Apoptosis and other cell death mechanisms after retinal detachment: Implications for photoreceptor rescue

Ophthalmologica

Volumn 226, Issue SUPPL. 1, 2011, Pages 10-17

  Lo, Amy C Y ^a   Woo, Tiffany T Y ^a   Wong, Raymond L M ^a   Wong, David ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Caspase; Mitochondria; Necrosis; Neuroprotection; Programmed cell death

Indexed keywords

APOPTOSIS INDUCING FACTOR; BASIC FIBROBLAST GROWTH FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE; CYTOKINE; DEATH RECEPTOR; FAS ANTIGEN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; INTERLEUKIN 6; MINOCYCLINE; MONOCYTE CHEMOTACTIC PROTEIN 1; NERVE GROWTH FACTOR; OXYGEN; PROTEIN BAX; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; STROMAL CELL DERIVED FACTOR 1;

APOPTOSIS; B CELL LYMPHOMA; CLINICAL TRIAL (TOPIC); CONFERENCE PAPER; ENDOPLASMIC RETICULUM STRESS; HUMAN; INTRACELLULAR SIGNALING; LASER COAGULATION; MITOCHONDRION; NECROSIS; NEUROPROTECTION; PHOTORECEPTOR; RETINA DETACHMENT; RETINA DETACHMENT SURGERY; RETINA EXUDATIVE DETACHMENT; RETINOPEXY; RHEGMATOGENOUS RETINA DETACHMENT; SCLERA BUCKLING PROCEDURE; TRACTIONAL RETINA DETACHMENT; VITRECTOMY;

APOPTOSIS; CELL SURVIVAL; CYTOPROTECTION; HUMANS; NECROSIS; PHOTORECEPTOR CELLS, VERTEBRATE; RETINAL DETACHMENT;

EID: 79960706234     PISSN: 00303755     EISSN: 14230267     Source Type: Journal    
DOI: 10.1159/000328206     Document Type: Conference Paper

References (96)

1. Stone J, Maslim J, Valter-Kocsi K, Mervin K, Bowers F, Chu Y, Barnett N, Provis J, Lewis G, Fisher SK, Bisti S, Gargini C, Cervetto L, Merin S, Peer J: Mechanisms of photoreceptor death and survival in mammalian retina. Prog Retin Eye Res 1999; 18: 689-735. (Pubitemid 29445799)
2. Voyvodic JT: Cell death in cortical development: how much? Why? So what? Neuron 1996; 16: 693-696. (Pubitemid 26124046)
3. Martin LJ: Neuronal cell death in nervous system development, disease, and injury. Int J Mol Med 2001; 7: 455-478.
4. Vila M, Przedborski S: Targeting programmed cell death in neurodegenerative diseases. Nat Rev Neurosci 2003; 4: 365-375. (Pubitemid 37280175)
5. Shahinfar S, Edward DP, Tso MO: A pathologic study of photoreceptor cell death in retinal photic injury. Curr Eye Res 1991; 10: 47-59.
6. Chang GQ, Hao Y, Wong F: Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron 1993; 11: 595-605. (Pubitemid 23321770)
7. Portera-Cailliau C, Sung CH, Nathans J, Adler R: Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc Natl Acad Sci USA 1994; 91: 974-978. (Pubitemid 24048491)
8. Tso MO, Zhang C, Abler AS, Chang CJ, Wong F, Chang GQ, Lam TT: Apoptosis leads to photoreceptor degeneration in inherited retinal dystrophy of RCS rats. Invest Ophthalmol Vis Sci 1994; 35: 2693-2699. (Pubitemid 24149780)
9. Gregory CY, Bird AC: Cell loss in retinal dystrophies by apoptosis: death by informed consent! Br J Ophthalmol 1995; 79: 186-190.
10. Smith SB, Bora N, McCool D, Kutty G, Wong P, Kutty RK, Wiggert B: Photoreceptor cells in the vitiligo mouse die by apoptosis: TRPM-2/clusterin expression is increased in the neural retina and in the retinal pigment epithelium. Invest Ophthalmol Vis Sci 1995; 36: 2193-2201.
11. Xu GZ, Li WW, Tso MO: Apoptosis in human retinal degenerations. Trans Am Ophthalmol Soc 1996; 94: 411-430, discussion 430-431.
12. Cheung AK, Lo AC, So KF, Chung SS, Chung SK: Gene deletion and pharmacological inhibition of aldose reductase protect against retinal ischemic injury. Exp Eye Res 2007; 85: 608-616. (Pubitemid 350011098)
13. Li SY, Fu ZJ, Ma H, Jang WC, So KF, Wong D, Lo AC: Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion. Invest Ophthalmol Vis Sci 2009; 50: 836-843.
14. Li SY, Yang D, Yeung CM, Yu WY, Chang RC, So KF, Wong D, Lo AC: Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury. PLoS One 2011; 6:e16380.
15. Hafezi F, Steinbach JP, Marti A, Munz K, Wang ZQ, Wagner EF, Aguzzi A, Remé CE: The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nat Med 1997; 3: 346-349. (Pubitemid 27112936)
16. Chang CJ, Lai WW, Edward DP, Tso MO: Apoptotic photoreceptor cell death after traumatic retinal detachment in humans. Arch Ophthalmol 1995; 113: 880-886.
17. Cook B, Lewis GP, Fisher SK, Adler R: Apoptotic photoreceptor degeneration in experimental retinal detachment. Invest Ophthalmol Vis Sci 1995; 36: 990-996.
18. Luthert PJ, Chong NH: Photoreceptor rescue. Eye (Lond) 1998; 12: 591-596. (Pubitemid 28356669)
19. Zacks DN, Hanninen V, Pantcheva M, Ezra E, Grosskreutz C, Miller JW: Caspase activation in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci 2003; 44: 1262-1267. (Pubitemid 36297848)
20. Zacks DN, Zheng QD, Han Y, Bakhru R, Miller JW: FAS-mediated apoptosis and its relation to intrinsic pathway activation in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci 2004; 45: 4563-4569. (Pubitemid 39564684)
21. Zacks DN, Boehlke C, Richards AL, Zheng QD: Role of the Fas-signaling pathway in photoreceptor neuroprotection. Arch Ophthalmol 2007; 125: 1389-1395. (Pubitemid 47606606)
22. Hisatomi T, Nakazawa T, Noda K, Almulki L, Miyahara S, Nakao S, Ito Y, She H, Kohno R, Michaud N, Ishibashi T, Hafezi-Moghadam A, Badley AD, Kroemer G, Miller JW: HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice. J Clin Invest 2008; 118: 2025-2038. (Pubitemid 351872323)
23. Mitry D, Charteris DG, Fleck BW, Campbell H, Singh J: The epidemiology of rhegmatogenous retinal detachment: geographical variation and clinical associations. Br J Ophthalmol 2010; 94: 678-684.
24. Tornambe PE, Hilton GF: Pneumatic retinopexy: a multicenter randomized controlled clinical trial comparing pneumatic retinopexy with scleral buckling. The Retinal Detachment Study Group. Ophthalmology 1989; 96: 772-783, discussion 784.
25. Mulvihill A, Fulcher T, Datta V, Acheson R: Pneumatic retinopexy versus scleral buckling: a randomised controlled trial. Ir J Med Sci 1996; 165: 274-277. (Pubitemid 26413408)
26. Ahmadieh H, Moradian S, Faghihi H, Parvaresh MM, Ghanbari H, Mehryar M, Heidari E, Behboudi H, Banaee T, Golestan B: Anatomic and visual outcomes of scleral buckling versus primary vitrectomy in pseudophakic and aphakic retinal detachment: sixmonth follow-up results of a single operation-report No 1. Ophthalmology 2005; 112: 1421-1429.
27. Brazitikos PD, Androudi S, Christen WG, Stangos NT: Primary pars plana vitrectomy versus scleral buckle surgery for the treatment of pseudophakic retinal detachment: a randomized clinical trial. Retina 2005; 25: 957-964. (Pubitemid 44735090)
28. Sharma YR, Karunanithi S, Azad RV, Vohra R, Pal N, Singh DV, Chandra P: Functional and anatomic outcome of scleral buckling versus primary vitrectomy in pseudophakic retinal detachment. Acta Ophthalmol Scand 2005; 83: 293-297. (Pubitemid 40872500)
29. Heimann H, Bartz-Schmidt KU, Bornfeld N, Weiss C, Hilgers RD, Foerster MH: Scleral buckling versus primary vitrectomy in rhegmatogenous retinal detachment: a prospective randomized multicenter clinical study. Ophthalmology 2007; 114: 2142-2154.
30. Brazitikos PD: The expanding role of primary pars plana vitrectomy in the treatment of rhegmatogenous noncomplicated retinal detachment. Semin Ophthalmol 2000; 15: 65-77. (Pubitemid 30408037)
31. Lavrik IN: Systems biology of apoptosis signaling networks. Curr Opin Biotechnol 2010; 21: 551-555.
32. Krammer PH: CD95's deadly mission in the immune system. Nature 2000; 407: 789-795.
33. Lavrik IN, Golks A, Krammer PH: Caspases: pharmacological manipulation of cell death. J Clin Invest 2005; 115: 2665-2672. (Pubitemid 41434390)
34. Fuentes-Prior P, Salvesen GS: The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem J 2004; 384: 201-232. (Pubitemid 39656233)
35. Ashkenazi A, Dixit VM: Death receptors: signaling and modulation. Science 1998; 281: 1305-1308. (Pubitemid 28406815)
36. Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH, Peter ME: Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J 1995; 14: 5579-5588.
37. Krammer PH, Arnold R, Lavrik IN: Life and death in peripheral T cells. Nat Rev Immunol 2007; 7: 532-542. (Pubitemid 46987784)
38. Green DR, Kroemer G: The pathophysiology of mitochondrial cell death. Science 2004; 305: 626-629. (Pubitemid 39006738)
39. Brenner D, Mak TW: Mitochondrial cell death effectors. Curr Opin Cell Biol 2009; 21: 871-877.
40. Lewis GP, Charteris DG, Sethi CS, Fisher SK: Animal models of retinal detachment and reattachment: identifying cellular events that may affect visual recovery. Eye (Lond) 2002; 16: 375-387. (Pubitemid 34845965)
41. Lewis GP, Sethi CS, Linberg KA, Charteris DG, Fisher SK: Experimental retinal reattachment: a new perspective. Mol Neurobiol 2003; 28: 159-175. (Pubitemid 38156430)
42. Fisher SK, Lewis GP, Linberg KA, Verardo MR: Cellular remodeling in mammalian retina: results from studies of experimental retinal detachment. Prog Retin Eye Res 2005; 24: 395-431. (Pubitemid 40238670)
43. Linberg KA, Sakai T, Lewis GP, Fisher SK: Experimental retinal detachment in the cone-dominant ground squirrel retina: morphology and basic immunocytochemistry. Vis Neurosci 2002; 19: 603-619. (Pubitemid 36033478)
44. Kroll AJ, Machemer R: Experimental retinal detachment in the owl monkey. V. Electron microscopy of the reattached retina. Am J Ophthalmol 1969; 67: 117-130.
45. Guerin CJ, Anderson DH, Fariss RN, Fisher SK: Retinal reattachment of the primate macula: photoreceptor recovery after shortterm detachment. Invest Ophthalmol Vis Sci 1989; 30: 1708-1725. (Pubitemid 19214991)
46. Hisatomi T, Sakamoto T, Goto Y, Yamanaka I, Oshima Y, Hata Y, Ishibashi T, Inomata H, Susin SA, Kroemer G: Critical role of photoreceptor apoptosis in functional damage after retinal detachment. Curr Eye Res 2002; 24: 161-172. (Pubitemid 35216125)
47. Kubay OV, Charteris DG, Newland HS, Raymond GL: Retinal detachment neuropathology and potential strategies for neuroprotection. Surv Ophthalmol 2005; 50: 463-475. (Pubitemid 41224781)
48. Wickham L, Charteris DG: Glial cell changes of the human retina in proliferative vitreoretinopathy. Dev Ophthalmol 2009; 44: 37-45.
49. Wickham L, Sethi CS, Lewis GP, Fisher SK, McLeod DC, Charteris DG: Glial and neural response in short-term human retinal detachment. Arch Ophthalmol 2006; 124: 1779-1782. (Pubitemid 44913205)
50. Hisatomi T, Sakamoto T, Sonoda KH, Tsutsumi C, Qiao H, Enaida H, Yamanaka I, Kubota T, Ishibashi T, Kura S, Susin SA, Kroemer G: Clearance of apoptotic photoreceptors: elimination of apoptotic debris into the subretinal space and macrophage-mediated phagocytosis via phosphatidylserine receptor and integrin v3 . Am J Pathol 2003; 162: 1869-1879. (Pubitemid 36613045)
51. Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609-619. (Pubitemid 23259742)
52. MacGibbon GA, Lawlor PA, Sirimanne ES, Walton MR, Connor B, Young D, Williams C, Gluckman P, Faull RL, Hughes P, Dragunow M: Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus. Brain Res 1997; 750: 223-234. (Pubitemid 27116267)
53. Eversole-Cire P, Chen J, Simon MI: Bax is not the heterodimerization partner necessary for sustained anti-photoreceptor-cell-death activity of Bcl-2. Invest Ophthalmol Vis Sci 2002; 43: 1636-1644. (Pubitemid 34462669)
54. Hisatomi T, Sakamoto T, Murata T, Yamanaka I, Oshima Y, Hata Y, Ishibashi T, Inomata H, Susin SA, Kroemer G: Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo. Am J Pathol 2001; 158: 1271-1278. (Pubitemid 32281291)
55. Bouchier-Hayes L, Lartigue L, Newmeyer DD: Mitochondria: pharmacological manipulation of cell death. J Clin Invest 2005; 115: 2640-2647. (Pubitemid 41434387)
56. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G: Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999; 397: 441-446.
57. Harding HP, Zhang Y, Ron D: Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 1999; 397: 271-274. (Pubitemid 29051178)
58. Patil CK, Li H, Walter P: Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response. PLoS Biol 2004; 2:E246.
59. Momoi T: Caspases involved in ER stressmediated cell death. J Chem Neuroanat 2004; 28: 101-105. (Pubitemid 39195255)
60. Lindholm D, Wootz H, Korhonen L: ER stress and neurodegenerative diseases. Cell Death Differ 2006; 13: 385-392.
61. Sekine Y, Takeda K, Ichijo H: The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases. Curr Mol Med 2006; 6: 87-97.
62. Yoshida H: ER stress and diseases. FEBS J 2007; 274: 630-658. (Pubitemid 46150855)
63. Roybal CN, Marmorstein LY, Vander Jagt DL, Abcouwer SF: Aberrant accumulation of fibulin-3 in the endoplasmic reticulum leads to activation of the unfolded protein response and VEGF expression. Invest Ophthalmol Vis Sci 2005; 46: 3973-3979. (Pubitemid 44264595)
64. Ryoo HD, Domingos PM, Kang MJ, Steller H: Unfolded protein response in a Drosophila model for retinal degeneration. EMBO J 2007; 26: 242-252. (Pubitemid 46094715)
65. Shimazawa M, Ito Y, Inokuchi Y, Hara H: Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage. Invest Ophthalmol Vis Sci 2007; 48: 3729-3736. (Pubitemid 351261111)
66. Shimazawa M, Inokuchi Y, Ito Y, Murata H, Aihara M, Miura M, Araie M, Hara H: Involvement of ER stress in retinal cell death. Mol Vis 2007; 13: 578-587. (Pubitemid 46561917)
67. Liu H, Qian J, Wang F, Sun X, Xu X, Xu W, Zhang X: Expression of two endoplasmic reticulum stress markers, GRP78 and GADD153, in rat retinal detachment model and its implication. Eye (Lond) 2010; 24: 137-144.
68. Trichonas G, Murakami Y, Thanos A, Morizane Y, Kayama M, Debouck CM, Hisatomi T, Miller JW, Vavvas DG: Receptorinteracting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis. Proc Natl Acad Sci USA 2010; 107: 21695-21700.
69. Festjens N, Vanden Berghe T, Cornelis S, Vandenabeele P: RIP1, a kinase on the crossroads of a cell's decision to live or die. Cell Death Differ 2007; 14: 400-410.
70. Arimura N, Ki-i Y, Hashiguchi T, Kawahara K, Biswas KK, Nakamura M, Sonoda Y, Yamakiri K, Okubo A, Sakamoto T, Maruyama I: Intraocular expression and release of highmobility group box 1 protein in retinal detachment. Lab Invest 2009; 89: 278-289.
71. Abu el-Asrar AM, van Damme J, Put W, Veckeneer M, Dralands L, Billiau A, Missotten L: Monocyte chemotactic protein-1 in proliferative vitreoretinal disorders. Am J Ophthalmol 1997; 123: 599-606. (Pubitemid 27203280)
72. Capeans C, de Rojas MV, Lojo S, Salorio MS: C-C chemokines in the vitreous of patients with proliferative vitreoretinopathy and proliferative diabetic retinopathy. Retina 1998; 18: 546-550. (Pubitemid 30387560)
73. Cassidy L, Barry P, Shaw C, Duffy J, Kennedy S: Platelet derived growth factor and fibroblast growth factor basic levels in the vitreous of patients with vitreoretinal disorders. Br J Ophthalmol 1998; 82: 181-185. (Pubitemid 28176995)
74. El-Ghrably IA, Dua HS, Orr GM, Fischer D, Tighe PJ: Detection of cytokine mRNA production in infiltrating cells in proliferative vitreoretinopathy using reverse transcription polymerase chain reaction. Br J Ophthalmol 1999; 83: 1296-1299. (Pubitemid 29511817)
75. Kon CH, Occleston NL, Aylward GW, Khaw PT: Expression of vitreous cytokines in proliferative vitreoretinopathy: a prospective study. Invest Ophthalmol Vis Sci 1999; 40: 705-712. (Pubitemid 29109449)
76. la Heij EC, van de Waarenburg MP, Blaauwgeers HG, Kessels AG, de Vente J, Liem AT, Steinbusch H, Hendrikse F: Levels of basic fibroblast growth factor, glutamine synthetase, and interleukin-6 in subretinal fluid from patients with retinal detachment. Am J Ophthalmol 2001; 132: 544-550.
77. Limb GA, Daniels JT, Pleass R, Charteris DG, Luthert PJ, Khaw PT: Differential expression of matrix metalloproteinases 2 and by glial Müller cells: response to soluble and extracellular matrix-bound tumor necrosis factor-. Am J Pathol 2002; 160: 1847-1855. (Pubitemid 34525664)
78. Mitamura Y, Takeuchi S, Yamamoto S, Yamamoto T, Tsukahara I, Matsuda A, Tagawa Y, Mizue Y, Nishihira J: Monocyte chemotactic protein-1 levels in the vitreous of patients with proliferative vitreoretinopathy. Jpn J Ophthalmol 2002; 46: 218-221. (Pubitemid 34309039)
79. Nakazawa T, Matsubara A, Noda K, Hisatomi T, She H, Skondra D, Miyahara S, Sobrin L, Thomas KL, Chen DF, Grosskreutz CL, Hafezi-Moghadam A, Miller JW: Characterization of cytokine responses to retinal detachment in rats. Mol Vis 2006; 12: 867-878. (Pubitemid 44184719)
80. Nakazawa T, Hisatomi T, Nakazawa C, Noda K, Maruyama K, She H, Matsubara A, Miyahara S, Nakao S, Yin Y, Benowitz L, Hafezi-Moghadam A, Miller JW: Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis. Proc Natl Acad Sci USA 2007; 104: 2425-2430. (Pubitemid 46391413)
81. Lewis G, Mervin K, Valter K, Maslim J, Kappel PJ, Stone J, Fisher S: Limiting the proliferation and reactivity of retinal Müller cells during experimental retinal detachment: the value of oxygen supplementation. Am J Ophthalmol 1999; 128: 165-172. (Pubitemid 29379768)
82. Mervin K, Valter K, Maslim J, Lewis G, Fisher S, Stone J: Limiting photoreceptor death and deconstruction during experimental retinal detachment: the value of oxygen supplementation. Am J Ophthalmol 1999; 128: 155-164. (Pubitemid 29379767)
83. Sakai T, Lewis GP, Linberg KA, Fisher SK: The ability of hyperoxia to limit the effects of experimental detachment in cone-dominated retina. Invest Ophthalmol Vis Sci 2001; 42: 3264-3273. (Pubitemid 33740689)
84. Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM: Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature 1990; 347: 83-86.
85. Lewis GP, Linberg KA, Geller SF, Guerin CJ, Fisher SK: Effects of the neurotrophin brainderived neurotrophic factor in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci 1999; 40: 1530-1544. (Pubitemid 29252345)
86. Sun X, Xu X, Wang F, Zhang X, Ho PC, Liu H, Qian J, Yu Z, Lu H, Xu W: Nerve growth factor helps protect retina in experimental retinal detachment. Ophthalmologica 2008; 222: 58-61. (Pubitemid 350308339)
87. Sun X, Xu X, Wang F, Zhang X, Yu Z, Lu H, Ho PC: Effects of nerve growth factor for retinal cell survival in experimental retinal detachment. Curr Eye Res 2007; 32: 765-772. (Pubitemid 47450622)
88. Wu WC, Lai CC, Chen SL, Xiao X, Chen TL, Tsai RJ, Kuo SW, Tsao YP: Gene therapy for detached retina by adeno-associated virus vector expressing glial cell line-derived neurotrophic factor. Invest Ophthalmol Vis Sci 2002; 43: 3480-3488. (Pubitemid 35334356)
89. Yang L, Bula D, Arroyo JG, Chen DF: Preventing retinal detachment-associated photoreceptor cell loss in Bax-deficient mice. Invest Ophthalmol Vis Sci 2004; 45: 648-654. (Pubitemid 38140526)
90. Besirli CG, Chinskey ND, Zheng QD, Zacks DN: Inhibition of retinal detachment-induced apoptosis in photoreceptors by a small peptide inhibitor of the Fas receptor. Invest Ophthalmol Vis Sci 2010; 51: 2177-2184.
91. Shyong MP, Lee FL, Hen WH, Kuo PC, Wu AC, Cheng HC, Chen SL, Tung TH, Tsao YP: Viral delivery of heme oxygenase-1 attenuates photoreceptor apoptosis in an experimental model of retinal detachment. Vision Res 2008; 48: 2394-2402.
92. Chong DY, Boehlke CS, Zheng QD, Zhang L, Han Y, Zacks DN: Interleukin-6 as a photoreceptor neuroprotectant in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci 2008; 49: 3193-3200.
93. Zadro-Lamoureux LA, Zacks DN, Baker AN, Zheng QD, Hauswirth WW, Tsilfidis C: XIAP effects on retinal detachment-induced photoreceptor apoptosis [corrected]. Invest Ophthalmol Vis Sci 2009; 50: 1448-1453.
94. Lewis GP, Chapin EA, Byun J, Luna G, Sherris D, Fisher SK: Müller cell reactivity and photoreceptor cell death are reduced after experimental retinal detachment using an inhibitor of the Akt/mTOR pathway. Invest Ophthalmol Vis Sci 2009; 50: 4429-4435.
95. Yang L, Kim JH, Kovacs KD, Arroyo JG, Chen DF: Minocycline inhibition of photoreceptor degeneration. Arch Ophthalmol 2009; 127: 1475-1480.
96. Otsuka H, Arimura N, Sonoda S, Nakamura M, Hashiguchi T, Maruyama I, Nakao S, Hafezi-Moghadam A, Sakamoto T: Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment. Am J Pathol 2010; 177: 2268-2277.