Oxime-Based Click Chemistry in the Development of 3-Isoxazolecarboxylic Acid Containing Inhibitors of Yersinia pestis Protein Tyrosine Phosphatase, YopH

ChemMedChem

Volumn 6, Issue 8, 2011, Pages 1363-1370

  Bahta, Medhanit ^a   Burke, Terrence R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Aminooxy platform; Docking studies; Inhibitors; Oxime based click chemistry; Substrate screening

Indexed keywords

3 ISOXAZOLECARBOXYLIC ACID; 4 NITROPHENYL PHOSPHATE; 6 NITRO (1,1' BIPHENYL) 3 YLDIHYDROGEN PHOSPHATE; AMINOOXYACETIC ACID; CARBOXYL GROUP; OXIME; PHOSPHORYLASE; UBIQUITINATED PROTEIN; UNCLASSIFIED DRUG; YERSINIA OUTER PROTEIN E;

ARTICLE; BINDING AFFINITY; BIOTRANSFORMATION; CLICK CHEMISTRY; DRUG SYNTHESIS; HYDROLYSIS KINETICS; IC 50; PRIORITY JOURNAL; SUZUKI REACTION; UBIQUITINATION; X RAY CRYSTALLOGRAPHY; YERSINIA PESTIS;

BACTERIAL OUTER MEMBRANE PROTEINS; BINDING SITES; CARBOXYLIC ACIDS; CATALYTIC DOMAIN; CLICK CHEMISTRY; COMPUTER SIMULATION; ISOXAZOLES; KINETICS; OXIMES; PROTEIN KINASE INHIBITORS; PROTEIN TYROSINE PHOSPHATASES; STRUCTURE-ACTIVITY RELATIONSHIP; YERSINIA PESTIS;

EID: 79960671715     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100200     Document Type: Article

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