메뉴 건너뛰기




Volumn 108, Issue 27, 2011, Pages 11046-11051

Structural contributions to multidrug recognition in the multidrug resistance (MDR) gene regulator, BmrR

Author keywords

Ligand binding; Ligand responsive transcription factor; Molecular recognition; Multidrug resistance; Multispecificity

Indexed keywords

BACTERIAL PROTEIN; MULTIDRUG RESISTANCE PROTEIN; PROTEIN BMRR; UNCLASSIFIED DRUG;

EID: 79960578420     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1104850108     Document Type: Article
Times cited : (35)

References (43)
  • 1
    • 65249146929 scopus 로고    scopus 로고
    • Multidrug resistance in bacteria
    • Nikaido H (2009) Multidrug resistance in bacteria. Annu Rev Biochem 78:119-146.
    • (2009) Annu Rev Biochem , vol.78 , pp. 119-146
    • Nikaido, H.1
  • 2
    • 34147214716 scopus 로고    scopus 로고
    • Multiple molecular mechanisms for multidrug resistance transporters
    • Higgins CF (2007) Multiple molecular mechanisms for multidrug resistance transporters. Nature 446:749-757.
    • (2007) Nature , vol.446 , pp. 749-757
    • Higgins, C.F.1
  • 4
    • 73649111071 scopus 로고    scopus 로고
    • Understanding polyspecificity of multidrug ABC transporters: Closing in on the gaps in ABCB1
    • Gutmann DA, Ward A, Urbatsch IL, Chang G, van Veen HW (2010) Understanding polyspecificity of multidrug ABC transporters: Closing in on the gaps in ABCB1. Trends Biochem Sci 35:36-42.
    • (2010) Trends Biochem Sci , vol.35 , pp. 36-42
    • Gutmann, D.A.1    Ward, A.2    Urbatsch, I.L.3    Chang, G.4    Van Veen, H.W.5
  • 6
    • 0035905808 scopus 로고    scopus 로고
    • Crystal structure of the transcription activator BmrR bound to DNA and a drug
    • DOI 10.1038/35053138
    • Heldwein EE, Brennan RG (2001) Crystal structure of the transcription activator BmrR bound to DNA and a drug. Nature 409:378-382. (Pubitemid 32151247)
    • (2001) Nature , vol.409 , Issue.6818 , pp. 378-382
    • Zheleznova, H.E.E.1    Brennan, R.G.2
  • 8
  • 9
    • 0038670226 scopus 로고    scopus 로고
    • Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump
    • DOI 10.1126/science.1083137
    • Yu EW, McDermott G, Zgurskaya HI, Nikaido H, Koshland DE (2003) Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science 300:976-980. (Pubitemid 36548884)
    • (2003) Science , vol.300 , Issue.5621 , pp. 976-980
    • Yu, E.W.1    McDermott, G.2    Zgurskaya, H.I.3    Nikaido, H.4    Koshland Jr., D.E.5
  • 10
    • 63449139456 scopus 로고    scopus 로고
    • Structure of P-glycoprotein reveals a molecular basis for polyspecific drug binding
    • Aller SG, et al. (2009) Structure of P-glycoprotein reveals a molecular basis for polyspecific drug binding. Science 323:1718-1722.
    • (2009) Science , vol.323 , pp. 1718-1722
    • Aller, S.G.1
  • 11
    • 0028104421 scopus 로고
    • A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates
    • Ahmed M, Borsch CM, Taylor SS, Vazquez-Laslop N, Neyfakh AA (1994) A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates. J Biol Chem 269:28506-28513. (Pubitemid 24354599)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.45 , pp. 28506-28513
    • Ahmed, M.1    Borsch, C.M.2    Taylor, S.S.3    Vazquez-Laslop, N.4    Neyfakh, A.A.5
  • 12
    • 2442452545 scopus 로고    scopus 로고
    • The Structural Mechanism for Transcription Activation by MerR Family Member Multidrug Transporter Activation, N Terminus
    • DOI 10.1074/jbc.M400960200
    • Newberry KJ, Brennan RG (2004) The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus. J Biol Chem 279:20356-20362. (Pubitemid 38623481)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.19 , pp. 20356-20362
    • Newberry, K.J.1    Brennan, R.G.2
  • 13
    • 55549108388 scopus 로고    scopus 로고
    • Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through Tyrosine expulsion
    • Newberry KJ, et al. (2008) Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through Tyrosine expulsion. J Biol Chem 283:26795-26804.
    • (2008) J Biol Chem , vol.283 , pp. 26795-26804
    • Newberry, K.J.1
  • 14
    • 77955981791 scopus 로고    scopus 로고
    • MD recognition by MDR gene regulators
    • Wade H (2010) MD recognition by MDR gene regulators. Curr Opin Struct Biol 20:489-496.
    • (2010) Curr Opin Struct Biol , vol.20 , pp. 489-496
    • Wade, H.1
  • 15
    • 3543012707 scopus 로고    scopus 로고
    • Crystallography & NMR system: A new software suite for macromolecular structure determination
    • Brunger AT, et al. (1998) Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr 54:905-921.
    • (1998) Acta Crystallogr D Biol Crystallogr , vol.54 , pp. 905-921
    • Brunger, A.T.1
  • 16
    • 0030841590 scopus 로고    scopus 로고
    • Collaborative Computational Project, number 4: Providing programs for protein crystallography
    • Dodson EJ, Winn M, Ralph A (1997) Collaborative Computational Project, number 4: Providing programs for protein crystallography. Methods Enzymol 277:620-633.
    • (1997) Methods Enzymol , vol.277 , pp. 620-633
    • Dodson, E.J.1    Winn, M.2    Ralph, A.3
  • 17
    • 76449098262 scopus 로고    scopus 로고
    • PHENIX: A comprehensive Python-based system for macromolecular structure solution
    • Adams PD, et al. (2010) PHENIX: A comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr 66:213-221.
    • (2010) Acta Crystallogr D Biol Crystallogr , vol.66 , pp. 213-221
    • Adams, P.D.1
  • 18
    • 0027772959 scopus 로고
    • Shape complementarity at protein/protein interfaces
    • DOI 10.1006/jmbi.1993.1648
    • Lawrence MC, Colman PM (1993) Shape complementarity at protein/protein interfaces. J Mol Biol 234:946-950. (Pubitemid 24027225)
    • (1993) Journal of Molecular Biology , vol.234 , Issue.4 , pp. 946-950
    • Lawrence, M.C.1    Colman, P.M.2
  • 20
    • 0038103565 scopus 로고    scopus 로고
    • X-ray snapshots of the maturation of an antibody response to a protein antigen
    • DOI 10.1038/nsb930
    • Li Y, Li H, Yang F, Smith-Gill SJ, Mariuzza RA (2003) X-ray snapshots of the maturation of an antibody response to a protein antigen. Nat Struct Biol 10:482-488. (Pubitemid 36637647)
    • (2003) Nature Structural Biology , vol.10 , Issue.6 , pp. 482-488
    • Li, Y.1    Li, H.2    Yang, F.3    Smith-Gill, S.J.4    Mariuzza, R.A.5
  • 21
    • 33748499821 scopus 로고    scopus 로고
    • Promiscuity in multidrug recognition and transport: The bacterial MFS Mdr transporters
    • DOI 10.1111/j.1365-2958.2006.05254.x
    • Lewinson O, Adler J, Sigal N, Bibi E (2006) Promiscuity in multidrug recognition and transport: The bacterial MFS Mdr transporters. Mol Microbiol 61:277-284. (Pubitemid 44356562)
    • (2006) Molecular Microbiology , vol.61 , Issue.2 , pp. 277-284
    • Lewinson, O.1    Adler, J.2    Sigal, N.3    Bibi, E.4
  • 22
    • 70350072949 scopus 로고    scopus 로고
    • Biochemical characterization of the multidrug regulator QacR distinguishes residues that are crucial to multidrug binding and induction of qacA transcription
    • Peters KM, Sharbeen G, Theis T, Skurray RA, Brown MH (2009) Biochemical characterization of the multidrug regulator QacR distinguishes residues that are crucial to multidrug binding and induction of qacA transcription. Biochemistry 48:9794-9800.
    • (2009) Biochemistry , vol.48 , pp. 9794-9800
    • Peters, K.M.1    Sharbeen, G.2    Theis, T.3    Skurray, R.A.4    Brown, M.H.5
  • 23
    • 4143103793 scopus 로고    scopus 로고
    • Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein
    • DOI 10.1038/sj.emboj.7600288
    • Schumacher MA, Miller MC, Brennan RG (2004) Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein. EMBO J 23:2923-2930. (Pubitemid 39093587)
    • (2004) EMBO Journal , vol.23 , Issue.15 , pp. 2923-2930
    • Schumacher, M.A.1    Miller, M.C.2    Brennan, R.G.3
  • 24
    • 0025275610 scopus 로고
    • On the nature of antibody combining sites: Unusual structural features that may confer on these sites an enhanced capacity for binding ligands
    • Padlan EA (1990) On the nature of antibody combining sites: Unusual structural features that may confer on these sites an enhanced capacity for binding ligands. Proteins 7:112-124.
    • (1990) Proteins , vol.7 , pp. 112-124
    • Padlan, E.A.1
  • 28
    • 77953591801 scopus 로고    scopus 로고
    • The functional capacity of the natural amino acids for molecular recognition
    • Birtalan S, Fisher RD, Sidhu SS (2010) The functional capacity of the natural amino acids for molecular recognition. Mol Biosyst 6:1186-1194.
    • (2010) Mol Biosyst , vol.6 , pp. 1186-1194
    • Birtalan, S.1    Fisher, R.D.2    Sidhu, S.S.3
  • 29
    • 0017187836 scopus 로고
    • Nature of accessible and buried surfaces in proteins
    • Chothia C (1976) Nature of accessible and buried surfaces in proteins. J Mol Biol 105:1-14.
    • (1976) J Mol Biol , vol.105 , pp. 1-14
    • Chothia, C.1
  • 30
    • 0026416668 scopus 로고
    • Reconciling the magnitude of the microscopic and macroscopic hydrophobic effects
    • Sharp KA, Nicholls A, Fine RF, Honig B (1991) Reconciling the magnitude of the microscopic and macroscopic hydrophobic effects. Science 252:106-109. (Pubitemid 21916946)
    • (1991) Science , vol.252 , Issue.5002 , pp. 106-109
    • Sharp, K.A.1    Nicholls, A.2    Fine, R.F.3    Honig, B.4
  • 31
    • 37249004920 scopus 로고    scopus 로고
    • Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
    • DOI 10.1038/nature06526, PII NATURE06526
    • Wells JA, McClendon CL (2007) Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 450:1001-1009. (Pubitemid 350273630)
    • (2007) Nature , vol.450 , Issue.7172 , pp. 1001-1009
    • Wells, J.A.1    McClendon, C.L.2
  • 33
    • 34447548576 scopus 로고    scopus 로고
    • Ligand efficiency indices for effective drug discovery
    • Abad-Zapatero C (2007) Ligand efficiency indices for effective drug discovery. Expert Opin Drug Discov 2:469-488.
    • (2007) Expert Opin Drug Discov , vol.2 , pp. 469-488
    • Abad-Zapatero, C.1
  • 36
    • 33645959824 scopus 로고    scopus 로고
    • Multiple paths to multispecificity
    • Mariuzza RA (2006) Multiple paths to multispecificity. Immunity 24:359-361.
    • (2006) Immunity , vol.24 , pp. 359-361
    • Mariuzza, R.A.1
  • 37
    • 13044272912 scopus 로고    scopus 로고
    • Automated analysis of interatomic contacts in proteins
    • DOI 10.1093/bioinformatics/15.4.327
    • Sobolev V, Sorokine A, Prilusky J, Abola EE, Edelman M (1999) Automated analysis of interatomic contacts in proteins. Bioinformatics 15:327-332. (Pubitemid 29213759)
    • (1999) Bioinformatics , vol.15 , Issue.4 , pp. 327-332
    • Sobolev, V.1    Sorokine, A.2    Prilusky, J.3    Abola, E.E.4    Edelman, M.5
  • 38
    • 0028922586 scopus 로고
    • LIGPLOT: A program to generate schematic diagrams of protein-ligand interactions
    • Wallace AC, Laskowski RA, Thornton JM (1995) LIGPLOT: A program to generate schematic diagrams of protein-ligand interactions. Protein Eng 8:127-134.
    • (1995) Protein Eng , vol.8 , pp. 127-134
    • Wallace, A.C.1    Laskowski, R.A.2    Thornton, J.M.3
  • 41
    • 0041989751 scopus 로고    scopus 로고
    • CASTp: Computed Atlas of Surface Topography of proteins
    • DOI 10.1093/nar/gkg512
    • Binkowski TA, Naghibzadeh S, Liang J (2003) CASTp: Computed atlas of surface topography of proteins. Nucleic Acids Res 31:3352-3355. (Pubitemid 37442157)
    • (2003) Nucleic Acids Research , vol.31 , Issue.13 , pp. 3352-3355
    • Binkowski, T.A.1    Naghibzadeh, S.2    Liang, J.3
  • 43
    • 3242886389 scopus 로고    scopus 로고
    • MOLPROBITY: Structure validation and all-atom contact analysis for nucleic acids and their complexes
    • Davis IW, Murray LW, Richardson JS, Richardson DC (2004) MOLPROBITY: Structure validation and all-atom contact analysis for nucleic acids and their complexes. Nucleic Acids Res 32:W615-619.
    • (2004) Nucleic Acids Res , vol.32
    • Davis, I.W.1    Murray, L.W.2    Richardson, J.S.3    Richardson, D.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.