Sodium valproate induces mitochondria-dependent apoptosis in human hepatoblastoma cells

Chinese Medical Journal

Volumn 124, Issue 14, 2011, Pages 2167-2172

  Wang, Wei ^a   Liao, Xiao Li ^a   Chen, Jing Hong ^a   Li, Dan Dan ^b   Lin, Chun Lan ^a   Yan, Yu Xia ^a   Tang, Yu Hui ^c   Jiang, Jian Wei ^a  

^a MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^c GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Apoptosis; C Jun N terminal kinases; Hepatoblastoma; Mitochondria; Sodium valproate

Indexed keywords

CASPASE 3; CASPASE 9; PROTEIN BAX; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE; VALPROIC ACID;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GROWTH INHIBITION; HEPATOBLASTOMA; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MITOCHONDRIAL MEMBRANE POTENTIAL; PLOIDY; PROTEIN EXPRESSION; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; FLOW CYTOMETRY; HEP G2 CELLS; HEPATOBLASTOMA; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; VALPROIC ACID;

EID: 79960692956     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2011.14.016     Document Type: Article

References (22)

1. Liu XG, Dai L, Yang C, Zhao ZH, Zhang XR, Zhang ZG, et al. Study on the signalling pathway of inhibitory effect of adreno-medullin on the growth of cultured glomerular mesangial cells. Chin Med J 2005; 118: 1374-1379.
2. 2+response accompanied with its weak inhibition of protein kinase C in human astrocytoma cells. Progr Neuro Psychopharmacol Biol Psychiatr 2007; 31: 600-604.
3. Greenblatt DY, Vaccaro AM, Jaskula-Sztul R, Ning L, Haymart M, Kunnimalaiyaan M, et al. Valproic acid activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells. Oncologist 2007; 12: 942-951.
4. Rocchi P, Tonelli R, Camerin C, Purgato S, Fronza R, Bianucci F, et al. p21WaHf1/Cip1 is a common target induced by short-chain fatty acid HDAC inhibitors (valproic acid, tributyrin and sodium butyrate) in neuroblastoma cells. Oncol Rep 2005; 13: 1139-1144.
5. + T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia. Blood 2010; 16: 1908-1918.
6. Shi CW, Zhao X, Li J, Cao LL, Sun JJ. Effects and mechanisms of VPA on cell apoptosis in the human hepotoma cell-HepG2. J Shandong Univ (Health Sci) (Chin) 2007; 45: 1239-1242.
7. Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003; 3: 768-780.
8. Gottlicher M, Minucci S, Zhu P, Kramer OH, Schimpf A, Giavara S, et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 2001; 20: 6969-6978.
9. Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007; 26: 3291-3310.
10. Friday BB, Adjei AA. Advances in targeting the Ras/Raf/MEK/Erk mitogen-activated protein kinase cascade with MEK inhibitors for cancer therapy. Clin Cancer Res 2008; 14: 342-346.
11. Shaul YD, Seger R. The MEK/ERK cascade: from signaling specificity to diverse functions. Biochim Biophys Acta 2007; 1773: 1213-1226.
12. Wagner EF, Nebreda AR. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 2009; 9: 537-549.
13. Dhanasekaran DN, Reddy EP. JNK signaling in apoptosis. Oncogene 2008; 27: 6245-6251.
14. Dhillon AS, Hagan S, Rath O, Kolch W. MAP kinase signalling pathways in cancer. Oncogene 2007; 26: 3279-3290.
15. Kaina B, Roos WP, Christmann M. DNA damage response and the balance between cell survival and cell death. Checkpoint Controls Targets Cancer Ther 2010; 2: 95-108.
16. Sung DK, Chang YS, Kang S, Song HY, Park WS, Lee BH. Comparative evaluation of hypoxic-ischemic brain injury by flow cytometric analysis of mitochondrial membrane potential with JC-1 in neonatal rats. J Neurosci Methods 2010; 193: 232-238.
17. Yamanegi K, Yamane J, Hata M, Ohyama H, Yamada N, Kato-Kogoe N, et al. Sodium valproate, a histone deacetylase inhibitor, decreases the secretion of soluble Fas by human osteosarcoma cells and increases their sensitivity to Fas-mediated cell death. J Cancer Res Clin Oncol 2009; 135: 879-889.
18. Fan J, Li R, Zhang R, Liu HL, Zhang N, Zhang FQ, et al. Effect of Bcl-2 and Bax on survival of side population cells from hepatocellular carcinoma cells. World J Gastroenterol 2007; 13: 6053-6059.
19. Wang LX, Sun Y, Chen C, Huang XY, Lin Q, Qian GQ, et al. Effects and mechanism of oridonin on pulmonary hypertension induced by chronic hypoxia-hypercapnia in rats. Chin Med J 2009; 122: 1380-1387.
20. Adams JM, Cory S. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 2007; 26: 1324-1337.
21. Mazumder S, Plesca D, Almasan A. Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis. Methods Mol Biol 2008; 414: 13-21.
22. Yao H, Tang X, Shao X, Feng L, Wu N, Yao K. Parthenolide protects human lens epithelial cells from oxidative stress-induced apoptosis via inhibition of activation of caspase-3 and caspase-9. Cell Res 2007; 17: 565-571.