Poly-Thymidine oligonucleotides mediate activation of murine glial cells primarily through TLR7, not TLR8

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Du, Min ^a   Butchi, Niranjan B ^a   Woods, Tyson ^a   Peterson, Karin E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10; MONOCYTE CHEMOTACTIC PROTEIN 1; OLIGONUCLEOTIDE; POLYTHYMIDINE OLIGONUCLEOTIDE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; UNCLASSIFIED DRUG; CL 075; CYTOKINE; MEMBRANE PROTEIN; MESSENGER RNA; POLYTHYMIDYLIC ACID; QUINOLINE DERIVATIVE; THIAZOLE DERIVATIVE; TLR7 PROTEIN, MOUSE; TLR8 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GLIA CELL; MICROGLIA; MOUSE; NERVE CELL CULTURE; NERVE CELL STIMULATION; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; BRAIN CORTEX; C57BL MOUSE; CELL SHAPE; CYTOLOGY; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; ENDOCYTOSIS; ENDOSOME; GENETICS; GLIA; METABOLISM; UPREGULATION;

MURINAE; VACCINIA VIRUS;

ANIMALS; CELL SHAPE; CEREBRAL CORTEX; CYTOKINES; DOWN-REGULATION; ENDOCYTOSIS; ENDOSOMES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; NEUROGLIA; OLIGONUCLEOTIDES; POLY T; QUINOLINES; RNA, MESSENGER; THIAZOLES; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8; UP-REGULATION;

EID: 79960621061     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022454     Document Type: Article

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