Plasminogen activators from snake venoms

Toxins and Hemostasis: From Bench to Bedside

Volumn , Issue , 2011, Pages 371-392

  Le Bonniec, Bernard F ^a   Libraire, Julie ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79960631291     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-90-481-9295-3_22     Document Type: Chapter

References (69)

1. Alfano, D., Franco, P., Vocca, I., Gambi, N., Pisa, V., Mancini, A., Caputi, M., Carriero, M.V., Iaccarino, I., Stoppelli, M.P., 2005. The urokinase plasminogen activator and its receptor: role in cell growth and apoptosis. Thromb. Haemost. 93, 205-211.
2. Appella, E., Robinson, E.A., Ullrich, S.J., Stoppelli, M.P., Corti, A., Cassani, G., Blasi, F., 1987. The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases. J. Biol. Chem. 262, 4437-4440.
3. Bajzar, L., Manuel, R., Nesheim, M.E., 1995. Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor. J. Biol. Chem. 270, 14477-14484.
4. Bergum, P.W., Gardell, S.J., 1992. Vampire bat salivary plasminogen activator exhibits a strict and fastidious requirement for polymeric fibrin as its cofactor, unlike human tissue-type plasminogen activator. A kinetic analysis. J. Biol. Chem. 267, 17726-17731.
5. Bianchini, E.P., Louvain, V.B., Marque, P.E., Juliano, M.A., Juliano, L., Le Bonniec, B.F., 2002. Mapping of the catalytic groove preferences of factor Xa reveals an inadequate selectivity for its macromolecule substrates. J. Biol. Chem. 277, 20527-20534.
6. Bode, W., 2005. The structure of thrombin, a chameleon-like proteinase. J. Thromb. Haemost. 3, 2379-2388.
7. Bode, W., Mayr, I., Baumann, U., Huber, R., Stone, S.R., Hofsteenge, J., 1989. The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment. EMBO J. 8, 3467-3475.
8. Braud, S., Le Bonniec, B.F., Bon, C., Wisner, A., 2002. The stratagem utilized by the plasminogen activator from the snake Trimeresurus stejnegeri to escape serpins. Biochemistry 41, 8478- 8484.
9. Braud, S., Parry, M.A., Maroun, R., Bon, C., Wisner, A., 2000. The contribution of residues 192 and 193 to the specificity of snake venom serine proteinases. J. Biol. Chem. 275, 1823-1828.
10. Budzynski, A. Z., 1985. Secretion of cellular plasminogen activators upon stimulation by Crotalinae snake venoms and their components. Thromb. Haemost. 54, 314 (Abstract).
11. Cao, Y., Yu, G.S., Yang, S.L., Gong, Y., 2001. Expression of a snake venom plasminogen activator TSV-PA in insect cells. Sheng Wu Gong Cheng Xue Bao. 17, 506-509.
12. Carmeliet, P., Collen, D., 1996. Gene manipulation and transfer of the plasminogen and coagulation system in mice. Semin. Thromb. Hemost. 22, 525-542.
13. Collen, D., Lijnen, H.R., 2004. Tissue-type plasminogen activator: A historical perspective and personal account. J. Thromb. Haemost. 2, 541-546.
14. Danø, K., Behrendt, N., Høyer-Hansen, G., Johnsen, M., Lund, L.R., Ploug, M., Rømer, J., 2005. Plasminogen activation and cancer. Thromb. Haemost. 93, 676-681.
15. Dekker, R.J., Eichinger, A., Stoop, A.A., Bode, W., Pannekoek, H., Horrevoets, A.J., 1999. The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop. J. Mol. Biol. 293, 613-627.
16. Ellis, V., Behrendt, N., Danø, K., 1991. Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor. J. Biol. Chem. 266, 12752-12758.
17. Felicori L.F. Chávez-Olórtegui C. Sánchez E.F., Specific identification of Lachesis muta muta snake venom using antibodies against the plasminogen activator enzyme, LV-PA, Toxicon 2005 45 803-806.
18. Gao, R., Zhang, Y., Meng, Q.X., Lee, W.H., Li, D.S., Xiong, Y.L., Wang, W.Y., 1998. Characterization of three fibrinogenolytic enzymes from Chinese green tree viper (Trimeresurus stejnegeri) venom. Toxicon 36, 457-467.
19. Gardell, S.J., Duong, L.T., Diehl, R.E., York, J.D., Hare, T.R., Register, R.B., Jacobs, J.W., Dixon, R.A., Friedman, P.A., 1989. Isolation, characterization, and cDNA cloning of a vampire bat salivary plasminogen activator. J. Biol. Chem. 264, 17947-17952.
20. Gettins, P.G., Olson, S.T., 2009. Exosite determinants of serpin specificity. J. Biol. Chem. 284, 20441-20445.
21. Gladson, C.L., Schleef, R.R., Binder, B.R., Loskutoff, D.J., Griffin, J.H., 1989. A comparison between activated protein C and des-1-41-light chain-activated protein C in reactions with type 1 plasminogen activator inhibitor. Blood 74, 173-181.
22. Hermogenes, A.L., Richardson, M., Magalhaes, A., Yarleque, A., Rodriguez, E., Sanchez, E.F., 2006. Interaction of a plasminogen activator proteinase, LV-PA with human α2-macroglobulin. Toxicon 47, 490-494.
23. Horrevoets, A.J., Smilde, A.E., Fredenburgh, J.C., Pannekoek, H., Nesheim, M.E., 1995. The activation-resistant conformation of recombinant human plasminogen is stabilized by basic residues in the amino-terminal hinge region. J. Biol. Chem. 270, 15770-15776.
24. Høyer-Hansen, G., Rønne, E., Solberg, H., Behrendt, N., Ploug, M., Lund, L.R., Ellis, V., Danø, K., 1992. Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligandbinding domain. J. Biol. Chem. 267, 18224-18229.
25. Hoylaerts, M., Rijken, D.C., Lijnen, H.R., Collen, D., 1982. Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin. J. Biol. Chem. 257, 2912-1919.
26. Jia, Y., Cantu, B.A., Sánchez, E.E., Pérez, J.C., 2008. Complementary DNA sequencing and identification of mRNAs from the venomous gland of Agkistrodon piscivorus leucostoma. Toxicon 51, 1457-1466.
27. Kamiguti, A.S., Desmond, H.P., Theakston, R.D., Hay, C.R., Zuzel, M., 1994. Ineffectiveness of the inhibition of the main haemorrhagic metalloproteinase from Bothrops jararaca venom by its only plasma inhibitor, alpha 2-macroglobulin. Biochim. Biophys. Acta 1200, 307-314.
28. Karbovs'kyl, V.L., Levkiv, M.I.U., Savchuk, O.M., Hornyts'ka, O.V., Volkov, H.L., Bukhan, T.S., 2006. Plasminogen activator from Agkistrodon halys halys venom Ukr. Biokhim. Zh. 78, 32-37.
29. Kisiel, W., Choi, E., Kondo, S., 1987. Isolation of a protein C activator from southern copperhead venom. Biochem. Biophys. Res. Commun. 143, 917-922.
30. Klein, J.D., Walker, F.J., 1986. Purification of a protein C activator from the venom of the southern copperhead snake (Agkistrodon contortrix contortrix). Biochemistry 25, 4175-4179.
31. Klöcking, H.P., Hoffmann, A., Markwardt, F., 1987. Release of plasminogen activator by batroxobin. Haemostasis 17, 235-237.
32. Lamba, D., Bauer, M., Huber, R., Fischer, S., Rudolph, R., Kohnert, U., Bode, W., 1996. The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator. J. Mol. Biol. 258, 117-35.
33. Le Bonniec, B.F., Esmon, C.T., 1991. Glu-192Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin. Proc. Natl. Acad. Sci. U.S.A. 88, 7371-7375.
34. Le Bonniec, B.F., Guinto, E.R., Esmon, C.T., 1992. The role of calcium ions in factor X activation by thrombin E192Q. J. Biol. Chem. 267, 6970-6976.
35. Le Bonniec, B.F., Guinto, E.R., MacGillivray, R.T., Stone, S.R., Esmon, C.T., 1993. The role of thrombin's Tyr-Pro-Pro-Trp motif in the interaction with fibrinogen, thrombomodulin, protein C, antithrombin III, and the Kunitz inhibitors. J. Biol. Chem. 268, 19055-19061.
36. Le Bonniec, B.F., Myles, T., Johnson, T., Knight, C.G., Tapparelli, C., Stone, S.R., 1996. Characterization of the P2'and P3' specificities of thrombin using fluorescence-quenched substrates and mapping of the subsites by mutagenesis. Biochemistry 35, 7114-7122.
37. Lijnen, H.R., Collen, D., 1998. t-Plasminogen activator, in: Barrett, A.J., Rawlings, N.D., Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes. Academic Press, London, UK, pp. 184-190.
38. Liu, S., Sun, M.Z., Greenaway, F.T., 2006. A novel plasminogen activator from Agkistrodon blomhoffii ussurensis venom (ABUSV-PA): purification and characterization. Biochem. Biophys. Res. Commun. 348, 1279-1287.
39. Lund, L.R., Green, K.A., Stoop, A.A., Ploug, M., Almholt, K., Lilla, J., Nielsen, B.S., Christensen, I.J., Craik, C.S., Werb, Z., Danø, K., Rømer, J., 2006. Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. EMBO J. 25, 2686-2697.
40. Madison, E.L., Coombs, G.S., Corey, D.R., 1995. Substrate specificity of tissue type plasminogen activator. Characterization of the fibrin independent specificity of t-PA for plasminogen. J. Biol. Chem. 270, 7558-7562.
41. Madison, E.L., Goldsmith, E.J., Gerard, R.D., Gething, M.J., Sambrook, J.F., 1989. Serpinresistant mutants of human tissue-type plasminogen activator. Nature 339, 721-724.
42. Madison, E.L., Goldsmith, E.J., Gerard, R.D., Gething, M.J., Sambrook, J.F., Bassel-Duby, R.S., 1990. Amino acid residues that affect interaction of tissue-type plasminogen activator with plasminogen activator inhibitor 1. Proc. Natl. Acad. Sci. U.S.A. 87, 3530-3533.
43. Mao, S.S., Holahan, M.A., Bailey, C., Wu, G., Colussi, D., Carroll, S.S., Cook, J.J., 2005. Demonstration of enhanced endogenous fibrinolysis in thrombin activatable fibrinolysis inhibitor-deficient mice. Blood Coagul. Fibrinolysis 16, 407-415.
44. Markland, F.S., 1998a. Snake venoms and the hemostatic system. Toxicon 36, 1749-1800.
45. Markland, F.S. Jr., 1998b. Snake venom fibrinogenolytic and fibrinolytic enzymes: An updated inventory. Registry of exogenous hemostatic factors of the scientific and standardization committee of the international society on thrombosis and haemostasis. Thromb. Haemost. 79, 668-674.
46. McMullen, B.A., Fujikawa, K., Kisiel, W., 1989. Primary structure of a protein C activator from Agkistrodon contortrix contortrix venom. Biochemistry. 28, 674-679.
47. Miles, L.A., Castellino, F.J., Gong, Y., 2003. Critical role for conversion of glu-plasminogen to Lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces. Trends Cardiovasc. Med. 13, 21-30.
48. Murakami, M.T., Arni, R.K., 2005. Crystallization and preliminary X-ray crystallographic studies of Protac, a commercial protein C activator isolated from Agkistrodon contortrix contortrix venom. Biochim. Biophys. Acta 1752, 202-204.
49. Pan, H., Du, X., Yang, G., Zhou, Y., Wu, X., 1999. cDNA cloning and expression of acutin. Biochem. Biophys. Res. Commun. 255, 412-415.
50. Park, D., Kim, H., Chung, K., Kim, D.S., Yun, Y., 1998. Expression and characterization of a novel plasminogen activator from Agkistrodon halys venom. Toxicon 36, 1807-1819.
51. Parry, M.A., Jacob, U., Huber, R., Wisner, A., Bon, C., Bode, W., 1998. The crystal structure of the novel snake venom plasminogen activator TSV-PA: A prototype structure for snake venom serine proteinases. Structure 6, 1195-1206.
52. Rawlings, N.D., 1998. Family S1 of trypsin, in: Barrett, A.J., Rawlings, N.D., Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes. Academic Press, London, UK, pp. 3-17.
53. Rojnuckarin, P., Intragumtornchai, T., Sattapiboon, R., Muanpasitporn, C., Pakmanee, N., Khow, O., Swasdikul, D., 1999. The effects of green pit viper (Trimeresurus albolabris and Trimeresurus macrops) venom on the fibrinolytic system in human. Toxicon 37, 743-755.
54. Sanchez, E.F., Felicori, L.F., Chavez-Olortegui, C., Magalhaes, H.B., Hermogenes, A.L., Diniz, M.V., Junqueira-de-Azevedo, I.L., Magalhaes, A., Richardson, M., 2006. Biochemical characterization and molecular cloning of a plasminogen activator proteinase (LV-PA) from bushmaster snake venom. Biochim. Biophys. Acta 1760, 1762-1771.
55. Sanchez, E.F., Santos, C.I., Magalhaes, A., Diniz, C.R., Figueiredo, S., Gilroy, J., Richardson, M., 2000. Isolation of a proteinase with plasminogen-activating activity from Lachesis muta muta (Bushmaster) snake venom. Arch. Biochem. Biophys. 378, 131-141.
56. Schneider, M., Nesheim, M., 2004. A study of the protection of plasmin from antiplasmin inhibition within an intact fibrin clot during the course of clot lysis. J. Biol. Chem. 279, 13333-13339.
57. Sottrup-Jensen, L., 1989. α-macroglobulins: structure, shape, and mechanism of proteinase complex formation. J. Biol. Chem. 264, 11539-11542.
58. Stocker, K., Fischer, H., Meier, J., Brogli, M., Svendsen, L., 1987. Characterization of the protein C activator Protac from the venom of the southern copperhead (Agkistrodon contortrix) snake. Toxicon 25, 239-252.
59. Stone, S.R., Betz, A., Hofsteenge, J., 1991. Mechanistic studies on thrombin catalysis. Biochemistry 30, 9841-9848.
60. Sugiki, M., Yoshida, E., Anai, K., Maruyama, M., 1998. Activation of single-chain urokinase-type plasminogen activator by a hemorrhagic metalloproteinase, jararafibrase I, in Bothrops jararaca venom. Toxicon 36, 993-1000.
61. Sunagawa, M., Hanashiro, K., Nakamura, M., Kosugi, T., 1996. Habutobin releases plasminogen activator (U-PA) from bovine pulmonary artery endothelial cells. Toxicon 34, 691-699.
62. Swenson, S., Markland, F.S. Jr., 2005. Snake venom fibrin(ogen)olytic enzymes. Toxicon 45, 1021-1039.
63. Thelwell, C., Longstaff, C., 2007. The regulation by fibrinogen and fibrin of tissue plasminogen activator kinetics and inhibition by plasminogen activator inhibitor 1. J. Thromb. Haemost. 5, 804-811.
64. van de Locht, A., Bode, W., Huber, R., Le Bonniec, B.F., Stone, S.R., Esmon, C.T., Stubbs, M.T., 1997. The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin. EMBO J. 16, 2977-84.
65. Wang, Y.M., Wang, S.R., Tsai, I.H., 2001. Serine protease isoforms of Deinagkistrodon acutus venom: cloning, sequencing and phylogenetic analysis. Biochem. J. 354, 161-168.
66. Wu, C., Dong, N., da Cunha, V., Martin-McNulty, B., Tran, K., Nagashima, M., Wu, Q., Morser, J., Wang, Y.X., 2003. Activated thrombin-activatable fibrinolysis inhibitor attenuates spontaneous fibrinolysis of batroxobin-induced fibrin deposition in rat lungs. Thromb. Haemost. 90, 414- 421.
67. Zhang, Y., Wisner, A., Maroun, R.C., Choumet, C., Xiong, Y., Bon, C., 1997. Trimeresurus stejnegeri snake venom plasminogen activator site-directed mutagenesis and molecular modeling. J. Biol. Chem. 272, 20531-20537.
68. Zhang, Y., Wisner, A., Xiong, Y., Bon, C., 1995. A novel plasminogen activator from snake venom. Purification, characterization, and molecular cloning. J. Biol. Chem. 270, 10246-10255.
69. Zhu, Z., Liang, Z., Zhang, T., Zhu, Z., Xu, W., Teng, M., Niu, L., 2005. Crystal structures and amidolytic activities of two glycosylated snake venom serine proteinases. J. Biol. Chem. 280, 10524-10529.