-
1
-
-
1542298958
-
Pharmacology of cardiac potassium channels
-
DOI 10.1016/j.cardiores.2003.12.026, PII S0008636304000021
-
J. Tamargo, R. Caballero, R. Gómez, C. Valenzuela, and E. Delpón Pharmacology of cardiac potassium channels Cardiovasc. Res. 62 2004 9 33 (Pubitemid 38326808)
-
(2004)
Cardiovascular Research
, vol.62
, Issue.1
, pp. 9-33
-
-
Tamargo, J.1
Caballero, R.2
Gomez, R.3
Valenzuela, C.4
Delpon, E.5
-
2
-
-
50249099700
-
The hERG potassium channel and hERG screening for drug-induced torsades de pointes
-
J.C. Hancox, M.J. McPate, A. El Harchi, and Y.H. Zhang The hERG potassium channel and hERG screening for drug-induced torsades de pointes Pharmacol. Ther. 119 2008 118 132
-
(2008)
Pharmacol. Ther.
, vol.119
, pp. 118-132
-
-
Hancox, J.C.1
McPate, M.J.2
El Harchi, A.3
Zhang, Y.H.4
-
4
-
-
0029007356
-
HERG, an inward rectifier in the voltage-gated potassium channel family
-
M.C. Trudeau, J.W. Warmke, B. Ganetzky, and G.A. Robertson HERG, an inward rectifier in the voltage-gated potassium channel family Science 269 1995 92 95
-
(1995)
Science
, vol.269
, pp. 92-95
-
-
Trudeau, M.C.1
Warmke, J.W.2
Ganetzky, B.3
Robertson, G.A.4
-
5
-
-
33645798617
-
The long QT syndrome family of cardiac ion channelopathies: A HuGE review
-
S.M. Modell, and M.H. Lehmann The long QT syndrome family of cardiac ion channelopathies: a HuGE review Genet. Med. 8 2006 143 155
-
(2006)
Genet. Med.
, vol.8
, pp. 143-155
-
-
Modell, S.M.1
Lehmann, M.H.2
-
6
-
-
33645317063
-
HERG potassium channels and cardiac arrhythmia
-
M.C. Sanguinetti, and M. Tristani-Firouzi hERG potassium channels and cardiac arrhythmia Nature 440 2006 463 469
-
(2006)
Nature
, vol.440
, pp. 463-469
-
-
Sanguinetti, M.C.1
Tristani-Firouzi, M.2
-
7
-
-
77956277962
-
Revealing the structural basis of action of hERG potassium channel activators and blockers
-
M. Perry, M. Sanguinetti, and J. Mitcheson Revealing the structural basis of action of hERG potassium channel activators and blockers J. Physiol. 588 2010 3157 3167
-
(2010)
J. Physiol.
, vol.588
, pp. 3157-3167
-
-
Perry, M.1
Sanguinetti, M.2
Mitcheson, J.3
-
9
-
-
58049191106
-
Short QT syndrome. Update on a recent entity
-
P. Maury, F. Extramiana, P. Sbragia, C. Giustetto, R. Schimpf, A. Duparc, C. Wolpert, I. Denjoy, M. Delay, M. Borgreffe, and F. Gaita Short QT syndrome. Update on a recent entity Arch. Cardiovasc. Dis. 101 2008 779 786
-
(2008)
Arch. Cardiovasc. Dis.
, vol.101
, pp. 779-786
-
-
Maury, P.1
Extramiana, F.2
Sbragia, P.3
Giustetto, C.4
Schimpf, R.5
Duparc, A.6
Wolpert, C.7
Denjoy, I.8
Delay, M.9
Borgreffe, M.10
Gaita, F.11
-
10
-
-
0346727397
-
Sudden Death Associated with Short-QT Syndrome Linked to Mutations in HERG
-
DOI 10.1161/01.CIR.0000109482.92774.3A
-
R. Brugada, K. Hong, R. Dumaine, J. Cordeiro, F. Gaita, M. Borggrefe, T.M. Menendez, J. Brugada, G.D. Pollevick, C. Wolpert, E. Burashnikov, K. Matuso, Y.S. Wu, A. Guerchicoff, F. Bianchi, C. Guistetto, R. Schimpf, P. Brugada, and C. Antzelevitch Sudden death associated with short-QT syndrome linked to mutations in HERG Circulation 109 2004 30 35 (Pubitemid 38056017)
-
(2004)
Circulation
, vol.109
, Issue.1
, pp. 30-35
-
-
Brugada, R.1
Hong, K.2
Dumaine, R.3
Cordeiro, J.4
Gaita, F.5
Borggrefe, M.6
Menendez, T.M.7
Brugada, J.8
Pollevick, G.D.9
Wolpert, C.10
Burashnikov, E.11
Matsuo, K.12
Wu, Y.S.13
Guerchicoff, A.14
Bianchi, F.15
Giustetto, C.16
Schimpf, R.17
Brugada, P.18
Antzelevitch, C.19
-
12
-
-
22144499678
-
Kr inactivation by mutation N588K in KCNH2: A link to arrhythmogenesis in short QT syndrome
-
DOI 10.1016/j.cardiores.2005.02.018, PII S0008636305001173
-
Kr inactivation by mutation N588K in KCNH2: a link to arrhythmogenesis in short QT syndrome Cardiovasc. Res. 67 2005 498 509 (Pubitemid 41019557)
-
(2005)
Cardiovascular Research
, vol.67
, Issue.3
, pp. 498-509
-
-
Cordeiro, J.M.1
Brugada, R.2
Wu, Y.S.3
Hong, K.4
Dumaine, R.5
-
14
-
-
65949120706
-
+ channel current during ventricular, Purkinje fibre and atrial action potentials: An action potential clamp study
-
+ channel current during ventricular, Purkinje fibre and atrial action potentials: an action potential clamp study J. Physiol. Pharmacol. 60 2009 23 41
-
(2009)
J. Physiol. Pharmacol.
, vol.60
, pp. 23-41
-
-
McPate, M.J.1
Zhang, H.2
Ideniran, I.3
Cordeiro, J.M.4
Witchel, H.J.5
Hancox, J.C.6
-
15
-
-
19944433739
-
Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG
-
DOI 10.1046/j.1540-8167.2005.04470.x
-
C. Wolpert, R. Schimpf, C. Giustetto, C. Antzelevitch, J.M. Cordeiro, R. Dumaine, R. Brugada, K. Hong, U. Bauersfeld, F. Gaita, and M. Borgreffe Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG J. Cardiovasc. Electophysiol. 16 2005 54 58 (Pubitemid 40165452)
-
(2005)
Journal of Cardiovascular Electrophysiology
, vol.16
, Issue.1
, pp. 54-58
-
-
Wolpert, C.1
Schimpf, R.2
Giustetto, C.3
Antzelevitch, C.4
Cordeiro, J.5
Dumaine, R.6
Brugada, R.7
Hong, K.8
Bauersfeld, U.9
Gaita, F.10
Borggrefe, M.11
-
17
-
-
6044255042
-
In silico study of action potential and QT interval shortening due to loss of inactivation of the cardiac rapid delayed rectifier potassium current
-
DOI 10.1016/j.bbrc.2004.07.176, PII S0006291X04016201
-
H. Zhang, and J.C. Hancox In silico study of action potential and QT interval shortening due to loss of inactivation of the cardiac rapid delayed rectifier potassium current Biochem. Biophys. Res. Commun. 17 2004 693 699 (Pubitemid 39490358)
-
(2004)
Biochemical and Biophysical Research Communications
, vol.322
, Issue.2
, pp. 693-699
-
-
Zhang, H.1
Hancox, J.C.2
-
18
-
-
20244364402
-
A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene
-
DOI 10.1161/01.RES.0000162101.76263.8c
-
S.G. Priori, S.V. Pandit, I. Rivolta, O. Berenfeld, E. Ronchetti, A. Dhamoon, C. Napolitano, J. Anumonwo, M.R. di Barletta, S. Gudapakkam, G. Bosi, M. Stramba-Badiale, and J. Jalife A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene Circ. Res. 96 2005 800 807 (Pubitemid 40559520)
-
(2005)
Circulation Research
, vol.96
, Issue.7
, pp. 800-807
-
-
Priori, S.G.1
Pandit, S.V.2
Rivolta, I.3
Berenfeld, O.4
Ronchetti, E.5
Dhamoon, A.6
Napolitano, C.7
Anumonwo, J.8
Di Barletta, M.R.9
Gudapakkam, S.10
Bosi, G.11
Stramba-Badiale, M.12
Jalife, J.13
-
19
-
-
24344461845
-
Modelling of short QT syndrome in a heterogeneous model of the human ventricular wall
-
D.L. Weiss, G. Seemann, F.B. Sachse, and O. Dossel Modelling of short QT syndrome in a heterogeneous model of the human ventricular wall Europace 7 2005 105 117
-
(2005)
Europace
, vol.7
, pp. 105-117
-
-
Weiss, D.L.1
Seemann, G.2
Sachse, F.B.3
Dossel, O.4
-
20
-
-
33645329354
-
Arrhythmogenesis in the short-QT syndrome associated with combined HERG channel gating defects: A simulation study
-
H. Itoh, M. Horie, M. Ito, and K. Imoto Arrhythmogenesis in the short-QT syndrome associated with combined HERG channel gating defects: a simulation study Circ. J. 70 2006 502 508
-
(2006)
Circ. J.
, vol.70
, pp. 502-508
-
-
Itoh, H.1
Horie, M.2
Ito, M.3
Imoto, K.4
-
21
-
-
10844274228
-
Amplified transmural dispersion of repolarization as the basis for arrhythmogenesis in a canine ventricular-wedge model of short-QT syndrome
-
DOI 10.1161/01.CIR.0000143078.48699.0C
-
F. Extramiana, and C. Antzelevitch Amplified transmural dispersion of repolarization as the basis for arrhythmogenesis in a canine ventricular-wedge model of short-QT syndrome Circulation 110 2004 3661 3666 (Pubitemid 39665254)
-
(2004)
Circulation
, vol.110
, Issue.24
, pp. 3661-3666
-
-
Extramiana, F.1
Antzelevitch, C.2
-
22
-
-
40849137601
-
Cellular basis for arrhythmogenesis in an experimental model of the SQT1 form of the short QT syndrome
-
C. Patel, and C. Antzelevitch Cellular basis for arrhythmogenesis in an experimental model of the SQT1 form of the short QT syndrome Hear. Rhythm. 5 2008 585 590
-
(2008)
Hear. Rhythm.
, vol.5
, pp. 585-590
-
-
Patel, C.1
Antzelevitch, C.2
-
23
-
-
34249090724
-
Reduction of dispersion of repolarization and prolongation of postrepolarization refractoriness explain the antiarrhythmic effects of quinidine in a model of short QT syndrome
-
DOI 10.1111/j.1540-8167.2007.00813.x
-
P. Milberg, R. Tegelkamp, N. Osada, R. Schimpf, C. Wolpert, G. Breithardt, M. Borgreffe, and L. Eckardt Reduction of dispersion of repolarization and prolongation of postrepolarization refractoriness explain the antiarrhythmic effects of quinidine in a model of short QT syndrome J. Cardiovasc. Electrophysiol. 18 2007 658 664 (Pubitemid 46800513)
-
(2007)
Journal of Cardiovascular Electrophysiology
, vol.18
, Issue.6
, pp. 658-664
-
-
Milberg, P.1
Tegelkamp, R.2
Osada, N.3
Schimpf, R.4
Wolpert, C.5
Breithardt, G.6
Borggrefe, M.7
Eckardt, L.8
-
24
-
-
74449091136
-
Cellular basis for atrial fibrillation in an experimental model of short QT1: Implications for a pharmacological approach to therapy
-
E. Nof, A. Burashnikov, and C. Antzelevitch Cellular basis for atrial fibrillation in an experimental model of short QT1: implications for a pharmacological approach to therapy Hear. Rhythm. 7 2010 251 257
-
(2010)
Hear. Rhythm.
, vol.7
, pp. 251-257
-
-
Nof, E.1
Burashnikov, A.2
Antzelevitch, C.3
-
25
-
-
39449089053
-
Deficient zebrafish ether-a-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants
-
DOI 10.1161/CIRCULATIONAHA.107.752220, PII 0000301720080219000005
-
D. Hassel, E.P. Scholz, N. Trano, O. Friedrich, S. Just, B. Meder, D.L. Weiss, E. Zitron, S. Marquart, B. Vogel, C.A. Carle, G. Seemann, M.C. Fishman, H.A. Katus, and W. Rottbauer Deficient zebrafish ether-a-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants Circulation 117 2008 866 875 (Pubitemid 351272584)
-
(2008)
Circulation
, vol.117
, Issue.7
, pp. 866-875
-
-
Hassel, D.1
Scholz, E.P.2
Trano, N.3
Friedrich, O.4
Just, S.5
Meder, B.6
Weiss, D.L.7
Zitron, E.8
Marquart, S.9
Vogel, B.10
Karle, C.A.11
Seemann, G.12
Fishman, M.C.13
Katus, H.A.14
Rottbauer, W.15
-
27
-
-
0036554839
-
A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?
-
DOI 10.1113/jphysiol.2001.013296
-
M. Weerapura, S. Nattel, D. Chartier, R. Caballero, and T.F. Hebert A comparison of currents carried by HERG with and without the coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link? J. Physiol. 540 2002 15 27 (Pubitemid 35174983)
-
(2002)
Journal of Physiology
, vol.540
, Issue.1
, pp. 15-27
-
-
Weerapura, M.1
Nattel, S.2
Chartier, D.3
Caballero, R.4
Hebert, T.E.5
-
28
-
-
23244441222
-
Voltage sensor of Kv1.2: Structural basis of electromechanical coupling
-
DOI 10.1126/science.1116270
-
S.B. Long, E.B. Campbell, and R. MacKinnon Voltage sensor of Kv1.2: structural basis of electromechanical coupling Science 309 2005 903 908 (Pubitemid 41099920)
-
(2005)
Science
, vol.309
, Issue.5736
, pp. 903-908
-
-
Long, S.B.1
Campbell, E.B.2
MacKinnon, R.3
-
31
-
-
0031733880
-
Time course and voltage dependence of expressed HERG current compared with native 'rapid' delayed rectifier K current during the cardiac ventricular action potential
-
J.C. Hancox, A.J. Levi, and H.J. Witchel Time course and voltage dependence of expressed HERG current compared with native 'rapid' delayed rectifier K current during the cardiac ventricular action potential Pflugers Archiv. 436 1998 843 853
-
(1998)
Pflugers Archiv.
, vol.436
, pp. 843-853
-
-
Hancox, J.C.1
Levi, A.J.2
Witchel, H.J.3
-
32
-
-
79551583347
-
A novel mutation in the KCNH2 gene associated with short QT syndrome
-
Y. Sun, X.Q. Quan, S. Fromme, R.H. Cox, P. Zhang, L. Zhang, D. Guo, J. Guo, C. Patel, P.R. Kowey, and G.X. Yan A novel mutation in the KCNH2 gene associated with short QT syndrome J. Mol. Cell. Cardiol. 50 2011 433 441
-
(2011)
J. Mol. Cell. Cardiol.
, vol.50
, pp. 433-441
-
-
Sun, Y.1
Quan, X.Q.2
Fromme, S.3
Cox, R.H.4
Zhang, P.5
Zhang, L.6
Guo, D.7
Guo, J.8
Patel, C.9
Kowey, P.R.10
Yan, G.X.11
-
34
-
-
78649307748
-
+ channels against premature stimulation
-
+ channels against premature stimulation J. Cardiovasc. Electrophysiol. 21 2010 1160 1169
-
(2010)
J. Cardiovasc. Electrophysiol.
, vol.21
, pp. 1160-1169
-
-
Du, C.Y.1
Adeniran, I.2
Cheng, H.3
Zhang, Y.H.4
El Harchi, A.5
McPate, M.J.6
Zhang, H.7
Orchard, C.H.8
Hancox, J.C.9
-
35
-
-
36248982122
-
+ channel in a lipid membrane-like environment
-
DOI 10.1038/nature06265, PII NATURE06265
-
+ channel in a lipid membrane-like environment Nature 450 2007 376 382 (Pubitemid 350126743)
-
(2007)
Nature
, vol.450
, Issue.7168
, pp. 376-382
-
-
Long, S.B.1
Tao, X.2
Campbell, E.B.3
MacKinnon, R.4
-
36
-
-
14644412444
-
Predicting drug-hERG channel interactions that cause acquired long QT syndrome
-
DOI 10.1016/j.tips.2005.01.003
-
M.C. Sanguinetti, and J.S. Mitcheson Predicting drug-hERG channel interactions that cause acquired long QT syndrome Trends Pharmacol. Sci. 26 2005 119 124 (Pubitemid 40313590)
-
(2005)
Trends in Pharmacological Sciences
, vol.26
, Issue.3
, pp. 119-124
-
-
Sanguinetti, M.C.1
Mitcheson, J.S.2
-
40
-
-
34250836484
-
Drug block of the hERG potassium channel: Insight from modeling
-
DOI 10.1002/prot.21400
-
P.J. Stansfeld, P. Gedeck, M. Gosling, B. Cox, J.S. Mitcheson, and M.J. Sutcliffe Drug block of the hERG potassium channel: insight from modeling Proteins 68 2007 568 580 (Pubitemid 46981949)
-
(2007)
Proteins: Structure, Function and Genetics
, vol.68
, Issue.2
, pp. 568-580
-
-
Stansfeld, P.J.1
Gedeck, P.2
Gosling, M.3
Cox, B.4
Mitcheson, J.S.5
Sutcliffe, M.J.6
-
41
-
-
33645317063
-
HERG potassium channels and cardiac arrhythmia
-
M.C. Sanguinetti, and M. Tristani-Firouzi hERG potassium channels and cardiac arrhythmia Nature 440 2006 463 469
-
(2006)
Nature
, vol.440
, pp. 463-469
-
-
Sanguinetti, M.C.1
Tristani-Firouzi, M.2
-
42
-
-
10344246598
-
Gating charges in the activation and inactivation processes of the hERG channel
-
DOI 10.1085/jgp.200409119
-
M. Zhang, J. Liu, and G.N. Tseng Gating charges in the activation and inactivation processes of the HERG channel J. General Physiol. 124 2004 703 718 (Pubitemid 39628137)
-
(2004)
Journal of General Physiology
, vol.124
, Issue.6
, pp. 703-718
-
-
Zhang, M.1
Liu, J.2
Tseng, G.-N.3
-
43
-
-
4344686915
-
Molecular basis of slow activation of the human ether-á-go-go related gene potassium channel
-
DOI 10.1113/jphysiol.2004.062588
-
R.N. Subbiah, C.E. Clarke, D.J. Smith, J.T. Zhao, T.J. Campbell, and J.I. Vandenberg Molecular basis of slow activation of the human ether-á-go-go related gene potassium channel J. Physiol. 558 2004 417 431 (Pubitemid 39117592)
-
(2004)
Journal of Physiology
, vol.558
, Issue.2
, pp. 417-431
-
-
Subbiah, R.N.1
Clarke, C.E.2
Smith, D.J.3
Zhao, J.T.4
Campbell, T.J.5
Vandenberg, J.I.6
-
45
-
-
14844318017
-
Regional specificity of human ether-a'-go-go-related gene channel activation and inactivation gating
-
DOI 10.1074/jbc.M411042200
-
D.R. Piper, W.A. Hinz, C.K. Tallurri, M.C. Sanguinetti, and M. Tristani-Firouzi Regional specificity of human ether-a-go-go-related gene channel activation and inactivation gating J. Biol. Chem. 280 2005 7206 7217 (Pubitemid 40341278)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.8
, pp. 7206-7217
-
-
Piper, D.R.1
Hinz, W.A.2
Tallurri, C.K.3
Sanguinetti, M.C.4
Tristani-Firouzi, M.5
-
46
-
-
0034327611
-
Hinges, swivels and switches: The role of prolines in signalling via transmembrane alpha-helices
-
M.S. Sansom, and H. Weinstein Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices Trends Pharmacol. Sci. 21 2000 445 451
-
(2000)
Trends Pharmacol. Sci.
, vol.21
, pp. 445-451
-
-
Sansom, M.S.1
Weinstein, H.2
-
47
-
-
0036845677
-
Structural and functional role of the extracellular S5-P linker in the HERG potassium channel
-
DOI 10.1085/jgp.20028687
-
J. Liu, M. Zhang, M. Jiang, and G.N. Tseng Structural and functional role of the extracellular S5-P linker in the HERG potassium channel J. Gen. Physiol. 120 2002 723 737 (Pubitemid 35332590)
-
(2002)
Journal of General Physiology
, vol.120
, Issue.5
, pp. 723-737
-
-
Liu, J.1
Zhang, M.2
Jiang, M.3
Tseng, G.-N.4
-
49
-
-
0000243829
-
PROCHECK: A program to check the stereochemical quality of protein structure
-
R.A. Laskowski, M.W. MacArthur, D.S. Moss, and J.M. Thornton PROCHECK: a program to check the stereochemical quality of protein structure J. Appl. Cryst. 26 1993 283 291
-
(1993)
J. Appl. Cryst.
, vol.26
, pp. 283-291
-
-
Laskowski, R.A.1
MacArthur, M.W.2
Moss, D.S.3
Thornton, J.M.4
-
51
-
-
59449093463
-
+ channel
-
+ channel J. Biol. Chem. 284 2009 1000 1008
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 1000-1008
-
-
Ju, P.1
Pages, G.2
Riek, R.P.3
Chen, P.4
Torres, A.M.5
Bansal, P.S.6
Kuyucak, S.7
Kuchel, P.W.8
Vandenberg, J.I.9
-
52
-
-
0032523746
-
+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation
-
DOI 10.1111/j.1469-7793.1998.129bo.x
-
+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation J. Physiol. 509 1998 129 137 (Pubitemid 28252017)
-
(1998)
Journal of Physiology
, vol.509
, Issue.1
, pp. 129-137
-
-
Zou, A.1
Xu, Q.P.2
Sanguinetti, M.C.3
-
53
-
-
34250749314
-
Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin
-
DOI 10.1016/j.bcp.2007.04.024, PII S0006295207002821
-
R.S. Duncan, M.J. McPate, J.M. Ridley, Z. Gao, A.F. James, D.J. Leishman, J.L. Leaney, H.J. Witchel, and J.C. Hancox Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin Biochem. Pharmacol. 74 2007 425 437 (Pubitemid 46963234)
-
(2007)
Biochemical Pharmacology
, vol.74
, Issue.3
, pp. 425-437
-
-
Duncan, R.S.1
McPate, M.J.2
Ridley, J.M.3
Gao, Z.4
James, A.F.5
Leishman, D.J.6
Leaney, J.L.7
Witchel, H.J.8
Hancox, J.C.9
|