Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H- carbazole as pharmacophore

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 24, 2010, Pages 7462-7465

  Li, Lianhai ^a,b   Beaulieu, Christian ^a   Carriere, Marie Claude ^a   Denis, Danielle ^a   Greig, Gillian ^a   Guay, Daniel ^a   O'Neill, Gary ^a   Zamboni, Robert ^a   Wang, Zhaoyin ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b NONE   (Canada)

Author keywords

Antagonist; DP1 receptor; Selectivity

Indexed keywords

1,2,3,4 TETRAHYDROCARBAZOLE DERIVATIVE; PROSTAGLANDIN D2 RECEPTOR; PROSTAGLANDIN D2 RECEPTOR ANTAGONIST; PROSTAGLANDIN RECEPTOR; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; THROMBOXANE A2 RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; LIGAND BINDING; PHARMACOPHORE;

CARBAZOLES; HUMANS; PROTEIN BINDING; RECEPTORS, PROSTAGLANDIN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 78449300334     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.018     Document Type: Article

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