Young and middle-aged rats exhibit isometric forelimb force control deficits in a model of early-stage Parkinson's disease

Behavioural Brain Research

Volumn 225, Issue 1, 2011, Pages 97-103

  Bethel Brown, Crystal S ^a   Morris, Jill K ^a   Stanford, John A ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

Behavioral; Force control; Force release; Forelimb; Isometric; Nigrostriatal; Operant; Parkinson's disease; Tremor

Indexed keywords

DOPAMINE; OXIDOPAMINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY POSTURE; CONTROLLED STUDY; DISEASE MODEL; FORELIMB; MALE; MOTOR CONTROL; MOTOR DYSFUNCTION; MUSCLE FORCE; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; TASK PERFORMANCE; TRAINING; TREMOR;

ADRENERGIC AGENTS; AGING; ANIMALS; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOPAMINE; FORELIMB; MALE; MOTOR ACTIVITY; OXIDOPAMINE; PARKINSON DISEASE; RATS; RATS, SPRAGUE-DAWLEY; STEREOTYPED BEHAVIOR; TIME FACTORS; TREMOR;

EID: 79960673874     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.07.002     Document Type: Article

References (56)

1. Agid Y., Javoy-Agid F., Ruberg M. Biochemistry of neurotransmitters in Parkinson's disease. Mov Disord 1987, 2:166-230.
2. Barnéoud P., Descombris E., Aubin N., Abrous D.N. Evaluation of simple and complex sensorimotor behaviours in rats with a partial lesion of the dopaminergic nigrostriatal system. Eur J Neurosci 2000, 12:322-336.
3. Benecke R., Rothwell J.C., Day B.L., Dick J.P., Marsden C.D. Motor strategies involved in the performance of sequential movements. Exp Brain Res 1986, 63:585-595.
4. Bethel-Brown C.S., Zhang H., Fowler S.C., Chertoff M.E., Watson G.S., Stanford J.A. Within-session analysis of amphetamine-elicited rotation behavior reveals differences between young and middle-aged F344/BN rats with partial unilateral striatal dopamine depletion. Pharmacol Biochem Behav 2010, 96:423-428.
5. Cass W.A., Harned M.E., Bailey S.L. Enhanced effects of 6-hydroxydopamine on evoked overflow of striatal dopamine in aged rats. Brain Res 2002, 938:29-37.
6. Caviness J.N., Shill H.A., Sabbagh M.N., Evidente V.G.H., Hernandes J.L., Adler C.H. Corticomuscular coherence is increased in the small postural tremor of Parkinson's disease. Mov Disord 2006, 21:492-499.
7. Deumens R., Blokland A., Prickaerts J. Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway. Exp Neurol 2002, 175:303-317.
8. Ding F., Luan L., Ai Y., Walton A., Gerhardt G.A., Gash D.M., et al. Development of a stable, early stage unilateral model of Parkinson's disease in middle-aged rhesus monkey. Exp Neurol 2008, 212:431-439.
9. Duval C., Strafella A.P., Sadikot A.F. The impact of ventrolateral thalamotomy on high-frequency components of tremor. Clin Neurophysiol 2005, 116:1391-1399.
10. Enna S.J., Reisman S.A., Stanford J.A. CGP 56999A, a GABA(B) receptor antagonist, enhances expression of brain-derived neurotrophic factor and attenuates dopamine depletion in the rat corpus striatum following a 6-hydroxydopamine lesion of the nigrostriatal pathway. Neurosci Lett 2006, 406:102-106.
11. Fearnley J.M., Lees A.J. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 1991, 114:2283-2301.
12. Fowler S.C., Davison K.H., Stanford J.A. Unlike haloperidol, clozapine slows and dampens rats' forelimb force oscillations and decreases force output in a press-while-licking behavioral task. Psychopharmacology 1994, 116:19-25.
13. Fowler S.C., Liao R.M., Skjoldager P. A new rodent model for neuroleptics-induced pseudo-parkinsonism: low doses of haloperidol increase forelimb tremor in the rat. Behav Neurosci 1990, 104:449-456.
14. Fowler S.C., Birkestrand B.R., Chen R., Moss S.J., Vorontsova E., Wang G., et al. A force-plate actometer for quantifying rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor. J Neurosci Methods 2001, 107:107-124.
15. Franz E.A., Miller J. Effects of response readiness on reaction time and force output in people with Parkinson's disease. Brain 2002, 125:1733-1750.
16. Gash D.M., Zhang Z., Ovadia A., Cass W.A., Yi A., Simmerman L., et al. Functional recovery in parkinsonian monkeys treated with GDNF. Nature 1996, 380:252-255.
17. Hebert M.A., Gerhardt G.A. Normal and drug-induced locomotor behavior in aging: comparison to evoked DA release and tissue content in Fischer 344 rats. Brain Res 1998, 797:42-54.
18. Hebert M.A., Gerhardt G.A. Age-related changes in the capacity, rate, and modulation of dopamine uptake within the striatum and nucleus accumbens of Fischer 344 rats: an in vivo electrochemical study. J Pharmacol Exp Ther 1999, 288:879-887.
19. Hebert M.A., Larson G.A., Zahniser N.R., Gerhardt G.A. Age-related reductions in [3H]WIN 35,428 binding to the dopamine transporter in nigrostriatal and mesolimbic brain regions of the Fischer 344 rat. J Pharmacol Exp Ther 1999, 288:1334-1339.
20. Homberg V., Reiners K., Hefter H., Freund H.J. The muscle activity spectrum: spectral analysis of muscle force as an estimator of overall motor unit activity. Electroencephalogr Clin Neurophysiol 1986, 63:209-222.
21. Hudson J.L., van Horne C.G., Stromber I., Brock S., Clayton J., Masserano J., et al. Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats. Brain Res 1993, 626:167-174.
22. Johnston R.E., Schallert T., Becker J.B. Akinesia and postural abnormality after unilateral dopamine depletion. Brain Res 1999, 104:189-196.
23. Jordan N., Sager H.J. The role of the striatum in motor learning: dissociations between isometric motor control processes in Parkinson's disease. Int J Neurosci 1994, 77:153-165.
24. Jordan N., Sagar H.J., Cooper J.A. A component analysis of the generation and release of isometric force in Parkinson's disease. J Neurol Neurosurg Psychiatry 1992, 55:572-576.
25. Klass M., Baudry S., Duchateau J. Voluntary activation during maximal contraction with advancing age: a brief review. Eur J Appl Physiol 2007, 100:543-551.
26. Kunesch E., Schnitzler A., Tyercha C., Knecht S., Stelmach G. Altered force release control in Parkinson's disease. Behav Brain Res 1995, 67:43-49.
27. Liao R.M., Fowler S.C., Kallman M.J. Quantifying operant behavior deficits in rats with bilateral 6-hydroxydopamine lesions of the ventrolateral striatum. Chin J Physiol 1997, 40:71-78.
28. Lindner M.D., Plone M.A., Francis J.M., Blaney T.J., Salamone J.D., Emerich D.F. Rats with partial striatal dopamine depletions exhibit robust and long-lasting behavioral deficits in a simple fixed-ratio bar-pressing task. Behav Brain Res 1997, 86:25-40.
29. Lindner M.D., Cain C.K., Plone M.A., Frydel B.R., Blaney T.J., Emerich DF, et al. Incomplete nigrostriatal dopaminergic cell loss and partial reductions in striatal dopamine produce akinesia, rigidity, tremor and cognitive deficits in middle-aged rats. Behav Brain Res 1999, 102:1-16.
30. Marshall J.F., Drew M.C., Neve K.A. Recovery of function after mesotelencephalic dopaminergic injury in senescence. Brain Res 1983, 259:249-260.
31. Miklyaeva E.I., Castañeda E., Whishaw I.Q. Skilled reaching deficits in unilateral dopamine-depleted rats: impairments in movement and posture and compensatory adjustments. J Neurosci 1994, 14:7148-7158.
32. National Research Council Guide for the care and use of laboratory animals 1996, National Academy Press, Washington, D.C.
33. Park J.H., Stelmach G.E. Force development during target-directed isometric force production in Parkinson's disease. Neurosci Lett 2007, 412:173-178.
34. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1998, Academic Press, San Diego. 4th ed.
35. Pradhan S.D., Brewer B.R., Carvell G.E., Sparto P.J., Delitto A., Matsuoka Y. Assessment of fine motor control in individuals with Parkinson's disease using force tracking with a secondary cognitive task. J Neurol Phys Ther 2010, 34:32-40.
36. Robichaud J.A., Pfann K.D., Vaillancourt D.E., Comella C.L., Corcos D.M. Force control and disease severity in Parkinson's disease. Mov Disord 2005, 20:441-450.
37. Salamone J.D., Correa M., Farrar A.M., Nunes E.J., Pardo M. Dopamine, behavioral economics, and effort. Front Behav Neurosci 2009, 3:13.
38. Schallert T., Hall S. 'Disengage' sensorimotor deficit following apparent recovery from unilateral dopamine depletion. Behav Brain Res 1988, 30:15-24.
39. Schallert T., DeRyck M., Whishaw I.Q., Ramirez V.D., Teitelbaum P. Excessive bracing reactions and their control by atropine and l-DOPA in an animal analog of Parkinsonism. Exp Neurol 1979, 64:33-43.
40. Stanford J.A., Bethel-Brown C.S., Fowler S.C. Press-while-licking task. Encyclopedia of movement disorders 2010, vol. 3:470-473. Elsevier, Oxford, U.K.
41. Stanford J.A., Fowler S.C. Similarities and differences between the subchronic and withdrawal effects of clozapine and olanzapine on forelimb force steadiness. Psychopharmacology 1997, 132:408-414.
42. Stanford J.A., Fowler S.C. Subchronic effects of clozapine and haloperidol on rats' forelimb force and duration during a press-while-licking task. Psychopharmacology 1997, 130:249-253.
43. Stanford J.A., Fowler S.C. Clozapine-like motor effects of the atypical antipsychotic risperidone in rats. Neurosci Lett 2000, 285:189-192.
44. Stanford J.A., Fowler S.C. Dantrolene diminishes forelimb force-related tremor at doses that do not decrease operant behavior in the rat. Exp Clin Psychopharmacol 2002, 10:385-391.
45. Stanford J.A., Hebert M.A., Gerhardt G.A. Biochemical and anatomical change in basal ganglia of aging animals. Functional neurobiology of aging 2001, 727-735. Academic Press, San Diego. P.R. in: Hof, C.V. Mobbs (Eds.).
46. Stanford J.A., Vorontsova E., Fowler S.C. The relationship between isometric force requirement and forelimb tremor in the rat. Physiol Behav 2000, 69:285-293.
47. Steg G., Ingvarsson P.E., Johnels B., Valls M., Thorselius M. Objective measurement of motor disability in Parkinson's disease. Acta Neurol Scand Suppl 1989, 126:67-75.
48. Tamas A., Lubics A., Lengvari I., Reglodi D. Effects of age, gender, and gonadectomy on neurochemistry and behavior in animal models of Parkinson's disease. Endocrine 2006, 29:275-287.
49. Tian S.L., Liu Y., Li L., Fu W.J., Peng Ch. Mechanomyography is more sensitive than EMG in detecting age-related sarcopenia. J Biomech 2010, 43:551-556.
50. Vaillancourt D.E., Newell K.M. The dynamics of resting and postural tremor in Parkinson's disease. Clin Neurophysiol 2000, 11:2046-2056.
51. Weintraub D., Comella C.L., Horn S. Parkinson's disease-Part 1: Pathophysiology, symptoms, burden, diagnosis, and assessment. Am J Manag Care 2008, 14:40-48.
52. Whishaw I.Q., Woodward N.C., Miklyaeya E.I., Pellis S.M. Analysis of limb use by control rats and unilateral DA-depleted rats in the Montoya staircase test: movements, impairments and compensatory strategies. Behav Brain Res 1997, 89:167-177.
53. Wierzbicka M.M., Wiegner A.W., Logigian E.L., Young R.R. Abnormal most-rapid isometric contractions in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 1991, 54:210-216.
54. Woodlee M.T., Kane J.R., Chang J., Cormack L.K., Schaller T. Enhanced function in the good forelimb of hemi-parkinson rats: compensatory adaptation for contralateral postural instability?. Exp Neurol 2008, 211:511-517.
55. Yamada H., Masuda T., Okada M. Age-related EMG variables during maximum voluntary contraction. Percept Mot Skills 2002, 95:10-14.
56. Ziv I., Avraham M., Dabby R., Zoldan J., Djaldetti R., Melamed E. Early-occurrence of manual motor blocks in Parkinson's disease: a quantitative assessment. Acta Neurol Scand 1999, 99:106-111.