. Invest. 2002, 109:1133-1137.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1133-1137
    • Schindler, C.W.1
  • 3
    • 0029069145 scopus 로고
    • Transcriptional responses to polypeptide ligands: the JAK-STAT pathway
    • Schindler C., Darnell J.E. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 1995, 64:621-651.
    • (1995) Annu. Rev. Biochem. , vol.64 , pp. 621-651
    • Schindler, C.1    Darnell, J.E.2
  • 4
    • 0032724019 scopus 로고    scopus 로고
    • Regulation of signal transducers and activators of transcription (STATs) by effectors of adipogenesis: coordinate regulation of STATs 1, 5A, and 5B with peroxisome proliferator-activated receptor-gamma and C/AAAT enhancer binding protein-alpha
    • Stewart W.C., et al. Regulation of signal transducers and activators of transcription (STATs) by effectors of adipogenesis: coordinate regulation of STATs 1, 5A, and 5B with peroxisome proliferator-activated receptor-gamma and C/AAAT enhancer binding protein-alpha. Biochim. Biophys. Acta 1999, 1452:188-196.
    • (1999) Biochim. Biophys. Acta , vol.1452 , pp. 188-196
    • Stewart, W.C.1
  • 5
    • 0035118857 scopus 로고    scopus 로고
    • Growth hormone receptor interaction with Jak proteins differs between tissues
    • Hellgren G., et al. Growth hormone receptor interaction with Jak proteins differs between tissues. J. Interferon Cytokine Res. 2001, 21:75-83.
    • (2001) J. Interferon Cytokine Res. , vol.21 , pp. 75-83
    • Hellgren, G.1
  • 6
    • 0032577926 scopus 로고    scopus 로고
    • Highly specific and quantitative activation of STATs in 3T3-L1 adipocytes
    • Balhoff J.P., Stephens J.M. Highly specific and quantitative activation of STATs in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 1998, 247:894-900.
    • (1998) Biochem. Biophys. Res. Commun. , vol.247 , pp. 894-900
    • Balhoff, J.P.1    Stephens, J.M.2
  • 7
    • 33747079946 scopus 로고    scopus 로고
    • Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I
    • Fleenor D., et al. Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I. Horm. Res. 2006, 66:101-110.
    • (2006) Horm. Res. , vol.66 , pp. 101-110
    • Fleenor, D.1
  • 8
    • 33847684669 scopus 로고    scopus 로고
    • Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARgamma pathway
    • Kawai M., et al. Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARgamma pathway. J. Mol. Endocrinol. 2007, 38:19-34.
    • (2007) J. Mol. Endocrinol. , vol.38 , pp. 19-34
    • Kawai, M.1
  • 9
    • 70450277113 scopus 로고    scopus 로고
    • Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway
    • McGillicuddy F.C., et al. Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. J. Biol. Chem. 2009, 284:31936-31944.
    • (2009) J. Biol. Chem. , vol.284 , pp. 31936-31944
    • McGillicuddy, F.C.1
  • 10
    • 0032553429 scopus 로고    scopus 로고
    • Activation of signal transducers and activators of transcription 1 and 3 by leukemia inhibitory factor, oncostatin-M, and interferon-gamma in adipocytes
    • Stephens J.M., et al. Activation of signal transducers and activators of transcription 1 and 3 by leukemia inhibitory factor, oncostatin-M, and interferon-gamma in adipocytes. J. Biol. Chem. 1998, 273:31408-31416.
    • (1998) J. Biol. Chem. , vol.273 , pp. 31408-31416
    • Stephens, J.M.1
  • 11
    • 33750597368 scopus 로고    scopus 로고
    • Modulation and lack of cross-talk between signal transducer and activator of transcription 5 and Suppressor of cytokine signaling-3 in insulin and growth hormone signaling in 3T3-L1 adipocytes
    • Story D.J., Stephens J.M. Modulation and lack of cross-talk between signal transducer and activator of transcription 5 and Suppressor of cytokine signaling-3 in insulin and growth hormone signaling in 3T3-L1 adipocytes. Obesity (Silver Spring) 2006, 14:1303-1311.
    • (2006) Obesity (Silver Spring) , vol.14 , pp. 1303-1311
    • Story, D.J.1    Stephens, J.M.2
  • 12
    • 0037428311 scopus 로고    scopus 로고
    • Growth hormone, but not insulin, activates STAT5 proteins in adipocytes in vitro and in vivo
    • Zvonic S., et al. Growth hormone, but not insulin, activates STAT5 proteins in adipocytes in vitro and in vivo. Biochem. Biophys. Res. Commun. 2003, 302:359-362.
    • (2003) Biochem. Biophys. Res. Commun. , vol.302 , pp. 359-362
    • Zvonic, S.1
  • 13
    • 0037462739 scopus 로고    scopus 로고
    • The regulation and activation of ciliary neurotrophic factor signaling proteins in adipocytes
    • Zvonic S., et al. The regulation and activation of ciliary neurotrophic factor signaling proteins in adipocytes. J. Biol. Chem. 2003, 278:2228-2235.
    • (2003) J. Biol. Chem. , vol.278 , pp. 2228-2235
    • Zvonic, S.1
  • 14
    • 9144232427 scopus 로고    scopus 로고
    • Effects of cardiotrophin on adipocytes
    • Zvonic S., et al. Effects of cardiotrophin on adipocytes. J. Biol. Chem. 2004, 279:47572-47579.
    • (2004) J. Biol. Chem. , vol.279 , pp. 47572-47579
    • Zvonic, S.1
  • 15
    • 0036106461 scopus 로고    scopus 로고
    • Direct effects of ciliary neurotrophic factor on brown adipocytes: evidence for a role in peripheral regulation of energy homeostasis
    • Ott V., et al. Direct effects of ciliary neurotrophic factor on brown adipocytes: evidence for a role in peripheral regulation of energy homeostasis. J. Endocrinol. 2002, 173:R1-R8.
    • (2002) J. Endocrinol. , vol.173
    • Ott, V.1
  • 16
    • 0026520997 scopus 로고
    • Interferon-gamma and interleukin-1 beta inhibit adipoconversion in cultured rodent preadipocytes
    • Gregoire F., et al. Interferon-gamma and interleukin-1 beta inhibit adipoconversion in cultured rodent preadipocytes. J. Cell. Physiol. 1992, 151:300-309.
    • (1992) J. Cell. Physiol. , vol.151 , pp. 300-309
    • Gregoire, F.1
  • 17
    • 0019308915 scopus 로고
    • Interferon inhibits the conversion of 3T3-L1 mouse fibroblasts into adipocytes
    • Keay S., Grossberg S.E. Interferon inhibits the conversion of 3T3-L1 mouse fibroblasts into adipocytes. Proc. Natl. Acad. Sci U.S.A. 1980, 77:4099-4103.
    • (1980) Proc. Natl. Acad. Sci U.S.A. , vol.77 , pp. 4099-4103
    • Keay, S.1    Grossberg, S.E.2
  • 18
    • 33846030487 scopus 로고    scopus 로고
    • Oncostatin M inhibits adipogenesis through the RAS/ERK and STAT5 signaling pathways
    • Miyaoka Y., et al. Oncostatin M inhibits adipogenesis through the RAS/ERK and STAT5 signaling pathways. J. Biol. Chem. 2006, 281:37913-37920.
    • (2006) J. Biol. Chem. , vol.281 , pp. 37913-37920
    • Miyaoka, Y.1
  • 19
    • 34547855102 scopus 로고    scopus 로고
    • Oncostatin M promotes osteogenesis and suppresses adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells
    • Song H.Y., et al. Oncostatin M promotes osteogenesis and suppresses adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells. J. Cell. Biochem. 2007, 101:1238-1251.
    • (2007) J. Cell. Biochem. , vol.101 , pp. 1238-1251
    • Song, H.Y.1
  • 20
    • 76749146390 scopus 로고    scopus 로고
    • Transcriptional factors that promote formation of white adipose tissue
    • White U.A., Stephens J.M. Transcriptional factors that promote formation of white adipose tissue. Mol. Cell. Endocrinol. 2010, 318:10-14.
    • (2010) Mol. Cell. Endocrinol. , vol.318 , pp. 10-14
    • White, U.A.1    Stephens, J.M.2
  • 21
    • 67649406466 scopus 로고    scopus 로고
    • Interaction of adipocyte fatty acid-binding protein (AFABP) and JAK2: AFABP/aP2 as a regulator of JAK2 signaling
    • Thompson B.R., et al. Interaction of adipocyte fatty acid-binding protein (AFABP) and JAK2: AFABP/aP2 as a regulator of JAK2 signaling. J. Biol. Chem. 2009, 284:13473-13480.
    • (2009) J. Biol. Chem. , vol.284 , pp. 13473-13480
    • Thompson, B.R.1
  • 22
    • 15844425315 scopus 로고    scopus 로고
    • The expression and regulation of STATs during 3T3-L1 adipocyte differentiation
    • Stephens J.M., et al. The expression and regulation of STATs during 3T3-L1 adipocyte differentiation. J. Biol. Chem. 1996, 271:10441-10444.
    • (1996) J. Biol. Chem. , vol.271 , pp. 10441-10444
    • Stephens, J.M.1
  • 23
    • 0034803657 scopus 로고    scopus 로고
    • Differential expression of signal transducers and activators of transcription during human adipogenesis
    • Harp J.B., et al. Differential expression of signal transducers and activators of transcription during human adipogenesis. Biochem. Biophys. Res. Commun. 2001, 281:907-912.
    • (2001) Biochem. Biophys. Res. Commun. , vol.281 , pp. 907-912
    • Harp, J.B.1
  • 24
    • 13344282731 scopus 로고    scopus 로고
    • Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
    • Meraz M.A., et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 1996, 84:431-442.
    • (1996) Cell , vol.84 , pp. 431-442
    • Meraz, M.A.1
  • 25
    • 0034456664 scopus 로고    scopus 로고
    • Activation of signal transducer and activator of transcription-3 during proliferative phases of 3T3-L1 adipogenesis
    • Deng J., et al. Activation of signal transducer and activator of transcription-3 during proliferative phases of 3T3-L1 adipogenesis. Endocrinology 2000, 141:2370-2376.
    • (2000) Endocrinology , vol.141 , pp. 2370-2376
    • Deng, J.1
  • 26
    • 70350674147 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor gamma (PPARgamma)
    • Wang D., et al. Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor gamma (PPARgamma). Biol. Cell 2010, 102:1-12.
    • (2010) Biol. Cell , vol.102 , pp. 1-12
    • Wang, D.1
  • 27
    • 79251643937 scopus 로고    scopus 로고
    • JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBPbeta transcription
    • Zhang K., et al. JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBPbeta transcription. J. Cell. Biochem. 2011, 112:488-497.
    • (2011) J. Cell. Biochem. , vol.112 , pp. 488-497
    • Zhang, K.1
  • 28
    • 28844499004 scopus 로고    scopus 로고
    • Protein inhibitor of activated STAT3 inhibits adipogenic gene expression
    • Deng J., et al. Protein inhibitor of activated STAT3 inhibits adipogenic gene expression. Biochem. Biophys. Res. Commun. 2006, 339:923-931.
    • (2006) Biochem. Biophys. Res. Commun. , vol.339 , pp. 923-931
    • Deng, J.1
  • 29
    • 33947359866 scopus 로고    scopus 로고
    • Midkine is an autocrine activator of signal transducer and activator of transcription 3 in 3T3-L1 cells
    • Cernkovich E.R., et al. Midkine is an autocrine activator of signal transducer and activator of transcription 3 in 3T3-L1 cells. Endocrinology 2007, 148:1598-1604.
    • (2007) Endocrinology , vol.148 , pp. 1598-1604
    • Cernkovich, E.R.1
  • 30
    • 0036083619 scopus 로고    scopus 로고
    • Proadipogenic effect of leptin on rat preadipocytes in vitro: activation of MAPK and STAT3 signaling pathways
    • Machinal-Quelin F., et al. Proadipogenic effect of leptin on rat preadipocytes in vitro: activation of MAPK and STAT3 signaling pathways. Am. J. Physiol. Cell Physiol. 2002, 282:C853-C863.
    • (2002) Am. J. Physiol. Cell Physiol. , vol.282
    • Machinal-Quelin, F.1
  • 31
    • 0029905399 scopus 로고    scopus 로고
    • Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta C/EBPdelta, and glucocorticoids
    • Wu Z., et al. Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta C/EBPdelta, and glucocorticoids. Mol. Cell. Biol. 1996, 16:4128-4136.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4128-4136
    • Wu, Z.1
  • 32
    • 0033584259 scopus 로고    scopus 로고
    • PPARgamma ligand-dependent induction of STAT1 STAT5A, and STAT5B during adipogenesis
    • Stephens J.M., et al. PPARgamma ligand-dependent induction of STAT1 STAT5A, and STAT5B during adipogenesis. Biochem. Biophys. Res. Commun. 1999, 262:216-222.
    • (1999) Biochem. Biophys. Res. Commun. , vol.262 , pp. 216-222
    • Stephens, J.M.1
  • 33
    • 0037312827 scopus 로고    scopus 로고
    • STAT5A promotes adipogenesis in nonprecursor cells and associates with the glucocorticoid receptor during adipocyte differentiation
    • Floyd Z.E., Stephens J.M. STAT5A promotes adipogenesis in nonprecursor cells and associates with the glucocorticoid receptor during adipocyte differentiation. Diabetes 2003, 52:308-314.
    • (2003) Diabetes , vol.52 , pp. 308-314
    • Floyd, Z.E.1    Stephens, J.M.2
  • 34
    • 34247345380 scopus 로고    scopus 로고
    • The modulation of STAT5A/GR complexes during fat cell differentiation and in mature adipocytes
    • Baugh J.E., et al. The modulation of STAT5A/GR complexes during fat cell differentiation and in mature adipocytes. Obesity (Silver Spring) 2007, 15:583-590.
    • (2007) Obesity (Silver Spring) , vol.15 , pp. 583-590
    • Baugh, J.E.1
  • 35
    • 0033605570 scopus 로고    scopus 로고
    • Growth hormone-dependent differentiation of 3T3-F442A preadipocytes requires Janus kinase/signal transducer and activator of transcription but not mitogen-activated protein kinase or p70 S6 kinase signaling
    • Yarwood S.J., et al. Growth hormone-dependent differentiation of 3T3-F442A preadipocytes requires Janus kinase/signal transducer and activator of transcription but not mitogen-activated protein kinase or p70 S6 kinase signaling. J. Biol. Chem. 1999, 274:8662-8668.
    • (1999) J. Biol. Chem. , vol.274 , pp. 8662-8668
    • Yarwood, S.J.1
  • 36
    • 0346849704 scopus 로고    scopus 로고
    • Constitutively active signal transducer and activator of transcription 5 can replace the requirement for growth hormone in adipogenesis of 3T3-F442A preadipocytes
    • Shang C.A., Waters M.J. Constitutively active signal transducer and activator of transcription 5 can replace the requirement for growth hormone in adipogenesis of 3T3-F442A preadipocytes. Mol. Endocrinol. 2003, 17:2494-2508.
    • (2003) Mol. Endocrinol. , vol.17 , pp. 2494-2508
    • Shang, C.A.1    Waters, M.J.2
  • 37
    • 85047685503 scopus 로고    scopus 로고
    • Stimulation of 3T3-L1 adipogenesis by signal transducer and activator of transcription 5
    • Nanbu-Wakao R., et al. Stimulation of 3T3-L1 adipogenesis by signal transducer and activator of transcription 5. Mol. Endocrinol. 2002, 16:1565-1576.
    • (2002) Mol. Endocrinol. , vol.16 , pp. 1565-1576
    • Nanbu-Wakao, R.1
  • 38
    • 80052175098 scopus 로고    scopus 로고
    • Stewart, W.C. et al. STAT5A expression in Swiss 3T3 cells promotes adipogenesis in vivo in an athymic mice model system. Obesity (Silver Spring).(in press)
    • Stewart, W.C. et al. (2011) STAT5A expression in Swiss 3T3 cells promotes adipogenesis in vivo in an athymic mice model system. Obesity (Silver Spring).(in press), doi:10.1038/oby.2011.66.
    • (2011)
  • 39
    • 0000943469 scopus 로고    scopus 로고
    • Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
    • Teglund S., et al. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 1998, 93:841-850.
    • (1998) Cell , vol.93 , pp. 841-850
    • Teglund, S.1
  • 40
    • 0037329337 scopus 로고    scopus 로고
    • A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population
    • Meirhaeghe A., et al. A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population. Arterioscler. Thromb. Vasc. Biol 2003, 23:289-294.
    • (2003) Arterioscler. Thromb. Vasc. Biol , vol.23 , pp. 289-294
    • Meirhaeghe, A.1
  • 41
    • 0032582349 scopus 로고    scopus 로고
    • PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter
    • Fajas L., et al. PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter. FEBS Lett. 1998, 438:55-60.
    • (1998) FEBS Lett. , vol.438 , pp. 55-60
    • Fajas, L.1
  • 42
    • 0035929376 scopus 로고    scopus 로고
    • The identification and characterization of a STAT 1 binding site in the PPARgamma2 promoter
    • Hogan J.C., Stephens J.M. The identification and characterization of a STAT 1 binding site in the PPARgamma2 promoter. Biochem. Biophys. Res. Commun. 2001, 287:484-492.
    • (2001) Biochem. Biophys. Res. Commun. , vol.287 , pp. 484-492
    • Hogan, J.C.1    Stephens, J.M.2
  • 43
    • 0035831494 scopus 로고    scopus 로고
    • Interferon-gamma-induced regulation of peroxisome proliferator-activated receptor gamma and STATs in adipocytes
    • Waite K.J., et al. Interferon-gamma-induced regulation of peroxisome proliferator-activated receptor gamma and STATs in adipocytes. J. Biol. Chem. 2001, 276:7062-7068.
    • (2001) J. Biol. Chem. , vol.276 , pp. 7062-7068
    • Waite, K.J.1
  • 44
    • 0033599038 scopus 로고    scopus 로고
    • Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension
    • Barroso I., et al. Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 1999, 402:880-883.
    • (1999) Nature , vol.402 , pp. 880-883
    • Barroso, I.1
  • 45
    • 0024498659 scopus 로고
    • Effect of interferon on glucose tolerance and insulin sensitivity
    • Koivisto V.A., et al. Effect of interferon on glucose tolerance and insulin sensitivity. Diabetes 1989, 38:641-647.
    • (1989) Diabetes , vol.38 , pp. 641-647
    • Koivisto, V.A.1
  • 46
    • 0031978359 scopus 로고    scopus 로고
    • Hyperglycaemia due to insulin resistance caused by interferon-gamma
    • Shiba T., et al. Hyperglycaemia due to insulin resistance caused by interferon-gamma. Diabet. Med. 1998, 15:435-436.
    • (1998) Diabet. Med. , vol.15 , pp. 435-436
    • Shiba, T.1
  • 48
    • 0029920693 scopus 로고    scopus 로고
    • Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis
    • Goldberg I.J. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J. Lipid Res. 1996, 37:693-707.
    • (1996) J. Lipid Res. , vol.37 , pp. 693-707
    • Goldberg, I.J.1
  • 49
    • 0027982085 scopus 로고
    • Cytokines induce catabolic effects in cultured adipocytes by multiple mechanisms
    • Doerrler W., et al. Cytokines induce catabolic effects in cultured adipocytes by multiple mechanisms. Cytokine 1994, 6:478-484.
    • (1994) Cytokine , vol.6 , pp. 478-484
    • Doerrler, W.1
  • 50
    • 0026529589 scopus 로고
    • Stimulation of lipolysis in cultured fat cells by tumor necrosis factor, interleukin-1, and the interferons is blocked by inhibition of prostaglandin synthesis
    • Feingold K.R., et al. Stimulation of lipolysis in cultured fat cells by tumor necrosis factor, interleukin-1, and the interferons is blocked by inhibition of prostaglandin synthesis. Endocrinology 1992, 130:10-16.
    • (1992) Endocrinology , vol.130 , pp. 10-16
    • Feingold, K.R.1
  • 51
    • 33646194752 scopus 로고    scopus 로고
    • STAT5 activators modulate acyl CoA oxidase (AOX) expression in adipocytes and STAT5A binds to the AOX promoter in vitro
    • Coulter A.A., Stephens J.M. STAT5 activators modulate acyl CoA oxidase (AOX) expression in adipocytes and STAT5A binds to the AOX promoter in vitro. Biochem. Biophys. Res. Commun. 2006, 344:1342-1345.
    • (2006) Biochem. Biophys. Res. Commun. , vol.344 , pp. 1342-1345
    • Coulter, A.A.1    Stephens, J.M.2
  • 52
    • 0034458535 scopus 로고    scopus 로고
    • Prolactin enhances CCAAT enhancer-binding protein-beta (C/EBP beta) and peroxisome proliferator-activated receptor gamma (PPAR gamma) messenger RNA expression and stimulates adipogenic conversion of NIH-3T3 cells
    • Nanbu-Wakao R., et al. Prolactin enhances CCAAT enhancer-binding protein-beta (C/EBP beta) and peroxisome proliferator-activated receptor gamma (PPAR gamma) messenger RNA expression and stimulates adipogenic conversion of NIH-3T3 cells. Mol. Endocrinol. 2000, 14:307-316.
    • (2000) Mol. Endocrinol. , vol.14 , pp. 307-316
    • Nanbu-Wakao, R.1
  • 53
    • 0038025842 scopus 로고    scopus 로고
    • The role of signal transducer and activator of transcription 5 in the inhibitory effects of GH on adipocyte differentiation
    • Richter H.E., et al. The role of signal transducer and activator of transcription 5 in the inhibitory effects of GH on adipocyte differentiation. J. Mol. Endocrinol. 2003, 30:139-150.
    • (2003) J. Mol. Endocrinol. , vol.30 , pp. 139-150
    • Richter, H.E.1
  • 54
    • 21344434092 scopus 로고    scopus 로고
    • The regulation of fatty acid synthase by STAT5A
    • Hogan J.C., Stephens J.M. The regulation of fatty acid synthase by STAT5A. Diabetes 2005, 54:1968-1975.
    • (2005) Diabetes , vol.54 , pp. 1968-1975
    • Hogan, J.C.1    Stephens, J.M.2
  • 55
    • 34249742693 scopus 로고    scopus 로고
    • The STAT5A-mediated induction of pyruvate dehydrogenase kinase 4 expression by prolactin or growth hormone in adipocytes
    • White U.A., et al. The STAT5A-mediated induction of pyruvate dehydrogenase kinase 4 expression by prolactin or growth hormone in adipocytes. Diabetes 2007, 56:1623-1629.
    • (2007) Diabetes , vol.56 , pp. 1623-1629
    • White, U.A.1
  • 56
    • 0034685029 scopus 로고    scopus 로고
    • Interleukin-4 mediates STAT6 activation in 3T3-L1 preadipocytes but not adipocytes
    • Deng J., et al. Interleukin-4 mediates STAT6 activation in 3T3-L1 preadipocytes but not adipocytes. Biochem. Biophys. Res. Commun. 2000, 267:516-520.
    • (2000) Biochem. Biophys. Res. Commun. , vol.267 , pp. 516-520
    • Deng, J.1
  • 57
    • 0037683665 scopus 로고    scopus 로고
    • Identification of functional prolactin (PRL) receptor gene expression: PRL inhibits lipoprotein lipase activity in human white adipose tissue
    • Ling C., et al. Identification of functional prolactin (PRL) receptor gene expression: PRL inhibits lipoprotein lipase activity in human white adipose tissue. J. Clin. Endocrinol. Metab. 2003, 88:1804-1808.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 1804-1808
    • Ling, C.1
  • 59
    • 0023234378 scopus 로고
    • The lipolytic effects of mouse placental lactogen II, mouse prolactin, and mouse growth hormone on adipose tissue from virgin and pregnant mice
    • Fielder P.J., Talamantes F. The lipolytic effects of mouse placental lactogen II, mouse prolactin, and mouse growth hormone on adipose tissue from virgin and pregnant mice. Endocrinology 1987, 121:493-497.
    • (1987) Endocrinology , vol.121 , pp. 493-497
    • Fielder, P.J.1    Talamantes, F.2
  • 60
    • 0019422191 scopus 로고
    • Prolactin and the regulation of adipose-tissue metabolism during lactation in rats
    • Flint D.J., et al. Prolactin and the regulation of adipose-tissue metabolism during lactation in rats. Mol. Cell. Endocrinol. 1981, 22:265-275.
    • (1981) Mol. Cell. Endocrinol. , vol.22 , pp. 265-275
    • Flint, D.J.1
  • 61
    • 0033575871 scopus 로고    scopus 로고
    • Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice
    • Fain J.N., et al. Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice. Biochem. Biophys. Res. Commun. 1999, 263:201-205.
    • (1999) Biochem. Biophys. Res. Commun. , vol.263 , pp. 201-205
    • Fain, J.N.1
  • 62
    • 79955474127 scopus 로고    scopus 로고
    • Gp130 cytokines exert differential patterns of crosstalk in adipocytes both in vitro and in vivo
    • White U.A., et al. Gp130 cytokines exert differential patterns of crosstalk in adipocytes both in vitro and in vivo. Obesity (Silver Spring) 2011, 10.1038/oby.2010.293.
    • (2011) Obesity (Silver Spring)
    • White, U.A.1
  • 63
    • 26644439030 scopus 로고    scopus 로고
    • Cross-talk among gp130 cytokines in adipocytes
    • Zvonic S., et al. Cross-talk among gp130 cytokines in adipocytes. J. Biol. Chem. 2005, 280:33856-33863.
    • (2005) J. Biol. Chem. , vol.280 , pp. 33856-33863
    • Zvonic, S.1
  • 64
    • 17844373625 scopus 로고    scopus 로고
    • Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis
    • Bates S.H., et al. Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metab. 2005, 1:169-178.
    • (2005) Cell Metab. , vol.1 , pp. 169-178
    • Bates, S.H.1
  • 65
    • 33745362866 scopus 로고    scopus 로고
    • Critical role of STAT3 in leptin's metabolic actions
    • Buettner C., et al. Critical role of STAT3 in leptin's metabolic actions. Cell Metab. 2006, 4:49-60.
    • (2006) Cell Metab. , vol.4 , pp. 49-60
    • Buettner, C.1
  • 66
    • 35648968069 scopus 로고    scopus 로고
    • The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms
    • Gong Y., et al. The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. J. Biol. Chem. 2007, 282:31019-31027.
    • (2007) J. Biol. Chem. , vol.282 , pp. 31019-31027
    • Gong, Y.1
  • 67
    • 40849124301 scopus 로고    scopus 로고
    • Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons
    • Piper M.L., et al. Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons. Mol. Endocrinol. 2008, 22:751-759.
    • (2008) Mol. Endocrinol. , vol.22 , pp. 751-759
    • Piper, M.L.1
  • 68
    • 0037422678 scopus 로고    scopus 로고
    • Stimulation of interleukin-6 release by interleukin-1beta from isolated human adipocytes
    • Flower L., et al. Stimulation of interleukin-6 release by interleukin-1beta from isolated human adipocytes. Cytokine 2003, 21:32-37.
    • (2003) Cytokine , vol.21 , pp. 32-37
    • Flower, L.1
  • 69
    • 0031762908 scopus 로고    scopus 로고
    • Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid
    • Fried S.K., et al. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J. Clin. Endocrinol. Metab. 1998, 83:847-850.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 847-850
    • Fried, S.K.1
  • 70
    • 38349016317 scopus 로고    scopus 로고
    • Cardiotrophin-1 is expressed in adipose tissue and upregulated in the metabolic syndrome
    • Natal C., et al. Cardiotrophin-1 is expressed in adipose tissue and upregulated in the metabolic syndrome. Am. J. Physiol. Endocrinol. Metab. 2008, 294:E52-E60.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.294
    • Natal, C.1
  • 71
    • 29344448655 scopus 로고    scopus 로고
    • LS14: a novel human adipocyte cell line that produces prolactin
    • Hugo E.R., et al. LS14: a novel human adipocyte cell line that produces prolactin. Endocrinology 2006, 147:306-313.
    • (2006) Endocrinology , vol.147 , pp. 306-313
    • Hugo, E.R.1
  • 72
    • 34347393307 scopus 로고    scopus 로고
    • Adipocyte prolactin: regulation of release and putative functions
    • Brandebourg T., et al. Adipocyte prolactin: regulation of release and putative functions. Diabetes Obes. Metab. 2007, 9:464-476.
    • (2007) Diabetes Obes. Metab. , vol.9 , pp. 464-476
    • Brandebourg, T.1
  • 73
    • 53749090713 scopus 로고    scopus 로고
    • Prolactin release by adipose explants, primary adipocytes, and LS14 adipocytes
    • Hugo E.R., et al. Prolactin release by adipose explants, primary adipocytes, and LS14 adipocytes. J. Clin. Endocrinol. Metab. 2008, 93:4006-4012.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 4006-4012
    • Hugo, E.R.1
  • 74
    • 33646020380 scopus 로고    scopus 로고
    • Induction of prolactin expression and release in human preadipocytes by cAMP activating ligands
    • McFarland-Mancini M., et al. Induction of prolactin expression and release in human preadipocytes by cAMP activating ligands. Biochem. Biophys. Res. Commun. 2006, 344:9-16.
    • (2006) Biochem. Biophys. Res. Commun. , vol.344 , pp. 9-16
    • McFarland-Mancini, M.1
  • 75
    • 70349150518 scopus 로고    scopus 로고
    • Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue
    • O'Rourke R.W., et al. Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue. Int. J. Obes. (Lond.) 2009, 33:978-990.
    • (2009) Int. J. Obes. (Lond.) , vol.33 , pp. 978-990
    • O'Rourke, R.W.1
  • 76
    • 70349563430 scopus 로고    scopus 로고
    • Interplay between human adipocytes and T lymphocytes in obesity: CCL20 as an adipochemokine and T lymphocytes as lipogenic modulators
    • Duffaut C., et al. Interplay between human adipocytes and T lymphocytes in obesity: CCL20 as an adipochemokine and T lymphocytes as lipogenic modulators. Arterioscler. Thromb. Vasc. Biol 2009, 29:1608-1614.
    • (2009) Arterioscler. Thromb. Vasc. Biol , vol.29 , pp. 1608-1614
    • Duffaut, C.1
  • 77
    • 54049086276 scopus 로고    scopus 로고
    • Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity
    • Rocha V.Z., et al. Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ. Res. 2008, 103:467-476.
    • (2008) Circ. Res. , vol.103 , pp. 467-476
    • Rocha, V.Z.1
  • 78
    • 77957108166 scopus 로고    scopus 로고
    • T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice
    • Strissel K.J., et al. T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice. Obesity (Silver Spring) 2010, 18:1918-1925.
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 1918-1925
    • Strissel, K.J.1
  • 79
    • 77956396699 scopus 로고    scopus 로고
    • Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance
    • Yang H., et al. Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J. Immunol. 2010, 185:1836-1845.
    • (2010) J. Immunol. , vol.185 , pp. 1836-1845
    • Yang, H.1
  • 80
    • 0037040272 scopus 로고    scopus 로고
    • Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPARgamma in adipocytes
    • Floyd Z.E., Stephens J.M. Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPARgamma in adipocytes. J. Biol. Chem. 2002, 277:4062-4068.
    • (2002) J. Biol. Chem. , vol.277 , pp. 4062-4068
    • Floyd, Z.E.1    Stephens, J.M.2
  • 81
    • 79953301147 scopus 로고    scopus 로고
    • Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2
    • Sos B.C., et al. Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2. J. Clin. Invest. 2011, 10.1172/JCI42894.
    • (2011) J. Clin. Invest.
    • Sos, B.C.1
  • 82
    • 34548321210 scopus 로고    scopus 로고
    • Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration
    • Cui Y., et al. Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration. Hepatology 2007, 46:504-513.
    • (2007) Hepatology , vol.46 , pp. 504-513
    • Cui, Y.1
  • 83
    • 78650850032 scopus 로고    scopus 로고
    • GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism
    • Barclay J.L., et al. GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism. Endocrinology 2011, 152:181-192.
    • (2011) Endocrinology , vol.152 , pp. 181-192
    • Barclay, J.L.1
  • 84
    • 11144357516 scopus 로고    scopus 로고
    • Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
    • Inoue H., et al. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nat. Med. 2004, 10:168-174.
    • (2004) Nat. Med. , vol.10 , pp. 168-174
    • Inoue, H.1
  • 85
    • 56049089150 scopus 로고    scopus 로고
    • Role of hepatic STAT3 in the regulation of lipid metabolism
    • Kinoshita S., et al. Role of hepatic STAT3 in the regulation of lipid metabolism. Kobe J. Med. Sci. 2008, 54:E200-E208.
    • (2008) Kobe J. Med. Sci. , vol.54
    • Kinoshita, S.1
  • 86
    • 41549123672 scopus 로고    scopus 로고
    • Adipose-specific disruption of signal transducer and activator of transcription 3 increases body weight and adiposity
    • Cernkovich E.R., et al. Adipose-specific disruption of signal transducer and activator of transcription 3 increases body weight and adiposity. Endocrinology 2008, 149:1581-1590.
    • (2008) Endocrinology , vol.149 , pp. 1581-1590
    • Cernkovich, E.R.1
  • 87
    • 0034598978 scopus 로고    scopus 로고
    • Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors
    • Sethi J.K., et al. Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors. FEBS Lett. 2000, 469:77-82.
    • (2000) FEBS Lett. , vol.469 , pp. 77-82
    • Sethi, J.K.1
  • 88
    • 21244465925 scopus 로고    scopus 로고
    • Effects of leukemia inhibitory factor on 3T3-L1 adipocytes
    • Hogan J.C., Stephens J.M. Effects of leukemia inhibitory factor on 3T3-L1 adipocytes. J. Endocrinol. 2005, 185:485-496.
    • (2005) J. Endocrinol. , vol.185 , pp. 485-496
    • Hogan, J.C.1    Stephens, J.M.2
  • 89
    • 0029968831 scopus 로고    scopus 로고
    • The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH
    • Smit L.S., et al. The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH. Mol. Endocrinol. 1996, 10:519-533.
    • (1996) Mol. Endocrinol. , vol.10 , pp. 519-533
    • Smit, L.S.1
  • 90
    • 10044251947 scopus 로고    scopus 로고
    • Interleukin 11 signaling in 3T3-L1 adipocytes
    • Tenney R., et al. Interleukin 11 signaling in 3T3-L1 adipocytes. J. Cell. Physiol. 2005, 202:160-166.
    • (2005) J. Cell. Physiol. , vol.202 , pp. 160-166
    • Tenney, R.1
  • 91
    • 0242580711 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
    • Rotter V., et al. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J. Biol. Chem. 2003, 278:45777-45784.
    • (2003) J. Biol. Chem. , vol.278 , pp. 45777-45784
    • Rotter, V.1
  • 92
    • 34248208781 scopus 로고    scopus 로고
    • Insulin antagonizes interleukin-6 signaling and is anti-inflammatory in 3T3-L1 adipocytes
    • Andersson C.X., et al. Insulin antagonizes interleukin-6 signaling and is anti-inflammatory in 3T3-L1 adipocytes. J. Biol. Chem. 2007, 282:9430-9435.
    • (2007) J. Biol. Chem. , vol.282 , pp. 9430-9435
    • Andersson, C.X.1
  • 93
    • 53049107629 scopus 로고    scopus 로고
    • Neuropoietin attenuates adipogenesis and induces insulin resistance in adipocytes
    • White U.A., et al. Neuropoietin attenuates adipogenesis and induces insulin resistance in adipocytes. J. Biol. Chem. 2008, 283:22505-22512.
    • (2008) J. Biol. Chem. , vol.283 , pp. 22505-22512
    • White, U.A.1
  • 94
    • 77951887829 scopus 로고    scopus 로고
    • Neuropoietin activates STAT3 independent of LIFR activation in adipocytes
    • White U.A., Stephens J.M. Neuropoietin activates STAT3 independent of LIFR activation in adipocytes. Biochem. Biophys. Res. Commun. 2010, 395:48-50.
    • (2010) Biochem. Biophys. Res. Commun. , vol.395 , pp. 48-50
    • White, U.A.1    Stephens, J.M.2


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