Sodium valproate at therapeutic concentrations changes Ca2+response accompanied with its weak inhibition of protein kinase C in human astrocytoma cells

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 31, Issue 3, 2007, Pages 600-604

  Kurita, Masatake ^a,b   Nishino, Satoshi ^a,b   Ohtomo, Kouji ^a   Rai, Mayumi ^a   Shirakawa, Hisayoshi ^a   Mashiko, Hirobumi ^a   Niwa, Shin Ichi ^a   Nakahata, Norimichi ^b  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

1321N1 human astrocytoma cells; Bipolar mood disorder; Intracellular calcium mobilization; Protein kinase C; Valproate

Indexed keywords

CALCIUM ION; CARBACHOL; LITHIUM CHLORIDE; LITHIUM ION; PROTEIN KINASE C; QUINUCLIDINYL BENZILATE; VALPROIC ACID;

ARTICLE; ASTROCYTOMA CELL; CALCIUM CELL LEVEL; CELL MEMBRANE; CONCENTRATION RESPONSE; CYTOSOL; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; MOOD DISORDER; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION;

ASTROCYTOMA; BINDING, COMPETITIVE; CALCIUM; CARBACHOL; CELL LINE, TUMOR; CELL MEMBRANE; CHOLINERGIC AGONISTS; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; MUSCARINIC ANTAGONISTS; PROTEIN KINASE C; QUINUCLIDINYL BENZILATE; TIME FACTORS; VALPROIC ACID;

EID: 33947496647     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2006.11.019     Document Type: Article

References (24)

1. Bebchuk J.M., Arfken C.L., Dolan-Manji S., Murphy J., Hasanat K., and Manji H.K. A preliminary investigation of a protein kinase C inhibitor in the treatment of acute mania. Arch Gen Psychiatry 57 (2000) 95-97
2. Berridge M.J., and Irvine R.F. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 312 (1984) 315-321
3. Bowden C.L. Predictors of response to divalproex and lithium. J Clin Psychiatry 3 (1995) 25-30
4. Casebolt T.L., and Jope R.S. Effects of chronic lithium treatment on protein kinase C and cyclic AMP-dependent protein phosphorylation. Biol Psychiatry 29 (1991) 233-243
5. Chen G., Manji H.K., Hawver D.B., Wright C.B., and Potter W.Z. Chronic sodium valproate selectively decreases protein kinase C alpha and epsilon in vitro. J Neurochem 63 (1994) 2361-2364
6. Fenn H.H., Robinson D., Luby V., Dangel C., Buxton E., Beattie M., et al. Trends in pharmacotherapy of schizoaffective and bipolar affective disorders: a 5-year naturalistic study. Am J Psychiatry 153 (1996) 711-713
7. Friedman E., Hoau Y.W., Levinson D., Connell T.A., and Singh H. Altered platelet protein kinase C activity in bipolar affective disorder, manic episode. Biol Psychiatry 33 (1993) 520-525
8. Hu K., Mochly-Rosen D., and Boutjdir M. Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Ca(2+) channels. Am J Physiol Heart Circ Physiol 279 (2000) 2658-2664
9. Johannessen C.U. Mechanisms of action of valproate. Neurochem Int 37 (2000) 103-110
10. Keck Jr. P., McElroy S.L., and Strakowski S.M. Anticonvulsants and antipsychotics in the treatment of bipolar disorder. J Clin Psychiatry 6 (1998) 74-81
11. 1 and muscarinic receptor-mediated signalling pathways by phorbol ester in human astrocytoma cells. Clin Exp Pharmacol Physiol 27 (2000) 208-211
12. 2+ response in protein kinase C down-regulated human astrocytoma cells. Eur J Pharmacol 442 (2002) 17-22
13. Lenox R.H., Watson D.G., Patel J., and Ellis J. Chronic lithium administration alters a prominent PKC substrate in rat hippocampus. Brain Res 570 (1992) 333-340
14. Manji H.K., and Lenox R.H. Ziskind-Somerfeld Research Award. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness. Biol Psychiatry 46 (1999) 1328-1351
15. Manji H.K., Etcheberrigaray R., Chen G., and Olds J.L. Lithium decreases membrane-associated protein kinase C in hippocampus: selectivity for the alpha isozyme. J Neurochem 61 (1993) 2303-2310
16. Manji H.K., Bebchuk J.M., Moore G.J., Glitz D., Hasanat K.A., and Chen G. Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: therapeutic implications. J Clin Psychiatry 60 (1999) 27-39
17. Moscovich D.G., Belmaker R.H., Agam G., and Livne A. Inositol-1-phosphatase in red blood cells of manic-depressive patients before and during treatment with lithium. Biol Psychiatry 27 (1990) 552-555
18. Nelsestuen G.L., and Bazzi M.D. Activation and regulation of protein kinase C enzymes. J Bioenerg Biomembranes 23 (1991) 43-61
19. Nishizuka Y., Shearman M.S., Oda T., Berry N., Shinomura T., Asaoka Y., et al. Protein kinase C family and nervous function. Prog Brain Res 89 (1991) 125-141
20. Rogawski M.A., and Porter R.J. Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol Rev 42 (1990) 223-286
21. Schou M. Forty years of lithium treatment. Arch Gen Psychiatry 54 (1997) 9-13
22. Sil'kis I.G. Activation by GABAb, reduction of the intracellular concentration of Ca++, and inhibition of protein kinases are possible mechanisms of the long-term posttetanic modification of the efficiency of inhibitory transmission in the new cortex. Neurosci Behav Physiol 26 (1996) 88-97
23. 2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306 (1983) 67-69
24. Yamaji T., Kagaya A., Uchitomi Y., Yokata N., and Yamawaki S. Effects of carbamazepine and sodium valproate on 5-HT-induced calcium increase in individual C6 rat glioma cells. Neuropsychobiology 34 (1996) 22-25