Incidence and persistence of 8-oxo-7,8-dihydroguanine within a hairpin intermediate exacerbates a toxic oxidation cycle associated with trinucleotide repeat expansion

DNA Repair

Volumn 10, Issue 8, 2011, Pages 887-896

  Jarem, Daniel A ^a   Wilson, Nicole R ^a   Schermerhorn, Kelly M ^a   Delaney, Sarah ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

OGG1; Toxic oxidation cycle; Trinucleotide repeat expansion

Indexed keywords

8 HYDROXYGUANINE; DOUBLE STRANDED DNA;

ARTICLE; CELL CYCLE; DISSOCIATION CONSTANT; DNA DAMAGE; DNA HAIRPIN; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SYNTHESIS; EXCISION REPAIR; GEL MOBILITY SHIFT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INCIDENCE; PRIORITY JOURNAL; SOMATIC CELL; TOXIC OXIDATION CYCLE; TRINUCLEOTIDE REPEAT;

BASE SEQUENCE; DNA GLYCOSYLASES; ENZYME ASSAYS; GUANINE; HUMANS; INVERTED REPEAT SEQUENCES; KINETICS; NUCLEIC ACID CONFORMATION; OXIDATION-REDUCTION; POLYDEOXYRIBONUCLEOTIDES; PROTEIN BINDING; TRINUCLEOTIDE REPEAT EXPANSION;

MAMMALIA;

EID: 79960698114     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2011.06.003     Document Type: Article

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