Angiotensin II type 2 receptor blockade inhibits fatty acid synthase production through activation of AMP-activated protein kinase in pancreatic cancer cells

Surgery

Volumn 150, Issue 2, 2011, Pages 284-298

  McGhee, Amy ^a   Sivarajah, Maheshwaran ^a   Gong, Qiaoke ^a   Lim, Suhyueh ^a   Chipitsyna, Galina ^a   Yeo, Charles J ^a   Arafat, Hwyda A ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETYL COENZYME A CARBOXYLASE; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; C 75; FATTY ACID SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LOSARTAN; MESSENGER RNA; PROTEIN KINASE LKB1; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER INVASION; CELL STIMULATION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG MECHANISM; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL PAPILLARY MUCINOUS TUMOR; LIPOGENESIS; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; STROMA CELL; TISSUE DISTRIBUTION; UPREGULATION; WESTERN BLOTTING;

AMP-ACTIVATED PROTEIN KINASES; ANGIOTENSIN II TYPE 2 RECEPTOR BLOCKERS; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; FATTY ACID SYNTHETASE COMPLEX; HUMANS; PANCREATIC NEOPLASMS; RECEPTOR, ANGIOTENSIN, TYPE 2;

EID: 79960906791     PISSN: 00396060     EISSN: 15327361     Source Type: Journal    
DOI: 10.1016/j.surg.2011.06.002     Document Type: Article

References (46)

1. A. Jemal, R. Siegel, J. Xu, and E. Ward Cancer statistics CA Cancer J Clin 60 2010 277 300
2. A.L. Warshaw, and C. Ferandez-Del Castillo Pancreatic carcinoma N Engl J Med 326 1992 455 465
3. J.A. Menendez, and R. Lupu Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis Nat Rev Cancer 7 2007 763 777 (Pubitemid 47469806)
4. T. Mashima, H. Seimiya, and T. Tsuruo De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy Br J Cancer 100 2009 1369 1372
5. O. Warburg On the origin of cancer cells Science 123 1956 309 314
6. F.P. Kuhajda, S. Piantadosi, and G.P. Pasternack Haptoglobin-related protein (Hpr) epitopes in breast cancer as a predictor of recurrence of the disease N Engl J Med 321 1989 636 641 (Pubitemid 19221307)
7. F.P. Kuhajda, K. Jenner, F.D. Wood, R.A. Hennigar, L.B. Jacobs, and J.D. Dick Fatty acid synthesis: a potential selective target for antineoplastic therapy Proc Natl Acad Sci U S A 91 1994 6379 6383 (Pubitemid 24200664)
8. S. Jackowski Coordination of membrane phospholipid synthesis with cell cycle J Biol Chem 269 1994 3858 3867 (Pubitemid 24237720)
9. L.C. Costello, and R.B. Franklin Tumor cell metabolism: the marriage of molecular genetics and proteomics with cellular intermediary metabolism; proceed with caution Mol Cancer 5 2006 59
10. L.C. Costello, and R.B. Franklin Why do tumour cells glycolyse? From glycolysis through citrate to lipogenesis Mol Cell Biochem 280 2005 1 8 (Pubitemid 41829794)
11. P.L. Alo, M. Amini, F. Piro, L. Pizzuti, V. Sebastiani, and C. Botti Immunohistochemical expression and prognostic significance of fatty acid synthase in pancreatic carcinoma Anticancer Res 27 2007 2523 2527 (Pubitemid 47228098)
12. K. Walter, S.M. Hong, S. Nyhan, M. Canto, N. Fedarko, and A. Klein Serum fatty acid synthase as a marker of pancreatic neoplasia Cancer Epidemiol Biomarkers Prev 18 2009 2380 2385
13. A. Horiguchi, T. Asano, T. Asano, K. Ito, M. Sumitomo, and M. Hayakawa Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma J Urol 180 2008 1137 1140
14. S.D. Silva, D.E. Perez, I.N. Nishimoto, F.A. Alves, C.A. Pinto, and L.P. Kowalski Fatty acid synthase expression in squamous cell carcinoma of the tongue:clinicopathological findings Oral Dis 14 2008 376 382 (Pubitemid 351533592)
15. S. Ogino, K. Nosho, J.A. Meyerhardt, G.J. Kirkner, A.T. Chan, and T. Kawasaki Cohort study of fatty acid synthase expression and patient survival in colon cancer J Clin Oncol 10 2008 5713 5720
16. C.D. Browne, E.J. Hindmarsh, and J.W. Smith Inhibition of endothelial cell proliferation and angiogenesis by orlistat, a fatty acid synthase inhibitor FASEB J 20 2006 2027 2035 (Pubitemid 44970363)
17. H. Liu, Y. Liu, and J.T. Zhang A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction Mol Cancer Ther 7 2008 263 270 (Pubitemid 351302520)
18. J.A. Menendez, L. Vellon, R. Colomer, and R. Lupu Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity Int J Cancer 115 2005 19 35 (Pubitemid 40559665)
19. R. Lupu, and J.A. Menendez Pharmacological inhibitors of fatty acid synthase (FASN)-catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? Curr Pharm Biotechnol 7 2006 495 502
20. E.S. Pizer, J. Thupari, W.F. Han, M.L. Pinn, F.J. Chrest, and G.L. Frehywot Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts Cancer Res 60 2000 213 218 (Pubitemid 30070736)
21. E. De Schrijver, K. Brusselmans, W. Heyns, G. Verhoeven, and J.V. Swinnen RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells Cancer Res 63 2003 3799 3804 (Pubitemid 36793069)
22. H.A. Arafat, Q. Gong, G. Chipitsyna, A. Rizvi, C.T. Saa, and C.J. Yeo Antihypertensives as novel antineoplastics: Angiotensin-I-Converting enzyme inhibitors and angiotensin II type 1 receptor blockers in pancreatic ductal adenocarcinoma J Am Coll Surg 204 2007 996 1003
23. P.S. Leung, and M.C. Chappell A local pancreatic rennin-angiotensin system: endocrine and exocrine roles Int J Biochem Cell Biol 35 2003 838 846 (Pubitemid 36379325)
24. I. Fleming, K. Kohlstedt, and R. Busse The tissue renin-angiotensin system and intracellular signaling Curr Opin Nephrol Hypertens 15 2006 8 13
25. A.F. Lever, D.J. Hole, C.R. Gillis, I.R. McCallum, G.T. McInnes, and P.L. MacKinnon Do inhibitors of angiotensin-I-converting enzyme protect against risk of cancer? Lancet 352 1998 179 184 (Pubitemid 28327802)
26. M.K. Reddy, K. Baskaran, and A. Molteni Inhibitors of angiotensin-converting enzyme modulate mitosis and gene expression in pancreatic cancer cells Proc Soc Exp Biol Med 210 1995 221 226 (Pubitemid 26020247)
27. R. Anandanadesan, Q. Gong, G. Chipitsyna, A. Witkiewicz, C.J. Yeo, and H.A. Arafat Angiotensin II induces vascular endothelial growth factor in pancreatic cancer cells through an angiotensin II type 1 receptor and ERK1/2 signaling J Gastrointest Surg 12 2008 57 66
28. N. Chehl, Q. Gong, G. Chipitsyna, T. Aziz, C.J. Yeo, and H.A. Arafat Angiotensin II regulates the expression of monocyte chemoattractant protein-1 in pancreatic cancer cells J Gastrointest Surg 13 2009 2189 2200
29. B.H. Jones, M.K. Standridge, and N. Moustaid Angiotensin II increases lipogenesis in 3T3-L1 and human adipose cells Endocrinology 138 1997 1512 1519 (Pubitemid 27137101)
30. S. Kim, I. Dugail, M. Standridge, K. Claycombe, J. Chun, and N. Moustaïd-Moussa Angiotensin II-responsive element is the insulin-responsive element in the adipocyte fatty acid synthase gene: role of adipocyte determination and differentiation factor 1/sterol-regulatory-element-binding protein 1c Biochem J 357 2001 899 904 (Pubitemid 32735173)
31. M. Hongo, N. Ishizaka, K. Furuta, N. Yahagi, K. Saito, and R. Sakurai Administration of angiotensin II, but not catecholamines, induces accumulation of lipids in the rat heart Eur J Pharmacol 604 2009 87 92
32. L. Yvan-Charvet, P. Even, M. Bloch-Faure, M. Guerre-Millo, N. Moustaid-Moussa, and P. Ferre Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance Diabetes 54 2005 991 999 (Pubitemid 40446313)
33. A. Scholze, K. Krueger, M. Diedrich, C. Räth, A. Torges, and V. Jankowski Superoxide dismutase type 1 in monocytes of chronic kidney disease patients Amino Acids 41 2011 427 438
34. D.G. Hardie, D. Carling, and M. Carlson The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67 1998 821 855 (Pubitemid 28411146)
35. W.W. Winder, and D.G. Hardie The AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes Am J Physiol 277 1999 E1 10
36. D.B. Shackelford, and R.J. Shaw The LKB1-AMPK pathway: metabolism and growth control in tumour suppression Nat Rev Cancer 9 2009 563 575
37. E. Furuta, S.K. Pai, R. Zhan, S. Bandyopadhyay, M. Watabe, and Y.Y. Mo Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1 Cancer Res 68 2008 1003 1011 (Pubitemid 351278386)
38. H.F. Cheng, B.N. Becker, K.D. Burns, and R.C. Harris Angiotensin II upregulates type-1 angiotensin II receptors in renal proximal tubule J Clin Invest 95 1995 2012 2019
39. W. Jiang, Z. Zhu, and H.J. Thompson Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver Cancer Res 68 2008 5492 5499
40. D.G. Hardie AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy Nat Rev Mol Cell Biol 8 2007 774 785 (Pubitemid 47462132)
41. D.G. Hardie New roles for the LKB1→AMPK pathway Curr Opin Cell Biol 17 2005 167 173
42. H. Motoshima, B.J. Goldstein, M. Igata, and E. Araki AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer J Physiol 574 2006 63 71 (Pubitemid 43905797)
43. D.G. Hardie, S.A. Hawley, and J.W. Scott AMP-activated protein kinase - development of the energy sensor concept J Physiol 574 2006 7 15 (Pubitemid 43905792)
44. R.H. Hruban, R.E. Wilentz, and A. Maitra Identification and analysis of precursors to invasive pancreatic cancer Methods Mol Med 103 2005 1 13
45. T. Ohta, K. Amaya, S. Yi, H. Kitagawa, M. Kayahara, and I. Ninomiya Angiotensin converting enzyme-independent, local angiotensin II-generation in human pancreatic ductal cancer tissues Int J Oncol 23 2003 593 598
46. J.M. Evans, L.A. Donnelly, A.M. Emslie-Smith, D.R. Alessi, and A.D. Morris Metformin and reduced risk of cancer in diabetic patients BMJ 330 2005 1304 1305 (Pubitemid 40813563)