-
1
-
-
2642522640
-
Genetic transformation of mouse embryos by microinjection of purified DNA
-
Gordon, J.W., Scangos, G.A. and Plotkin, D.J. (1980) Genetic transformation of mouse embryos by microinjection of purified DNA. Proc. Natl. Acad. Sci. U.S.A. 77, 7380-7384
-
(1980)
Proc. Natl. Acad. Sci. U.S.A.
, vol.77
, pp. 7380-7384
-
-
Gordon, J.W.1
Scangos, G.A.2
Plotkin, D.J.3
-
2
-
-
77953437225
-
The biology and pathology of the familial Parkinson's disease protein LRRK2
-
Suppl. 1
-
Dauer, W. and Ho, C.C. (2010) The biology and pathology of the familial Parkinson's disease protein LRRK2. Mov. Disord. 25, S40-S43, Suppl. 1
-
(2010)
Mov. Disord.
, vol.25
-
-
Dauer, W.1
Ho, C.C.2
-
3
-
-
77952888334
-
Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: A systematic review
-
Correia Guedes, L., Ferreira, J.J., Rosa, M.M., Coelho, M., Bonifati, V. and Sampaio, C. (2010) Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: a systematic review. Parkinsonism Relat. Disord. 16, 237-242
-
(2010)
Parkinsonism Relat. Disord.
, vol.16
, pp. 237-242
-
-
Correia Guedes, L.1
Ferreira, J.J.2
Rosa, M.M.3
Coelho, M.4
Bonifati, V.5
Sampaio, C.6
-
4
-
-
65549124540
-
Leucine-rich repeat kinase 2 (LRRK2): A key player in the pathogenesis of Parkinson's disease
-
Gandhi, P.N., Chen, S.G. and Wilson-Delfosse, A.L. (2009) Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease. J. Neurosci. Res. 87, 1283-1295
-
(2009)
J. Neurosci. Res.
, vol.87
, pp. 1283-1295
-
-
Gandhi, P.N.1
Chen, S.G.2
Wilson-Delfosse, A.L.3
-
5
-
-
8844233579
-
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
-
DOI 10.1016/j.neuron.2004.11.005, PII S0896627304007202
-
Zimprich, A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M., Lincoln, S., Kachergus, J., Hulihan, M., Uitti, R.J., Calne, D.B. et al. (2004) Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology. Neuron 44, 601-607 (Pubitemid 39531225)
-
(2004)
Neuron
, vol.44
, Issue.4
, pp. 601-607
-
-
Zimprich, A.1
Biskup, S.2
Leitner, P.3
Lichtner, P.4
Farrer, M.5
Lincoln, S.6
Kachergus, J.7
Hulihan, M.8
Uitti, R.J.9
Calne, D.B.10
Stoessl, A.J.11
Pfeiffer, R.F.12
Patenge, N.13
Carbajal, I.C.14
Vieregge, P.15
Asmus, F.16
Muller-Myhsok, B.17
Dickson, D.W.18
Meitinger, T.19
Strom, T.M.20
Wszolek, Z.K.21
Gasser, T.22
more..
-
6
-
-
34250199013
-
Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain
-
DOI 10.1016/j.brainres.2007.04.034, PII S0006899307008657
-
Higashi, S., Biskup, S., West, A.B., Trinkaus, D., Dawson, V.L., Faull, R.L.M., Waldvogel, H.J., Arai, H., Dawson, T.M., Moore, D.J. and Emson, P.C. (2007) Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain. Brain Res. 1155, 208-219 (Pubitemid 46900930)
-
(2007)
Brain Research
, vol.1155
, Issue.1
, pp. 208-219
-
-
Higashi, S.1
Biskup, S.2
West, A.B.3
Trinkaus, D.4
Dawson, V.L.5
Faull, R.L.M.6
Waldvogel, H.J.7
Arai, H.8
Dawson, T.M.9
Moore, D.J.10
Emson, P.C.11
-
7
-
-
33749463769
-
LRRK2 expression in normal and pathologic human brain and in human cell lines
-
Miklossy, J., Arai, T., Guo, J.P., Klegeris, A., Yu, S., McGeer, E.G. and McGeer, P.L. (2006) LRRK2 expression in normal and pathologic human brain and in human cell lines. J. Neuropathol. Exp. Neurol. 65, 953-963
-
(2006)
J. Neuropathol. Exp. Neurol.
, vol.65
, pp. 953-963
-
-
Miklossy, J.1
Arai, T.2
Guo, J.P.3
Klegeris, A.4
Yu, S.5
McGeer, E.G.6
McGeer, P.L.7
-
8
-
-
42549123597
-
LRRK2 is a component of granular α-synuclein pathology in the brainstem of Parkinson's disease
-
Alegre-Abarrategui, J., Ansorge, O., Esiri, M. and Wade-Martins, R. (2008) LRRK2 is a component of granular α-synuclein pathology in the brainstem of Parkinson's disease. Neuropathol. Appl. Neurobiol. 34, 272-283
-
(2008)
Neuropathol. Appl. Neurobiol.
, vol.34
, pp. 272-283
-
-
Alegre-Abarrategui, J.1
Ansorge, O.2
Esiri, M.3
Wade-Martins, R.4
-
9
-
-
34547107314
-
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease
-
DOI 10.1016/j.neuroscience.2007.05.027, PII S0306452207006616
-
Melrose, H.L., Kent, C.B., Taylor, J.P., Dachsel, J.C., Hinkle, K.M., Lincoln, S.J., Mok, S.S., Culvenor, J.G., Masters, C.L., Tyndall, G.M. et al. (2007) A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease. Neuroscience 147, 1047-1058 (Pubitemid 47102551)
-
(2007)
Neuroscience
, vol.147
, Issue.4
, pp. 1047-1058
-
-
Melrose, H.L.1
Kent, C.B.2
Taylor, J.P.3
Dachsel, J.C.4
Hinkle, K.M.5
Lincoln, S.J.6
Mok, S.S.7
Culvenor, J.G.8
Masters, C.L.9
Tyndall, G.M.10
Bass, D.I.11
Ahmed, Z.12
Andorfer, C.A.13
Ross, O.A.14
Wszolek, Z.K.15
Delldonne, A.16
Dickson, D.W.17
Farrer, M.J.18
-
10
-
-
76149134717
-
Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S
-
Li, X., Patel, J.C., Wang, J., Avshalumov, M.V., Nicholson, C., Buxbaum, J.D., Elder, G.A., Rice, M.E. and Yue, Z. (2010) Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S. J. Neurosci. 30, 1788-1797
-
(2010)
J. Neurosci.
, vol.30
, pp. 1788-1797
-
-
Li, X.1
Patel, J.C.2
Wang, J.3
Avshalumov, M.V.4
Nicholson, C.5
Buxbaum, J.D.6
Elder, G.A.7
Rice, M.E.8
Yue, Z.9
-
11
-
-
67649813448
-
R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
-
R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat. Neurosci. 12, 826-828
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 826-828
-
-
Li, Y.1
Liu, W.2
Oo, T.F.3
Wang, L.4
Tang, Y.5
Jackson-Lewis, V.6
Zhou, C.7
Geghman, K.8
Bogdanov, M.9
Przedborski, S.10
-
12
-
-
33646146878
-
Anatomical localization of leucine-rich repeat kinase 2 in mouse brain
-
DOI 10.1016/j.neuroscience.2006.01.017, PII S0306452206001175
-
Melrose, H., Lincoln, S., Tyndall, G., Dickson, D. and Farrer, M. (2006) Anatomical localization of leucine-rich repeat kinase 2 in mouse brain. Neuroscience 139, 791-794 (Pubitemid 44308089)
-
(2006)
Neuroscience
, vol.139
, Issue.3
, pp. 791-794
-
-
Melrose, H.1
Lincoln, S.2
Tyndall, G.3
Dickson, D.4
Farrer, M.5
-
13
-
-
4644236043
-
Causal relation between α-synuclein gene duplication and familial Parkinson's disease
-
DOI 10.1016/S0140-6736(04)17104-3, PII S0140673604171043
-
Ibáñez, P., Bonnet, A.M., Débarges, B., Lohmann, E., Tison, F., Pollak, P., Agid, Y., Dürr, A. and Brice, P.A. (2004) Causal relation between α-synuclein gene duplication and familial Parkinson's disease. Lancet 364, 1169-1171 (Pubitemid 39296605)
-
(2004)
Lancet
, vol.364
, Issue.9440
, pp. 1169-1171
-
-
Ibanez, P.1
Bonnet, A.-M.2
Debarges, B.3
Lohmann, E.4
Tison, F.5
Pollak, P.6
Agid, Y.7
Durr, A.8
Brice, P.A.9
-
14
-
-
4644290985
-
α-synuclein locus duplication as a cause of familial Parkinson's disease
-
DOI 10.1016/S0140-6736(04)17103-1, PII S0140673604171031
-
Chartier-Harlin, M.C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., Levecque, C., Larvor, L., Andrieux, J., Hulihan, M. et al. (2004) α-Synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 364, 1167-1169 (Pubitemid 39296604)
-
(2004)
Lancet
, vol.364
, Issue.9440
, pp. 1167-1169
-
-
Chartier-Harlin, M.-C.1
Kachergus, J.2
Roumier, C.3
Mouroux, V.4
Douay, X.5
Lincoln, S.6
Levecque, C.7
Larvor, L.8
Andrieux, J.9
Hulihan, M.10
Waucquier, N.11
Defebvre, L.12
Amouyel, P.13
Farrer, M.14
Destee, A.15
-
15
-
-
78149466909
-
α-Synuclein and dopamine at the crossroads of Parkinson's disease
-
Venda, L.L., Cragg, S.J., Buchman, V.L. and Wade-Martins, R. (2010) α-Synuclein and dopamine at the crossroads of Parkinson's disease. Trends Neurosci. 33, 559-568
-
(2010)
Trends Neurosci.
, vol.33
, pp. 559-568
-
-
Venda, L.L.1
Cragg, S.J.2
Buchman, V.L.3
Wade-Martins, R.4
-
16
-
-
77956393934
-
α-Synuclein, lipids and Parkinson's disease
-
Ruipérez, V., Darios, F. and Davletov, B. (2010) α-Synuclein, lipids and Parkinson's disease. Prog. Lipid Res. 49, 420-428
-
(2010)
Prog. Lipid Res.
, vol.49
, pp. 420-428
-
-
Ruipérez, V.1
Darios, F.2
Davletov, B.3
-
17
-
-
33747769942
-
α-Synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers
-
Beyer, K. (2006) α-Synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers. Acta Neuropathol. 112, 237-251
-
(2006)
Acta Neuropathol.
, vol.112
, pp. 237-251
-
-
Beyer, K.1
-
18
-
-
77952478217
-
Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes
-
Kuo, Y.M., Li, Z., Jiao, Y., Gaborit, N., Pani, A.K., Orrison, B.M., Bruneau, B.G., Giasson, B.I., Smeyne, R.J., Gershon, M.D. and Nussbaum, R.L. (2010) Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes. Hum. Mol. Genet. 19, 1633-1650
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 1633-1650
-
-
Kuo, Y.M.1
Li, Z.2
Jiao, Y.3
Gaborit, N.4
Pani, A.K.5
Orrison, B.M.6
Bruneau, B.G.7
Giasson, B.I.8
Smeyne, R.J.9
Gershon, M.D.10
Nussbaum, R.L.11
-
19
-
-
0016708285
-
Olfactory function in patients with Parkinson's disease
-
Ansari, K.A. and Johnson, A. (1975) Olfactory function in patients with Parkinson's disease. J. Chronic Dis. 28, 493-497
-
(1975)
J. Chronic Dis.
, vol.28
, pp. 493-497
-
-
Ansari, K.A.1
Johnson, A.2
-
20
-
-
0026609580
-
Gastrointestinal dysfunction in Parkinson's disease: Frequency and pathophysiology
-
Edwards, L.L., Quigley, E.M.M. and Pfeiffer, R.F. (1992) Gastrointestinal dysfunction in Parkinson's disease: frequency and pathophysiology. Neurology 42, 726-732
-
(1992)
Neurology
, vol.42
, pp. 726-732
-
-
Edwards, L.L.1
Quigley, E.M.M.2
Pfeiffer, R.F.3
-
21
-
-
34547770262
-
Association of α-synuclein gene haplotypes with Parkinson's disease
-
Parsian, A.J., Racette, B.A., Zhao, J.H., Sinha, R., Patra, B., Perlmutter, J.S. and Parsian, A. (2007) Association of α-synuclein gene haplotypes with Parkinson's disease. Parkinsonism Relat. Disord. 13, 343-347
-
(2007)
Parkinsonism Relat. Disord.
, vol.13
, pp. 343-347
-
-
Parsian, A.J.1
Racette, B.A.2
Zhao, J.H.3
Sinha, R.4
Patra, B.5
Perlmutter, J.S.6
Parsian, A.7
-
22
-
-
68749088554
-
Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human α-synuclein in transgenic mouse brain
-
Cronin, K.D., Ge, D., Manninger, P., Linnertz, C., Rossoshek, A., Orrison, B.M., Bernard, D.J., El-Agnaf, O.M.A., Schlossmacher, M.G., Nussbaum, R.L. and Chiba-Falek, O. (2009) Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human α-synuclein in transgenic mouse brain. Hum. Mol. Genet. 18, 3274-3285
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 3274-3285
-
-
Cronin, K.D.1
Ge, D.2
Manninger, P.3
Linnertz, C.4
Rossoshek, A.5
Orrison, B.M.6
Bernard, D.J.7
El-Agnaf, O.M.A.8
Schlossmacher, M.G.9
Nussbaum, R.L.10
Chiba-Falek, O.11
-
23
-
-
70549088602
-
Genome-wide association study reveals genetic risk underlying Parkinson's disease
-
Simón-Sánchez, J., Schulte, C., Bras, J.M., Sharma, M., Gibbs, J.R., Berg, D., Paisan-Ruiz, C., Lichtner, P., Scholz, S.W., Hernandez, D.G. et al. (2009) Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat. Genet. 41, 1308-1312
-
(2009)
Nat. Genet.
, vol.41
, pp. 1308-1312
-
-
Simón-Sánchez, J.1
Schulte, C.2
Bras, J.M.3
Sharma, M.4
Gibbs, J.R.5
Berg, D.6
Paisan-Ruiz, C.7
Lichtner, P.8
Scholz, S.W.9
Hernandez, D.G.10
-
24
-
-
67349142329
-
Mechanisms of tau-induced neurodegeneration
-
Iqbal, K., Liu, F., Gong, C.X., del Alonso, A.C. and Grundke-Iqbal, I. (2009) Mechanisms of tau-induced neurodegeneration. Acta Neuropathol. 118, 53-69
-
(2009)
Acta Neuropathol.
, vol.118
, pp. 53-69
-
-
Iqbal, K.1
Liu, F.2
Gong, C.X.3
Del Alonso, A.C.4
Grundke-Iqbal, I.5
-
25
-
-
0034940160
-
Neurodegenerative tauopathies
-
Lee, V.M.Y., Goedert, M. and Trojanowski, J.Q. (2001) Neurodegenerative tauopathies. Annu. Rev. Neurosci. 24, 1121-1159
-
(2001)
Annu. Rev. Neurosci.
, vol.24
, pp. 1121-1159
-
-
Lee, V.M.Y.1
Goedert, M.2
Trojanowski, J.Q.3
-
26
-
-
0024745894
-
Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
-
Goedert, M., Spillantini, M.G., Jakes, R., Rutherford, D. and Crowther, R.A. (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 3, 519-526
-
(1989)
Neuron
, vol.3
, pp. 519-526
-
-
Goedert, M.1
Spillantini, M.G.2
Jakes, R.3
Rutherford, D.4
Crowther, R.A.5
-
27
-
-
0034016093
-
Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes
-
Duff, K., Knight, H., Refolo, L.M., Sanders, S., Yu, X., Picciano, M., Malester, B., Hutton, M., Adamson, J., Goedert, M. et al. (2000) Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes. Neurobiol. Dis. 7, 87-98
-
(2000)
Neurobiol. Dis.
, vol.7
, pp. 87-98
-
-
Duff, K.1
Knight, H.2
Refolo, L.M.3
Sanders, S.4
Yu, X.5
Picciano, M.6
Malester, B.7
Hutton, M.8
Adamson, J.9
Goedert, M.10
-
28
-
-
0041803006
-
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
-
DOI 10.1046/j.1471-4159.2003.01879.x
-
Andorfer, C., Kress, Y., Espinoza, M., De Silva, R., Tucker, K.L., Barde, Y.A., Duff, K. and Davies, P. (2003) Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J. Neurochem. 86, 582-590 (Pubitemid 36897439)
-
(2003)
Journal of Neurochemistry
, vol.86
, Issue.3
, pp. 582-590
-
-
Andorfer, C.1
Kress, Y.2
Espinoza, M.3
De Silva, R.4
Tucker, K.L.5
Barde, Y.-A.6
Duff, K.7
Davies, P.8
-
29
-
-
20044367108
-
Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms
-
DOI 10.1523/JNEUROSCI.4637-04.2005
-
Andorfer, C., Acker, C.M., Kress, Y., Hof, P.R., Duff, K. and Davies, P. (2005) Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. J. Neurosci. 25, 5446-5454 (Pubitemid 40770926)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.22
, pp. 5446-5454
-
-
Andorfer, C.1
Acker, C.M.2
Kress, Y.3
Hof, P.R.4
Duff, K.5
Davies, P.6
-
30
-
-
1642432069
-
GENSAT: A genomic resource for neuroscience research
-
Geschwind, D. (2004) GENSAT: a genomic resource for neuroscience research. Lancet Neurol. 3, 82
-
(2004)
Lancet Neurol.
, vol.3
, pp. 82
-
-
Geschwind, D.1
-
31
-
-
11144357454
-
Gene expression nervous system atlas (GENSAT)
-
Heintz, N. (2004) Gene expression nervous system atlas (GENSAT). Nat. Neurosci. 7, 483
-
(2004)
Nat. Neurosci.
, vol.7
, pp. 483
-
-
Heintz, N.1
|