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Volumn 11, Issue 16, 2011, Pages 3390-3401

Quantitative phosphoproteomics of transforming growth factor-β signaling in colon cancer cells

Author keywords

Cancer; Cell biology; Mass spectrometry; Phosphorylation; Smad4; Transforming growth factor

Indexed keywords

AMINO ACID; CASEIN; CYCLIN DEPENDENT KINASE; HEPATOMA DERIVED GROWTH FACTOR; MEMBRANE PROTEIN; PHOSPHOPEPTIDE; PROGRAMMED CELL DEATH PROTEIN 4; SMAD4 PROTEIN; STABLE ISOTOPE; TITANIUM DIOXIDE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 79960815170     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.201100036     Document Type: Article
Times cited : (26)

References (59)
  • 1
    • 0034678908 scopus 로고    scopus 로고
    • Transcriptional control by the TGF-beta/Smad signaling system
    • Massague, J., Wotton, D., Transcriptional control by the TGF-beta/Smad signaling system. EMBO J. 2000, 19, 1745-1754.
    • (2000) EMBO J. , vol.19 , pp. 1745-1754
    • Massague, J.1    Wotton, D.2
  • 2
    • 0036467496 scopus 로고    scopus 로고
    • TGF-beta signaling: positive and negative effects on tumorigenesis
    • Wakefield, L. M., Roberts, A. B., TGF-beta signaling: positive and negative effects on tumorigenesis. Curr. Opin. Genet. Dev. 2002, 12, 22-29.
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 22-29
    • Wakefield, L.M.1    Roberts, A.B.2
  • 3
    • 0037204990 scopus 로고    scopus 로고
    • Signal transduction by the TGF-beta superfamily
    • Attisano, L., Wrana, J. L., Signal transduction by the TGF-beta superfamily. Science 2002, 296, 1646-1647.
    • (2002) Science , vol.296 , pp. 1646-1647
    • Attisano, L.1    Wrana, J.L.2
  • 4
    • 0029073142 scopus 로고
    • Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
    • Datto, M. B., Li, Y., Panus, J. F., Howe, D. J. et al., Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA 1995, 92, 5545-5549.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5545-5549
    • Datto, M.B.1    Li, Y.2    Panus, J.F.3    Howe, D.J.4
  • 5
    • 0025329363 scopus 로고
    • Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation
    • Pietenpol, J. A., Holt, J. T., Stein, R. W., Moses, H. L., Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation. Proc. Natl. Acad. Sci. USA 1990, 87, 3758-3762.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 3758-3762
    • Pietenpol, J.A.1    Holt, J.T.2    Stein, R.W.3    Moses, H.L.4
  • 6
    • 0030614715 scopus 로고    scopus 로고
    • The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2
    • Reynisdottir, I., Massague, J., The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2. Genes Dev. 1997, 11, 492-503.
    • (1997) Genes Dev. , vol.11 , pp. 492-503
    • Reynisdottir, I.1    Massague, J.2
  • 7
    • 77956682613 scopus 로고    scopus 로고
    • Regulation of TGF-beta signalling by protein phosphatases
    • Liu, T., Feng, X. H., Regulation of TGF-beta signalling by protein phosphatases. Biochem. J. 2010, 430, 191-198.
    • (2010) Biochem. J. , vol.430 , pp. 191-198
    • Liu, T.1    Feng, X.H.2
  • 8
    • 58149239730 scopus 로고    scopus 로고
    • Phospho-control of TGF-beta superfamily signaling
    • Wrighton, K. H., Lin, X., Feng, X. H., Phospho-control of TGF-beta superfamily signaling. Cell. Res. 2009, 19, 8-20.
    • (2009) Cell. Res. , vol.19 , pp. 8-20
    • Wrighton, K.H.1    Lin, X.2    Feng, X.H.3
  • 9
    • 0035501062 scopus 로고    scopus 로고
    • TGF-beta signaling in cancer - a double-edged sword
    • Akhurst, R. J., Derynck, R., TGF-beta signaling in cancer - a double-edged sword. Trends Cell. Biol. 2001, 11, S44-S51.
    • (2001) Trends Cell. Biol. , vol.11
    • Akhurst, R.J.1    Derynck, R.2
  • 10
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck, R., Zhang, Y. E., Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003, 425, 577-584.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 11
    • 0242490137 scopus 로고    scopus 로고
    • Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells
    • Duda, D. G., Sunamura, M., Lefter, L. P., Furukawa, T. et al., Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells. Oncogene 2003, 22, 6857-6864.
    • (2003) Oncogene , vol.22 , pp. 6857-6864
    • Duda, D.G.1    Sunamura, M.2    Lefter, L.P.3    Furukawa, T.4
  • 12
    • 34248584887 scopus 로고    scopus 로고
    • Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion
    • Galliher, A. J., Schiemann, W. P., Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion. Cancer Res. 2007, 67, 3752-3758.
    • (2007) Cancer Res. , vol.67 , pp. 3752-3758
    • Galliher, A.J.1    Schiemann, W.P.2
  • 13
    • 0037099745 scopus 로고    scopus 로고
    • TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses
    • Yu, L., Hebert, M. C., Zhang, Y. E., TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses. EMBO J. 2002, 21, 3749-3759.
    • (2002) EMBO J. , vol.21 , pp. 3749-3759
    • Yu, L.1    Hebert, M.C.2    Zhang, Y.E.3
  • 14
    • 33750322988 scopus 로고    scopus 로고
    • TGF-beta receptor-binding proteins: complex interactions
    • Runyan, C. E., Poncelet, A. C., Schnaper, H. W., TGF-beta receptor-binding proteins: complex interactions. Cell Signal. 2006, 18, 2077-2088.
    • (2006) Cell Signal. , vol.18 , pp. 2077-2088
    • Runyan, C.E.1    Poncelet, A.C.2    Schnaper, H.W.3
  • 15
    • 0037099745 scopus 로고    scopus 로고
    • TGF-[beta] receptor-activated p38 MAP kinase mediates Smad-independent TGF-[beta] responses
    • Yu, L., Hebert, M. C., Zhang, Y. E., TGF-[beta] receptor-activated p38 MAP kinase mediates Smad-independent TGF-[beta] responses. EMBO J. 2002, 21, 3749-3759.
    • (2002) EMBO J. , vol.21 , pp. 3749-3759
    • Yu, L.1    Hebert, M.C.2    Zhang, Y.E.3
  • 17
    • 24344483878 scopus 로고    scopus 로고
    • Smad4 dependency defines two classes of transforming growth factor beta (TGF-beta) target genes and distinguishes TGF-beta-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses
    • Levy, L., Hill, C. S., Smad4 dependency defines two classes of transforming growth factor beta (TGF-beta) target genes and distinguishes TGF-beta-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Mol. Cell. Biol. 2005, 25, 8108-8125.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 8108-8125
    • Levy, L.1    Hill, C.S.2
  • 18
    • 0033587016 scopus 로고    scopus 로고
    • DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression
    • Schwarte-Waldhoff, I., Klein, S., Blass-Kampmann, S., Hintelmann, A. et al., DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression. Oncogene 1999, 18, 3152-3158.
    • (1999) Oncogene , vol.18 , pp. 3152-3158
    • Schwarte-Waldhoff, I.1    Klein, S.2    Blass-Kampmann, S.3    Hintelmann, A.4
  • 19
    • 77957892223 scopus 로고    scopus 로고
    • Proteomics of Smad4 regulated transforming growth factor-beta signalling in colon cancer cells
    • Ali, N. A., McKay, M. J., Molloy, M. P., Proteomics of Smad4 regulated transforming growth factor-beta signalling in colon cancer cells. Mol. Biosyst. 2010, 6, 2332-2338.
    • (2010) Mol. Biosyst. , vol.6 , pp. 2332-2338
    • Ali, N.A.1    McKay, M.J.2    Molloy, M.P.3
  • 20
    • 34248640261 scopus 로고    scopus 로고
    • Highly selective enrichment of phosphorylated peptides using titanium dioxide
    • Thingholm, T. E., Jorgensen, T. J., Jensen, O. N., Larsen, M. R., Highly selective enrichment of phosphorylated peptides using titanium dioxide. Nat. Protoc. 2006, 1, 1929-1935.
    • (2006) Nat. Protoc. , vol.1 , pp. 1929-1935
    • Thingholm, T.E.1    Jorgensen, T.J.2    Jensen, O.N.3    Larsen, M.R.4
  • 21
    • 34848889259 scopus 로고    scopus 로고
    • The Paragon Algorithm, a next generation search engine that uses sequence temperature values and feature probabilities to identify peptides from tandem mass spectra
    • Shilov, I. V., Seymour, S. L., Patel, A. A., Loboda, A. et al., The Paragon Algorithm, a next generation search engine that uses sequence temperature values and feature probabilities to identify peptides from tandem mass spectra. Mol. Cell. Proteomics 2007, 6, 1638-1655.
    • (2007) Mol. Cell. Proteomics , vol.6 , pp. 1638-1655
    • Shilov, I.V.1    Seymour, S.L.2    Patel, A.A.3    Loboda, A.4
  • 22
    • 70349567386 scopus 로고    scopus 로고
    • SH2D4A regulates cell proliferation via the ERalpha/PLC-gamma/PKC pathway
    • Li, T., Li, W., Lu, J., Liu, H. et al., SH2D4A regulates cell proliferation via the ERalpha/PLC-gamma/PKC pathway. BMB Rep. 2009, 42, 516-522.
    • (2009) BMB Rep. , vol.42 , pp. 516-522
    • Li, T.1    Li, W.2    Lu, J.3    Liu, H.4
  • 23
    • 65349140628 scopus 로고    scopus 로고
    • Kinase-specific prediction of protein phosphorylation sites
    • x.
    • Miller, M. L., Blom, N., Kinase-specific prediction of protein phosphorylation sites. Methods Mol. Biol. 2009, 527, 299-310, x.
    • (2009) Methods Mol. Biol. , vol.527 , pp. 299-310
    • Miller, M.L.1    Blom, N.2
  • 24
    • 75149166083 scopus 로고    scopus 로고
    • Immunohistochemical and proteomic evaluation of nuclear ubiquitous casein and cyclin-dependent kinases substrate in invasive ductal carcinoma of the breast
    • Ziolkowski, P., Gamian, E., Osiecka, B., Zougman, A., Wisniewski, J. R., Immunohistochemical and proteomic evaluation of nuclear ubiquitous casein and cyclin-dependent kinases substrate in invasive ductal carcinoma of the breast. J. Biomed. Biotechnol. 2009, 2009, 919645.
    • (2009) J. Biomed. Biotechnol. , vol.2009 , pp. 919645
    • Ziolkowski, P.1    Gamian, E.2    Osiecka, B.3    Zougman, A.4    Wisniewski, J.R.5
  • 25
    • 57349161921 scopus 로고    scopus 로고
    • Constitutive and dynamic phosphorylation and acetylation sites on NUCKS, a hypermodified nuclear protein, studied by quantitative proteomics
    • Wisniewski, J. R., Zougman, A., Kruger, S., Ziolkowski, P. et al., Constitutive and dynamic phosphorylation and acetylation sites on NUCKS, a hypermodified nuclear protein, studied by quantitative proteomics. Proteins 2008, 73, 710-718.
    • (2008) Proteins , vol.73 , pp. 710-718
    • Wisniewski, J.R.1    Zougman, A.2    Kruger, S.3    Ziolkowski, P.4
  • 26
    • 55049115827 scopus 로고    scopus 로고
    • Identification of CDK2 substrates in human cell lysates
    • Chi, Y., Welcker, M., Hizli, A. A., Posakony, J. J. et al., Identification of CDK2 substrates in human cell lysates. Genome Biol. 2008, 9, R149.
    • (2008) Genome Biol. , vol.9
    • Chi, Y.1    Welcker, M.2    Hizli, A.A.3    Posakony, J.J.4
  • 27
    • 33646538780 scopus 로고    scopus 로고
    • Aerosol delivery of urocanic acid-modified chitosan/programmed cell death 4 complex regulated apoptosis, cell cycle, and angiogenesis in lungs of K-ras null mice
    • Jin, H., Kim, T. H., Hwang, S. K., Chang, S. H. et al., Aerosol delivery of urocanic acid-modified chitosan/programmed cell death 4 complex regulated apoptosis, cell cycle, and angiogenesis in lungs of K-ras null mice. Mol. Cancer Ther. 2006, 5, 1041-1049.
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 1041-1049
    • Jin, H.1    Kim, T.H.2    Hwang, S.K.3    Chang, S.H.4
  • 28
    • 33846990947 scopus 로고    scopus 로고
    • Expression patterns of programmed cell death 4 protein in normal human skin and some representative skin lesions
    • Matsuhashi, S., Narisawa, Y., Ozaki, I., Mizuta, T., Expression patterns of programmed cell death 4 protein in normal human skin and some representative skin lesions. Exp. Dermatol. 2007, 16, 179-184.
    • (2007) Exp. Dermatol. , vol.16 , pp. 179-184
    • Matsuhashi, S.1    Narisawa, Y.2    Ozaki, I.3    Mizuta, T.4
  • 29
    • 35248889933 scopus 로고    scopus 로고
    • Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer
    • Mudduluru, G., Medved, F., Grobholz, R., Jost, C. et al., Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer. Cancer 2007, 110, 1697-1707.
    • (2007) Cancer , vol.110 , pp. 1697-1707
    • Mudduluru, G.1    Medved, F.2    Grobholz, R.3    Jost, C.4
  • 30
    • 73649143900 scopus 로고    scopus 로고
    • Characterization of the phosphoproteome in LNCaP prostate cancer cells by in-gel isoelectric focusing and tandem mass spectrometry
    • Chen, L., Giorgianni, F., Beranova-Giorgianni, S., Characterization of the phosphoproteome in LNCaP prostate cancer cells by in-gel isoelectric focusing and tandem mass spectrometry. J. Proteome Res. 2010, 9, 174-178.
    • (2010) J. Proteome Res. , vol.9 , pp. 174-178
    • Chen, L.1    Giorgianni, F.2    Beranova-Giorgianni, S.3
  • 31
    • 29244472037 scopus 로고    scopus 로고
    • Akt phosphorylates and regulates Pdcd4 tumor suppressor protein
    • Palamarchuk, A., Efanov, A., Maximov, V., Aqeilan, R. I. et al., Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. Cancer Res. 2005, 65, 11282-11286.
    • (2005) Cancer Res. , vol.65 , pp. 11282-11286
    • Palamarchuk, A.1    Efanov, A.2    Maximov, V.3    Aqeilan, R.I.4
  • 32
    • 33750325725 scopus 로고    scopus 로고
    • S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth
    • Dorrello, N. V., Peschiaroli, A., Guardavaccaro, D., Colburn, N. H. et al., S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science 2006, 314, 467-471.
    • (2006) Science , vol.314 , pp. 467-471
    • Dorrello, N.V.1    Peschiaroli, A.2    Guardavaccaro, D.3    Colburn, N.H.4
  • 33
    • 33749868662 scopus 로고    scopus 로고
    • Involvement of programmed cell death 4 in transforming growth factor-beta1-induced apoptosis in human hepatocellular carcinoma
    • Zhang, H., Ozaki, I., Mizuta, T., Hamajima, H. et al., Involvement of programmed cell death 4 in transforming growth factor-beta1-induced apoptosis in human hepatocellular carcinoma. Oncogene 2006, 25, 6101-6112.
    • (2006) Oncogene , vol.25 , pp. 6101-6112
    • Zhang, H.1    Ozaki, I.2    Mizuta, T.3    Hamajima, H.4
  • 34
    • 0032697488 scopus 로고    scopus 로고
    • TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton
    • Fu, C. A., Shen, M., Huang, B. C., Lasaga, J. et al., TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton. J. Biol. Chem. 1999, 274, 30729-30737.
    • (1999) J. Biol. Chem. , vol.274 , pp. 30729-30737
    • Fu, C.A.1    Shen, M.2    Huang, B.C.3    Lasaga, J.4
  • 36
    • 70350759551 scopus 로고    scopus 로고
    • The kinase TNIK is an essential activator of Wnt target genes
    • Mahmoudi, T., Li, V. S., Ng, S. S., Taouatas, N. et al., The kinase TNIK is an essential activator of Wnt target genes. EMBO J. 2009, 28, 3329-3340.
    • (2009) EMBO J. , vol.28 , pp. 3329-3340
    • Mahmoudi, T.1    Li, V.S.2    Ng, S.S.3    Taouatas, N.4
  • 37
    • 77953775569 scopus 로고    scopus 로고
    • Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth
    • Shitashige, M., Satow, R., Jigami, T., Aoki, K. et al., Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth. Cancer Res. 2010, 70, 5024-5033.
    • (2010) Cancer Res. , vol.70 , pp. 5024-5033
    • Shitashige, M.1    Satow, R.2    Jigami, T.3    Aoki, K.4
  • 38
    • 0026616796 scopus 로고
    • Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase
    • Parker, L. L., Piwnica-Worms, H., Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science 1992, 257, 1955-1957.
    • (1992) Science , vol.257 , pp. 1955-1957
    • Parker, L.L.1    Piwnica-Worms, H.2
  • 39
    • 0031297716 scopus 로고    scopus 로고
    • Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14
    • Fattaey, A., Booher, R. N., Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14. Prog. Cell Cycle Res. 1997, 3, 233-240.
    • (1997) Prog. Cell Cycle Res. , vol.3 , pp. 233-240
    • Fattaey, A.1    Booher, R.N.2
  • 40
    • 0028783413 scopus 로고
    • Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15
    • Mueller, P. R., Coleman, T. R., Kumagai, A., Dunphy, W. G., Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. Science 1995, 270, 86-90.
    • (1995) Science , vol.270 , pp. 86-90
    • Mueller, P.R.1    Coleman, T.R.2    Kumagai, A.3    Dunphy, W.G.4
  • 41
    • 0031466305 scopus 로고    scopus 로고
    • Cyclin-dependent kinases: engines, clocks, and microprocessors
    • Morgan, D. O., Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell. Dev. Biol. 1997, 13, 261-291.
    • (1997) Annu. Rev. Cell. Dev. Biol. , vol.13 , pp. 261-291
    • Morgan, D.O.1
  • 42
    • 8644219655 scopus 로고    scopus 로고
    • Living with or without cyclins and cyclin-dependent kinases
    • Sherr, C. J., Roberts, J. M., Living with or without cyclins and cyclin-dependent kinases. Genes Dev. 2004, 18, 2699-2711.
    • (2004) Genes Dev. , vol.18 , pp. 2699-2711
    • Sherr, C.J.1    Roberts, J.M.2
  • 43
    • 0032728975 scopus 로고    scopus 로고
    • Human cyclin A is required for mitosis until mid prophase
    • Furuno, N., den Elzen, N., Pines, J., Human cyclin A is required for mitosis until mid prophase. J. Cell. Biol. 1999, 147, 295-306.
    • (1999) J. Cell. Biol. , vol.147 , pp. 295-306
    • Furuno, N.1    den Elzen, N.2    Pines, J.3
  • 44
    • 0024573538 scopus 로고
    • The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells
    • Riabowol, K., Draetta, G., Brizuela, L., Vandre, D., Beach, D., The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell 1989, 57, 393-401.
    • (1989) Cell , vol.57 , pp. 393-401
    • Riabowol, K.1    Draetta, G.2    Brizuela, L.3    Vandre, D.4    Beach, D.5
  • 45
    • 1942421702 scopus 로고    scopus 로고
    • Cyclin C/cdk3 promotes Rb-dependent G0 exit
    • Ren, S., Rollins, B. J., Cyclin C/cdk3 promotes Rb-dependent G0 exit. Cell 2004, 117, 239-251.
    • (2004) Cell , vol.117 , pp. 239-251
    • Ren, S.1    Rollins, B.J.2
  • 46
    • 69249230769 scopus 로고    scopus 로고
    • Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms
    • Satyanarayana, A., Kaldis, P., Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms. Oncogene 2009, 28, 2925-2939.
    • (2009) Oncogene , vol.28 , pp. 2925-2939
    • Satyanarayana, A.1    Kaldis, P.2
  • 47
    • 0030978315 scopus 로고    scopus 로고
    • Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15
    • Iavarone, A., Massague, J., Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15. Nature 1997, 387, 417-422.
    • (1997) Nature , vol.387 , pp. 417-422
    • Iavarone, A.1    Massague, J.2
  • 48
    • 1442284076 scopus 로고    scopus 로고
    • Negative regulation of SCFSkp2 ubiquitin ligase by TGF-beta signaling
    • Wang, W., Ungermannova, D., Jin, J., Harper, J. W., Liu, X., Negative regulation of SCFSkp2 ubiquitin ligase by TGF-beta signaling. Oncogene 2004, 23, 1064-1075.
    • (2004) Oncogene , vol.23 , pp. 1064-1075
    • Wang, W.1    Ungermannova, D.2    Jin, J.3    Harper, J.W.4    Liu, X.5
  • 49
    • 0028043462 scopus 로고
    • Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein
    • Nakamura, H., Izumoto, Y., Kambe, H., Kuroda, T. et al., Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein. J. Biol. Chem. 1994, 269, 25143-25149.
    • (1994) J. Biol. Chem. , vol.269 , pp. 25143-25149
    • Nakamura, H.1    Izumoto, Y.2    Kambe, H.3    Kuroda, T.4
  • 50
    • 34547106044 scopus 로고    scopus 로고
    • Hepatoma-derived growth factor is a novel prognostic factor for gastrointestinal stromal tumors
    • Chang, K. C., Tai, M. H., Lin, J. W., Wang, C. C. et al., Hepatoma-derived growth factor is a novel prognostic factor for gastrointestinal stromal tumors. Int. J. Cancer 2007, 121, 1059-1065.
    • (2007) Int. J. Cancer , vol.121 , pp. 1059-1065
    • Chang, K.C.1    Tai, M.H.2    Lin, J.W.3    Wang, C.C.4
  • 51
    • 31544442216 scopus 로고    scopus 로고
    • Hepatoma-derived growth factor is a novel prognostic factor for hepatocellular carcinoma
    • Yoshida, K., Tomita, Y., Okuda, Y., Yamamoto, S. et al., Hepatoma-derived growth factor is a novel prognostic factor for hepatocellular carcinoma. Ann. Surg. Oncol. 2006, 13, 159-167.
    • (2006) Ann. Surg. Oncol. , vol.13 , pp. 159-167
    • Yoshida, K.1    Tomita, Y.2    Okuda, Y.3    Yamamoto, S.4
  • 52
    • 4344714365 scopus 로고    scopus 로고
    • Expression of hepatoma-derived growth factor is a strong prognostic predictor for patients with early-stage non-small-cell lung cancer
    • Ren, H., Tang, X., Lee, J. J., Feng, L. et al., Expression of hepatoma-derived growth factor is a strong prognostic predictor for patients with early-stage non-small-cell lung cancer. J. Clin. Oncol. 2004, 22, 3230-3237.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 3230-3237
    • Ren, H.1    Tang, X.2    Lee, J.J.3    Feng, L.4
  • 53
    • 33750712750 scopus 로고    scopus 로고
    • Hepatoma-derived growth factor is a novel prognostic factor for patients with pancreatic cancer
    • Uyama, H., Tomita, Y., Nakamura, H., Nakamori, S. et al., Hepatoma-derived growth factor is a novel prognostic factor for patients with pancreatic cancer. Clin. Cancer Res. 2006, 12, 6043-6048.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 6043-6048
    • Uyama, H.1    Tomita, Y.2    Nakamura, H.3    Nakamori, S.4
  • 54
    • 79952511445 scopus 로고    scopus 로고
    • Secretion of hepatoma-derived growth factor is regulated by N-terminal processing
    • Thakar, K., Krocher, T., Savant, S., Gollnast, D. et al., Secretion of hepatoma-derived growth factor is regulated by N-terminal processing. Biol. Chem. 2010, 391, 1401-1410.
    • (2010) Biol. Chem. , vol.391 , pp. 1401-1410
    • Thakar, K.1    Krocher, T.2    Savant, S.3    Gollnast, D.4
  • 55
    • 0035813180 scopus 로고    scopus 로고
    • Nuclear targeting is required for hepatoma-derived growth factor-stimulated mitogenesis in vascular smooth muscle cells
    • Everett, A. D., Stoops, T., McNamara, C. A., Nuclear targeting is required for hepatoma-derived growth factor-stimulated mitogenesis in vascular smooth muscle cells. J. Biol. Chem. 2001, 276, 37564-37568.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37564-37568
    • Everett, A.D.1    Stoops, T.2    McNamara, C.A.3
  • 56
    • 0037155928 scopus 로고    scopus 로고
    • Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals
    • Kishima, Y., Yamamoto, H., Izumoto, Y., Yoshida, K. et al., Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals. J. Biol. Chem. 2002, 277, 10315-10322.
    • (2002) J. Biol. Chem. , vol.277 , pp. 10315-10322
    • Kishima, Y.1    Yamamoto, H.2    Izumoto, Y.3    Yoshida, K.4
  • 57
    • 49349098646 scopus 로고    scopus 로고
    • Downregulation of hepatoma-derived growth factor activates the Bad-mediated apoptotic pathway in human cancer cells
    • Tsang, T. Y., Tang, W. Y., Tsang, W. P., Co, N. N. et al., Downregulation of hepatoma-derived growth factor activates the Bad-mediated apoptotic pathway in human cancer cells. Apoptosis 2008, 13, 1135-1147.
    • (2008) Apoptosis , vol.13 , pp. 1135-1147
    • Tsang, T.Y.1    Tang, W.Y.2    Tsang, W.P.3    Co, N.N.4
  • 58
    • 60149109389 scopus 로고    scopus 로고
    • Hepatoma-derived growth factor represses SET and MYND domain containing 1 gene expression through interaction with C-terminal binding protein
    • Yang, J., Everett, A. D., Hepatoma-derived growth factor represses SET and MYND domain containing 1 gene expression through interaction with C-terminal binding protein. J. Mol. Biol. 2009, 386, 938-950.
    • (2009) J. Mol. Biol. , vol.386 , pp. 938-950
    • Yang, J.1    Everett, A.D.2
  • 59
    • 30944436222 scopus 로고    scopus 로고
    • Smad3 phosphorylation by cyclin-dependent kinases
    • Liu, F., Smad3 phosphorylation by cyclin-dependent kinases. Cytokine Growth Factor Rev. 2006, 17, 9-17.
    • (2006) Cytokine Growth Factor Rev. , vol.17 , pp. 9-17
    • Liu, F.1


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