Neuropoietin activates STAT3 independent of LIFR activation in adipocytes

Biochemical and Biophysical Research Communications

Volumn 395, Issue 1, 2010, Pages 48-50

  White, Ursula A ^a   Stephens, Jacqueline M ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

Adipocytes; Leukemia inhibitory factor receptor (LIFR); Neuropoietin (NP)

Indexed keywords

GLYCOPROTEIN GP 130; LEUKEMIA INHIBITORY FACTOR RECEPTOR; NEUROPOIETIN; STAT3 PROTEIN; TYROSINE; UNCLASSIFIED DRUG; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA; LIFR PROTEIN, MOUSE; NEUROPOIETIN, MOUSE; ONCOSTATIN M RECEPTOR BETA; OSMR PROTEIN, MOUSE; STAT3 PROTEIN, MOUSE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CELL STRAIN 3T3; DRUG EFFECT; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CYTOKINE RECEPTOR GP130; INTERLEUKIN-6; LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT; MICE; ONCOSTATIN M RECEPTOR BETA SUBUNIT; PHOSPHORYLATION; STAT3 TRANSCRIPTION FACTOR;

EID: 77951887829     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.03.132     Document Type: Article

References (11)

1. D. Derouet, F. Rousseau, F. Alfonsi, J. Froger, J. Hermann, F. Barbier, D. Perret, C. Diveu, C. Guillet, L. Preisser, A. Dumont, M. Barbado, A. Morel, O. deLapeyriere, H. Gascan, S. Chevalier, Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor, Proc. Natl. Acad. Sci. USA 101 (2004) 4827-4832.
2. M. Ohno, J. Kohyama, M. Namihira, T. Sanosaka, J.A. Takahashi, N. Hashimoto, K. Nakashima, Neuropoietin induces neuroepithelial cells to differentiate into astrocytes via activation of STAT3, Cytokine 36 (2006) 17-22.
3. U.A. White, W.C. Stewart, R.L. Mynatt, J.M. Stephens, Neuropoietin attenuates adipogenesis and induces insulin resistance in adipocytes, J. Biol. Chem. 283 (2008) 22505-22512.
4. P.C. Heinrich, I. Behrmann, S. Haan, H.M. Hermanns, G. Muller-Newen, F. Schaper, Principles of interleukin (IL)-6-type cytokine signalling and its regulation, Biochem. J. 374 (2003) 1-20.
5. S. Zvonic, J.E. Baugh Jr., P. Arbour-Reily, R.L. Mynatt, J.M. Stephens, Cross-talk among gp130 cytokines in adipocytes, J. Biol. Chem. 280 (2005) 33856-33863.
6. F. Blanchard, L. Duplomb, Y. Wang, O. Robledo, E. Kinzie, V. Pitard, A. Godard, Y. Jacques, H. Baumann, Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinase, J. Biol. Chem. 275 (2000) 28793-28801.
7. F. Blanchard, Y. Wang, E. Kinzie, L. Duplomb, A. Godard, H. Baumann, Oncostatin M regulates the synthesis and turnover of gp130, leukemia inhibitory factor receptor alpha, and oncostatin M receptor beta by distinct mechanisms, J. Biol. Chem. 276 (2001) 47038-47045.
8. B. Mosley, I.C. De, D. Friend, N. Boiani, B. Thoma, L.S. Park, D. Cosman, Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation, J. Biol. Chem. 271 (1996) 32635-32643.
9. U.K. Laemmli, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227 (1970) 680-685.
10. N.E. Wolins, B.K. Quaynor, J.R. Skinner, A. Tzekov, C. Park, K. Choi, P.E. Bickel, OP9 mouse stromal cells rapidly differentiate into adipocytes: characterization of a useful new model of adipogenesis, J. Lipid Res. 47 (2006) 450-460.
11. M. Ichihara, T. Hara, H. Kim, T. Murate, A. Miyajima, Oncostatin M and leukemia inhibitory factor do not use the same functional receptor in mice, Blood 90 (1997) 165-173.