Study on the signalling pathway of inhibitory effect of adrenomedullin on the growth of cultured glomerular mesangial cells

Chinese Medical Journal

Volumn 118, Issue 16, 2005, Pages 1374-1379

  Liu, Xue Guang ^a   Dai, Lu ^a   Yang, Chen ^a   Zhao, Zhong Hua ^a   Zhang, Xiu Rong ^a   Zhang, Zhi Gang ^a   Guo, Mu Yi ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Adrenomedullin; Glomerular mesangium; Mitogen activated protein kinases

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADENYLATE CYCLASE ACTIVATOR; ADRENOMEDULLIN; BROXURIDINE; CALCITONIN GENE RELATED PEPTIDE; CURCUMIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FORSKOLIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GLOMERULUS; GROWTH INHIBITION; MESANGIUM CELL; NONHUMAN; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADRENOMEDULLIN; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLOMERULAR MESANGIUM; JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDES; RATS; SIGNAL TRANSDUCTION;

EID: 24044500591     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Kitamura K, Kangawa K, Kawamoto M, et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 1993;192:553-560.
2. Jougasaki M, Wei CM, Aarhus LL, et al. Renal localization and actions of adrenomendullin: a natriuretic peptide. Am J Physiol 1995;268:F657-663.
3. Masashi M, Akira S, Tetsuya N, et al. Role of adrenomedullin and its receptor system in renal pathophysiology. Peptides 2001;22:1925-1931.
4. Liu XG, Zhang ZG, Zhang XR, et al. The localization of adrenomdullin in rat kidney tissue and its inhibitory effect of the growth of cultured rat mesangial cells. Chin Med Sci J (Chin) 2002;17:129-133.
5. Chini EN, Choi E, Grande JP, et al. Adrenomedullin suppresses mitogenesis in rat mesangial cells via cAMP pathway. Biochem Biophys Res commun 1995;215:868-873.
6. Michibata H, Mukoyama M, Tanaka I, et al. Autocrine/paracrine role of adrenomedullin in cultured endothelial and mesangial cells. Kidney Int 1998;53:979-985.
7. Segawa K, Minami K, Sata T, et al. Inhibitory effect of adrenomedullin on rat mesangial cell mitogenesis. Nephron 1996;74:577-579.
8. Parameswaran N, Nambi P, Brooks DP, et al. Regulation of glomerular mesangial cell proliferation in culture by adrenomedullin. Eur J Pharmacol 1999;372:85-95.
9. Parameswaran N, Hall CS, McCabe LR, et al. Adrenomedullin increases AP-1 expression in rat mesangial cells via activation of protein kinase-A and p38 MAPK. Cell Physiol Biochem 2003;13:367-74.
10. Nishikimi T, Mori Y, Kobayashi N, et al. Renoprotective effect of chronic adrenomedullin infusion in Dahl salt-sensitive rats. Hypertension 2002;39:1077-1082.
11. Nishimatsu H, Hirata Y, Shindo T, et al. Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury: studies on transgenic/knockout mice of adrenomedullin gene. Circ Res 2002;90:657-663.
12. Shi Y, Yoshihara F, Nakahama H, et al. A novel immunosuppressant FTY720 ameliorates proteinuria and alterations of intrarenal adrenomedullin in rats with autoimmune glomerulonephritis. Regul Pept 2005;15: 127:233-238.
13. Mukoyama M, Nagae T, Yokoi H, et al. Renal actions and renoprotective role of adrenomedullin. Nippon Rinsho 2004;62(Suppl 9):237-241.
14. Matsumoto M, Fujimoto S, Iwatsubo S, et al. Adrenomedullin (AM) and receptor-activity-modifying proteins in glomeruli with Thy. 1 glomerulonephritis. Clin Exp Nephrol 2004;8:316-321.
15. Zhang M, Guo MY, Chen Q, et al. Isolation and culture of rat glomerular mesangial cells. Acta Acad Med Shanghai (Chin) 1995;22:207-209.
16. Kohno M, Yasunari K, Minami M, et al. Regulation of rat mesangial cell migration by PDGF, angiotensin II, and adrenomedullin. J Am Soc Nephrol 1999;10:2495-2502.
17. Chini EN, Chini CC, Bolliger C, et al. Cytoprotective effects of adrenomedullin in glomerular cell injury: centrol role of cAMP signaling pathway. Kidney Int 1997;52:917-925.
18. Kohno M, Yasunari K, Yokokawa K, et al. Interaction of adrenomedullin and PDGF on rat mesangial cell production of endothelin. Hypertension 1996;27:663-667.
19. Tian W, Zhang Z and Cohen DM. MAPK signaling and the kidney. Am J Physiol Ren Physiol 2000;279:F593-604.
20. Parameswaran N, Spielman WS, Pullen M, et al. Mechanism of adrenomedullin-stimulated hyaluronic acid release in rat mesangial cells. Eur J Pharmacol 1999;370:313-318.
21. Dotsch J, Schoof E, Schocklmann HO, et al. Nitric oxide increases adrenomedullin receptor function in rat mesangial cells. Kidney Int 2002;61:1707-1713.
22. Parameswaran N, Nowak W, Hall CS, et al. Cellular and molecular actions of adrenomedullin in glomerular mesangial cells. Peptides 2001;22:1919-1924.
23. Parameswaran N, Spielman WS, Brooks DP, et al. SB203580 reverses adrenomedullin's effect on proliferation, and apoptosis in cultured mesangial cells. Eur J Pharmacol 1999;371:75-82.
24. Huang H, Ma C, Yang M, et al. Adrenomedullin impairs the profibrotic effects of transforming growth factor-beta1 through recruiting Smad6 protein in human renal tubular cells. Cell Physiol Biochem 2005;15:117-124.
25. Yoshio T, Koji I, Maho O, et al. Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator. FEBS J 2004;556:53-58.