Discovery of selective indole-based prostaglandin D2 receptor antagonist

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 15, 2011, Pages 4574-4588

  Iwahashi, Maki ^a   Shimabukuro, Atsushi ^a   Onoda, Takahiro ^a   Matsunaga, Yoko ^a   Okada, Yutaka ^a   Matsumoto, Ryoji ^a   Nambu, Fumio ^a   Nakai, Hisao ^a   Toda, Masaaki ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Antagonist; DP receptor; Indole; Prostaglandin

Indexed keywords

(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHYL 4 METHYLBENZENESULFONATE; 2 CHLORO 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOIC ACID; 2 CHLORO 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL CHLORIDE; 2 FLUORO 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOIC ACID; 2 FLUORO 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL CHLORIDE; 2 METHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOIC ACID; 2 METHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL CHLORIDE; 3 CHLORO 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOIC ACID; 3 CHLORO 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL CHLORIDE; 3 FLUORO 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOIC ACID; 3 FLUORO 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL CHLORIDE; 3 METHOXY 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOIC ACID; 3 METHOXY 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL CHLORIDE; 3 METHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOIC ACID; 3 METHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL CHLORIDE; 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOIC ACID; 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL CHLORIDE; INDOLE DERIVATIVE; METHYL 2 CHLORO 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOATE; METHYL 2 FLUORO 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOATE; METHYL 2 METHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOATE; METHYL 3 CHLORO 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOATE; METHYL 3 FLUORO 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOATE; METHYL 3 METHOXY 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOATE; METHYL 3 METHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOATE; METHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOATE; PROSTAGLANDIN D2; PROSTAGLANDIN D2 RECEPTOR BLOCKING AGENT; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACYLATION; ALKYLATION; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD VESSEL PERMEABILITY; CARBON NUCLEAR MAGNETIC RESONANCE; CONJUNCTIVA; CONTROLLED STUDY; CRYSTALLIZATION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGENATION; HYDROLYSIS; NONHUMAN; PROCESS OPTIMIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CAPILLARY PERMEABILITY; CHO CELLS; CONJUNCTIVA; CRICETINAE; CRICETULUS; DRUG DISCOVERY; GUINEA PIGS; HUMANS; INDOLES; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN;

CAVIA;

EID: 79960558645     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.014     Document Type: Article

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