Impairments and compensation in mouth and limb use in free feeding after unilateral dopamine depletions in a rat analog of human Parkinson's disease

Behavioural Brain Research

Volumn 84, Issue 1-2, 1997, Pages 167-177

  Whishaw, Ian Q ^a   Coles, Brenda L K ^a   Pellis, Sergio M ^a   Miklyaeva, Elena I ^a  

^a UNIVERSITY OF LETHBRIDGE   (Canada)

Author keywords

6 OHDA lesion; compensation; dopamine; eating; forelimb use; mouth use; posture; recovery of function

Indexed keywords

DOPAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; JAW MOVEMENT; MOTOR CONTROL; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN CHEMISTRY; DOPAMINE; EXTREMITIES; FEEDING BEHAVIOR; FEMALE; FOOD; HEAD MOVEMENTS; MOUTH; OXIDOPAMINE; PARKINSON DISEASE, SECONDARY; PSYCHOMOTOR PERFORMANCE; RATS; ROTATION; SUBSTANTIA NIGRA; SYMPATHOLYTICS; VIDEOTAPE RECORDING;

EID: 0031058014     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(96)00148-9     Document Type: Article

References (42)

1. Berridge, K.C., Substantia nigra 6-OHDA lesions mimic striatopallidal disruption of syntactic grooming chains: a neural systems analysis of sequence control, Psychobiology, 17 (1989) 377-385.
2. Bjorklund, A., Dunnett, S.B. and Nikkhah, G., Nigral transplants in the rat Parkinson Model: functional limitations and strategies to enhance nigrostriatal reconstruction. In S.B. Dunnett and A. Bjorklund (Eds.), Functional Neural Transplantation, Raven Press, New York, 1994, pp. 47-69.
3. Carli, M., Evenden, J.L. and Robbins, T.W., Depletion of unilateral striatal dopamine impairs initiation of contralateral actions and not sensory attention, Nature, 313 (1985) 679-682.
4. Castañeda, E., Whishaw, I.Q. and Robinson, T.E., Changes in striatal dopamine neurotransmission assessed with microdialysis following recovery from a bilateral 6-OHDA lesion: variation as a function of lesion size, J. Neurosci., 10 (1990) 1847-1854.
5. Dunnett, S.B., Functional analysis of neural grafts in the neostriatum. In A. Bjorklund, A.J. Aguayo, D. Ottoson (Eds.), Brain Repair, Macmillan, London, 1990, pp. 365-373.
6. Dunnett, S.B., Whishaw, I.Q., Rogers, D.C. and Jones, G.H., Dopamine-rich grafts ameliorate whole body motor asymmetry and sensory neglect but not independent skilled limb use in rats with 6-hydroxydopamine lesions, Brain Res., 415 (1987) 63-78.
7. Ellard, C.G., Stewart, D.J., Donaghy, S. and Vanderwolf, C.H., Behavioral effects of neocortical and cingulate lesions in the Mongolian gerbil, Behav. Brain Res., 36 (1990) 41-51.
8. Evenden, J.L. and Robbins, T.W., Effects of unilateral 6-hydroxydopamine lesions of the caudate-putamen on skilled forepaw use in the rat, Behav. Brain Res., 14 (1984) 61-68.
9. Hefti, F., Melamed, E., Sahakian, B.J. and Wurtman, R.J., Circling behavior in rats with partial unilateral nigrostriatal lesions: affect of amphetamine, apomorphine and dopa, Pharmacol. Biochem. Behav., 12 (1980) 185-188.
10. Ivanco, T.L., Pellis, S.M. and Whishaw, I.Q., Skilled forelimb movements in prey catching and in reaching by rats (Rattus nor-vegicus) and opossums (Monodelphis domestica): relations to anatomical differences in motor systems, Behav. Brain Res., 79 (1996) 163-182.
11. Kalil, K. and Schneider, G.E., Motor performance following unilateral pyramidal tract lesions in the hamster, Brain Res., 100 (1975) 170-174.
12. Marshall, J.F. and Ungerstedt, U., Supersensitivity to apomorphine following destruction of the ascending dopamine neurons: quantification using the rotational model, Eur. J. Pharmacol, 41 (1977) 361-367.
13. Marshall, J.F., Richardson, J.S. and Teitelbaum, P., Nigrostriatal bundle damage and the lateral hypothalamic syndrome, J. Comp. Physiol. Psychoi., 87 (1977) 808-830.
14. Martens, D.J., Whishaw, E.Q., Miklyaeva, E.I. and Pellis, S.M., Spatio-temporal impairments in limb and body movements during righting in Hemiparkinsonian rat analogue: relevance to axial apraxia in humans, Brain Res., in press.
15. Martin, J.P., The Basal Ganglia and Posture, Pittman, London, 1967.
16. Miklyaeva, E.I., Castañeda, E. and Whishaw, I.Q., Skilled reaching deficits in unilateral dopamine-depleted rats: impairments in movement and posture and compensatory adjustments, Neuroscience, 14(1994) 7148-7158.
17. Miklyaeva, E.I., Martens, D.J. and Whishaw, I.Q., Impairments and compensatory adjustments in spontaneous movement after unilateral dopamine depletion in rats, Brain Res., 681 (1995) 23-40.
18. Miklyaeva, E.I. and Whishaw, I.Q., HemiParkinson analogue rats display active support in good limbs versus passive support in bad limbs on a skilled reaching task of variable height, Behav. Neurosci., 110 (1996) 117-125.
19. Montoya, C.P., Astell, S. and Dunnett, S.B., Effects of nigral and striatal grafts on skilled forelimb use in the rat, Prog. Brain Res., 82 (1990) 459-566.
20. Nikkhah, G., Duan, W.M., Knappe, U., Jodicke, A. and Bjorklund, A., Restoration of complex sensorimotor behavior and skilled forelimb use by a modified nigral cell suspension transplantation approach in the rat Parkinson model, Neuroscience, 56 (1993) 33-43.
21. Pellis, S.M., Pellis, V.C., Chjesire, R.M, Rowland, N.E. and Teitelbaum, P., Abnormal gait sequence in the locomotion released by atropine in catecholamine deficient akinetic rats, Proc. Natl. Acad. Sci. USA, 84 (1987) 8750-8753.
22. Reh, T. and Kalil, K., Functional role of regrowing pyramidal tract fibers, J. Comp. Neurol., 211 (1982) 81-91.
23. Robinson, T.E., Castañeda, E. and Whishaw, I.Q., Compensatory changes in striatal dopamine neurons following recovery from injury induced by 6-OHDA or metamphetamine: a review of evidence from microdialysis studies, Canad. J. Psychol., 44 (1990) 253-275.
24. Robinson., T.E., Mocsary, Z., Camp, D.M. and Whishaw, I.Q., Time course of recovery of extracellular dopamine following partial damage to the nigrostriatal dopamine system, J. Neurosci., 14 (1994) 2687-2696.
25. Sabol, K.E., Neill, D.B., Wages, S.A., Church, W.H. and Justice, J.B., Dopamine depletion in a striatal subregion disrupts performance of a skilled motor task in the rat, Brain Res., 335 (1985) 108-120.
26. Schultz, Q., Depletion of dopamine in the striatum as an experimental model of Parkinsonism: direct effects and adaptive mechanisms, Prog. Neurobiol, 8 (1982) 121-166.
27. Sacks, O.W., Awakenings, Duckworth, London, 1973.
28. Schallert, T., Norton, D. and Jones, T.A., A clinically relevant unilateral rat model of Parkinsonian akinesia, J. Neural Transplant Plastic., 3 (1992) 332-333.
29. Schauert, T., Whishaw, I.Q., DeRyck, M. and Teitelbaum, P., Compulsive, abnormal walking caused by anticholinergics in aki-netic, 6-hydroxydopamine-treated rats, Science, 199 (1978) 1461-1463.
30. Schallen, T., Whishaw, I.Q., DeRyck, M. and Teitelbaum, P., Compulsive, abnormal walking caused by anticholinergics in akinetic, 6-hydroxydopamine-treated rats, Science, 199 (1978) 1461-1463.
31. Schallen, T., Upchurch, M., Lobaugh, N., Farrar, S.B., Spirduso, W.W. and Wilcox, R.E., Tactile extinction: distinguishing between sensorimotor and motor asymmetries in rats with unilateral nigrostriatal damage, Pharmacol. Biochem. Behav., 16 (1982) 455-462.
32. Schneider, J.S. and Olazabao, U.E., Behaviorally specific limb use deficits following globus pallidus lesions in rats, Brain Res., 308 (1984) 360-368.
33. Siegfried, B. and Bures, J., Handedness in rats: blockade of reaching behavior by unilateral 6-OHDA injections into substantia nigra and caudate nucleus, Physiol. Psychol, 8 (1980) 360-368.
34. Uguru-Okorie, C.C. and Arbuthnott, G.W., Altered paw preference after unilateral 6-hydroxydopamine injections into lateral hypothalamus, Neuropsychologia, 19 (1981) 463-467.
35. Ungerstedt, U., Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system, Acta Physiol. Scand., Suppl, 367 (1971) 96-122.
36. Whishaw, I.Q. and Coles, B.L.K., Varieties of paw and digit movement during spontaneous food handling in rats: postures, bimanual coordination, preferences, and the effect of forelimb cortex lesions, Behav. Brain Res., 11 (1996) 125-148.
37. Whishaw, I.Q., Dringenberg, H.C. and Pellis, S.M., Spontaneous forelimb grasping in free feeding by rats: motor cortex aids limb and digit positioning, Behav. Brain Res., 48 (1992) 113-125.
38. Whishaw, I.Q., O'Connor, W.T. and Dunnett, S.B., The contributions of motor cortex, nigrostriatal dopamine and caudate-putamen to skilled forelimb use in the rat, Brain, 109 (1986) 805-843.
39. Whishaw, I.Q. and Pellis, S.M., The structure of skilled forelimb reaching in the rat: a proximally driven movement with a single distal rotatory component, Behav. Brain Res., 41 (1990) 49-59.
40. Winer, B.J., Statistical Principles in Experimental Design, McGraw-Hill, New York, 1962.
41. Zigmond, M.J. and Stricker, E.M., Recovery of feeding and drinking by rats after intraventricular 6-hydroxydopamine or lateral hypothalamic lesions, Science, 182 (1973) 717-720.
42. Zigmond, M.J., Abercrombie, E.D., Berger, T.W., Grace, A.A. and Striker, E.M., Compensations after lesions of central dopaminergic neurons: some clinical and basic implications, Trends Neurosci., 13 (1990) 290-296.