Müller cell reactivity and photoreceptor cell death are reduced after experimental retinal detachment using an inhibitor of the Akt/mToR pathway

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 9, 2009, Pages 4429-4435

  Lewis, Geoffrey P ^a   Chapin, Ethan A ^a   Byun, Jiyun ^b   Luna, Gabriel ^a   Sherris, David ^c   Fisher, Steven K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAYACHITRA INC   (United States)

^c Paloma Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BALANCED SALT SOLUTION; BROXURIDINE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PALOMID 529; PROTEIN KINASE B INHIBITOR; UNCLASSIFIED DRUG; BENZOPYRAN DERIVATIVE; BIOLOGICAL MARKER; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR;

ADULT ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CELL PROLIFERATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG EFFECT; FLUORESCENCE; IMMUNOCYTOCHEMISTRY; MACROPHAGE; MICROGLIA; MUELLER CELL; NONHUMAN; PHOTORECEPTOR CELL; PRIORITY JOURNAL; RABBIT; RETINA DETACHMENT; SCAR FORMATION; ANIMAL; CELL SURVIVAL; DISEASE MODEL; DRUG ANTAGONISM; GLIA; INJECTION; METABOLISM; PATHOLOGY; PHYSIOLOGY; RETINA NERVE CELL; VITREOUS BODY;

ANIMALS; APOPTOSIS; BENZOPYRANS; BIOLOGICAL MARKERS; CELL COUNT; CELL PROLIFERATION; CELL SURVIVAL; DISEASE MODELS, ANIMAL; INJECTIONS; MACROPHAGES; MICROSCOPY, CONFOCAL; NEUROGLIA; PHOTORECEPTOR CELLS, VERTEBRATE; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RABBITS; RETINAL DETACHMENT; RETINAL NEURONS; VITREOUS BODY;

EID: 70349241743     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-3445     Document Type: Article

References (40)

1. Fisher SK, Erickson PA, Lewis GP, Anderson DH. Intraretinal proliferation induced by retinal detachment. Invest Ophthalmol Vis Sci. 1991;32:1739-1748.
2. Kampik A, Kenyon KR, Michels RG, Green WR, de la Cruz ZC. Epiretinal and vitreous membranes: comparative study of 56 cases. Arch Ophthalmol. 1981;99:1445-1454.
3. Hiscott PS, Grierson I, Macleod D. Natural history of fibrocellular epiretinal membranes: a quantitative, autoradiographic, and immunohistochemical study. Br J Ophthalmol. 1985;69:810-823.
4. Vinores SA, Campochiaro PA, Conway BP. Ultrastructural and electron-immunocytochemical characterization of cells in epiretinal membranes. Invest Ophthalmol Vis Sci. 1990;31:14 -28.
5. Guérin CJ, Wolfshagen RW, Eifrig DE, Anderson DH. Immunocytochemical identification of Müller's glia as a component of human epiretinal membranes (published correction appears in Invest Ophthalmol Vis Sci. 1990;31:2360). Invest Ophthalmol Vis Sci. 1990;31:1483-1491.
6. Anderson DH, Guerin CJ, Erickson PA, Stern WH, Fisher SK. Morphological recovery in the reattached retina. Invest Ophthalmol Vis Sci. 1986;27:168-186.
7. Machemer R, Aaberg TM, Freeman HM, Irvine AR, Lean JS, Michels RM. An updated classification of retinal detachment with proliferative vitreoretinopathy. Am J Ophthalmol. 1991;112:159-165.
8. Greven CM, Sanders RJ, Brown GC, et al. Pseudophakic retinal detachments: anatomic and visual results. Ophthalmology. 1992; 99:257-262.
9. Gartry DS, Chignell AH, Franks WA, Wong D. Pars plana vitrectomy for the treatment of rhegmatogenous retinal detachment uncomplicated by advanced proliferative vitreoretinopathy. Br J Ophthalmol. 1993;77:199-203.
10. Girard P, Mimoun G, Karpouzas I, Montefiore G. Clinical risk factors for proliferative vitreoretinopathy after retinal detachment surgery. Retina. 1994;14:417-424.
11. Bonnet M, Fleury J, Guenoun S, Yaniali A, Dumas C, Hajjar C. Cryopexy in primary rhegmatogenous retinal detachment: a risk factor for postoperative proliferative vitreoretinopathy? Graefes Arch Clin Exp Ophthalmol. 1996;234:739-743.
12. Duquesne N, Bonnet M, Adeleine P. Preoperative vitreous hemorrhage associated with rhegmatogenous retinal detachment: a risk factor for postoperative proliferative vitreoretinopathy? Graefes Arch Clin Exp Ophthalmol. 1996;234:677-682.
13. Speicher MA, Fu AD, Martin JP, von Fricken MA. Primary vitrectomy alone for repair of retinal detachments following cataract surgery. Retina. 2000;20:459-464.
14. Lewis H, Aaberg TM, Abrams GW. Causes of failure after initial vitreoretinal surgery for severe proliferative vitreoretinopathy. Am J Ophthalmol. 1991;111:8-14.
15. Cook B, Lewis GP, Fisher SK, Adler R. Apoptotic photoreceptor degeneration in experimental retinal detachment. Invest Ophthalmol Vis Sci. 1995;36:990-996.
16. Chang CJ, Lai WW, Edward DP, Tso MO. Apoptotic photoreceptor cell death after traumatic retinal detachment in humans. Arch Ophthalmol. 1995;113:880-886.
17. Sebag J, Sadun AA. Apoptotic photoreceptor cell death after traumatic retinal detachment in humans. Arch Ophthalmol. 1996;114: 1158-1159.
18. Hisatomi T, Sakamoto T, Goto Y, et al. Critical role of photoreceptor apoptosis in functional damage after retinal detachment. Curr Eye Res. 2002;24:161-172.
19. Zacks DN, Zheng QD, Han Y, Bakhru R, Miller JW. FAS-mediated apoptosis and its relation to intrinsic pathway activation in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci. 2004;45:4563-4569.
20. Arroyo JG, Yang L, Bula D, Chen DF. Photoreceptor apoptosis in human retinal detachment. Am J Ophthalmol. 2005;139:605-610.
21. Quintyn JC, Ranty ML, Mathis A. Photoreceptor apoptosis in human retinal detachment. Am J Ophthalmol. 2006;141:227.
22. Lewis GP, Sethi CS, Linberg KA, Charteris DG, Fisher SK. Experimental retinal reattachment: a new perspective. Mol Neurobiol. 2003;28:159-175.
23. Charteris DG, Aylward GW, Wong D, et al. A randomized controlled trial of combined 5-flurouracil and low molecular weight heparin in management of established proliferative vitreoretinopathy. Ophthalmology. 2004;111:2240-2245.
24. Wickham L, Bruce C, Wong D, McGurn D, Charteris D. Randomized controlled trial of combined 5-flurouracil and low-molecularweight heparin in the management of unselected rhegmatogenous retinal detachments undergoing primary vitrectomy. Ophthalmology. 2007;114:698-704.
25. Fisher SK, Lewis GP, Linberg KA, Verardo MR. Cellular remodeling in mammalian retina: results from studies of experimental retinal detachment. Prog Retinal Eye Res. 2005;24:395-431.
26. Fisher SK, Lewis, GP. Cellular effects of detachment on the neural retina and the retinal pigment epithelium. In: Ryan SJ, Wilkinson CP, eds. Retina. 4th ed. St. Louis: Mosby; 2006:1991-2012.
27. Geller SF, Lewis GP, Fisher SK. FGFR1, signaling, and AP-1 expression following retinal detachment: reactive Müller and RPE cells. Invest Ophthalmol Vis Sci. 2001;42:1363-1369.
28. Geller SF, Lewis GP, Anderson DH, Fisher SK. Use of the MIB-1 antibody for detecting proliferating cells in the retina. Invest Ophthalmol Vis Sci. 1995;36:737-744.
29. Sethi CS, Lewis GP, Fisher SK, et al. Glial remodeling and neural plasticity in human retinal detachment with proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2005;46:329-342.
30. Xue Q, Hopkins B, Perruzzi C, Udayakum D, Sherris D, Benjamin LE. Palomid 529, a novel small-molecule drug, is a TORC1/TORC2inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability. Cancer Res. 2008;68:1-7.
31. Sarbassov DD, Ali SM, Sabatini DM. Growing roles for the mTOR pathway. Curr Opin Cell Biol. 2005;17:596-603.
32. Granville CA, Memmott RM, Gills JJ, Dennis PA. Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/ mammalian target of rapamycin pathway. Clin Cancer Res. 2006; 12:679-689.
33. Eibl KH, Lewis GP, Betts KE, Gandorfer A, Kampik A, Fisher SK. The effect of alkylphosphocholines on intraretinal proliferation initiated by experimental retinal detachment. Invest Ophthalmol Vis Sci. 2007;48:1305-1311.
34. Byun J. Quantitative Analysis and Modeling of Confocal Retinal Images. Santa Barbara, CA: University of California at Santa Barbara; 2007. Thesis.
35. LaVail MM, Unoki K, Yasumura D, Matthes MT, Yancopoulos GD, Steinberg RH. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Natl Acad Sci U S A. 1992;89:11249-11253.
36. Lewis GP, Sethi CS, Carter KM, Charteris DG, Fisher SK. Microglial cell activation following retinal detachment: a comparison between species. Mol Vis. 2005;11:491-500.
37. Tsanou E, Ioachim E, Stefaniotou M, et al. Immunohistochemical study of angiogenesis and proliferative activity in epiretinal membranes. Int J Clin Pract. 2005;59:1157-1161.
38. Zhang X, Barile G, Chang S, et al. Apoptosis and cell proliferation in proliferative retinal disorders: PCNA, Ki-67, caspse-3, and PARP expression. Curr Eye Res. 2005;30:395-403.
39. Zhou P, Zhao MW, Li XX, Yu WZ, Bian ZM. SiRNA targeting mammalian target of rapamycin (mTor) attenuates experimental proliferative vitreoretinopathy. Curr Eye Res. 2007;32:973-984.
40. Yu K, Rajala RVS, McGinnis JM, et al. Involvement of insulin/phosphoinositide 3-kinase/Akt signal pathway in 17B-estradiol-mediated neuroprotection. J Biol Chem. 2004;279:13086-13094.