Interaction of a plasminogen activator proteinase, LV-PA with human α2-macroglobulin

Toxicon

Volumn 47, Issue 4, 2006, Pages 490-494

  Hermogenes, Ana L ^a   Richardson, Michael ^a   Magalhaes, Arinos ^a   Yarleque, Armando ^b   Rodriguez, Edith ^b   Sanchez, Eladio F ^a  

^a Research and Development Center   (Brazil)

^b UNIVERSIDAD NACIONAL MAYOR DE SAN MARCOS   (Peru)

Author keywords

2 macroglobulin; Fibrinolysis; Lachesis muta; Plasminogen activator; Serineproteinase

Indexed keywords

ALPHA 2 MACROGLOBULIN; CASEIN; DIMETHYLCASEIN; FIBRINOGEN; PLASMINOGEN; PLASMINOGEN ACTIVATOR; PROTEIN LACHESIS VENOM PLASMINOGEN ACTIVATOR; SNAKE VENOM; SYNTHETIC PEPTIDE; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG;

ARTICLE; FIBRINOLYSIS; MOLECULAR WEIGHT; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN ISOLATION; PROTEIN PROTEIN INTERACTION;

ALPHA-MACROGLOBULINS; ANTIPLASMIN; CROTALID VENOMS; DRUG INTERACTIONS; HUMANS; PLASMINOGEN ACTIVATORS; SERINE ENDOPEPTIDASES; TISSUE PLASMINOGEN ACTIVATOR;

LACHESIS; LACHESIS MUTA; LACHESIS MUTA MUTA;

EID: 33644845405     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2005.12.009     Document Type: Article

References (17)

1. A.J. Barrett, M.A. Brown, and C.A. Sayers The electrophoretically 'slow' and fast forms of the alpha 2-macroglobulin molecule Biochem. J. 181 1979 401 418
2. S. Braud, C. Bon, and A. Wisner Snake venom proteins acting on hemostasis Biochimie 82 2000 851 859
3. D. Collen, and H.R. Lijnen Basic and clinical aspects of fibrinolysis and thrombolysis Blood 78 1991 3114 3124
4. D. Collen, B. Van Hoef, B. Scholtt, M. Hartmann, K.H. Guehrs, and H.R. Lijnen Mechanisms of activation of mammalian plasma fibrinolytic systems with streptokinase and with recombinat staphylokinase Eur. J. Biochem. 216 1993 307 314
5. S.R. Feldman, S.L. Gonias, and S.V. Pizzo Model of α2-macroglobulin structure and function Proc. Natl Acad. Sci. USA 82 1985 5700 5704
6. L.F. Felicori, C. Chavez-Olortegui, and E.F. Sanchez Specific identification of Lachesis muta muta snake venom using antibodies against the plasminogen activator enzyme, LV-PA Toxicon 45 2005 803 806
7. J.B. Howell, T. Beck, B. Bates, and M.J. Hunter Interaction of α2-macroglobulin with trypsin, chymotrypsin, plasmin, and papain Arch. Biochem. Biophys. 221 1983 261 270
8. F.S. Markland Snake venoms and the hemostatic system Toxicon 36 1998 1749 1800
9. D. Park, H. Kim, K. Chung, D.-S. Kim, and Y. Yun Expression and characterization of a novel plasminogen activator from Agkistrodon halys venom Toxicon 36 1998 1807 1819
10. M.A.A. Parry, X.C. Zhang, and W. Bode Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues TIBS 25 2000 53 59
11. E.F. Sanchez, C.I. Santos, A. Magalhaes, S. Figueiredo, C.R. Diniz, and M. Richardson Isolation of a proteinase with plasminogen activating activity from Lachesis muta muta (bushmaster) snake venom Arch. Biochem. Biophys. 378 2000 131 141
12. L. Sottrup-Jensen Macroglobulins: structure, shape, and mechanism of proteinase complex formation J. Biol. Chem. 264 1989 11539 11542
13. L. Sottrup-Jensen Role of internal thiol esters in the α-macroglobulin-proteinase binding mechanisms Ann. NY Acad. Sci. USA 737 1994 172 187
14. L. Sottrup-Jensen, O. Sand, L. Kristensen, and H.G. Fey The α2-macroglobulin bait region J. Biol. Chem. 264 1989 15781 15789
15. J.P. Steiner, M. Migliorini, and D.K. Strickland Characterization of the reaction of plasmin with α2-macroglobulin: effect of antifibrinolytic agents Biochemistry 26 1987 8487 8495
16. D.K. Strickland, J.P. Steiner, M. Migliorini, and F.D. Battey Identification of a monoclonal antibody specific for a neoantigenic determinant on α2-macroglobulin: use for the purification and characterization of binary proteinase-inhibitor complexes Biochemistry 27 1988 1458 1466
17. Y. Zhang, A. Wisner, Y. Xiong, and C. Bon Novel plasminogen activator from snake venom J. Biol. Chem. 270 1995 10246 10255