Effects of short-term and long-term metformin treatment on menstrual cyclicity in women with polycystic ovary syndrome

Fertility and Sterility

Volumn 86, Issue 1, 2006, Pages 230-232

  Essah, Paulina A ^a   Apridonidze, Teimuraz ^a   Iuorno, Maria J ^a   Nestler, John E ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METFORMIN;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FOLLOW UP; GASTROINTESTINAL SYMPTOM; HUMAN; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TREATMENT DURATION;

ADULT; FEMALE; HUMANS; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; LONGITUDINAL STUDIES; MENSTRUAL CYCLE; METFORMIN; POLYCYSTIC OVARY SYNDROME; RETROSPECTIVE STUDIES; TIME FACTORS; TREATMENT OUTCOME; WOMEN;

EID: 33745481313     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2005.12.036     Document Type: Article

References (8)

1. Dunaif A., Segal K.R., Shelley D.R., Green G., Dobrjansky A., and Licholai T. Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome. Diabetes 41 (1992) 1257-1266
2. Fleming R., Hopkinson Z.E., Wallace A.M., Greer I.A., and Sattar N. Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial. J Clin Endocrinol Metab 87 (2002) 569-574
3. Zawadzki J.K., and Dunaif A. Diagnostic criteria for polycystic ovary syndrome. towards a rational approach (1992), Blackwell Scientific, Boston 377-384
4. Treloar A.E., Boynton R.E., Behn B.G., and Brown B.W. Variation of the human menstrual cycle through reproductive life. Int J Fertil 12 (1967) 77-126
5. Dunaif A. Insulin resistance and the polycystic ovary syndrome. mechanism and implications for pathogenesis. Endocr Rev 18 (1997) 774-800
6. Costello M.F., and Eden J.A. A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome. Fertil Steril 79 (2003) 1-13
7. Glueck C.J., Wang P., Fontaine R., Tracy T., and Sieve-Smith L. Metformin-induced resumption of normal menses in 39 of 43 (91%) previously amenorrheic women with the polycystic ovary syndrome. Metabolism 48 (1999) 511-519
8. Moghetti P., Castello R., Negri C., Tosi F., Perrone F., Caputo M., et al. Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome. a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. J Clin Endocrinol Metab 85 (2000) 139-146