Biochemical characterization and molecular cloning of a plasminogen activator proteinase (LV-PA) from bushmaster snake venom

Biochimica et Biophysica Acta - General Subjects

Volumn 1760, Issue 12, 2006, Pages 1762-1771

  Sanchez, Eladio F ^a   Felicori, Liza F ^b   Chavez Olortegui, Carlos ^b   Magalhaes, Henrique B P ^b   Hermogenes, Ana L ^a   Diniz, Marcelo V ^a   Junqueira de Azevedo, Inacio de L M ^c   Magalhaes, Arinos ^a   Richardson, Michael ^a  

^a Ezequiel Dias Foundation   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c INSTITUTO BUTANTAN   (Brazil)

Author keywords

Bushmaster; cDNA; Fibrinolysis; Lachesis muta; Plasminogen activator; Serine proteinase

Indexed keywords

ASPARAGINE; CHROMOGENIC SUBSTRATE; COMPLEMENTARY DNA; ENZYME; N GLYCOSIDASE F; PLASMINOGEN ACTIVATOR; PLASMINOGEN ACTIVATOR PROTEINASE; PLASMINOGEN ACTIVATOR PROTEINASE INHIBITOR; PROTEINASE; SNAKE VENOM; TRYPSIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOMATION; BLOOD CLOTTING; CONTROLLED STUDY; DNA LIBRARY; DNA SEQUENCE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSED SEQUENCE TAG; GENE CONSTRUCT; GLYCOSYLATION; IMMUNOREACTIVITY; LACHESIS MUTA MUTA; MALE; MICHAELIS CONSTANT; MOLECULAR CLONING; MOLECULAR PHYLOGENY; MOLECULAR WEIGHT; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN PROCESSING; RAT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SNAKE; THROMBOCYTE FUNCTION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLYCOSYLATION; KINETICS; MOLECULAR SEQUENCE DATA; PEPTIDE HYDROLASES; PLASMINOGEN ACTIVATORS; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; VIPER VENOMS;

GLOYDIUS HALYS; LACHESIS MUTA; LACHESIS MUTA MUTA; MAMMALIA; VIPERIDAE; VIRIDOVIPERA STEJNEGERI;

EID: 33750630967     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2006.08.023     Document Type: Article

References (41)

1. Lijnen H.R., and Collen D. Matrix metalloproteinases system deficiencies and matrix degradation. Thromb. Haemost. 82 (1999) 837-845
2. Collen D., and Lijnen H.R. Basic and clinical aspects of fibrinolysis and thrombolysis. Blood 78 (1991) 3114-3124
3. Carmeliet P., and Collen D. Gene targeting and gene transfer studies of the plasminogen/plasmin system: implications in thrombosis, hemostasis, neointima formation, and atherosclerosis. FASEB J. 9 (1995) 934-938
4. Pepper M.S. Extracellular proteolysis and angiogenesis. Thromb. Haemost. 86 (2001) 346-355
5. Parry A.A., Zhang X.C., and Bode W. Molecular mechanism of plasminogen activation: bacterial cofactors provide clues. TIBS 25 (2000) 53-59
6. Chandler H.A. Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration. Curr. Opin. Cell Biol. 9 (1997) 714-724
7. Collen D. Ham-Wasserman Lecture: Role of the plasminogen system in fibrin-homeostasis and tissue remodeling. Hematology 2001 (2001) 1-9
8. Lijnen H.R., and Collen D. Development of a new fibrinolytic agents. In: Bloom A.L., Forbes C.D., Thomas D.P., and Tuddenham E.G.D. (Eds). Haemostasis and Thrombosis (1994), Churchill Livingstone, Edinburgh 625-637
9. Braud S., Bon C., and Wisner A. Snake venom proteins acting on hemostasis. Biochimie 82 (2000) 851-859
10. Markland F.S. Snake venoms and the hemostatic system. Toxicon 36 (1998) 1749-1800
11. Marsh N., and Williams V. Practical applications of snake venom toxins in haemostasis. Toxicon 45 (2005) 1171-1181
12. Perona J.J., and Craik C.S. Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold. J. Biol. Chem. 272 (1997) 29987-29990
13. Rawlings N.D. In: Barrett A.J., Rawlings N.D., and Woessner J.F. (Eds). Handbook of Proteolytic Enzymes: family S1 of trypsin (1998), Academic Press, London 3-17
14. Markland F.S. Snake venoms. Drugs 3 (1997) 1-10
15. Zhang Y., Wisner A., Xiong Y., and Bon C. A novel plasminogen activator from snake venom. Purification, characterization, and molecular cloning. J. Biol. Chem. 270 (1995) 10246-10255
16. Magalhaes A., Ferreira R.N., Richardson M., Gontijo S., Yarleque A., Magalhaes H.B., Bloch C., and Sanchez E.F. Coagulant thrombin-like enzymes from the venoms of Brazilian and Peruvian bushmaster (Lachesis muta muta) snakes. Comp. Biochem. Physiol. 136B (2003) 255-266
17. Estevao-Costa M.I., Diniz C.R., Magalhaes A., Markland F.S., and Sanchez E.F. Action of metalloproteinases mutalysin I and II on several components of hemostatic and fibrinolytic systems. Thromb. Res. 99 (2000) 363-376
18. Sanchez E.F. Mutalysins. In: Barrett A.J., Rawlings N.D., and Woessner J.F. (Eds). Handbook of Proteolytic Enzymes. 2nd Ed. (2004), Elsevier Ltd 692-694
19. Felicori L.F., Souza C.T., Velarde D.T., Magalhaes A., Almeida A.P., Figueiredo S., Richardson M., Diniz C.R., and Sanchez E.F. Kallikrein-like proteinase from bushmaster snake venom. Protein Expr. Purif. 30 (2003) 32-42
20. Weinberg M.L.D., Felicori L.F., Bello C., Magalhaes H.P.B., Almeida A.P., Magalhaes A., and Sanchez E.F. Biochemical properties of a bushmaster snake venom serine proteinase (LV-Ka), and its kining releasing activity evaluated in mesenteric arterial rings. J. Pharmacol. Sci. 96 (2004) 333-342
21. Sanchez E.F., Santos C.I., Magalhaes A., Diniz C.R., Figueiredo S., Gilroy J., and Richardson M. Isolation of a proteinase with plasminogen-activating activity from Lachesis muta muta (bushmaster) snake venom. Arch. Biochem. Biophys. 378 (2000) 131-141
22. Hermogenes L., Richardson M., Magalhaes A., Yarleque A., Rodriguez E., and Sanchez E.F. Interaction of a plasminogen activator proteinase, LV-PA with human α2-macroglobulin. Toxicon 47 (2006) 490-494
23. Park D., Kim H., Chung K., Kim D.-S., and Yun Y. Expression and characterization of a novel plasminogen activator from Agkistrodon halys venom. Toxicon 36 (1998) 1807-1819
24. Felicori L.F., Chavez-Olortegui C., and Sanchez E.F. Specific identification of Lachesis muta muta snake venom using antibodies against the plasminogen activator enzyme. LV-PA. Toxicon 45 (2005) 803-806
25. Henschen A. Analysis of cysteine residues, disulphide bridges and sulphydryl groups in proteins. In: Wittmann-Liebold B., Salnikow J., and Erdmann V.A. (Eds) (1986), Springer-Verlag, Berlin 244-255
26. Junqueira R.G., and Mares-Guia M. Statistical treatment for solution of a family of simultaneous equations derived from enzyme inhibition studies. Braz. J. Med. Biol. Res. 23 (1990) 773-784
27. Chirgwin J.M., Przybyla A.E., MacDonald R.J., and Rutter W.J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18 (1979) 5294-5299
28. Pelham H.R., and Jackson R.J. An efficient mRNA-dependent translation system from reticulocyte lysates. Eur. J. Biochem. 67 (1976) 247-256
29. Junqueira de Acevedo I.L., Farsky S.H., Oliveira M.L., and Ho P.L. Molecular cloning and expression of a functional snake venom vascular endothelium growh factor (VEGF) from the Bothrops insularis pit viper. A new member of the VEGF family of proteins. J. Biol. Chem. 276 (2001) 39836-39842
30. Bendtsen J.D., Nielsen H., Von Heine G., and Brunak S. Improved prediction of signal peptides: Signal P 3.0. J. Mol. Biol. 340 (2004) 783-795
31. Madison E.L., Goldsmith E.J., Gerard R.D., Gething M.J., and Sambrook J.F. Serpin-resistant mutants of tissue-type plasminogen activator. Nature 339 (1989) 721-724
32. Parry M.A.A., Jacob U., Huber R., Wisner A., Bon C., and Bode W. The crystal structure for snake venom serine proteinases. Structure 6 (1998) 1195-1206
33. Sasa M. Diet and snake venom evolution: can local selection alone explain intraspecific venom variation?. Toxicon 37 (1999) 249-252
34. Zhang Y., Wisner A., Maroun R.C., Choumet V., Xiong Y., and Bon C. Trimeresurus stejnegeri snake venom plasminogen activator. Site directed mutagenesis and molecular modeling. J. Biol. Chem. 272 (1997) 20531-20537
35. Wang Y.-M., Wang S.-R., and Tsai I.-H. Serine proteinase isoforms of Deinagkistrodon acutus venom: cloning, sequencing and phylogenetic analysis. Biochem. J. 354 (2001) 161-168
36. Serrano M.T., and Maroun R.C. Snake venom serine proteinases: sequence homology vs. substrate specificity, a paradox to be solved. Toxicon 45 (2005) 1115-1132
37. Maroun R.C. Molecular basis for the partition of the essential functions of thrombin among snake venom serine proteinases. Haemostasis 31 (2001) 247-256
38. Deshimaru M., Ogawa T., Nakashima K., Nobuhisa I., Chijiwa T., Shimohigashi Y., Fukumaki Y., Niwa M., Yamashina I., Hattori S., and Ohno M. Accelerated evolution of crotaline snake venom gland serine proteases. FEBS Lett. 397 (1996) 83-88
39. Magalhaes A., Da Fonseca B.B.C., Diniz C.R., Gilroy J., and Richardson M. The complete amino acid sequence of a thrombin-like enzyme/gyroxin analogue from venom of the bushmaster snake (Lachesis muta muta). FEBS Lett. 329 (1993) 116-120
40. Harrison R.A., Wüster W., and Theakston R.D.G. The conserved structure of snake venom toxins confers extensive immunological cross-reactivity to toxin-specific antibody. Toxicon 41 (2003) 441-449
41. Pennica D., Holmes W.E., Kor W.J., Harkins R.N., Vehar G.A., Ward C.A., Bennett W.F., Yelverton E., Seeburg P.H., Heyneker H.L., Goeddel D.V., and Collen D. Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli. Nature 301 (1983) 214-221