Influence of LH and high-density lipoprotein cholesterol (HDL-C) on metformin response in women with polycystic ovary syndrome

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 157, Issue 2, 2011, Pages 180-184

  MacIel, Gustavo Arantes Rosa ^a   Hayashida, Sylvia Asaka Yamashita ^a   Da Costa, Lia Cruz Vaz ^a   Marcondes, José Antonio Miguel ^a   Da Fonseca, Angela Maggio ^a   Soares Jr , José Maria ^a   Baracat, Edmund Chada ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Anovulation; Insulin resistance; LH; Metformin; Polycystic ovary syndrome

Indexed keywords

ANDROSTENEDIONE; CHOLESTEROL; ESTRADIOL; FOLLITROPIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYPROGESTERONE; INSULIN; LUTEINIZING HORMONE; METFORMIN; PRASTERONE SULFATE; PROGESTERONE; TESTOSTERONE; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; DRUG RESPONSE; FEMALE; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; ORAL GLUCOSE TOLERANCE TEST; OVARY POLYCYSTIC DISEASE; PREDICTION; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 79960698645     PISSN: 03012115     EISSN: 18727654     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2011.03.028     Document Type: Article

References (33)

1. R.J. Chang, R.M. Nakamura, H.L. Judd, and S.A. Kaplan Insulin resistance in nonobese patients with polycystic ovarian disease J Clin Endocrinol Metab 57 1983 356 359 (Pubitemid 13032489)
2. A. Dunaif, J.R. Givens, F.P. Haseltine, and G.R. Merriam J.M. Hershman, Polycystic ovary syndrome 1992 Blackwell Scientific Publications, Inc. London
3. G.A.R. Maciel, J.M. Soares, E.L. Alves da Motta, M. Abi Haidar, G.R. de Lima, and E.C. Baracat Nonobese women with polycystic ovary syndrome respond better than obese women to treatment with metformin Fertil Steril 81 2 2004 355 360 (Pubitemid 38223916)
4. A.A. Bremer, and W.L. Miller The serine phosphorylation hypothesis of polycystic ovary syndrome: a unifying mechanism for hyperandrogenemia and insulin resistance Fertil Steril 89 5 2008 1039 1048
5. R.S. Legro, H.X. Barnhart, and W.D. Schlaff Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene J Clin Endocrinol Metab 93 3 2008 792 800 (Pubitemid 351398555)
6. G. Önalan, U. Goktolga, T. Ceyhan, T. Bagis, R. Onalan, and R. Pabucu Predictive value of glucose-insulin ratio in PCOS and profile of women who will benefit from metformin therapy: obese, lean, hyper or normoinsulinemic? Eur J Obstet Gynecol Reprod Biol 123 2 2005 204 211 (Pubitemid 41728367)
7. P. Moghetti, R. Castello, and C. Negri Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation J Clin Endocrinol Metab 85 1 2000 139 146 (Pubitemid 32268804)
8. J.H.M. Vrbíková, L. Stárka, and K. Vondra Prediction of the effect of metformin treatment in patients with polycystic ovary syndrome Gynecol Obstet Invest 53 2002 100 104 (Pubitemid 34310085)
9. R. Azziz, E. Carmina, and D. Dewailly Criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an androgen excess society guideline J Clin Endocrinol Metab 91 11 2006 4237 4245 (Pubitemid 44833391)
10. D. Ferriman, and J. Gallwey Clinical assessment of body hair growth in women J Clin Endocrinol Metab 21 1961 1440
11. ESHRE/ASRM PCW-TR Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) Hum Reprod 19 1 2004 41 47
12. L.C. Morin-Papunen, R.M. Koivunen, A. Ruokonen, and H.K. Martikainen Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome Fertil Steril 69 4 1998 691 696 (Pubitemid 28188465)
13. P.A. Essah, T. Apridonidze, M.J. Iuorno, and J.E. Nestler Effects of short-term and long-term metformin treatment on menstrual cyclicity in women with polycystic ovary syndrome Fertil Steril 86 1 2006 230 232 (Pubitemid 43962958)
14. S. Eisenhardt, N. Schwarzmann, and V. Henschel Early effects of metformin in women with polycystic ovary syndrome: a prospective randomized, double-blind, placebo-controlled trial J Clin Endocrinol Metab 91 3 2006 946 952 (Pubitemid 43357763)
15. E. Shikata, R. Yamamoto, and H. Takane Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin J Hum Genet 52 2 2007 117 122 (Pubitemid 46185105)
16. B.V.A. Geloneze, C.F. Stabe, J.C. Pareja, L.E. Rosado, E.C. Queiroz, and MA. Tambascia BRAMS investigators, HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome: Brazilian metabolic syndrome study (BRAMS) Arq Bras Endocrinol Metabol 53 2 2009 281 287
17. J.A.M. Marcondes, S.A.Y. Yamashita, G.A.R. Maciel, E.C. Baracat, and Halpern A Metformin in normal-weight hirsute women with polycystic ovary syndrome with normal insulin sensitivity Gynecol Endocrinol 23 5 2007 273 278 (Pubitemid 46897699)
18. D. Kleinbaum Statistics in the health sciences: logistic regression 1994 Springer-Verlag New York
19. R. McCall Fundamental statistics for psychology 1970 Harcourt, Brace & World New York
20. K.D. Young, and R.J. Lewis What is confidence? Part 2: detailed definition and determination of confidence intervals Ann Emerg Med 30 3 1997 311 318 (Pubitemid 27371873)
21. J.K. Distefano, and R.M. Watanabe Pharmacogenetics of anti-diabetes drugs Pharmaceuticals (Basel) 3 8 2010 2610 2646
22. A.J. Morales, G.A. Laughlin, T. Beutzow, H. Maheshwari, G. Baumann, and S.S. Yen Insulin, somatotropic, and luteinizing hormone axes in lean and obese women with polycystic ovary syndrome: common and distinct features J Clin Endocrinol Metab 81 1996 2854 2864 (Pubitemid 26326301)
23. J. Waldstreicher, N.F. Santoro, J.E. Hall, M. Filicori, and W.F. Crowley Jr. Hyperfunction of the hypothalamic-pituitary axis in women with polycystic ovarian disease: indirect evidence for partial gonadotroph desensitization J Clin Endocrinol Metab 66 1 1988 165 172 (Pubitemid 18027747)
24. A. Arroyo, G.A. Laughlin, A.J. Morales, and S.S.C. Yen Inappropriate gonadotropin secretion in polycystic ovary syndrome: influence of adiposity J Clin Endocrinol Metab 82 11 1997 3728 3733 (Pubitemid 27509362)
25. A.D. Genazzani, C. Battaglia, B. Malavasi, C. Strucchi, F. Tortolani, and O. Gamba Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome Fertil Steril 81 1 2004 114 119 (Pubitemid 38058335)
26. A.V. Roland, and S.M. Moenter Prenatal androgenization of female mice programs an increase in firing activity of gonadotropin-releasing hormone (GnRH) neurons that is reversed by metformin treatment in adulthood Endocrinology 152 2 2011 618 628
27. E.Y. Adashi, A.J.W. Hsueh, and S.S.C. Yen Insulin enhancement of luteinizing hormone and follicle-stimulating hormone release by cultured pituitary cells Endocrinology 108 4 1981 1441 1449 (Pubitemid 11079170)
28. R. Soldani, A. Cagnacci, and S.S. Yen Insulin, insulin-like growth factor I (IGF-I) and IGF-II enhance basal and gonadotropin-releasing hormone-stimulated luteinizing hormone release from rat anterior pituitary cells in vitro Eur J Endocrinol 131 6 1994 641 645 (Pubitemid 24377196)
29. M.A. Lawson, S. Jain, S. Sun, K. Patel, P.J. Malcolm, and R.J. Chang Evidence for insulin suppression of baseline luteinizing hormone in women with polycystic ovarian syndrome and normal women J Clin Endocrinol Metab 93 6 2008 2089 2096 (Pubitemid 351831520)
30. K.J. Brothers, S. Wu, and S.A. DiVall Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor Cell Metab 12 3 2010 295 305
31. M.-J. Chen, W.-S. Yang, J.-H. Yang, C.K. Hsiao, Y.-S. Yang, and H.-N. Ho Low sex hormone-binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS Hum Reprod 21 9 2006 2266 2271 (Pubitemid 44530599)
32. H.J. Teede, S.K. Hutchison, and S. Zoungas The management of insulin resistance in polycystic ovary syndrome Trends Endocrinol Metab 18 7 2007 273 279 (Pubitemid 47337061)
33. S. Sam, and A. Dunaif Polycystic ovary syndrome: syndrome XX? Trends Endocrinol Metab 14 8 2003 365 370 (Pubitemid 37236957)