메뉴 건너뛰기




Volumn 128, Issue 3, 2011, Pages 713-723

Clinical potential of the mTOR targets S6K1 and S6K2 in breast cancer

Author keywords

11q13; 17q21 23; Gene amplification; mTOR; S6 kinase; Tamoxifen response

Indexed keywords

CYCLOPHOSPHAMIDE; ESTROGEN RECEPTOR; FLUOROURACIL; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; METHOTREXATE; PROGESTERONE RECEPTOR; PROTEIN S6K1; PROTEIN S6K2; S6 KINASE; TAMOXIFEN; UNCLASSIFIED DRUG;

EID: 79960838434     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-1058-x     Document Type: Article
Times cited : (53)

References (52)
  • 1
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • 19339977 10.1038/nrm2672
    • XM Ma J Blenis 2009 Molecular mechanisms of mTOR-mediated translational control Nat Rev Mol Cell Biol 10 307 318 19339977 10.1038/nrm2672
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 2
    • 34347220473 scopus 로고    scopus 로고
    • Defining the Role of mTOR in Cancer
    • DOI 10.1016/j.ccr.2007.05.008, PII S1535610807001511
    • DA Guertin DM Sabatini 2007 Defining the role of mTOR in cancer Cancer Cell 12 9 22 17613433 10.1016/j.ccr.2007.05.008 1:CAS:528:DC%2BD2sXotVyqsr0%3D (Pubitemid 47001784)
    • (2007) Cancer Cell , vol.12 , Issue.1 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 3
    • 34250749822 scopus 로고    scopus 로고
    • PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer
    • DOI 10.1158/1078-0432.CCR-06-1609
    • G Perez-Tenorio L Alkhori B Olsson MA Waltersson B Nordenskjöld LE Rutqvist L Skoog O Stål 2007 PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer Clin Cancer Res 13 3577 3584 17575221 10.1158/1078-0432.CCR-06-1609 1:CAS:528:DC%2BD2sXmsFCqtbk%3D (Pubitemid 46955118)
    • (2007) Clinical Cancer Research , vol.13 , Issue.12 , pp. 3577-3584
    • Perez-Tenorio, G.1    Alkhori, L.2    Olsson, B.3    Waltersson, M.A.4    Nordenskjold, B.5    Rutqvist, L.E.6    Skoog, L.7    Stal, O.8
  • 4
    • 20144387695 scopus 로고    scopus 로고
    • PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
    • DOI 10.1158/0008-5472-CAN-04-3913
    • LH Saal K Holm M Maurer L Memeo T Su X Wang JS Yu PO Malmström M Mansukhani J Enoksson H Hibshoosh Å Borg R Parsons 2005 PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma Cancer Res 65 2554 2559 15805248 10.1158/0008-5472-CAN-04-3913 1:CAS:528:DC%2BD2MXjtVeqsrc%3D (Pubitemid 40490050)
    • (2005) Cancer Research , vol.65 , Issue.7 , pp. 2554-2559
    • Saal, L.H.1    Holm, K.2    Maurer, M.3    Memeo, L.4    Su, T.5    Wang, X.6    Yu, J.S.7    Malmstrom, P.-O.8    Mansukhani, M.9    Enoksson, J.10    Hibshoosh, H.11    Borg, A.12    Parsons, R.13
  • 6
    • 22344446415 scopus 로고    scopus 로고
    • Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer
    • DOI 10.1158/1078-0432.CCR-04-2402
    • M Bärlund A Boulay J Rudloff J Ye S Zumstein-Mecker T O'Reilly DB Evans S Chen HA Lane 2005 Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer Clin Cancer Res 11 5319 5328 10.1158/1078-0432.CCR-04-2402 (Pubitemid 41003721)
    • (2005) Clinical Cancer Research , vol.11 , Issue.14 , pp. 5319-5328
    • Boulay, A.1    Rudloff, J.2    Ye, J.3    Zumstein-Mecker, S.4    O'Reilly, T.5    Evans, D.B.6    Chen, S.7    Lane, H.A.8
  • 7
    • 0037240275 scopus 로고    scopus 로고
    • ErbB (HER) receptors can abrogate antiestrogen action in human breast cancer by multiple signaling mechanisms
    • H Kurokawa CL Arteaga 2003 ErbB (HER) receptors can abrogate antiestrogen action in human breast cancer by multiple signaling mechanisms Clin Cancer Res 9 511S 515S 12538508 1:CAS:528:DC%2BD3sXnt1yisw%3D%3D (Pubitemid 36105795)
    • (2003) Clinical Cancer Research , vol.9 , Issue.1
    • Kurokawa, H.1    Arteaga, C.L.2
  • 10
    • 6944235337 scopus 로고    scopus 로고
    • Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt activity
    • DOI 10.1158/1078-0432.CCR-04-0035
    • LA deGraffenried WE Friedrichs DH Russell EJ Donzis AK Middleton JM Silva RA Roth M Hidalgo 2004 Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt activity Clin Cancer Res 10 8059 8067 15585641 10.1158/1078-0432.CCR-04-0035 1:CAS:528:DC%2BD2cXhtVCrs7vN (Pubitemid 39587547)
    • (2004) Clinical Cancer Research , vol.10 , Issue.23 , pp. 8059-8067
    • DeGraffenried, L.A.1    Friedrichs, W.E.2    Russell, D.H.3    Donzis, E.J.4    Middleton, A.K.5    Silva, J.M.6    Roth, R.A.7    Hidalgo, M.8
  • 12
    • 0037200004 scopus 로고    scopus 로고
    • Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin
    • DOI 10.1074/jbc.M204080200
    • IH Park R Bachmann H Shirazi J Chen 2002 Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin J Biol Chem 277 31423 31429 12087098 10.1074/jbc.M204080200 1:CAS:528:DC%2BD38XmslOqsLo%3D (Pubitemid 34968942)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.35 , pp. 31423-31429
    • Park, I.-H.1    Bachmann, R.2    Shirazi, H.3    Chen, J.4
  • 13
    • 37549028779 scopus 로고    scopus 로고
    • Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function
    • 18092230 10.1080/08977190701779101 1:CAS:528:DC%2BD2sXhsVCgsbbN
    • K Jastrzebski KM Hannan EB Tchoubrieva RD Hannan RB Pearson 2007 Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function Growth Factors 25 209 226 18092230 10.1080/08977190701779101 1:CAS:528:DC%2BD2sXhsVCgsbbN
    • (2007) Growth Factors , vol.25 , pp. 209-226
    • Jastrzebski, K.1    Hannan, K.M.2    Tchoubrieva, E.B.3    Hannan, R.D.4    Pearson, R.B.5
  • 14
    • 0033539154 scopus 로고    scopus 로고
    • Characterization of S6K2, a novel kinase homologous to S6K1
    • DOI 10.1038/sj.onc.1202894
    • KK Lee-Fruman CJ Kuo J Lippincott N Terada J Blenis 1999 Characterization of S6K2, a novel kinase homologous to S6K1 Oncogene 18 5108 5114 10490847 10.1038/sj.onc.1202894 1:CAS:528:DyaK1MXmtlart78%3D (Pubitemid 29443756)
    • (1999) Oncogene , vol.18 , Issue.36 , pp. 5108-5114
    • Lee-Fruman, K.K.1    Kuo, C.J.2    Lippincott, J.3    Terada, N.4    Blenis, J.5
  • 15
    • 0032538890 scopus 로고    scopus 로고
    • Disruption of the p705(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase
    • H Shima M Pende Y Chen S Fumagalli G Thomas SC Kozma 1998 Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase EMBO J 17 6649 6659 9822608 10.1093/emboj/17.22.6649 1:CAS:528:DyaK1cXnvF2jt70%3D (Pubitemid 28521798)
    • (1998) EMBO Journal , vol.17 , Issue.22 , pp. 6649-6659
    • Shima, H.1    Pende, M.2    Chen, Y.3    Fumagalli, S.4    Thomas, G.5    Kozma, S.C.6
  • 16
    • 0032843917 scopus 로고    scopus 로고
    • Drosophila S6 kinase: A regulator of cell size
    • DOI 10.1126/science.285.5436.2126
    • J Montagne MJ Stewart H Stocker E Hafen SC Kozma G Thomas 1999 Drosophila S6 kinase: a regulator of cell size Science 285 2126 2129 10497130 10.1126/science.285.5436.2126 1:CAS:528:DyaK1MXmt12jsLY%3D (Pubitemid 29451430)
    • (1999) Science , vol.285 , Issue.5436 , pp. 2126-2129
    • Montagne, J.1    Stewart, M.J.2    Stocker, H.3    Hafen, E.4    Kozma, S.C.5    Thomas, G.6
  • 17
    • 11144356304 scopus 로고    scopus 로고
    • -/- Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway
    • DOI 10.1128/MCB.24.8.3112-3124.2004
    • M Pende SH Um V Mieulet M Sticker VL Goss J Mestan M Mueller S Fumagalli SC Kozma G Thomas 2004 S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway Mol Cell Biol 24 3112 3124 15060135 10.1128/MCB.24.8.3112-3124.2004 1:CAS:528: DC%2BD2cXjtFKjsb8%3D (Pubitemid 38452057)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.8 , pp. 3112-3124
    • Pende, M.1    Um, S.H.2    Mieulet, V.3    Sticker, M.4    Goss, V.L.5    Mestan, J.6    Mueller, M.7    Fumagalli, S.8    Kozma, S.C.9    Thomas, G.10
  • 18
    • 0027012928 scopus 로고
    • C-erbB2 amplification and overexpression in human tumors
    • 1360230 1:CAS:528:DyaK3sXitFShuro%3D
    • FJ Lofts WJ Gullick 1992 c-erbB2 amplification and overexpression in human tumors Cancer Treat Res 61 161 179 1360230 1:CAS:528:DyaK3sXitFShuro%3D
    • (1992) Cancer Treat Res , vol.61 , pp. 161-179
    • Lofts, F.J.1    Gullick, W.J.2
  • 19
    • 17544402448 scopus 로고
    • Clinical and pathologic significance of the c-erbB-2 (HER-2/neu) oncogene
    • 1346551 1:STN:280:DyaK387ktVyqsQ%3D%3D
    • TP Singleton JG Strickler 1992 Clinical and pathologic significance of the c-erbB-2 (HER-2/neu) oncogene Pathol Annu 27 Pt 1 165 190 1346551 1:STN:280:DyaK387ktVyqsQ%3D%3D
    • (1992) Pathol Annu , vol.271 , pp. 165-190
    • Singleton, T.P.1    Strickler, J.G.2
  • 20
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • DJ Slamon GM Clark SG Wong WJ Levin A Ullrich WL McGuire 1987 Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene Science 235 177 182 3798106 10.1126/science.3798106 1:CAS:528:DyaL2sXhtVSht7s%3D (Pubitemid 17231334)
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 22
    • 35549002845 scopus 로고    scopus 로고
    • Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer
    • DOI 10.1038/sj.onc.1210506, PII 1210506
    • J Bostner M Ahnström Waltersson T Fornander L Skoog B Nordenskjöld O Stål 2007 Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer Oncogene 26 6997 7005 17486065 10.1038/sj.onc.1210506 1:CAS:528:DC%2BD2sXht1Wgt7rJ (Pubitemid 350014611)
    • (2007) Oncogene , vol.26 , Issue.49 , pp. 6997-7005
    • Bostner, J.1    Ahnstrom Waltersson, M.2    Fornander, T.3    Skoog, L.4    Nordenskjold, B.5    Stal, O.6
  • 23
    • 24744449148 scopus 로고    scopus 로고
    • Adverse effect of adjuvant tamoxifen in premenopausal breast cancer with cyclin D1 gene amplification
    • DOI 10.1158/0008-5472.CAN-05-0746
    • K Jirström M Stendahl L Ryden A Kronblad PO Bendahl O Stål G Landberg 2005 Adverse effect of adjuvant tamoxifen in premenopausal breast cancer with cyclin D1 gene amplification Cancer Res 65 8009 8016 16140974 (Pubitemid 41297281)
    • (2005) Cancer Research , vol.65 , Issue.17 , pp. 8009-8016
    • Jirstrom, K.1    Stendahl, M.2    Ryden, L.3    Kronblad, A.4    Bendahl, P.-O.5    Stal, O.6    Landberg, G.7
  • 26
    • 46749148110 scopus 로고    scopus 로고
    • Activation of the mTOR signaling pathway in breast cancer and its correlation with the clinicopathologic variables
    • DOI 10.1007/s10549-007-9746-x
    • WC Noh YH Kim MS Kim JS Koh HA Kim NM Moon NS Paik 2008 Activation of the mTOR signaling pathway in breast cancer and its correlation with the clinicopathologic variables Breast Cancer Res Treat 110 477 483 17805960 10.1007/s10549-007-9746-x 1:CAS:528:DC%2BD1cXosVOgtL4%3D (Pubitemid 351962593)
    • (2008) Breast Cancer Research and Treatment , vol.110 , Issue.3 , pp. 477-483
    • Noh, W.C.1    Kim, Y.H.2    Kim, M.S.3    Koh, J.S.4    Kim, H.-A.5    Moon, N.M.6    Paik, N.-S.7
  • 28
    • 33746751444 scopus 로고    scopus 로고
    • Long-term follow-up of the Stockholm randomized trials of postoperative radiation therapy versus adjuvant chemotherapy among 'high risk' pre- and postmenopausal breast cancer patients
    • DOI 10.1080/02841860600702068, PII M02MVQ0680802338
    • LE Rutqvist H Johansson 2006 Long-term follow-up of the Stockholm randomized trials of postoperative radiation therapy versus adjuvant chemotherapy among 'high risk' pre- and postmenopausal breast cancer patients Acta Oncol 45 517 527 16864164 10.1080/02841860600702068 1:CAS:528: DC%2BD28XhtVWrtb%2FO (Pubitemid 44172627)
    • (2006) Acta Oncologica , vol.45 , Issue.5 , pp. 517-527
    • Rutqvist, L.1    Johansson, H.2
  • 29
    • 33847120754 scopus 로고    scopus 로고
    • Long-term follow-up of the randomized Stockholm trial on adjuvant tamoxifen among postmenopausal patients with early stage breast cancer
    • DOI 10.1080/02841860601034834, PII 770504131
    • LE Rutqvist H Johansson 2007 Long-term follow-up of the randomized Stockholm trial on adjuvant tamoxifen among postmenopausal patients with early stage breast cancer Acta Oncol 46 133 145 17453361 10.1080/02841860601034834 1:CAS:528:DC%2BD2sXjs1GlsL0%3D (Pubitemid 46277056)
    • (2007) Acta Oncologica , vol.46 , Issue.2 , pp. 133-145
    • Rutqvist, L.E.1    Johansson, H.2
  • 30
    • 2942594508 scopus 로고    scopus 로고
    • Mutation and accumulation of p53 related to results of adjuvant therapy of postmenopausal breast cancer patients
    • DOI 10.1080/02841860410029474
    • MS Askmalm J Carstensen B Nordenskjöld B Olsson LE Rutqvist L Skoog O Stål 2004 Mutation and accumulation of p53 related to results of adjuvant therapy of postmenopausal breast cancer patients Acta Oncol 43 235 244 15244246 10.1080/02841860410029474 1:CAS:528:DC%2BD2cXlslSlur8%3D (Pubitemid 38757044)
    • (2004) Acta Oncologica , vol.43 , Issue.3 , pp. 235-244
    • Askmalm, M.S.1    Carstensen, J.2    Nordenskjold, B.3    Olsson, B.4    Rutqvist, L.E.5    Skoog, L.6    Stal, O.7
  • 31
    • 66149186856 scopus 로고    scopus 로고
    • Ratio of 17HSD1 to 17HSD2 protein expression predicts the outcome of tamoxifen treatment in postmenopausal breast cancer patients
    • 19401349 10.1158/1078-0432.CCR-08-2599 1:CAS:528:DC%2BD1MXmtVKls7k%3D
    • A Jansson L Delander C Gunnarsson T Fornander L Skoog B Nordenskjöld O Stål 2009 Ratio of 17HSD1 to 17HSD2 protein expression predicts the outcome of tamoxifen treatment in postmenopausal breast cancer patients Clin Cancer Res 15 3610 3616 19401349 10.1158/1078-0432.CCR-08-2599 1:CAS:528:DC%2BD1MXmtVKls7k%3D
    • (2009) Clin Cancer Res , vol.15 , pp. 3610-3616
    • Jansson, A.1    Delander, L.2    Gunnarsson, C.3    Fornander, T.4    Skoog, L.5    Nordenskjöld, B.6    Stål, O.7
  • 33
    • 0033119602 scopus 로고    scopus 로고
    • Localization of PS6K to chromosomal region 17q23 and determination of its amplification in breast cancer
    • FJ Couch XY Wang GJ Wu J Qian RB Jenkins CD James 1999 Localization of PS6K to chromosomal region 17q23 and determination of its amplification in breast cancer Cancer Res 59 1408 1411 10197603 1:CAS:528:DyaK1MXisVWkt7c%3D (Pubitemid 29160100)
    • (1999) Cancer Research , vol.59 , Issue.7 , pp. 1408-1411
    • Couch, F.J.1    Wang, X.-Y.2    Wu, G.-J.3    Qian, J.4    Jenkins, R.B.5    James, C.D.6
  • 34
    • 33746255899 scopus 로고    scopus 로고
    • Gene amplification in cancer
    • DOI 10.1016/j.tig.2006.06.007, PII S0168952506001752
    • DG Albertson 2006 Gene amplification in cancer Trends Genet 22 447 455 16787682 10.1016/j.tig.2006.06.007 1:CAS:528:DC%2BD28XntlCksbs%3D (Pubitemid 44093770)
    • (2006) Trends in Genetics , vol.22 , Issue.8 , pp. 447-455
    • Albertson, D.G.1
  • 38
    • 0041845193 scopus 로고    scopus 로고
    • Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1
    • DOI 10.1042/BJ20021794
    • S Phin D Kupferwasser J Lam KK Lee-Fruman 2003 Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1 Biochem J 373 583 591 12713446 10.1042/BJ20021794 1:CAS:528:DC%2BD3sXmsFGrtbw%3D (Pubitemid 36897860)
    • (2003) Biochemical Journal , vol.373 , Issue.2 , pp. 583-591
    • Phin, S.1    Kupferwasser, D.2    Lam, J.3    Lee-Fruman, K.K.4
  • 39
    • 34247508924 scopus 로고    scopus 로고
    • Unraveling the mechanisms of endocrine resistance in breast cancer: New therapeutic opportunities
    • DOI 10.1158/1078-0432.CCR-06-2540
    • S Massarweh R Schiff 2007 Unraveling the mechanisms of endocrine resistance in breast cancer: new therapeutic opportunities Clin Cancer Res 13 1950 1954 17404074 10.1158/1078-0432.CCR-06-2540 1:CAS:528:DC%2BD2sXjs12rsbo%3D (Pubitemid 46649859)
    • (2007) Clinical Cancer Research , vol.13 , Issue.7 , pp. 1950-1954
    • Massarweh, S.1    Schiff, R.2
  • 40
    • 65249190250 scopus 로고    scopus 로고
    • S6 kinase 1 regulates estrogen receptor alpha in control of breast cancer cell proliferation
    • 19112174 10.1074/jbc.M807532200 1:CAS:528:DC%2BD1MXisVSku7s%3D
    • RL Yamnik A Digilova DC Davis ZN Brodt CJ Murphy MK Holz 2009 S6 kinase 1 regulates estrogen receptor alpha in control of breast cancer cell proliferation J Biol Chem 284 6361 6369 19112174 10.1074/jbc.M807532200 1:CAS:528:DC%2BD1MXisVSku7s%3D
    • (2009) J Biol Chem , vol.284 , pp. 6361-6369
    • Yamnik, R.L.1    Digilova, A.2    Davis, D.C.3    Brodt, Z.N.4    Murphy, C.J.5    Holz, M.K.6
  • 41
    • 35348904493 scopus 로고    scopus 로고
    • 167 is indicative of longer disease-free and overall survival in breast cancer patients
    • DOI 10.1158/1078-0432.CCR-07-0822
    • J Jiang N Sarwar D Peston E Kulinskaya S Shousha RC Coombes S Ali 2007 Phosphorylation of estrogen receptor-alpha at Ser167 is indicative of longer disease-free and overall survival in breast cancer patients Clin Cancer Res 13 5769 5776 17908967 10.1158/1078-0432.CCR-07-0822 1:CAS:528:DC%2BD2sXhtFSntL3F (Pubitemid 47583902)
    • (2007) Clinical Cancer Research , vol.13 , Issue.19 , pp. 5769-5776
    • Jiang, J.1    Sarwar, N.2    Peston, D.3    Kulinskaya, E.4    Shousha, S.5    Coombes, R.C.6    Ali, S.7
  • 42
    • 33644873967 scopus 로고    scopus 로고
    • Phosphorylation of estrogen receptor alpha serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer
    • 16168121 10.1186/bcr1285 1:CAS:528:DC%2BD2MXpvFOgtb8%3D
    • H Yamashita M Nishio S Kobayashi Y Ando H Sugiura Z Zhang M Hamaguchi K Mita Y Fujii H Iwase 2005 Phosphorylation of estrogen receptor alpha serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer Breast Cancer Res 7 R753 R764 16168121 10.1186/bcr1285 1:CAS:528:DC%2BD2MXpvFOgtb8%3D
    • (2005) Breast Cancer Res , vol.7
    • Yamashita, H.1    Nishio, M.2    Kobayashi, S.3    Ando, Y.4    Sugiura, H.5    Zhang, Z.6    Hamaguchi, M.7    Mita, K.8    Fujii, Y.9    Iwase, H.10
  • 43
    • 33845607197 scopus 로고    scopus 로고
    • The molecular basis of the interaction between the proline-rich SH3-binding motif of PNRC and estrogen receptor alpha
    • DOI 10.1093/nar/gkl764
    • D Zhou JJ Ye Y Li K Lui S Chen 2006 The molecular basis of the interaction between the proline-rich SH3-binding motif of PNRC and estrogen receptor alpha Nucleic Acids Res 34 5974 5986 17068076 10.1093/nar/gkl764 1:CAS:528:DC%2BD28Xht1Ohu7bO (Pubitemid 44941176)
    • (2006) Nucleic Acids Research , vol.34 , Issue.20 , pp. 5974-5986
    • Zhou, D.1    Ye, J.J.2    Li, Y.3    Lui, K.4    Chen, S.5
  • 44
    • 21644480047 scopus 로고    scopus 로고
    • Activation of the phosphatidylinositol 3-kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells
    • 15586221
    • K Söderlund G Perez-Tenorio O Stål 2005 Activation of the phosphatidylinositol 3-kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells Int J Oncol 26 25 32 15586221
    • (2005) Int J Oncol , vol.26 , pp. 25-32
    • Söderlund, K.1    Perez-Tenorio, G.2    Stål, O.3
  • 45
    • 3242686392 scopus 로고    scopus 로고
    • Sensitization of breast cancer cells to radiation by trastuzumab
    • 14617784 1:CAS:528:DC%2BD3sXovFCqtLo%3D
    • K Liang Y Lu W Jin KK Ang L Milas Z Fan 2003 Sensitization of breast cancer cells to radiation by trastuzumab Mol Cancer Ther 2 1113 1120 14617784 1:CAS:528:DC%2BD3sXovFCqtLo%3D
    • (2003) Mol Cancer Ther , vol.2 , pp. 1113-1120
    • Liang, K.1    Lu, Y.2    Jin, W.3    Ang, K.K.4    Milas, L.5    Fan, Z.6
  • 46
    • 34548515767 scopus 로고    scopus 로고
    • The BRCA1/BRCA2/Rad51 complex is a prognostic and predictive factor in early breast cancer
    • DOI 10.1016/j.radonc.2007.06.012, PII S0167814007003374
    • K Söderlund L Skoog T Fornander MS Askmalm 2007 The BRCA1/BRCA2/Rad51 complex is a prognostic and predictive factor in early breast cancer Radiother Oncol 84 242 251 17707537 10.1016/j.radonc.2007.06.012 (Pubitemid 47371156)
    • (2007) Radiotherapy and Oncology , vol.84 , Issue.3 , pp. 242-251
    • Soderlund, K.1    Skoog, L.2    Fornander, T.3    Askmalm, M.S.4
  • 47
    • 0242610826 scopus 로고    scopus 로고
    • Gleevec-Mediated Inhibition of Rad51 Expression and Enhancement of Tumor Cell Radiosensitivity
    • JS Russell K Brady WE Burgan MA Cerra KA Oswald K Camphausen PJ Tofilon 2003 Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity Cancer Res 63 7377 7383 14612536 1:CAS:528: DC%2BD3sXovVGltL0%3D (Pubitemid 37413479)
    • (2003) Cancer Research , vol.63 , Issue.21 , pp. 7377-7383
    • Russell, J.S.1    Brady, K.2    Burgan, W.E.3    Cerra, M.A.4    Oswald, K.A.5    Camphausen, K.6    Tofilon, P.J.7
  • 49
    • 0032540152 scopus 로고    scopus 로고
    • In vitro and in vivo potentiation of radiosensitivity of malignant gliomas by antisense inhibition of the RAD51 gene
    • DOI 10.1006/bbrc.1998.8440
    • T Ohnishi T Taki S Hiraga N Arita T Morita 1998 In vitro and in vivo potentiation of radiosensitivity of malignant gliomas by antisense inhibition of the RAD51 gene Biochem Biophys Res Commun 245 319 324 9571148 10.1006/bbrc.1998.8440 1:CAS:528:DyaK1cXivVOqs7w%3D (Pubitemid 28418498)
    • (1998) Biochemical and Biophysical Research Communications , vol.245 , Issue.2 , pp. 319-324
    • Ohnishi, T.1    Taki, T.2    Hiraga, S.3    Arita, N.4    Morita, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.