Evaluation of simple and complex sensorimotor behaviours in rats with a partial lesion of the dopaminergic nigrostriatal system

European Journal of Neuroscience

Volumn 12, Issue 1, 2000, Pages 322-336

  Barnéoud, Pascal ^a   Descombris, Eric ^a   Aubin, Nadine ^a   Abrous, Djoher N ^b  

^a SANOFI   (France)

^b Domaine de Carreire   (United States)

Author keywords

Dopamine; Partial lesion; Paw reaching; Rat

Indexed keywords

AMPHETAMINE; DOPAMINE; OXIDOPAMINE;

AKINESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; DENERVATION; DOPAMINERGIC NERVE CELL; FEMALE; FOREBRAIN; IMMUNOHISTOCHEMISTRY; LIMB MOVEMENT; MOTOR COORDINATION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SENSORIMOTOR CORTEX;

AMPHETAMINE; ANIMALS; APOMORPHINE; CORPUS STRIATUM; DENERVATION; DOPAMINE; FEMALE; FORELIMB; FUNCTIONAL LATERALITY; GAIT; MOTOR ACTIVITY; OXIDOPAMINE; POSTURE; PSYCHOMOTOR PERFORMANCE; RATS; ROTATION;

EID: 0033959547     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00896.x     Document Type: Article

References (43)

1. Abrous, D.N., Torres, E.M. & Dunnett, S.B. (1993.) Dopaminergic grafts implanted into the neonatal or adult striatum: comparative effects on rotation and paw reaching deficits induced by subsequent unilateral nigrostriatal lesions in adulthood. Neuroscience, 54, 657-658.
2. Abrous, D.N. & Dunnett, S.B. (1994) Paw reaching in rats: the staircase test. Neurosci. Protoc., 10, 1-11.
3. Agid, Y., Javoy-Agid, F. & Ruberg, M. (1987) Biochemistry of neurotransmitters in Parkinson's disease. In Marsden, C.D. & Fahn, S. (eds), Movement Disorders 2. Butterworths, London, pp. 166-230.
4. Amalric, M., Moukhles, H., Nieoullon, A. & Daszuta, A. (1995) Complex deficits on reaction time performance following bilateral intrastriatal 6-OHDA infusion in the rat. Eur. J. Neurosci., 7, 972-980.
5. Barnéoud, P., Parmentier, S., Mazadier, M., Miquet, J.M., Boireau, A., Dubédat, P. & Blanchard, J.-C. (1995) Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat. Neuroscience, 67, 837-848.
6. Berger, K., Przedborski, S. & Cadet, J.L. (1991) Retrograde degeneration of nigrostriatal neurons induced by intrastriatal 6-hydroxydopamine injection in rats. Brain Res. Bull., 26, 301-307.
7. Björklund, A., Rosenblad, C., Winkler, C. & Kirik, D. (1997) Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease. Neurobiol. Dis., 4, 186-200.
8. Carli, M., Evenden, J.L. & Robbins, T.W. (1985) Depletion of unilateral striatal dopamine impairs initiation of contralateral actions and not sensory attention. Nature, 313, 679-682.
9. Carman, L.S., Gage, F.H. & Shults, C.W. (1991) Partial lesion of the substantia nigra: relation between extent of lesion and rotational behavior. Brain Res., 553, 275-283.
10. Chang, J.-W., Wachtel, S.R., Young, D. & Kang, U.-J. (1999) Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: studies on medial forebrain bundle and striatal lesions. Neuroscience, 88, 617-628.
11. Cousins, M.S. & Salamone, J.D. (1996) Involvement of ventrolateral striatal dopamine in movement initiation and execution: a microdialysis and behavioral investigation. Neuroscience, 70, 849-859.
12. Desjardins, S., Mayo, W., Vallée, M., Hancock, D., Le Moal, M., Simon, H. & Abrous, D.N. (1997) Effect of aging on the basal expression of c-fos, c-jun, and egr-1 proteins in the hippocampus. Neurobiol. Aging, 18, 37-44.
13. Dunnett, S.B. & Iversen, S.D. (1982) Sensorimotor impairments following localized kainic acid and 6-hydroxydopamine lesions of the neostriatum. Brain Res., 248, 121-127.
14. Fornaguera, J., Carey, R.J., Huston, J.P. & Schwarting, R.K.W. (1994) Behavioral asymmetries and recovery in rats with different degrees of unilateral striatal dopamine depletion. Brain Res., 664, 178-188.
15. Harding, A.E. (1993) Movement disorders. In Walton, J. (ed.), Brain Diseases of the Nervous System. Oxford University Press, New York, pp. 395-401.
16. Hefti, F., Melamed, E., Sahakian, B.J. & Wurtman, R.J. (1980) Circling behavior in rats with partial, unilateral nigro-striatal lesions: effects of amphetamine, apomorphine, and DOPA. Pharmacol. Biochem. Behav., 12, 185-188.
17. Herman, J.P. & Ahrous, D.N. (1994) Dopaminergic neural grafts after fifteen years: results and perspectives. Prog. Neurobiol., 44, 1-35.
18. Hudson, J.L., Van Horne, C.G., Strömberg, I., Brock, S., Clayton, J., Masserano, J., Hoffer, B.J. & Gerhardt, G.A. (1993) Correlation of apomorphine-and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats. Brain Res., 626, 167-174.
19. Ichitani, Y., Okamura, H., Matsumoto, Y., Nagatsu, I. & Ibata, Y. (1991) Degeneration of the nigral dopamine neurons after 6-hydroxydopamine injection into the rat striatum. Brain Res., 549, 350-353.
20. Kirik, D., Rosenblad, C. & Björklund, A. (1998) Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat. Exp. Neurol., 152, 259-277.
21. Lang, A.E. & Lozano, A.M. (1998) Parkinson's disease (second of two parts). N. Engl. J. Med., 339, 1130-1143.
22. Lee, C.S., Sauer, H. & Björklund, A. (1996) Dopaminergic neuronal degeneration and motor impairments following axon terminal lesion by intrastriatal 6-hydroxydopamine in the rat. Neuroscience, 72, 641-653.
23. Lindner, M.D., Plone, M.A., Francis, J.M., Blaney, T.J., Salamone, J.D. & Emerich, D.F. (1997) Rats with partial striatal dopamine depletions exhibit robust and long-lasting behavioral deficits in a simple fixed ratio barpressing task. Behav. Brain Res., 86, 25-40.
24. Miklyaeva, E.I., Castaneda, E. & Whishaw, I.Q. (1994) Skilled reaching deficits in unilateral dopamine-depleted rats: impairments in movement and posture and compensatory adjustments. J. Neurosci., 14, 7148-7158.
25. Montoya, C.P., Campbell-Hope, L.J., Pemberton, K.D. & Dunnett, S.B. (1991) The 'staircase test': a measure of independent forelimb reaching and grasping abilities in rats. J. Neurosci., 36, 219-228. .
26. Olsson, M., Nikkhah, G., Bentlage, C. & Björklund, A. (1995) Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J. Neurosci., 15, 3863-3875.
27. Paxinos, G. & Watson, C. (1982) The rat brain in stereotaxic coordinates. Academic Press, Sydney.
28. Przedborski, S., Levivier, M., Jiang, H., Ferreira, M., Jackson-Lewis, V., Donaldson, D. & Togasaki, D.M. (1995) Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine. Neuroscience, 67, 631-647.
29. Robinson, T.E., Mocsary, Z., Camp, D.M. & Whishaw, I.Q. (1994) Time course of recovery of extracellular dopamine following partial damage to the nigrostriatal dopamine system. J. Neurosci., 14, 2687-2696.
30. Rosenblad, C., Martinez-Serrano, A. & Björklund, A, (1998) Intrastriatal glial cell line-derived neurotrophic factor promotes sprouting of spared nigrostriatal dopaminergic afferents and induces recovery of function in a rat model of Parkinson's disease. Neuroscience, 82, 129-137.
31. Sabol, K.E., Neill, D.B., Wages, S.A., Church, W.H. & Justice, J.B. (1985) Dopamine depletion in a striatal subregion disrupts performance of a skilled motor task in the rat. Brain Res., 335, 33-43.
32. Sakai, K. & Gash, D.M. (1994) Effect of bilateral 6-OHDA lesions of the substantia nigra on locomotor activity in the rat. Brain Res., 633, 144-150.
33. Salamone, J.D., Kurth, P.A., McCullough, L.D., Sokolowski, J.D. & Cousins, M.S. (1993) The role of brain dopamine in response initiation: effects of haloperidol and regionally specific dopamine depletions on the local rate of instrumental responding. Brain Res., 628, 218-226.
34. Sauer, H. & Oertel, W.H. (1994) Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat. Neuroscience, 59, 401-415.
35. Schallert, T., Norton, D. & Jones, D.A. (1992) A clinically relevant unilateral model of Parkinsonian akinesia. J. Neurotransplant. Plast., 3, 332-333.
36. Ungerstedt, U. & Arbuthnott, G.W. (1970) Quantitative recording of rotational behaviour in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system. Brain Res., 24, 485-493.
37. Whishaw, I.Q., O'Connor, W.T. & Dunnett, S.B. (1986) The contributions of motor cortex, nigrostriatal dopamine and caudate-putamen to skilled forelimb use in the rat. Brain, 109, 805-843.
38. Whishaw, I.Q., Pellis, S.M. & Gorny, B.P. (1992) Skilled reaching in rats and humans: evidence for parallel development or homology. Behav. Brain Res., 47, 59-70.
39. Whishaw, I.Q., Woodward, N.C., Miklyaeva, E. & Pellis, S.M. (1997) Analysis of limb use by control rats and unilateral DA-depleted rats in the Montoya staircase test: movements, impairments and compensatory strategies. Behav. Brain Res., 89, 167-177.
40. Whishaw, I.Q. & Pellis, S.M. (1990) The structure of skilled forelimb reaching in the rat: a proximally driven movement with a single distal rotatory component. Behav. Brain Res., 41, 49-59.
41. Wood, P.L. & Altar, C.A. (1988) Dopamine release in vivo from nigrostriatal, mesolimbic, and mesocortical neurons: utility of 3-methoxytyramine measurements. Pharmacol. Rev., 40, 163-187.
42. Zigmond, M.J., Abercrombie, E.D., Berger, T.W., Grace, A.A. & Stricker, E.M. (1990) Compensations after lesions of central dopaminergic neurons: some clinical and basic implications. Trends Neurosci., 13, 290-296.
43. Zigmond, M.J. & Stricker, E.M. (1989) Animal models of Parkinsonism using selective neurotoxins: clinical and basic implications. Int. Rev. Neurobiol., 31, 1-79.