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Volumn 155, Issue 2, 2011, Pages 114-121

Will cell reprogramming resolve the embryonic stem cell controversy? a narrative review

Author keywords

[No Author keywords available]

Indexed keywords

KRUPPEL LIKE FACTOR 4; LENTIVIRUS VECTOR; MYC PROTEIN; RETROVIRUS VECTOR;

EID: 79960607693     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/0003-4819-155-2-201107190-00007     Document Type: Review
Times cited : (18)

References (80)
  • 2
    • 33845315254 scopus 로고    scopus 로고
    • Human embryonic stem cells: A journey beyond cell replacement therapies
    • Menendez P, Bueno C, Wang L. Human embryonic stem cells: a journey beyond cell replacement therapies. Cytotherapy. 2006;8:530-41.
    • (2006) Cytotherapy , vol.8 , pp. 530-541
    • Menendez, P.1    Bueno, C.2    Wang, L.3
  • 3
    • 79960613817 scopus 로고    scopus 로고
    • Nuclear cloning, embryonic stem cells, and gene transfer
    • In: Rasko JE, O'Sullivan G, Ankeny RA, eds., Cambridge, UK: Cambridge Univ Pr
    • Jaenisch R. Nuclear cloning, embryonic stem cells, and gene transfer. In: Rasko JE, O'Sullivan G, Ankeny RA, eds. The Ethics of Inheritable Genetic Modification: A Dividing Line? Cambridge, UK: Cambridge Univ Pr; 2006:35-55.
    • (2006) The Ethics of Inheritable Genetic Modification: A Dividing Line , pp. 35-55
    • Jaenisch, R.1
  • 5
    • 39449113141 scopus 로고    scopus 로고
    • Development of human cloned blastocysts following somatic cell nuclear transfer with adult fibroblasts
    • French AJ, Adams CA, Anderson LS, Kitchen JR, Hughes MR, Wood SH. Development of human cloned blastocysts following somatic cell nuclear transfer with adult fibroblasts. Stem Cells. 2008;26:485-93.
    • (2008) Stem Cells , vol.26 , pp. 485-493
    • French, A.J.1    Adams, C.A.2    Anderson, L.S.3    Kitchen, J.R.4    Hughes, M.R.5    Wood, S.H.6
  • 6
    • 62349130208 scopus 로고    scopus 로고
    • Human embryos derived by somatic cell nuclear transfer using an alternative enucleation approach
    • Li J, Liu X, Wang H, Zhang S, Liu F, Wang X, et al. Human embryos derived by somatic cell nuclear transfer using an alternative enucleation approach. Cloning Stem Cells. 2009;11:39-50.
    • (2009) Cloning Stem Cells , vol.11 , pp. 39-50
    • Li, J.1    Liu, X.2    Wang, H.3    Zhang, S.4    Liu, F.5    Wang, X.6
  • 7
    • 79960611427 scopus 로고    scopus 로고
    • The Hinxton Group, on 14 March 2011
    • The Hinxton Group. World stem cell policies. Accessed at www.hinxtongroup.org/wp.html on 14 March 2011.
    • World Stem Cell Policies
  • 8
    • 77954923316 scopus 로고    scopus 로고
    • Embryo stem cell research: Ten years of controversy
    • Robertson JA. Embryo stem cell research: ten years of controversy. J Law Med Ethics. 2010;38:191-203.
    • (2010) J Law Med Ethics , vol.38 , pp. 191-203
    • Robertson, J.A.1
  • 9
    • 33747606516 scopus 로고    scopus 로고
    • The White House; Bush GW, Press release]. 9 August 2001, on 14 March 2011
    • The White House; Bush GW. President discusses stem cell research [Press release]. 9 August 2001. Accessed at http://georgewbush-whitehouse.archives.gov/news/releases/2001/08/20010809-2.html on 14 March 2011.
    • President Discusses Stem Cell Research
  • 11
    • 79960615984 scopus 로고    scopus 로고
    • Supp. 2d 63 (D. DC 2010)
    • Sherley et al. v. Sebelius et al, 704 F. Supp. 2d 63 (D. DC 2010).
    • (2010) V. Sebelius Et Al , vol.704
    • Sherley1
  • 12
    • 77956320527 scopus 로고    scopus 로고
    • Stem-cell work thrown into limbo
    • Wadman M. Stem-cell work thrown into limbo. Nature. 2010;467:12-3.
    • (2010) Nature , vol.467 , pp. 12-13
    • Wadman, M.1
  • 13
    • 84861138990 scopus 로고    scopus 로고
    • US stem-cell funding ban overturned
    • Wadman M. US stem-cell funding ban overturned. Nature. 2011;473:15.
    • (2011) Nature , vol.473 , pp. 15
    • Wadman, M.1
  • 14
    • 79960577996 scopus 로고    scopus 로고
    • Alternative sources of human pluri-potent stem cells
    • The President's Council on Bioethics, Washington, DC: U.S. Department of Health and Human Services, on 14 March 2011
    • The President's Council on Bioethics. Alternative sources of human pluri-potent stem cells. White paper. Washington, DC: U.S. Department of Health and Human Services; 2005. Accessed at http://bioethics.georgetown.edu/pcbe/reports/white_paper/alternative_sources_white_paper.pdf on 14 March 2011.
    • (2005) White Paper
  • 15
    • 39449104790 scopus 로고    scopus 로고
    • Alternative sources of pluripotent stem cells: Scientific solutions to an ethical dilemma
    • Rao M, Condic ML. Alternative sources of pluripotent stem cells: scientific solutions to an ethical dilemma. Stem Cells Dev. 2008;17:1-10.
    • (2008) Stem Cells Dev , vol.17 , pp. 1-10
    • Rao, M.1    Condic, M.L.2
  • 16
    • 45049084038 scopus 로고    scopus 로고
    • Alternative sources of pluripotency: Science, ethics, and stem cells
    • Kastenberg ZJ, Odorico JS. Alternative sources of pluripotency: science, ethics, and stem cells. Transplant Rev (Orlando). 2008;22:215-22.
    • (2008) Transplant Rev (Orlando) , vol.22 , pp. 215-222
    • Kastenberg, Z.J.1    Odorico, J.S.2
  • 17
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663-76.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 18
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861-72.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6
  • 20
    • 38049187707 scopus 로고    scopus 로고
    • Repro-gramming of human somatic cells to pluripotency with defined factors
    • Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, et al. Repro-gramming of human somatic cells to pluripotency with defined factors. Nature. 2008;451:141-6.
    • (2008) Nature , vol.451 , pp. 141-146
    • Park, I.H.1    Zhao, R.2    West, J.A.3    Yabuuchi, A.4    Huo, H.5    Ince, T.A.6
  • 21
    • 84891991691 scopus 로고    scopus 로고
    • The White House, [Press release]. 20 Novemeber 2007, on 14 March 2011
    • The White House: Bush GW. Statement by the press secretary [Press release]. 20 Novemeber 2007. Accessed at http://georgewbush-whitehouse.archives.gov/news/releases/2007/11/20071120-5.html on 14 March 2011.
    • Statement By the Press Secretary
    • Bush, G.W.1
  • 22
    • 65549115150 scopus 로고    scopus 로고
    • Generation of retinal cells from mouse and human induced pluripotent stem cells
    • Hirami Y, Osakada F, Takahashi K, Okita K, Yamanaka S, Ikeda H, et al. Generation of retinal cells from mouse and human induced pluripotent stem cells. Neurosci Lett. 2009;458:126-31.
    • (2009) Neurosci Lett , vol.458 , pp. 126-131
    • Hirami, Y.1    Osakada, F.2    Takahashi, K.3    Okita, K.4    Yamanaka, S.5    Ikeda, H.6
  • 23
  • 24
    • 67650095306 scopus 로고    scopus 로고
    • Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells
    • Raya A, Rodríguez-Piza I, Guenechea G, Vassena R, Navarro S, Barrero MJ, et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature. 2009;460:53-9.
    • (2009) Nature , vol.460 , pp. 53-59
    • Raya, A.1    Rodríguez-Piza, I.2    Guenechea, G.3    Vassena, R.4    Navarro, S.5    Barrero, M.J.6
  • 26
    • 57649128308 scopus 로고    scopus 로고
    • Generation of insulin-secreting islet-like clusters from human skin fibroblasts
    • Tateishi K, He J, Taranova O, Liang G, D'Alessio AC, Zhang Y. Generation of insulin-secreting islet-like clusters from human skin fibroblasts. J Biol Chem. 2008;283:31601-7.
    • (2008) J Biol Chem , vol.283 , pp. 31601-31607
    • Tateishi, K.1    He, J.2    Taranova, O.3    Liang, G.4    D'alessio, A.C.5    Zhang, Y.6
  • 28
    • 0037299046 scopus 로고    scopus 로고
    • Transdifferentiation: An attractive concept in search of evidence [Editorial]
    • Rasko JE. Transdifferentiation: an attractive concept in search of evidence [Editorial]. Pathology. 2003;35:5.
    • (2003) Pathology , vol.35 , pp. 5
    • Rasko, J.E.1
  • 29
    • 79952054299 scopus 로고    scopus 로고
    • Proceedings of a symposium
    • Law, science, and innovation, Austin, Texas, USA
    • Law, science, and innovation. Proceedings of a symposium. May 2009. Austin, Texas, USA. J Law Med Ethics. 2010;38:175-440.
    • (2009) J Law Med Ethics. 2010;38 , pp. 175-440
  • 30
    • 79952219919 scopus 로고    scopus 로고
    • Single cell transcriptional profiling reveals heterogeneity of human induced plu-ripotent stem cells
    • Narsinh KH, Sun N, Sanchez-Freire V, Lee AS, Almeida P, Hu S, et al. Single cell transcriptional profiling reveals heterogeneity of human induced plu-ripotent stem cells. J Clin Invest. 2011;121:1217-21.
    • (2011) J Clin Invest , vol.121 , pp. 1217-1221
    • Narsinh, K.H.1    Sun, N.2    Sanchez-Freire, V.3    Lee, A.S.4    Almeida, P.5    Hu, S.6
  • 31
    • 77749279749 scopus 로고    scopus 로고
    • Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency
    • Hu BY, Weick JP, Yu J, Ma LX, Zhang XQ, Thomson JA, et al. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc Natl Acad Sci U S A. 2010;107:4335-40.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 4335-4340
    • Hu, B.Y.1    Weick, J.P.2    Yu, J.3    Ma, L.X.4    Zhang, X.Q.5    Thomson, J.A.6
  • 32
    • 77950995392 scopus 로고    scopus 로고
    • Heman-gioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence
    • Feng Q, Lu SJ, Klimanskaya I, Gomes I, Kim D, Chung Y, et al. Heman-gioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence. Stem Cells. 2010;28:704-12.
    • (2010) Stem Cells , vol.28 , pp. 704-712
    • Feng, Q.1    Lu, S.J.2    Klimanskaya, I.3    Gomes, I.4    Kim, D.5    Chung, Y.6
  • 33
    • 77956214743 scopus 로고    scopus 로고
    • Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells
    • Urbach A, Bar-Nur O, Daley GQ, Benvenisty N. Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell Stem Cell. 2010;6:407-11.
    • (2010) Cell Stem Cell , vol.6 , pp. 407-411
    • Urbach, A.1    Bar-Nur, O.2    Daley, G.Q.3    Benvenisty, N.4
  • 34
    • 69349089552 scopus 로고    scopus 로고
    • Differentiation stage determines potential of hematopoietic cells for repro-gramming into induced pluripotent stem cells
    • Eminli S, Foudi A, Stadtfeld M, Maherali N, Ahfeldt T, Mostoslavsky G, et al. Differentiation stage determines potential of hematopoietic cells for repro-gramming into induced pluripotent stem cells. Nat Genet. 2009;41:968-76.
    • (2009) Nat Genet , vol.41 , pp. 968-976
    • Eminli, S.1    Foudi, A.2    Stadtfeld, M.3    Maherali, N.4    Ahfeldt, T.5    Mostoslavsky, G.6
  • 36
    • 77955449906 scopus 로고    scopus 로고
    • Epigenetic memory in induced pluripotent stem cells
    • Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, et al. Epigenetic memory in induced pluripotent stem cells. Nature. 2010;467:285-90.
    • (2010) Nature , vol.467 , pp. 285-290
    • Kim, K.1    Doi, A.2    Wen, B.3    Ng, K.4    Zhao, R.5    Cahan, P.6
  • 37
    • 78650752402 scopus 로고    scopus 로고
    • Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
    • Polo JM, Liu S, Figueroa ME, Kulalert W, Eminli S, Tan KY, et al. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol. 2010;28:848-55.
    • (2010) Nat Biotechnol , vol.28 , pp. 848-855
    • Polo, J.M.1    Liu, S.2    Figueroa, M.E.3    Kulalert, W.4    Eminli, S.5    Tan, K.Y.6
  • 39
    • 65649116572 scopus 로고    scopus 로고
    • Human induced pluripotent stem cells free of vector and transgene sequences
    • Yu J, Hu K, Smuga-Otto K, Tian S, Stewart R, Slukvin II, et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science. 2009;324:797-801.
    • (2009) Science , vol.324 , pp. 797-801
    • Yu, J.1    Hu, K.2    Smuga-Otto, K.3    Tian, S.4    Stewart, R.5    Slukvin, I.I.6
  • 40
    • 79953826088 scopus 로고    scopus 로고
    • Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells
    • Hu K, Yu J, Suknuntha K, Tian S, Montgomery K, Choi KD, et al. Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells. Blood. 2011; 117:e109-19.
    • (2011) Blood , vol.117
    • Hu, K.1    Yu, J.2    Suknuntha, K.3    Tian, S.4    Montgomery, K.5    Choi, K.D.6
  • 41
    • 66049135249 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cells using recombinant proteins
    • Zhou H, Wu S, Joo JY, Zhu S, Han DW, Lin T, et al. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell. 2009; 4:381-4.
    • (2009) Cell Stem Cell , vol.4 , pp. 381-384
    • Zhou, H.1    Wu, S.2    Joo, J.Y.3    Zhu, S.4    Han, D.W.5    Lin, T.6
  • 42
    • 66049143859 scopus 로고    scopus 로고
    • Generation of human induced pluripotent stem cells by direct delivery of repro-gramming proteins
    • Kim D, Kim CH, Moon JI, Chung YG, Chang MY, Han BS, et al. Generation of human induced pluripotent stem cells by direct delivery of repro-gramming proteins. Cell Stem Cell. 2009;4:472-6.
    • (2009) Cell Stem Cell , vol.4 , pp. 472-476
    • Kim, D.1    Kim, C.H.2    Moon, J.I.3    Chung, Y.G.4    Chang, M.Y.5    Han, B.S.6
  • 43
    • 77958536106 scopus 로고    scopus 로고
    • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
    • Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell. 2010;7:618-30.
    • (2010) Cell Stem Cell , vol.7 , pp. 618-630
    • Warren, L.1    Manos, P.D.2    Ahfeldt, T.3    Loh, Y.H.4    Li, H.5    Lau, F.6
  • 46
    • 34848817130 scopus 로고    scopus 로고
    • New advances in iPS cell research do not obviate the need for human embryonic stem cells [Letter]
    • Hyun I, Hochedlinger K, Jaenisch R, Yamanaka S. New advances in iPS cell research do not obviate the need for human embryonic stem cells [Letter]. Cell Stem Cell. 2007;1:367-8.
    • (2007) Cell Stem Cell , vol.1 , pp. 367-368
    • Hyun, I.1    Hochedlinger, K.2    Jaenisch, R.3    Yamanaka, S.4
  • 47
    • 79960597747 scopus 로고    scopus 로고
    • Presented at World Stem Cell 2008 Summit, Madison, Wisconsin, 22-23 September 2008, on 14 March 2011
    • Thomson J. Keynote presentation: Reprogramming-a new vision for creating patient specific cells. Presented at World Stem Cell 2008 Summit, Madison, Wisconsin, 22-23 September 2008. Accessed at http://gpi.fullviewmedia.com/world-stem-cell-summit/html/03_Reprogramming-A-New-Vision-for-Creating-Patient-Specifc-Cells.html on 14 March 2011.
    • Keynote Presentation: Reprogramming-a New Vision For Creating Patient Specific Cells
    • Thomson, J.1
  • 48
    • 84925835354 scopus 로고    scopus 로고
    • Cell biology. A seismic shift for stem cell research
    • Holden C, Vogel G. Cell biology. A seismic shift for stem cell research. Science. 2008;319:560-3.
    • (2008) Science , vol.319 , pp. 560-563
    • Holden, C.1    Vogel, G.2
  • 49
    • 78650971216 scopus 로고    scopus 로고
    • Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture
    • Laurent LC, Ulitsky I, Slavin I, Tran H, Schork A, Morey R, et al. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell. 2011;8:106-18.
    • (2011) Cell Stem Cell , vol.8 , pp. 106-118
    • Laurent, L.C.1    Ulitsky, I.2    Slavin, I.3    Tran, H.4    Schork, A.5    Morey, R.6
  • 50
    • 79952261648 scopus 로고    scopus 로고
    • Stem cells: The dark side of induced pluripotency
    • Pera MF. Stem cells: the dark side of induced pluripotency. Nature. 2011; 471:46-7.
    • (2011) Nature , vol.471 , pp. 46-47
    • Pera, M.F.1
  • 51
    • 65249166946 scopus 로고    scopus 로고
    • Moral complicity in induced pluripotent stem cell research
    • Brown MT. Moral complicity in induced pluripotent stem cell research. Kennedy Inst Ethics J. 2009;19:1-22.
    • (2009) Kennedy Inst Ethics J , vol.19 , pp. 1-22
    • Brown, M.T.1
  • 52
    • 39449131243 scopus 로고    scopus 로고
    • Stem cells from skin cells: The ethical questions
    • Hyun I. Stem cells from skin cells: the ethical questions. Hastings Cent Rep. 2008;38:20-2.
    • (2008) Hastings Cent Rep , vol.38 , pp. 20-22
    • Hyun, I.1
  • 53
    • 44349144442 scopus 로고    scopus 로고
    • Human stem cell ethics: Beyond the embryo
    • Sugarman J. Human stem cell ethics: beyond the embryo. Cell Stem Cell. 2008;2:529-33.
    • (2008) Cell Stem Cell , vol.2 , pp. 529-533
    • Sugarman, J.1
  • 54
    • 61349127907 scopus 로고    scopus 로고
    • Obtaining consent for future research with induced pluripotent cells: Opportunities and challenges
    • Aalto-Setala K, Conklin BR, Lo B. Obtaining consent for future research with induced pluripotent cells: opportunities and challenges. PLoS Biol. 2009;7: e42.
    • (2009) PLoS Biol , vol.e42 , pp. 7
    • Aalto-Setala, K.1    Conklin, B.R.2    Lo, B.3
  • 55
    • 70349604814 scopus 로고    scopus 로고
    • Emerging ethical, legal and social issues associated with stem cell research and the current role of the moral status of the embryo
    • Zarzeczny A, Caulfield T. Emerging ethical, legal and social issues associated with stem cell research and the current role of the moral status of the embryo. Stem Cell Rev. 2009;5:96-101.
    • (2009) Stem Cell Rev , vol.5 , pp. 96-101
    • Zarzeczny, A.1    Caulfield, T.2
  • 56
    • 70349332754 scopus 로고    scopus 로고
    • Gold standards in the diamond age: The commodification of pluripotency
    • Sipp D. Gold standards in the diamond age: the commodification of pluripotency. Cell Stem Cell. 2009;5:360-3.
    • (2009) Cell Stem Cell , vol.5 , pp. 360-363
    • Sipp, D.1
  • 57
    • 41349116799 scopus 로고    scopus 로고
    • Stem cells: 5 things to know before jumping on the iPS bandwagon
    • Cyranoski D. Stem cells: 5 things to know before jumping on the iPS bandwagon. Nature. 2008;452:406-8.
    • (2008) Nature , vol.452 , pp. 406-408
    • Cyranoski, D.1
  • 59
    • 33845322280 scopus 로고    scopus 로고
    • Embryonic stem cells as a potential source of gametes
    • Ko K, Scholer HR. Embryonic stem cells as a potential source of gametes. Semin Reprod Med. 2006;24:322-9.
    • (2006) Semin Reprod Med , vol.24 , pp. 322-329
    • Ko, K.1    Scholer, H.R.2
  • 60
    • 65649126708 scopus 로고    scopus 로고
    • Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells
    • Park TS, Galic Z, Conway AE, Lindgren A, van Handel BJ, Magnusson M, et al. Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells. Stem Cells. 2009;27:783-95.
    • (2009) Stem Cells , vol.27 , pp. 783-795
    • Park, T.S.1    Galic, Z.2    Conway, A.E.3    Lindgren, A.4    van Handel, B.J.5    Magnusson, M.6
  • 61
    • 70449651657 scopus 로고    scopus 로고
    • Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation
    • Kee K, Angeles VT, Flores M, Nguyen HN, Reijo Pera RA. Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation. Nature. 2009;462:222-5.
    • (2009) Nature , vol.462 , pp. 222-225
    • Kee, K.1    Angeles, V.T.2    Flores, M.3    Nguyen, H.N.4    Reijo Pera, R.A.5
  • 62
    • 0346562866 scopus 로고    scopus 로고
    • Derivation of embryonic germ cells and male gametes from embryonic stem cells
    • Geijsen N, Horoschak M, Kim K, Gribnau J, Eggan K, Daley GQ. Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature. 2004;427:148-54.
    • (2004) Nature , vol.427 , pp. 148-154
    • Geijsen, N.1    Horoschak, M.2    Kim, K.3    Gribnau, J.4    Eggan, K.5    Daley, G.Q.6
  • 64
    • 33745499559 scopus 로고    scopus 로고
    • In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice
    • Nayernia K, Nolte J, Michelmann HW, Lee JH, Rathsack K, Drusen-heimer N, et al. In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice. Dev Cell. 2006;11:125-32.
    • (2006) Dev Cell , vol.11 , pp. 125-132
    • Nayernia, K.1    Nolte, J.2    Michelmann, H.W.3    Lee, J.H.4    Rathsack, K.5    Drusen-Heimer, N.6
  • 66
    • 67449138828 scopus 로고    scopus 로고
    • Science, ethics and policy challenges of pluripotent stem cell-derived gametes
    • The Hinxton Group
    • The Hinxton Group. Science, ethics and policy challenges of pluripotent stem cell-derived gametes. Rev Derecho Genoma Hum. 2008;29:219-22.
    • (2008) Rev Derecho Genoma Hum , vol.29 , pp. 219-222
  • 67
    • 79960618694 scopus 로고    scopus 로고
    • The National Archives. Human Fertilisation and Embryology Act 2008, on 14 March 2011
    • The National Archives. Human Fertilisation and Embryology Act 2008. Statute c. 22. Accessed at www.legislation.gov.uk/ukpga/2008/22/contents on 14 March 2011.
    • Statute C , pp. 22
  • 68
    • 79960615983 scopus 로고    scopus 로고
    • The Hinxton Group, Updated November 2009, on 14 March 2011
    • The Hinxton Group. United States: Current Legislation. Updated November 2009. Accessed at www.hinxtongroup.org/usa_map.html on 14 March 2011.
    • United States: Current Legislation
  • 69
    • 78149361499 scopus 로고    scopus 로고
    • Ethical aspects of the use of stem cell derived gametes for reproduction
    • Mertes H, Pennings G. Ethical aspects of the use of stem cell derived gametes for reproduction. Health Care Anal. 2010;18:267-78.
    • (2010) Health Care Anal , vol.18 , pp. 267-278
    • Mertes, H.1    Pennings, G.2
  • 70
    • 55249118425 scopus 로고    scopus 로고
    • Designer babies: Choosing our children's genes
    • Steinbock B. Designer babies: choosing our children's genes. Lancet. 2008; 372:1294-5.
    • (2008) Lancet , vol.372 , pp. 1294-1295
    • Steinbock, B.1
  • 72
    • 33947534506 scopus 로고    scopus 로고
    • Stem cells to gametes: How far should we go?
    • Whittaker P. Stem cells to gametes: how far should we go? Hum Fertil (Camb). 2007;10:1-5.
    • (2007) Hum Fertil (Camb) , vol.10 , pp. 1-5
    • Whittaker, P.1
  • 73
  • 74
    • 67849133023 scopus 로고    scopus 로고
    • IPS cells can support full-term development of tetraploid blastocyst-complemented embryos
    • Kang L, Wang J, Zhang Y, Kou Z, Gao S. IPS cells can support full-term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell. 2009;5:135-8.
    • (2009) Cell Stem Cell , vol.5 , pp. 135-138
    • Kang, L.1    Wang, J.2    Zhang, Y.3    Kou, Z.4    Gao, S.5
  • 75
    • 69949089630 scopus 로고    scopus 로고
    • IPS cells produce viable mice through tetraploid complementation
    • Zhao XY, Li W, Lv Z, Liu L, Tong M, Hai T, et al. IPS cells produce viable mice through tetraploid complementation. Nature. 2009;461:86-90.
    • (2009) Nature , vol.461 , pp. 86-90
    • Zhao, X.Y.1    Li, W.2    Lv, Z.3    Liu, L.4    Tong, M.5    Hai, T.6
  • 76
    • 48749109906 scopus 로고    scopus 로고
    • Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts
    • Mali P, Ye Z, Hommond HH, Yu X, Lin J, Chen G, et al. Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts. Stem Cells. 2008;26:1998-2005.
    • (2008) Stem Cells , vol.26 , pp. 1998-2005
    • Mali, P.1    Ye, Z.2    Hommond, H.H.3    Yu, X.4    Lin, J.5    Chen, G.6
  • 77
    • 65249121330 scopus 로고    scopus 로고
    • Ontological and ethical implications of direct nuclear reprogramming
    • Magill G, Neaves WB. Ontological and ethical implications of direct nuclear reprogramming. Kennedy Inst Ethics J. 2009;19:23-32.
    • (2009) Kennedy Inst Ethics J , vol.19 , pp. 23-32
    • Magill, G.1    Neaves, W.B.2
  • 78
    • 67651204314 scopus 로고    scopus 로고
    • Ontological and ethical implications of direct nuclear reprogramming: Response to Magill and Neaves
    • Condic ML, Lee P, George RP. Ontological and ethical implications of direct nuclear reprogramming: response to Magill and Neaves. Kennedy Inst Ethics J. 2009;19:33-40.
    • (2009) Kennedy Inst Ethics J , vol.19 , pp. 33-40
    • Condic, M.L.1    Lee, P.2    George, R.P.3
  • 79
    • 73849142666 scopus 로고    scopus 로고
    • To be, or not to be? Are induced pluripotent stem cells potential babies, and does it matter
    • Devolder K. To be, or not to be? Are induced pluripotent stem cells potential babies, and does it matter? EMBO Rep. 2009;10:1285-7.
    • (2009) EMBO Rep , vol.10 , pp. 1285-1287
    • Devolder, K.1
  • 80
    • 73449083422 scopus 로고    scopus 로고
    • Moral status revisited: The challenge of reversed potency
    • Baertschi B, Mauron A. Moral status revisited: the challenge of reversed potency. Bioethics. 2010;24:96-103.
    • (2010) Bioethics , vol.24 , pp. 96-103
    • Baertschi, B.1    Mauron, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.